| Co-Investigator(Kenkyū-buntansha) |
庄野 禎久 九州大学, 大学院・医学研究院脳神経外科学, 准教授 (00346793)
溝口 昌弘 九州大学, 大学病院脳神経外科学, 講師 (50380621)
宮城 靖 九州大学, デジタルメディシンイニシアティブ, 准教授 (10380403)
前田 善久 九州大学, 大学病院, 助手 (30380455)
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| Budget Amount *help |
¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2006: ¥28,730,000 (Direct Cost: ¥22,100,000、Indirect Cost: ¥6,630,000)
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| Research Abstract |
The expression of PAR-1 was up-regulated and the contractile response to thrombin was markedly enhanced in the cerebral artery of rabbit subarachnoid hemorrhage (SAH) model. The intrathecal administration of a PAR-1 antagonist prevented the up-regulation of PAR-1 and the enhancement of the contractile responses to thrombin after SAH. Following SAH, thrombin activates PAR-1, thereby up-regulating the expression of PAR-1, which culminates in the increased contractile response to thrombin in the rabbit cerebral artery. The up-regulation of the receptor expression and the enhancement of the agonist-induced contraction were observed in various G protein-coupled receptors and these agonists.
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