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Study of the pathomechanism in the prion infection

Research Project

Project/Area Number 18209031
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionTohoku University

Principal Investigator

KITAMOTO Tetsuyuki  Tohoku University, 大学院・医学系研究科, 教授 (20192560)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥48,880,000 (Direct Cost: ¥37,600,000、Indirect Cost: ¥11,280,000)
Fiscal Year 2008: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2007: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2006: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Keywords遺伝子 / 感染症 / 神経科学 / 痴呆 / プリオン / 神経化学
Research Abstract

プリオン感染に関してその感染源を特定できる方法として、トレースバック現象を見いだし報告した。また、このトレースバック現象を利用して、従来感染源が不明であった硬膜移植後CJD with plaques(dCJD/PLと略す)の感染源が孤発性CJDのVV2であることを証明し、またMV2も感染源になりうることを学術論文として報告した。dCJD/PLの感染源を特定したのは世界初である。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (48 results)

All 2009 2008 2007 2006

All Journal Article (48 results) (of which Peer Reviewed: 36 results)

  • [Journal Article] The number of octapeptide repeat affects the expression and conversion of prion protein2009

    • Author(s)
      Hiraga C, Kobayashi A, Kitamoto T
    • Journal Title

      Biochem Biophys Res Commun (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human PrP219K is converted to PrPSc but shows heterozygous inhibition in vCJD infection2009

    • Author(s)
      Hizume M, Kobayashi A, Teruya K, Ohashi H, Ironside JW, Mohri S, Kitamoto T
    • Journal Title

      J Biol Chem 284

      Pages: 3603-3609

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Yamada M Medical procedures and risk for sporadic Creutzfeldt-Jakob disease, Japan, 1999-20082009

    • Author(s)
      Hamaguchi T, Noguchi-Shinohara M, Nozaki I, Nakamura Y, Sato T, Kitamoto T, Mizusawa H
    • Journal Title

      Emerg Infect Dis. 15

      Pages: 265-271

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heterozygous inhibition in prion infection The stone fence model2009

    • Author(s)
      Kobayashi A, Hizume M, Teruya K, Mohri S, Kitamoto T
    • Journal Title

      Prion 3

      Pages: 1-4

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coexistence of Creutzfeldt-Jakob disease, Lewy body disease, and Alzheimer's disease pathology : An autopsy case showing typical clinical features of Creutzfeldt-Jakob disease2009

    • Author(s)
      Haraguchi T, Terada S, Ishizu H, Sakai K, Tanabe Y, Nagai T, Takata H, Nobukuni K, Ihara Y, Kitamoto T, Kuroda S.
    • Journal Title

      Neuropathology (in press)

    • NAID

      10028191795

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Medical procedures and risk for sporadic Creutzfeldt-Jakob disease, Japan, 1999-20082009

    • Author(s)
      Hamaguchi T, Noguchi-Shinohara M, Nozaki I, Nakamura Y, Sato T, Kitamoto T, Mizusawa H, Yamada M
    • Journal Title

      Emerg Infect Dis 15

      Pages: 265-71

    • NAID

      120002104596

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The number of octapeptide repeat affects the expression and conversion of prion protein2009

    • Author(s)
      Hiraga C, Kobayashi A, Kitamoto T.
    • Journal Title

      Biochem Biophys Res Commun (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterozygous inhibition in prion infection-The stone fence model2009

    • Author(s)
      Kobayashi A, Hizume M, Teruya K, Mohri S, Kitamoto T
    • Journal Title

      Prion 3

      Pages: 1-4

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thr but Asn of the N-glycosylation sites of PrP is indispensable for its misfolding2008

    • Author(s)
      Ikeda s, kobayashi A, Kitamoto T
    • Journal Title

      Biochem Biophys Res Commun 369(4)

      Pages: 1195-1198

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathologic characteristics of five autopsied cases of dura mater-associated Creutzfeldt-Jakob disease2008

    • Author(s)
      Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Kitamoto T, Sobue G
    • Journal Title

      Neuropathology 28(1)

      Pages: 51-61

    • NAID

      10025824159

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MM1-type sporadic Creutzfeldt-Jakob disease with unusually prolonged disease duration presenting with panencephalopathic-type pathology2008

    • Author(s)
      Hoshino A, Iwasaki Y, Izumi M, Kimura S, Ibi T, Kitamoto T, Yoshida M, Hashizume Y, Sahashi K
    • Journal Title

      Neuropathology 28(3)

      Pages: 326-332

    • NAID

      10029319665

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MM2-cortical-type sporadic Creutzfeldt-Jakob disease with early stage cerebral cortical pathology presenting with a rapidly progressive clinical course2008

    • Author(s)
      Niimi Y, Iwasaki Y, Umemura T, Tranaka F, Yoshida M, Hashizume Y, Kitamoto T, Hirayama M, Sobue G
    • Journal Title

      Neuropathology 28(6)

      Pages: 645-651

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plaque-type deposition of prion protein in the damaged white matter of sporadic Creutzfeldt-Jakob disease MM1 patients2008

    • Author(s)
      Kobayashi A, Arima K, Ogawa M, Murata M, Fukuda T, Kitamoto T
    • Journal Title

      Acta Neuropathol 116(5)

      Pages: 561-566

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thr but Asn of the N-glycosylation sites of PrP is dispensable for its misfolding2008

    • Author(s)
      Ikeda S, Kobayashi A, Kitamoto T
    • Journal Title

      Biochem Biophys Res Commun 369

      Pages: 1195-1198

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathologic characteristics of five autopsied cases of duramater-associated Creutzfeldt-Jakob disease2008

    • Author(s)
      Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Kitamoto T, Sobue G.
    • Journal Title

      Neuropathology 28(1)

      Pages: 51-61

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MM1-type sporadic Creutzfeldt-Jakob disease with unusually prolonged disease duration presenting with panencephalopathic-type pathology2008

    • Author(s)
      Hoshino A, Iwasaki Y, Izumi M, Kimura S, Ibi T, Kitamoto T, Yoshida M, Hashizume Y, Sahashi K.
    • Journal Title

      Neuropathology 28(3)

      Pages: 326-332

    • NAID

      10029319665

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thr but Asn of the N-glycosylation sites of PrP is indispensable for its misfolding2008

    • Author(s)
      Ikeda S, Kobayashi A, Kitamoto T.
    • Journal Title

      Biochem Biophys Res Commun 364(9)

      Pages: 1195-1198

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MM2-cortical-type sporadic Creutzfeldt-Jakob disease with early stage cerebral cortical pathology presenting with a rapidly progressive clinical course2008

    • Author(s)
      Niimi Y, Iwasaki Y, Umemura T, Tanaka F, Yoshida M, Hashizume Y, Kitamoto T, Hirayama M, Sobue G.
    • Journal Title

      Neuropathology 28(6)

      Pages: 645-651

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plaque-type deposition of prion protein in the damaged white matter of sporadic Creutzfeldt-Jakob disease MM1 patients2008

    • Author(s)
      Kobayashi A, Arima K, Ogawa M, Murata M, Fukuda T, Kitamoto T.
    • Journal Title

      Acta Neuropathol 116(5)

      Pages: 561-566

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human PrP 219K is converted to PrPsc but shows heterozygous inhibition in vCJD infection2008

    • Author(s)
      Hizume M, Kobayashi A, Teruya K, Ohashi H, Ironside J W, Mohri S, and Kitamoto T.
    • Journal Title

      J. Biol. Chem 284

      Pages: 3603-3609

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution2007

    • Author(s)
      Shiga Y, Satoh K, Kitamoto T, Kanno S, Nakashima I, Sato S, Fujihara K, Takata H, Nobukuni K, Kuroda S, Takano H, Umeda Y, Konno H, Nagasato K, Satoh A, Matsuda Y, Hidaka M, Takahashi H, Sano Y, Kim K, Konishi T, Doh-ura K, Sato T, Sasaki K, Nakamura Y, Yamada M, Mizusawa H, Itoyama Y
    • Journal Title

      J Neurol 254(11)

      Pages: 1509-1517

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Aquaporin-4 immunoreactivity in sporadic Creutzfeldt-Jakob disease2007

    • Author(s)
      Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Ito M, Kitamoto T, Wakayama Y, Sobue G
    • Journal Title

      Neuropathology 27

      Pages: 314-323

    • NAID

      10021235965

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a new prion strain2007

    • Author(s)
      Kobayashi A, Asano M, Mohri S, Kitamoto T
    • Journal Title

      J Biol Chem 282

      Pages: 30022-30028

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features and diagnosis of dura mater graft associatedCreutzfeldt Jakob disease2007

    • Author(s)
      Noguchi-Shinohara M, Hamaguchi T, Kitamoto T, Sato T, Nakamura Y,Mizusawa H, Yamada M
    • Journal Title

      Neurology 69(4)

      Pages: 360-367

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amyloid precursor protein cytoplasmic domainwithphospho-Thr668accumulates inAlzheimer's disease and its transgenic models : a role tomediate interaction of Abeta and tau2007

    • Author(s)
      Shin RW, Ogino K, Shimabuku A, Taki T, Nakashima H, Ishihara T, KitamotoT
    • Journal Title

      Acta Neuropathol(Berl) 113(6)

      Pages: 627-636

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ophthalmic surgery in prion diseases2007

    • Author(s)
      Hamaguchi T, Noguchi-Shinohara M, Nakamura Y, Sato T, KitamotoT,Mizusawa H, Yamada M
    • Journal Title

      Emerg Infect Dis 13(1)

      Pages: 162-164

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thr but Asn of the N-glycosylation sites of PrP is indispensable for its misfolding.2007

    • Author(s)
      Ikeda S Kobayashi A, Kitamoto T
    • Journal Title

      Biochem Biophys Res Commun 369

      Pages: 1195-1198

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution.2007

    • Author(s)
      Shiga Y, Satoh K, Kitamoto T, Kanno S, Nakashima I, Sato S, Fujihara K, Takata H, Nobukuni K, Kuroda S, Takano H, Umeda Y, Konno H, Nagasato K, Satoh A, Matsuda Y, Hidaka M, Takahashi H, Sano Y, Kim K, Konishi T, Doh-Ura K, Sato T, Sasaki K, Nakamura Y, Yamada M,Mizusawa H,Itoyama Y.
    • Journal Title

      J Neurol. 254

      Pages: 1509-1517

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Aquaporin-4 immunoreactivity in sporadic Creutzfeldt-Jakob disease.2007

    • Author(s)
      Iwasaki Y, Mimuro M, Yoshida M, Hashizume Y, Ito M, Kitamoto T, Wakayama Y, Sobue G.
    • Journal Title

      Neuropathology. 27

      Pages: 314-323

    • NAID

      10021235965

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a new prion strain.2007

    • Author(s)
      Kobayashi A, Asano M, Mohri S, Kitamoto T.
    • Journal Title

      J Biol Chem 282

      Pages: 30022-30028

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ophthalmic surgery in prion diseases.2007

    • Author(s)
      Hamaguchi T, oguchi-Shinohara M, Nakamura Y, Sato T, Kitamoto T, Mizusawa H, Yamada M.
    • Journal Title

      Emerg Infect Dis 13

      Pages: 162-164

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Amyloid precursor protein cytoplasmic domain with phospho- Th668 accumulates in Alzheimer's disease and its transgenic models: a role tomediate interaction of A beta and tau.2007

    • Author(s)
      Shin RW, Ogino K, Shimabuku A, Taki T, Nakashima H, Ishihara T, Kitamoto T.
    • Journal Title

      Acta Neuropathol 113

      Pages: 627-636

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Clinical features and diagnosis of dura mater graft associated Creutz feldt Jakob disease2007

    • Author(s)
      Noguchi-Shinohara M, Hamaguchi T, Kitamoto T, Sato T, Nakamura Y, Mizusawa H, Yamada M.
    • Journal Title

      Neurology 69

      Pages: 360-367

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Autopsy case of sporadic Creutzfeldt-Jakob disease presenting with signs suggestive of brainstem and spinal cord involvement2006

    • Author(s)
      Iwasaki Y, Iijima M, Kimura S, Yoshida M, Hashizume Y, Yamada M, Kitamoto T, sobue G
    • Journal Title

      Neuropathology 26(6)

      Pages: 550-556

    • NAID

      10019264481

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathologic characteristics of sporadic Japanese Creutzfeldt-Jakob disease classified according to prion protein gene polymorphism and prion protein type2006

    • Author(s)
      Iwasaki Y, Yoshida M, Hashizume Y, Kitamoto T, Sobue
    • Journal Title

      Acta Neuropathol(Berl) 112(5)

      Pages: 561-571

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MM2-thalamic-type sporadic Creutzfeldt-Jakob disease with widespread neocortical pathology2006

    • Author(s)
      Hirose K, Iwasaki Y, Izumi M, Yoshida M, Hashizume Y, Kitamoto T, Sahashi K
    • Journal Title

      Acta Neuropathol(Berl) 112(4)

      Pages: 503-511

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Severe cortical involvement in MV2 Creutzfeldt-Jakob disease : an autopsy case report2006

    • Author(s)
      Ishihara K, Sugie M, Shiota J, Kawamura M, Kitamoto T, Nakano I
    • Journal Title

      Neuropathology 26(5)

      Pages: 433-437

    • NAID

      10019264032

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The MM2-cortical form of sporadic Creutzfeldt-Jakob disease presenting with visual disturbance2006

    • Author(s)
      Nozaki I, Hamaguchi T, Noguchi-Shimohara M, Ono k, Shirasaki H, Komai K, Kitamoto T, Yamada M
    • Journal Title

      Neurology 67(3)

      Pages: 531-3

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autopsy case of Creutzfeldt-Jakob disease with Met/Val heterozygosity at codon 129 and type 1 protease-resistant prion protein presenting some florid-type plaques and many Kuru plaques in the cerebellum2006

    • Author(s)
      Kawauchi Y, Kamitani T, Yagishita S, Kitamoto T, Kishida H
    • Journal Title

      Neuropathology 26(4)

      Pages: 313-317

    • NAID

      10018059032

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] vCJD prion acquires altered virulence through trans -species infection2006

    • Author(s)
      Asano M
    • Journal Title

      Biochem Biophys Res Commun 342(1)

      Pages: 293-299

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Increased asymmetric pulvinar magnetic resonance imaging signals in Creutzfeldt-Jakob disease with florid plaques following a cadaveric dura mater graft.2006

    • Author(s)
      Wakisaka Y
    • Journal Title

      Neuropathology 26(1)

      Pages: 82-88

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The first Japanese case of variant Creutzfeldt-Jakob disease showing periodic electroencephalogram.2006

    • Author(s)
      Yamada M
    • Journal Title

      Lancet 367(9513)

      Pages: 874-874

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The MM2-cortical form of sporadic Creutzfeldt-Jakob disease presenting with visual disturbance.2006

    • Author(s)
      Nozaki I
    • Journal Title

      Neurology 67(3)

      Pages: 531-533

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clinicopathologic characteristics of sporadic Japanese Creutzfeldt-Jakob disease classified according to prion protein gene polymorphism and prion protein type.2006

    • Author(s)
      Iwasaki Y
    • Journal Title

      Acta Neuropathol (Berl) 112(5)

      Pages: 561-571

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Autopsy case of Creutzfeldt-Jakob disease with Met/Val heterozygosity at codon 129 and type 1 protease-resistant prion protein presenting some florid-type plaques and many Kuru plaques in the cerebellum.2006

    • Author(s)
      Kawauchi Y
    • Journal Title

      Neuropathology 26(4)

      Pages: 313-317

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MM2-thalamic-type sporadic Creutzfeldt-Jakob disease with widespread neocortical pathology2006

    • Author(s)
      Hirose K
    • Journal Title

      Acta Neuropathol (Berl) 112(4)

      Pages: 503-511

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Autopsy case of sporadic Creutzfeldt-Jakob disease presenting with signs suggestive of brainstem and spinal cord involvement.2006

    • Author(s)
      Iwasaki Y
    • Journal Title

      Neuropathology 26(6)

      Pages: 550-556

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Severe cortical involvement in MV2 Creutzfeldt-Jakob disease : an autopsy case report2006

    • Author(s)
      Ishihara K
    • Journal Title

      Neuropathology 26(5)

      Pages: 433-437

    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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