Development of Artificial Trachea with the use of in situ Tissue Engineering
Project/Area Number |
18209044
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Thoracic surgery
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Research Institution | Kyoto University |
Principal Investigator |
NAKAMURA Tatsuo Kyoto University, 再生医科学研究所, 准教授 (70227908)
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Co-Investigator(Kenkyū-buntansha) |
IWATA Hiroo 京都大学, 再生医科学研究所, 教授 (30160120)
TSUTSUMI Sadami 京都大学, 再生医科学研究所, 教授 (00028739)
TAKIGAWA Toshikazu 京都大学, 工学(系)研究科(研究院), 教授 (50201603)
|
Co-Investigator(Renkei-kenkyūsha) |
IWATA Hiroo 京都大学, 再生医科学研究所, 教授 (30160120)
TAKIGAWA Toshikazu 京都大学, 工学(系)研究科(研究院), 教授 (50201603)
|
Project Period (FY) |
2006 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥49,270,000 (Direct Cost: ¥37,900,000、Indirect Cost: ¥11,370,000)
Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2007: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2006: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
|
Keywords | 人工気管 / 再生医学 / 組織工学 / コラーゲン / バイオマテリアル / 気道再建 |
Research Abstract |
生体内で自己組織を再生させるというin situ Tissue Engineeringの手法を用いて、臨床応用可能で安全な人工気管の開発を行った。気道を支える軟骨に相応する部分は非吸収性のポリプロピレンステントを用いた自己組織再生型の人工気管を改良し、これをビーグル犬で効能と安全性を評価することにより、性能の向上に直結する技術革新につながった。
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Report
(4 results)
Research Products
(117 results)
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[Journal Article] In situ Tissue Engineering of the cricoid and trachea in a canine mode2008
Author(s)
Omori, K., Nakamura, T., Kanemaru, S., Magrufov, A., Yamashita, M., Shimizu, Y.
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Journal Title
Ann Otol Rhinol Laryngol 117
Pages: 609-13
Related Report
Peer Reviewed
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[Journal Article] Clinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea2008
Author(s)
Omori, K., Tada, Y., Suzuki, T., Nomoto, Y., Matsuzuka, T., Kobayashi, K., Nakamura, T., Kanemaru, S., Yamashita, M., Asato, R.
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Journal Title
Ann Otol Rhinol Laryngol 117
Pages: 673-8
Related Report
Peer Reviewed
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[Journal Article] Expression of extracellular matrix proteins in the vocal folds and bone marrow derived stromal cells of rats2008
Author(s)
Ohno, T., Hirano, S., Kanemaru, S., Yamashita, M., Umeda, H., Suehiro, A., Nakamura, T., Ito, J.
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Journal Title
Eur Arch Otorhinolaryngol 265
Pages: 669-674
Related Report
Peer Reviewed
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[Journal Article] Replacement of the left main bronchus with a Tissue-Engineered prosthesis in a canine model2008
Author(s)
Sato, T., Tao, H., Araki, M., Ueda, H., Omori, K., Nakamura, T.
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Journal Title
Ann Thorac Surg 86
Pages: 422-428
Related Report
Peer Reviewed
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[Journal Article] Effect of fibroblasts on epithelial regeneration on the surface of a bioengineered trachea2008
Author(s)
Nomoto, Y., Koayashi, K., Tada, Y., Wada, I., Nakamura, T., Omori, K.
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Journal Title
Ann Otol Rhinol Laryngol 117
Pages: 59-64
Related Report
Peer Reviewed
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[Journal Article] A regenerative approach for partial tracheal defects, an in vivo canine model2008
Author(s)
Yamashita, M., Kanemaru, S., Hirano, S., Tamura, Y., Umeda, H., Ohno, T., Suehiro, A., Omori, K., Nakamura, T., Ito, J.
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Journal Title
Inflammation and Regeneration 27
Pages: 570-574
NAID
Related Report
Peer Reviewed
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[Journal Article] Tracheal regeneration after partial resection : A tissue engineering approach2007
Author(s)
Yamashita, M., Kanemaru, S., Hirano, S., Magrufov, A., Tamaki, H., Tamura, Y., Kishimoto, M., Omori, K., Nakamura, T., Ito, J.
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Journal Title
Laryngoscope 117
Pages: 497-502
Related Report
Peer Reviewed
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[Journal Article] Experimental regeneration of canine larynx : a trial with tissue engineering techniques2007
Author(s)
Yamashita, M., Omori, K., Kanemaru, S., Magrufov, A., Tamura,Y., Umeda, H., Kishimoto, M., Nakamura, T., Ito, J.
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Journal Title
Acta Otolaryngol 557
Pages: 66-72
Related Report
Peer Reviewed
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[Journal Article] Experimental repair of phrenic nerve using a polyglycolic acid and collagen tube2007
Author(s)
Yoshitani, M, Fukuda, S., Itoi, S., Morino, S., Tao, H., Nakada, A., Inada, Y., Endo, K., Nakamura, T.
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Journal Title
J Thorac Cardiovasc Surg 133
Pages: 726-32
Related Report
Peer Reviewed
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[Journal Article] Cranial bone regeneration using a composite scaffold of beta-tricalcium phosphate, collagen, and autologous bone fragments2006
Author(s)
Kishimoto, M., Kanemaru, S., Yamashita, M., Nakamura, T., Tamura, Y., Tamaki, H., Omori, K., Ito, J.
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Journal Title
Laryngoscope 116
Pages: 212-216
Related Report
Peer Reviewed
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[Journal Article] Effect of fibroblasts on tracheal epithelial regeneration in vitro2006
Author(s)
Kobayashi, K., Nomoto, Y., Suzuki, T., Tada, Y., Miyake, M., Hazama, A., Kanemaru, S., Nakamura, T., Omori, K.
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Journal Title
Tissue Eng 12
Pages: 2619-28
Related Report
Peer Reviewed
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[Journal Article] Bronchoscopic treatment of postpneumonectomy bronchopleural fistula with a collagen screw plug2006
Author(s)
Tao, H., Araki, M., Sato, T., Morino, S., Kawanami, R., Yoshitani, M., Nakamura, T.
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Journal Title
J Thorac Cardiovasc Surg 132
Pages: 99-104
Related Report
Peer Reviewed
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[Journal Article] Tissue engineering of small intestinal tissue using collagen sponge scaffolds seeded with smooth muscle cells2006
Author(s)
Nakase, Y., Hagiwara, A., Nakamura, T., Kin, S., Nakashima, S., Yoshikawa, T., Fukuda, K., Kuriu, Y., Miyagawa, K., Sakakura, C., Otsuji, E., Shimizu, Y., Ikada, Y., Yamagishi, H.
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Journal Title
Tissue Eng 12
Pages: 403-412
Related Report
Peer Reviewed
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[Journal Article] Tissue Engineering for regeneration of the tracheal epithelium2006
Author(s)
Nomoto, Y., Suzuki, T., Tada, Y., Kobayashi, K., Miyake, M., Hazama, A., Wada, I., Kanemaru, S., Nakamura, T., Omori, K.
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Journal Title
Ann Otol Rhinol Laryngol 115
Pages: 501-6
Related Report
Peer Reviewed
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[Journal Article] Noninvasive assessment of pulmonary emphysema using dynamic contrast-enhanced magnetic resonance imaging2006
Author(s)
Morino, S., Toba, T., Araki, M., Azuma, T., Tsutsumi, S., Tao, H., Nakamura, T., Nagayasu, T., Tagawa, T.
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Journal Title
Exp Lung Res 32
Pages: 55-67
Related Report
Peer Reviewed
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[Journal Article] In situ Tissue Engineering for the tracheal reconstruction using a luminar-remodeling type of artificial trachea
Author(s)
Nakamura, T., Sato, T., Araki, M., Ichihara, S., Nakada, A., Yoshitani, M., Itoi, S., Yamashit, M., Kanemaru, S., Omori, K., Hori, Y., Endo, K., Inada, Y., Hayyakawa, K.
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Journal Title
The Journal of Thoracic and Cardiovascular Surgery (in press)
Related Report
Peer Reviewed
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[Journal Article] Development of a new tissue-engineered sheet for reconstruction of the stomach
Author(s)
Araki, M., Tao, H., Sato, T., Nakajima, N., Nagayasu, T. , Nakamura, T.
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Journal Title
Related Report
Peer Reviewed
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[Presentation] Application of in situ Tissue Engineering for artificial trachea. American Society for Artificial Internal Organs2008
Author(s)
Nakamura, T., Nakada, A., Sato, T., Araki, M., Ichihara, S., Shigeno, K., Inada, Y., Endo, K.
Organizer
54^<th> Annual Conference
Place of Presentation
San Francisco
Related Report
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[Presentation] New surgical approach for COPD: Covering lung with an elastic net2008
Author(s)
Sato, T., Sakai, H., Hamakawa, H., Takahashi, A., Date, H., Nakamura, T.
Organizer
American Thoracic Society International Conference
Place of Presentation
Toronto, Canada
Related Report
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[Presentation] Hepatocyto growth factor dyug delivery system for the treatment of vocal fold scarring in a canine model2007
Author(s)
Ohno, T., Hirano, S., Kanemaru, S., Tamura, Y., Yamashita, M., Umeda, H., Suehiro, A., Nakamura, T., Ito, J.
Organizer
The 2007 annual meeting of the American Broncho-Esophagological Association
Place of Presentation
San Diego
Year and Date
2007-04-27
Related Report
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[Presentation] The behavior of the autologous bone marrow derived stromal cells implantation in the vocal fold on healing process2007
Author(s)
Kanemaru, S., Nakamura, T., Yamashita, M., Umeda, H., Ohno, T., Hirano, S., Ito, J., Omori, K
Organizer
The 2007 annual meeting of the American Broncho-EsophagoAssociation
Place of Presentation
San Diego
Year and Date
2007-04-27
Related Report
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[Presentation] The Destiny and the behavio of the autologous bone marrow derived stromal cells implanted into the vocal fold2007
Author(s)
Kanemaru, S., Yamashita, M., Umeda, H., Ohno, T., Suehiro, A., Hirano, S., Omori, K., Nakamura, T., Ito, J.
Organizer
COB symposium 2007
Place of Presentation
Kobe
Year and Date
2007-03-26
Related Report
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[Presentation] Tissue engineered canine cranial bone regeneration with the concept of guided bone regeneration2007
Author(s)
Umeda, H., Kanemaru, S., Yamashita, M., Suehiro, A., Tamura, Y., Hirano, S., Nakamura, T., Omori, K., Ito, J.
Organizer
2007 TERMIS-EU Meeting
Place of Presentation
London
Related Report
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[Presentation] Behavior of implanted bone narrow derived stromal cells2007
Author(s)
Kanemaru, S., Yamashita, M., Umeda, H., Ohno, T., Suehiro, A., Hirano, S., Tamura, Y., Omori, K., Nakamura, T., Ito, J.
Organizer
2007 TERMIS-EU Meeting
Place of Presentation
London
Related Report
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[Presentation] An artificial nerve(biodegradable nerve guide tube)and peripheral nerve regeneration. American Society for Artificial Internal Organs,2007
Author(s)
Nakamura, T., Ichihara, S., Nakada, A., Satoh, T., Itoi, S., Shigeno, K., Kanemaru, S., Inada, Y., Fujikawa, T., Moroi, K., Endo, K.
Organizer
53^<nd> Annval Conflence
Place of Presentation
Chicago
Related Report
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[Presentation] Clinical application of in situ tissue engineering for the laryngeal and tracheal tissue2006
Author(s)
Omori, K., Tada, Y., Suzuki, T., Nomoto, Y., Nakamura, T., Kanemaru, S., Yamashita, M., Asato, R.
Organizer
127^<th> AmLaryngological Association
Place of Presentation
Chicago
Related Report
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[Presentation] Tissue engineered regeneration of recurrent laryngeal nerve by two types of artificial nerev conduits2006
Author(s)
Kanemaru, S., Yamashita, M., Magrufov, A., Umeda, H., Tamura, T., Omori,K., Nakamura, T., Ito, J.
Organizer
127^<th> American Laryngological Association
Place of Presentation
Chicago
Related Report
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