Research of the Molecular Network Regulating Endochondral Ossification

• Project/Area Number: 18209047
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: KAWAGUCHI Hiroshi The University of Tokyo, 医学部附属病院, 准教授 (40282660)
• Co-Investigator(Kenkyū-buntansha): CHUNG Ung-Il 東京大学, 大学院・工学系研究科, 教授 (30345053) ; NAKAMURA Kozo 東京大学, 医学部附属病院, 教授 (60126133) ; IKEDA Toshiyuki 東京大学, 医学部附属病院, 特任助教 (80322759) ; SAITO Taku 東京大学, 医学部附属病院, 特任助教 (30456107)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000); Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000); Fiscal Year 2008: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000); Fiscal Year 2007: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000); Fiscal Year 2006: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
• Keywords: 骨 / 軟骨代謝学 / 軟骨代謝 / 転写因子 / p63 / 軟骨細胞 / 軟骨内骨化 / 軟骨

Research Abstract

We identified a transcription factor p63 as the potent inducer of SOX6, a member of SOX family essential for chondrocyte generation and differentiation. In this study, we revealed that p63 was extensively expressed in chondrocytes, that p63 was indispensable for development of limb cartilage, and that p63 played important roles in every differentiation stages of chondrocytes.

Research Products

• [Journal Article] Aktl in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions (2010)
  • Author(s): Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Kugimiya F, Higashikawa A, Yano F, Ogata N, Nakamura K, Chung UI, Kawaguchi H.
  • Journal Title: Arthritis Rheum 62(3) Pages: 826-36
• [Journal Article] Mechanisms underlying catabolic and anabolic functions of parathyroid hormone on bone by combination of culture systems of mouse cells (2010)
  • Author(s): Shinoda Y, Kawaguchi H, Higashikawa A, Hirata M, Miura T, Saito T, Nakamura K, Chung UI, Ogata N.
  • Journal Title: J Cell Biochem. 109(4) Pages: 755-63
• [Journal Article] Selection of highly osteogenic and chondrogenic cells from bone marrow stromal cells in biocompatible polymer-coated plates. (2010)
  • Author(s): G Liu, Hiroshi Kawaguchi, et al
  • Journal Title: J Biomed Mater Res A 92A Pages: 1273-82
  • Peer Reviewed
• [Journal Article] Akt1 in chondrocytes controls cartilage calcification during endochondral ossification under physiological and pathological conditions. (2010)
  • Author(s): Atsushi Fukai, Hiroshi Kawaguchi, et al
  • Journal Title: Arthritis Rheum 62 Pages: 826-836
  • Peer Reviewed
• [Journal Article] Mechanisms underlying catabolic and anabolic functions of parathyroid hormone on bone by combination of culture systems of mouse cells. (2010)
  • Author(s): Yusuke Shinoda, et al
  • Journal Title: J Cell Biochem 109 Pages: 755-763
  • Peer Reviewed
• [Journal Article] Self-initiated surface grafting with poly(2-methacryloyloxyethyl phosphorylcholine)on poly(ether-ether-ketone). (2010)
  • Author(s): Masayuki Kyomoto, Hiroshi Kawaguchi, et al
  • Journal Title: Biomaterials 31 Pages: 1017-1024
  • Peer Reviewed
• [Journal Article] The prevention of peritendinous adhesions by a phosphlipid polymer hydrogel formed in situ by spontaneous intermolecular interactions. (2010)
  • Author(s): Noriyuki Ishiyama, Hiroshi Kawaguchi, et al
  • Journal Title: Biomaterials 31 Pages: 4009-4016
  • Peer Reviewed
• [Journal Article] Runx1 and Runx2 cooperate during sternal morphogenesis. (2010)
  • Author(s): Ayako Kimura, Hiroshi Kawaguchi, et al
  • Journal Title: Development 137 Pages: 1159-1167
  • Peer Reviewed
• [Journal Article] Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER : identification of sorting nexin 19 as a novel factor (2009)
  • Author(s): Kan A, Ikeda T, Saito T, Yano F, Fukai A, Hojo H, Ogasawara T, Ogata N, Nakamura K, Chung UI, Kawaguchi H.
  • Journal Title: Arthritis Rheum. 60(11) Pages: 3314-23
• [Journal Article] Accelerated cartilage resorption by chondroclasts during bone fracture healing in osteoprotegerin-deficient mice (2009)
  • Author(s): Ota N, Takaishi H, Kosaki N, Takito J, Yoda M, Tohmonda T, Kimura T, Okada Y, Yasuda H, Kawaguchi H, Matsumoto M, Chiba K, Ikegami H, Toyama Y.
  • Journal Title: Endocrinology 150(11) Pages: 4823-34
• [Journal Article] C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57 (2009)
  • Author(s): Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Saito T, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H.
  • Journal Title: PLoS One. 4(2)
• [Journal Article] Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene (2009)
  • Author(s): Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Takeshita K, Nakamura K, Chung UI, Kawaguchi H.
  • Journal Title: Arthritis Rheum 60(1) Pages: 166-78
• [Journal Article] Association of occupational activity with radiographic knee osteoarthritis and lumbar spondylosis in elderly patients of population-based cohorts : a large-scale population-based study (2009)
  • Author(s): Muraki S, Akune T, Oka H, Mabuchi A, En-Yo Y, Yoshida M, Saika A, Nakamura K, Kawaguchi H, Yoshimura N.
  • Journal Title: Arthritis Rheum 61(6) Pages: 779-86
• [Journal Article] Wear resistance of artificial hip joints with poly(2-methacryloyloxyethyl phosphorylcholine)grafted polyethylene : Comparisons with the effect of polyethylene cross-linking and ceramic femoral heads. (2009)
  • Author(s): Toru Moro, Hiroshi Kawaguchi, et al
  • Journal Title: Biomaterials 30 Pages: 2995-3001
  • Peer Reviewed
• [Journal Article] Association of occupational activity with radiographic knee osteoarthritis and lumbar spondylosis in elderly patients of population-based cohorts : A large-scale population-based study. (2009)
  • Author(s): Shigeyuki Muraki, Hiroshi Kawaguchi, et al
  • Journal Title: Arthritis Rheum 61 Pages: 779-786
  • Peer Reviewed
• [Journal Article] Effects of mobility/immobility of surface modification by 2-methacryloyloxyethyl phosphorylcholine polymer on the durability of polyethylene for artificial joints. (2009)
  • Author(s): Masayuki Kyomoto, Hiroshi Kawaguchi, et al
  • Journal Title: J Biomed Mater Res A 90 Pages: 362-371
  • Peer Reviewed
• [Journal Article] Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. (2009)
  • Author(s): Kazuhito Morioka, Hiroshi Kawaguchi, et al
  • Journal Title: Cancer Sci 100 Pages: 1227-1233
  • NAID: 10027191977
  • Peer Reviewed
• [Journal Article] Epidemiology of lumbar osteoporosis and osteoarthritis and their causal relationship-Is osteoarthritis a predictor for osteoporosis or vice versa? : The Miyama study. (2009)
  • Author(s): Noriko Yoshimura, Hiroshi Kawaguchi, et al
  • Journal Title: Osteoporosis Int 20 Pages: 999-1008
  • Peer Reviewed
• [Journal Article] Transcriptional induction of SOX9 by NF-κB family member RelA in chondrogenic cells. (2009)
  • Author(s): Masahiro Ushita, Hiroshi Kawaguchi, et al
  • Journal Title: Osteoarthritis Cartilage 17 Pages: 1065-1075
  • Peer Reviewed
• [Journal Article] Prevalence of radiographic lumbar spondylosis and its association with low back pain in the elderly of population-based cohorts : the ROAD study. (2009)
  • Author(s): Shigeyuki Muraki, Hiroshi Kawaguchi, et al
  • Journal Title: Ann Rheum Dis 68 Pages: 1401-1406
  • Peer Reviewed
• [Journal Article] Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporos is in Japanese men and women : the research on osteoarthritis/osteoporosis against disability study. (2009)
  • Author(s): Noriko Yoshimura, Hiroshi Kawaguchi, et al
  • Journal Title: J Bone Miner Metab 27 Pages: 620-628
  • Peer Reviewed
• [Journal Article] Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts : The ROAD study. (2009)
  • Author(s): Shigeyuki Muraki, Hiroshi Kawaguchi, et al
  • Journal Title: Osteoarthritis Cartilage 17 Pages: 1137-1143
  • Peer Reviewed
• [Journal Article] Screening of chondrogenic factors by a real-time fluorescence monitoring cell line ATDC5-C2ER : Identification of sorting nexin 19 as a novel factor. (2009)
  • Author(s): Akinori Kan, Hiroshi Kawaguchi, et al
  • Journal Title: Arthritis Rheum 60 Pages: 3314-3323
  • Peer Reviewed
• [Journal Article] Superlubricious surface mimicking articular cartilage by grafting poly(2-methacryloyloxyethyl phosphorylcholine)on orthopaedic metal bearings. (2009)
  • Author(s): Masayuki Kyomoto, Hiroshi Kawaguchi, et al
  • Journal Title: J Biomed Mater Res A 91 Pages: 730-741
  • Peer Reviewed
• [Journal Article] Low dietary vitamin K intake is associated with radiographic knee osteoarthritis in the Japanese elderly : Dietary survey in a population-based cohort of the ROAD study. (2009)
  • Author(s): Hiroyuki Oka, Hiroshi Kawaguchi, et al
  • Journal Title: J Orthop Sci 14 Pages: 687-692
  • Peer Reviewed
• [Journal Article] Lubricity and stability of poly(2-methacryloyloxyethyl phosphorylcholine)polymer layer on Co-Cr-Mo surface for hemi-arthroplasty to prevent degeneration of articular cartilage. (2009)
  • Author(s): Masayuki Kyomoto, Hiroshi Kawaguchi, et al
  • Journal Title: Biomaterials 31 Pages: 658-668
  • Peer Reviewed
• [Journal Article] Cohort profile : Research on Osteoarthritis/Osteoporosis Against Disability study. (2009)
  • Author(s): Noriko Yoshimura, Hiroshi Kawaguchi, et al
  • Journal Title: Int J Epidemiol
  • Peer Reviewed
• [Journal Article] Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells (2009)
  • Author(s): Ushita M, Ikeda T, Chung U, Kawaguchi H(その他5名)
  • Journal Title: Osteoarthritis Cartilage, E-pub
• [Journal Article] C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of (2009)
  • Author(s): Hirata M, Ikeda T, Chung U, Kawaguchi H(その他9名)
  • Journal Title: PLoS ONE 4 Pages: 57-57
• [Journal Article] Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene (2009)
  • Author(s): Higashikawa A, Ikeda T, Chung U, Kawaguchi H (その他9名)
  • Journal Title: Arthritis Rheum 60 Pages: 166-78
• [Journal Article] The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration : findings in murine models and in human disease (2008)
  • Author(s): Sato S, Kimura A, Ozdemir J, Asou Y, Miyazaki M, Jinno T, Ae K, Liu X, Osaki M, Takeuchi Y, Fukumoto S, Kawaguchi H, Haro H, Shinomiya K, Karsenty G, Takeda S.
  • Journal Title: Arthritis Rheum. 58(9) Pages: 2764-75
• [Journal Article] Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9 (2008)
  • Author(s): Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.
  • Journal Title: J Biol Chem. 283(36) Pages: 24682-9
• [Journal Article] Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes (2008)
  • Author(s): Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung UI, Kawaguchi H.
  • Journal Title: J Clin Invest. 118(7) Pages: 2506-15
• [Journal Article] Patchedl haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity (2008)
  • Author(s): Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung UI.
  • Journal Title: Dev Cell. 14(5) Pages: 689-99
• [Journal Article] Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders (2008)
  • Author(s): Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M, Kudo I, Uematsu S, Akira S, Chung UI, Nakamura K, Kawaguchi H.
  • Journal Title: Arthritis Rheum. 58(1) Pages: 172-83
• [Journal Article] Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity (2008)
  • Author(s): Ohba S, Ikeda T, Chung U, Kawaguchi H (その他11名)
  • Journal Title: Dev Cell 14 Pages: 689-99
• [Journal Article] Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes (2008)
  • Author(s): Kawasaki Y, Ikeda T, Chung U, KawaguchiH (その他14名)
  • Journal Title: J Clin Invest 118 Pages: 2506-15
• [Journal Article] Analysis of the Runx2 promoter in osseous and non-osseos cells and identification of HIF2A as a potent transcriptional activaitor. (2008)
  • Author(s): Hiroyuki Tamiya, et al.
  • Journal Title: Gene 416 Pages: 53-60
  • Peer Reviewed
• [Journal Article] Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity (2008)
  • Author(s): Shinsuke Ohba, et al.
  • Journal Title: Dev Cell 14 Pages: 689-699
  • Peer Reviewed
• [Journal Article] hosphorylation of GSK-3β by cGMP-dependent protein kinase promptes hypertrophic differentiation of murine chondrocytes. (2008)
  • Author(s): Yosuke Kawasaki, et al.
  • Journal Title: J Clin Invest 118 Pages: 2506-2515
  • Peer Reviewed
• [Journal Article] Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9. (2008)
  • Author(s): Yosuke Shinoda, et al.
  • Journal Title: J Biol Chem 283 Pages: 24682-24689
  • Peer Reviewed
• [Journal Article] Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis. (2008)
  • Author(s): Yasushi Oshima, et al.
  • Journal Title: J Biol Chem 283 Pages: 26499-26508
  • Peer Reviewed
• [Journal Article] Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type x collagen gene. (2008)
  • Author(s): Akiro Higashikawa, et al.
  • Journal Title: Arthritis Rheum 60 Pages: 166-178
  • Peer Reviewed
• [Journal Article] C/EBPβ promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57^<Kip2> (2008)
  • Author(s): Makoto Hirata, et al.
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] Continuous activation of Gαq in osteoblasts results inosteoPenia through impaired osteoblast differentiation (2008)
  • Author(s): Naoshi Ogata, et. al.
  • Journal Title: J Biol Chem 282 Pages: 35757-64
  • Peer Reviewed
• [Journal Article] Aktl in osteoblasts and osteoclasts controls bone remodeling (2007)
  • Author(s): Kawamura N, Kugimiya F, Oshima Y, Ohba S, Ikeda T, Saito T, Shinoda Y, Kawasaki Y, Ogata N, Hoshi K, Akiyama T, Chen WS, Hay N, Tobe K, Kadowaki T, Azuma Y, Tanaka S, Nakamura K, Chung UI, Kawaguchi H.
  • Journal Title: PLoS One. 2(10)
• [Journal Article] Continuous activation of G alpha q in osteoblasts results in osteopenia through impaired osteoblast differentiation (2007)
  • Author(s): Ogata N, Kawaguchi H, Chung UI, Roth SI, Segre GV.
  • Journal Title: J Biol Chem. 282(49) Pages: 35757-64
• [Journal Article] S100A1 and S100B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes (2007)
  • Author(s): Saito T, Ikeda T, Nakamura K, Chung UI, Kawaguchi H.
  • Journal Title: EMBO Rep. 8(5) Pages: 504-9
• [Journal Article] Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor (2007)
  • Author(s): Ohba S, Ikeda T, Kugimiya F, Yano F, Lichtler AC, Nakamura K, Takato T, Kawaguchi H, Chung UI.
  • Journal Title: FASEB J. 21(8) Pages: 1777-87
• [Journal Article] Identification and characterization of the human SOX_6 promoter (2007)
  • Author(s): Ikeda T, Chung U, Kawaguchi H (その他7名)
  • Journal Title: Biochem Biophys Res Commun 357 Pages: 383-90
• [Journal Article] Local application of recombinant human fibroblast growth factor-2 On bone rePair:a dose-escalatlon prospective trial on patients with osteotomy (2007)
  • Author(s): Hiroshi Kawaguchi, et. al.
  • Journal Title: J Orthop Res 25 Pages: 480-487
  • Peer Reviewed
• [Journal Article] SIOOAI and B,transcriPtional targets of SOX trio,inhibitterminal differentiation of chondrocytes (2007)
  • Author(s): Taku Saito, et. al.
  • Journal Title: EMBO Rep 8 Pages: 504-509
  • Peer Reviewed
• [Journal Article] Identification and characterization of the human SOX6 Promoter (2007)
  • Author(s): Toshiyuki lkeda, et. al.
  • Journal Title: Biochem Biophys Res Commun 357 Pages: 383-390
  • Peer Reviewed
• [Journal Article] Identification of a potent combination of osteogenic genes forbone regeneration using embryonic stem(ES)cell-based sensor (2007)
  • Author(s): Shinsuke Ohba, et. al.
  • Journal Title: FASEB J 21 Pages: 1777-1787
  • Peer Reviewed
• [Journal Article] A noveI osteogenic helioxanthin-derivative acts in a BMP-dependent manner (2007)
  • Author(s): Shinsuke Ohba, et. al.
  • Journal Title: Biochem Biophys Res Commun 357 Pages: 854-860
  • Peer Reviewed
• [Journal Article] Runx2 determines bone maturity and turnover rate in postnatalbone deveioPment and is involved in bone loss in estrogendeficiency (2007)
  • Author(s): Zenjiro Maruyama, et. al.
  • Journal Title: Dev Dynam 236 Pages: 1876-1890
  • Peer Reviewed
• [Journal Article] OPtimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes (2007)
  • Author(s): Guangyao Liu, et. al.
  • Journal Title: J Biol Chem 282 Pages: 20407-20415
  • Peer Reviewed
• [Journal Article] GSK-3β controls osteogenesis through regulating Runx2activity (2007)
  • Author(s): Fumitaka Kugimiya, et. al.
  • Journal Title: PLoS ONE 2
  • Peer Reviewed
• [Journal Article] Prevention of cartilage destruction with intraarticularosteocIastogenesis inhibitory factor/osteoProtegerin in a murine model of osteoarethritis (2007)
  • Author(s): Sadanori Shimizu, et. al.
  • Journal Title: Arthritis Rheum 56 Pages: 3358-3365
  • Peer Reviewed
• [Journal Article] Aktl in osteoblasts and osteoclasts controIs bone remodeIing (2007)
  • Author(s): Naohiro Kawamura, et. al.
  • Journal Title: PLoS ONE 2
  • Peer Reviewed
• [Journal Article] Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice. (2007)
  • Author(s): Naoto Kosaki, et al.
  • Journal Title: Biochem Biophys Res Commun 354 Pages: 846-851
• [Journal Article] Local application of recombinant human fibroblast growth factor-2 on bone repair : a dose-escalation prosective trial on patients with osteotomy. (2007)
  • Author(s): Hiroshi Kawaguchi, et al.
  • Journal Title: J Orthop Res 25 Pages: 480-487
• [Journal Article] Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability (2006)
  • Author(s): Kamekura S, Kawasaki Y, Hoshi K, Shimoaka T, Chikuda H, Maruyama Z, Komori T, Sato S, Takeda S, Karsenty G, Nakamura K, Chung UI, Kawaguchi H.
  • Journal Title: Arthritis Rheum. 54(8) Pages: 2462-70
• [Journal Article] Carminerin contributes to chondrocyte calcification during endochondral ossification (2006)
  • Author(s): Yamada T, Kawano H, Koshizuka Y, Fukuda T, Yoshimura K, Kamekura S, Saito T, Ikeda T, Kawasaki Y, Azuma Y, Ikegawa S, Hoshi K, Chung UI, Nakamura K, Kato S, Kawaguchi H.
  • Journal Title: Nat Med. 12(6) Pages: 665-70
• [Journal Article] Suppression of adjuvant-induced arthritic bone destruction by cyclooxygenase-2 selective agents with and without inhibitory potency against carbonic anhydrase II. (2006)
  • Author(s): Mika Katagiri, et al.
  • Journal Title: J Bone Miner Res 21 Pages: 219-227
• [Journal Article] Carminerin contributes to chondrocyte calcification during endochondral ossification (2006)
  • Author(s): Takashi Yamada, et al.
  • Journal Title: Nature Med 12 Pages: 665-670
• [Journal Article] Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint after induction of knee joint instability. (2006)
  • Author(s): Satoru Kamekura, et al.
  • Journal Title: Arthritis Rheum 54 Pages: 2462-2470
• [Journal Article] Physiological role of bone morphogenetic proteins in osteogenesis. (2006)
  • Author(s): Fumitaka Kugimiya, et al.
  • Journal Title: J Bone Miner Metab. 24 Pages: 95-99
• [Journal Article] Molecular backgrounds of age-related osteoporosis from mouse genetics approaches. (2006)
  • Author(s): Hiroshi Kawaguchi, et al.
  • Journal Title: Rev Endocr Metab Disord 7 Pages: 17-22
• [Journal Article] Risk factors for knee osteoarthritis in Japanese men : a case-control study. (2006)
  • Author(s): Noriko Yoshimura, et al.
  • Journal Title: Mod Rheumatol 16 Pages: 24-29
• [Journal Article] Cartilage tissue engineering using human auricular chondrocytes embedded in different hydrogel materials. (2006)
  • Author(s): Hisayo Yamaoka, et al.
  • Journal Title: J Biomed Mater Res A 78 Pages: 1-11
• [Journal Article] Decreased activities of daily living and associations with bone loss among aged residents in a rural Japanese community : the Miyama Study. (2006)
  • Author(s): Hiroyuki Oka, et al.
  • Journal Title: J Bone Miner Metab 24 Pages: 307-313
• [Journal Article] Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. (2006)
  • Author(s): Yusuke Shinoda, et al.
  • Journal Title: J Cell Biochem 99 Pages: 196-208
• [Journal Article] Distinct association of gene polymorphisms of estrogen receptor and vitamin D receptor with lumbar spondylosis in postmenopausal women. (2006)
  • Author(s): Yu Koshizuka, et al.
  • Journal Title: Eur Spine J 15 Pages: 1521-1528
• [Journal Article] Grafting of biocompatible polymer for longevity of artificial hip joints. (2006)
  • Author(s): Toru Moro, et al.
  • Journal Title: Clin Orthop Rel Res 453 Pages: 58-63
• [Journal Article] Tailor-made tricalcium phosphate bone implant directly fabricated by a three-dimensional ink-jet printer. (2006)
  • Author(s): Kazuyo Igawa, et al.
  • Journal Title: J Artif Organs 9 Pages: 234-240
• [Journal Article] 骨・軟骨再生促進因子 (2006)
  • Author(s): 川口浩
  • Journal Title: 分子リウマチ 3-2 Pages: 107-115
• [Journal Article] Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development
  • Author(s): Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H.
  • Journal Title: Nat Med (in press)
• [Journal Article] GSK-3beta controls osteogenesis through regulating Runx2 activity
  • Author(s): Kugimiya F, Kawaguchi H, Ohba S, Kawamura N, Hirata M, Chikuda H, Azuma Y, Woodgett JR, Nakamura K, Chung UI.
• [Journal Article] Identification and characterization of the human SOX6 promoter.
  • Author(s): Toshiyuki Ikeda, et al.
  • Journal Title: Biochem Biophys Res Commun (印刷中)
• [Journal Article] Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem(ES) cell-based sensor.
  • Author(s): Shinsuke Ohba, et al.
  • Journal Title: FASEB J (印刷中)
• [Journal Article] S100A1 and B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes.
  • Author(s): Taku Saito, et al.
  • Journal Title: EMBO Rep (印刷中)
• [Presentation] Molecular backgrounds of cartilage degeneration during os teoarthritis progression (Special Lecture : OARSI-KORS Cosponsored Symposium) (2009)
  • Author(s): Kawaguchi H
  • Organizer: The 35^<th> Annual Meeting of the Korean Orthopaedic Research Society
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-10-14
• [Presentation] Molecular backgrounds of cartilage degeneration during osteoarthritis progression(Special Lecture : OARSI-KORS Co-sponsored Symposium). (2009)
  • Author(s): Hiroshi Kawaguchi
  • Organizer: The 35^<th> Annual Meeting of the Korean Orthopaedic Research Society
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-10-14
• [Presentation] Transcriptional regul ation of osteoarthritis progression (2008)
  • Author(s): Kawaguchi H
  • Organizer: The 13th Congress of the Asia Pacif is League of Associations for Rheuma tology (APLAR 2008)
  • Place of Presentation: Yokohama
• [Presentation] Transcriptional regulation of osteoarthritis progression (2008)
  • Author(s): Hiroshi Kawaguchi
  • Organizer: The 13th Congress of the Asia Pacific League of Associlations for Rheumatology(APLAR 2008)
  • Place of Presentation: Yokohama
• [Presentation] p63 Plays a Centr al Role in Cartilage Development by Directly Regulating Key Genes for Ch ondrogenesis (2007)
  • Author(s): Ikeda T, et al.
  • Organizer: ASBMR 29^<th> Annual Meeting
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2007-09-18
• [Presentation] p63 Plays a Central Role in Cartilage Development by Directly Regulating Key Genes for Chondrogenesis (2007)
  • Author(s): Toshiyuki Ikeda et.al
  • Organizer: The American Society for Bone and Mineral Research 29th Annual Meeting
  • Place of Presentation: Hawaii,USA.
  • Year and Date: 2007-09-18
• [Presentation] p63 Plays a Central Role in Cartilage Development by Directly Regulating Key Genes for Chondrogenesis (2007)
  • Author(s): Tbshiyuld Ikeda
  • Organizer: ASBMR 29thAnnual Meeting
  • Place of Presentation: Hawah,USA
  • Year and Date: 2007-09-18
• [Presentation] p63は軟骨の初期分化から後期分化までを統合的に支配するマスター転写因子である (2007)
  • Author(s): 池田敏之ら
  • Organizer: 第25回日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-19
• [Book] OPLL -Ossification of the Posterior Longitudinal Ligament - 2nd Edition(edited by K. Yonenobu, T. Nakamura, Y. Toyama. Springer-Verlag Tokyo) (2006)
  • Author(s): Hiroshi Kawaguchi, et al.
  • Total Pages: 1023
• [Book] OPLL - Ossification of the Posterior Longitudinal Ligament - 2nd Edition" edited by K. Yonenobu, T. Nakamura, and Y. Toyama (2006)
  • Author(s): Hiroshi Kawaguchi, et al.
  • Total Pages: 1023
  • Publisher: Springer-Verlag Tokyo
• [Remarks]
  • URL: http://www.h.u-tokyo.ac.jp/ortho/
• [Remarks]
  • URL: http://www.h.u-tokyo.ac.jp/ortho/
• [Remarks]
  • URL: http://www.h.u-tokyo.ac.jp/ortho/
• [Patent(Industrial Property Rights)] 低摩耗性摺動部材及びそれを用いた人工関節 (2006)
  • Inventor(s): 京本政之, 二塚健, 石原一彦, 金野智浩, 中村耕三, 高取吉雄, 川口浩, 茂呂徹, 橋本雅美
  • Industrial Property Rights Holder: 同左
  • Filing Date: 2006-12-15