Study of the pathomechanism in the prion infection
| Project/Area Number |
18209031
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
KITAMOTO Tetsuyuki Tohoku University, 大学院・医学系研究科, 教授 (20192560)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥48,880,000 (Direct Cost: ¥37,600,000、Indirect Cost: ¥11,280,000)
Fiscal Year 2008: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2007: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2006: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
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| Keywords | 遺伝子 / 感染症 / 神経科学 / 痴呆 / プリオン / 神経化学 |
|---|
| Research Abstract |
プリオン感染に関してその感染源を特定できる方法として、トレースバック現象を見いだし報告した。また、このトレースバック現象を利用して、従来感染源が不明であった硬膜移植後CJD with plaques(dCJD/PLと略す)の感染源が孤発性CJDのVV2であることを証明し、またMV2も感染源になりうることを学術論文として報告した。dCJD/PLの感染源を特定したのは世界初である。
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Coexistence of Creutzfeldt-Jakob disease, Lewy body disease, and Alzheimer's disease pathology : An autopsy case showing typical clinical features of Creutzfeldt-Jakob disease2009
Author(s)
Haraguchi T, Terada S, Ishizu H, Sakai K, Tanabe Y, Nagai T, Takata H, Nobukuni K, Ihara Y, Kitamoto T, Kuroda S.
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Journal Title
Neuropathology (in press)
NAID
Related Report
Peer Reviewed
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[Journal Article] Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution2007
Author(s)
Shiga Y, Satoh K, Kitamoto T, Kanno S, Nakashima I, Sato S, Fujihara K, Takata H, Nobukuni K, Kuroda S, Takano H, Umeda Y, Konno H, Nagasato K, Satoh A, Matsuda Y, Hidaka M, Takahashi H, Sano Y, Kim K, Konishi T, Doh-ura K, Sato T, Sasaki K, Nakamura Y, Yamada M, Mizusawa H, Itoyama Y
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Journal Title
J Neurol 254(11)
Pages: 1509-1517
Related Report
Peer Reviewed
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[Journal Article] Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution.2007
Author(s)
Shiga Y, Satoh K, Kitamoto T, Kanno S, Nakashima I, Sato S, Fujihara K, Takata H, Nobukuni K, Kuroda S, Takano H, Umeda Y, Konno H, Nagasato K, Satoh A, Matsuda Y, Hidaka M, Takahashi H, Sano Y, Kim K, Konishi T, Doh-Ura K, Sato T, Sasaki K, Nakamura Y, Yamada M,Mizusawa H,Itoyama Y.
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Journal Title
J Neurol. 254
Pages: 1509-1517
Related Report
Peer Reviewed
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