Evaluation of urinary stone formation with respect to environmental/genetic factors, and assessment of recurrence risk and therapeutic agents

• Project/Area Number: 18209050
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: KOHRI Kenjiro Nagoya City University, 大学院・医学研究科, 教授 (30122047)
• Co-Investigator(Kenkyū-buntansha): TOZAWA Keiichi 名古屋市立大学, 大学院・医学研究科, 准教授 (40264733) ; YASUI Takahiro 名古屋市立大学, 大学院・医学研究科, 講師 (40326153) ; ITOH Yasunori 名古屋市立大学, 大学院・医学研究科, 講師 (70295608)
• Co-Investigator(Renkei-kenkyūsha): KOHRI Kenjiro 名古屋市立大学, 大学院・医学研究科, 教授 (30122047)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000); Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000); Fiscal Year 2007: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000); Fiscal Year 2006: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
• Keywords: 尿路結石 / メタボリックシンドローム / 遺伝子診断 / 一塩基多型 / 創薬

Research Abstract

尿路結石は遺伝因子に環境因子が重なり、発症すると考えられる。遺伝因子ではオステオポンチンの一塩基多型が尿路結石診断に有用であることを証明し、全ゲノム遺伝子の解析から新規の関連遺伝子を発見した。環境因子では、結石形成時にはメタボリックシンドローム関連遺伝子の発現が変化すること、肥満、高脂肪食が尿路結石の原因になることを明らかにし、抗酸化ストレス薬剤が予防効果をもつことを発見した。

Research Products

• [Journal Article] Genome-Wide Analysis of genes related to kidney stone formation and elimination in the calcium oxalate nephrolithiasis model mouse : detection of stone-preventive factors and involvement of macrophage activity (2008)
  • Author(s): Okada A, Yasui T, Hamamoto S, Hirose M, Kubota Y, Itoh Y, Tozawa K, Hayashi Y, Kohri K
  • Journal Title: J Bone Miner Res[Epub ahead of print]
  • Peer Reviewed
• [Journal Article] Prevalence and epidemiologic characteristics of lower urinary tract stones in Japan (2008)
  • Author(s): Yasui T, Iguchi M, Suzuki S, Okada A, Itoh Y, Tozawa K, Kohri K
  • Journal Title: Urology 72(5) Pages: 1001-5
  • Peer Reviewed
• [Journal Article] Eicosapentaenoic acid has a preventive effect on the recurrence of nephrolithiasis (2008)
  • Author(s): Yasui T, Suzuki S, Itoh Y, Tozawa K, Tokudome S, Kohri K
  • Journal Title: Urol Int 81(2) Pages: 135-8
  • Peer Reviewed
• [Journal Article] NF-kappaB activation in renal tubular epithelial cells by oxalate stimulation (2008)
  • Author(s): Tozawa K, Yasui T, Okada A, Hirose M, Hamamoto S, Itoh Y, Kohri K
  • Journal Title: Int J Urol 15(10) Pages: 924-8
  • Peer Reviewed
• [Journal Article] Glyoxylate induces renal tubular cell injury and microstructural changes in experimental mouse (2008)
  • Author(s): Hirose M, Tozawa K, Okada A, Hamamoto S, Shimizu H, Kubota Y, Itoh Y, Yasui T, Kohri K
  • Journal Title: Urol Res 36(3-4) Pages: 139-47
  • Peer Reviewed
• [Journal Article] Morphological conversion of calcium oxalate crystals into stones is regulated by osteopontin in mouse kidney (2008)
  • Author(s): Okada A, Nomura S, Saeki Y, Higashibata Y, Hamamoto S, Hirose M, Itoh Y, Yasui T, Tozawa K, Kohri K
  • Journal Title: J Bone Miner Res 23(10) Pages: 1629-37
  • Peer Reviewed
• [Journal Article] Risk of renal stone formation induced by long-term bed rest could be decreased by premedication with bisphosphonate and increased by resistive exercise (2008)
  • Author(s): Okada A, Ohshima H, Itoh Y, Yasui T, Tozawa K, Kohri K
  • Journal Title: Int J Urol 15(7) Pages: 630-5
  • NAID: 10021279067
  • Peer Reviewed
• [Journal Article] Prevalence and epidemiological characteristics of urolithiasis in Japan : national trends between 1965 and 2005 (2008)
  • Author(s): Yasui T, Iguchi M, Suzuki S, Kohri K
  • Journal Title: Urology 71(2) Pages: 209-13
  • Peer Reviewed
• [Journal Article] メタボリックシンドロームから再発予防を考える (2008)
  • Author(s): 伊藤恭典、安井孝周、吉村麦、戸澤啓一、郡健二郎
  • Journal Title: 泌尿器外科 21(5) Pages: 675-681
• [Journal Article] 疫学から再発予防を考える (2008)
  • Author(s): 井口正典、安井孝周、郡健二郎
  • Journal Title: 泌尿器外科 21(5) Pages: 655-661
• [Journal Article] オステオポンチン一塩基多型(SNPs)による尿路結石発症リスクの解析と予防への応用 (2008)
  • Author(s): 安井孝周、高兵、岡田淳志、廣瀬靖彦、浜本周造、小林隆宏、宇佐美雅之、広瀬真仁、吉村麦、伊藤恭典、戸澤啓一、郡健二郎
  • Journal Title: 腎泌尿器疾患予防医学研究会会誌 16(1) Pages: 143-145
• [Journal Article] 高齢者の尿路結石症 (2008)
  • Author(s): 戸澤啓一、安井孝周、伊藤恭典、郡健二郎
  • Journal Title: 日本腎泌尿器疾患予防医学研究会誌 16(1) Pages: 44-46
• [Journal Article] Prevalence and epidemiological characteristics of urolithiasisin Japan : national trends between 1965 and 2005. (2008)
  • Author(s): Takahiro Yasui
  • Journal Title: Urology 71 Pages: 209-213
  • Peer Reviewed
• [Journal Article] Risk of renal stone formation induced by long-term bed rest could be decreased by premedication with bisphosphonate and increased by resistive exercise. (2008)
  • Author(s): Atsushi Okada
  • Journal Title: Int J Urol 15 Pages: 630-635
  • Peer Reviewed
• [Journal Article] Morphological conversion of calcium oxalate crystals into stones is regulated by osteopontin in mouse kidney. (2008)
  • Author(s): Atsushi Okada
  • Journal Title: J Bone Miner Res 15 Pages: 630-635
  • Peer Reviewed
• [Journal Article] Glyoxylate induces renal tubular cell injury and microstructural changes in experimental mouse. (2008)
  • Author(s): Masahito Hirose
  • Journal Title: Urol Res 36 Pages: 139-147
  • Peer Reviewed
• [Journal Article] NF-kappaB activation in renal tubular epithelial cells by oxalate stimulation. (2008)
  • Author(s): Keiichi Tozawa
  • Journal Title: Int J Urol 15 Pages: 924-928
  • Peer Reviewed
• [Journal Article] Eicosapentaenoic acid has a preventive effect on the recurrence of nephrolithiasis. (2008)
  • Author(s): Takahiro Yasui
  • Journal Title: Urol Int 81 Pages: 135-138
  • Peer Reviewed
• [Journal Article] Prevalence and epidemiologic characteristics of lower urinarytract stones in Japan. (2008)
  • Author(s): Takahiro Yasui
  • Journal Title: Urology 72 Pages: 1001-1005
  • Peer Reviewed
• [Journal Article] Genome-Wide Analysis of Genes Related to Kidney stone Formation and Elimination in the Calcium Oxalate Nephrolithiasis Model Mouse : Detection of Stone-Preventive Factors and Involvement of Macrophage Activity. (2008)
  • Author(s): Atsushi Okada
  • Journal Title: J Bone Miner Res (Dec 29. [Epub ahead of print])
  • Peer Reviewed
• [Journal Article] Prevalence and epidemiological characteristics of urolithiasis in Japan: national trends between 1965 and 2005 (2008)
  • Author(s): Takahiro Yasui
  • Journal Title: Urology 71 Pages: 209-213
  • Peer Reviewed
• [Journal Article] The risk of renal stone formation induced by long-term bed rest could be decreased by premedication with bisphosphonate, but might increase by resistive exercise (2008)
  • Author(s): Atsushi Okada
  • Journal Title: Intenarional Journal of Urology (in press)
  • Peer Reviewed
• [Journal Article] Eicosapentaenoic acid has a preventive effect to the recurrence of nephr olithiasis (2008)
  • Author(s): Takahiro Yasui
  • Journal Title: Urologia Internationalis (in press)
  • Peer Reviewed
• [Journal Article] Aortic calcification in urolithiasis patients (2007)
  • Author(s): Yasui T, Itoh Y, Bing G, Okada A, Tozawa K, Kohri K
  • Journal Title: Scand J Urol Nephrol 41(5) Pages: 419-21
  • Peer Reviewed
• [Journal Article] Examination of alpha 1 adrenoceptor subtypes in the human ureter (2007)
  • Author(s): Itoh Y, Kojima Y, Yasui T, Tozawa K, Sasaki S, Kohri K
  • Journal Title: Int J Urol 14(8) Pages: 749-53
  • NAID: 10019530314
  • Peer Reviewed
• [Journal Article] Association of osteopontin gene haplotypes with nephrolithiasis (2007)
  • Author(s): Gao B, Yasui T, Itoh Y, Li Z, Okada A, Tozawa K, Hayashi Y, Kohri K
  • Journal Title: Kidney Int 72(5) Pages: 592-8
  • Peer Reviewed
• [Journal Article] A polymorphism of matrix Gla protein gene is associated with kidney stones (2007)
  • Author(s): Gao B, Yasui T, Itoh Y, Tozawa K, Hayashi Y, Kohri K
  • Journal Title: J Urol 177(6) Pages: 2361-5
  • Peer Reviewed
• [Journal Article] Successful formation of calcium oxalate crystal deposition in mouse kidney by intraabdominal glyoxylate injection (2007)
  • Author(s): Okada A, Nomura S, Higashibata Y, Hirose M, Gao B, Yoshimura M, Itoh Y, Yasui T, Tozawa K, Kohri K
  • Journal Title: Urol Res 35(2) Pages: 89-99
  • Peer Reviewed
• [Journal Article] Management of urethral calculi associated with hairballs after urethroplasty for severe hypospadias (2007)
  • Author(s): Hayashi Y, Yasui T, Kojima Y, Maruyama T, Tozawa K, Kohri K
  • Journal Title: Int J Urol 14(2) Pages: 161-3
  • NAID: 10018850021
  • Peer Reviewed
• [Journal Article] 尿路結石症診療ガイドライン・レビュー (2007)
  • Author(s): 安井孝周、佐々木昌一、郡健二郎
  • Journal Title: 日本医師会雑誌 136(5) Pages: 908-912
• [Journal Article] 成分分析からのアプローチ(特集 : これだけは知っておきたい-尿路結石症の再発予防) (2007)
  • Author(s): 伊藤恭典、安井孝周、岡田淳志、戸澤啓一、郡健二郎
  • Journal Title: 臨床泌尿器科 61(7) Pages: 495-499
  • NAID: 40015518573
• [Journal Article] 疫学の最新の話題 (2007)
  • Author(s): 安井孝周、井口正典、郡健二郎
  • Journal Title: Pharma Medica 25(2) Pages: 15-19
• [Journal Article] 宇宙空間における尿路結石症 (2007)
  • Author(s): 伊藤恭典、岡田淳志、安井孝周、戸澤啓一、郡健二郎
  • Journal Title: Pharma Medica 25(2) Pages: 33-36
• [Journal Article] ガイドラインの最新の話題 (2007)
  • Author(s): 戸澤啓一、安井孝周、伊藤恭典、郡健二郎
  • Journal Title: Pharma Medica 25(2) Pages: 55-58
• [Journal Article] Association of haplotypes in the osteopontin gene with nephrolithiasis (2007)
  • Author(s): Bing Gao
  • Journal Title: Kidney Internationalis 72 Pages: 592-598
  • Peer Reviewed
• [Journal Article] A polymorphism of matrix gla protein gene is associated with kidney stone (2007)
  • Author(s): Bing Gao
  • Journal Title: Journal of Urology 177 Pages: 2361-2365
  • Peer Reviewed
• [Journal Article] Aortic calcification in urolithiasis patients (2007)
  • Author(s): Takahiro Yasui
  • Journal Title: Scandinavian Journal of Urology and Nephrology 41 Pages: 419-421
  • Peer Reviewed
• [Journal Article] Successful formation of calcium oxalate stone in mouse kidney by intra abdominal glyoxylate injection (2007)
  • Author(s): Atsushi Okada
  • Journal Title: Urological Research 35 Pages: 89-99
  • Peer Reviewed
• [Journal Article] Examination of alpha 1 adrenoceptor subtypes in human ureter (2007)
  • Author(s): Yasunori Itoh
  • Journal Title: Intenarional Journal of Urology 14 Pages: 749-753
  • Peer Reviewed
• [Journal Article] A polymorphism of matrix gla protein gene is associated with kidney stone (2007)
  • Author(s): Bing Gao, et al.
  • Journal Title: Journal of Urology (印刷中)
• [Journal Article] Examination of alpha 1 adrenoceptor subtypes (2007)
  • Author(s): Yasunori Itoh, et al.
  • Journal Title: Int J Urol (印刷中)
• [Journal Article] Aortic calcification in urolithiasis patients (2007)
  • Author(s): Takahiro Yasui, et al.
  • Journal Title: Scandinavian Journal of Urology and Nephrology (印刷中)
• [Journal Article] Successful formation of calcium oxalate stone in mouse kidney by intraabdominal glyoxylate injection (2007)
  • Author(s): Atsushi Okada, et al.
  • Journal Title: Urol Res (印刷中)
• [Journal Article] Abnormal glycosylation of serum IgG in patients with IgA nephropathy (2006)
  • Author(s): Homma H, Tozawa K, Yasui T, Itoh Y, Hayashi Y, Kohri K
  • Journal Title: Clin Exp Nephrol 10(3) Pages: 180-5
  • NAID: 10020573089
• [Journal Article] 不十分な術前・術後検査が危ない : 画像検査 (2006)
  • Author(s): 安井孝周、岡田淳志、伊藤恭典、戸澤啓一、郡健二郎
  • Journal Title: Jpn J Endourol ESWL 19 Pages: 148-153
  • NAID: 10027164244
• [Journal Article] 尿路結石の形成機序と再発予防における新時代の到来 (2006)
  • Author(s): 郡健二郎、安井孝周、井口正典
  • Journal Title: 日本医事新報 4286 Pages: 57-61
• [Journal Article] メタボリック症候群と泌尿器科疾患 : 尿路結石. (2006)
  • Author(s): 安井孝周、吉村麦、岡田淳志、廣瀬真仁、伊藤恭典、戸澤啓一、郡健二郎
  • Journal Title: 腎と透析 60(4) Pages: 627-631
• [Journal Article] Abnormal glycosylation of serum IgG in patients with IgA nephropathy. (2006)
  • Author(s): Hideki Homma, et al.
  • Journal Title: Clin Exp Nephrol. 10・3 Pages: 180-185
• [Journal Article] Effects of impaired functional domains of osteopontin on renal crystal formation : Analyses of OPN-transgenic and OPN-knockout mice
  • Author(s): Hamamoto S, Nomura S, Yasui T, Okada A, Hirose M, Shimizu M, Itoh Y, Tozawa K, Kohri K
  • Journal Title: J Bone Miner Res (in press)
  • Peer Reviewed
• [Journal Article] Alendronate reduces the excretion of risk factors for calcium phosphate stone formation in postmenopausal woman with osteoporosis
  • Author(s): Yasui T, Itoh Y, Okada A, Hamamoto S, Hirose M, Kobayashi T, Tozawa K, Kohri K
  • Journal Title: Urol Int. (in press)
  • Peer Reviewed
• [Presentation] ゲノムワイド解析を用いた結石形成および消失メカニズムの解明 (2008)
  • Author(s): 岡田淳志、小林隆宏、廣瀬泰彦、宇佐美雅之、吉村麦、伊藤恭典、安井孝周、戸澤啓一、郡健二郎
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜
• [Presentation] 尿路結石形成に特異的に関わるオステオポンチンドメインの機能解析 (2008)
  • Author(s): 浜本周造、岡田淳志、広瀬真仁、小林隆宏、伊藤恭典、安井孝周、戸澤啓一、最上徹、郡健二郎
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜
• [Presentation] 腎尿細管細胞障害からみた尿路結石の初期形成機序の解明 (2008)
  • Author(s): 広瀬真仁、廣瀬泰彦、浜本周造、宇佐美雅之、岡田淳志、伊藤恭典、安井孝周、戸澤啓一、郡健二郎
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜
• [Presentation] 尿路結石形成における転写因子NF-・Bの役割 (2008)
  • Author(s): 戸澤啓一、李正道、安井孝周、岡田淳志、吉村麦、宇佐美雅之、広瀬真仁、廣瀬泰彦、濱本周造、伊藤恭典、郡健二郎
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜
• [Presentation] 尿路結石患者におけるオステオポンチン一塩基多型(SNPs)の解析 (2007)
  • Author(s): 戸澤啓一
  • Organizer: 日本尿路結石症学会第17回学術集会
  • Place of Presentation: 久留米市、福岡県
  • Year and Date: 2007-08-25
• [Presentation] 尿路結石形成におけるオステオポンチンドメインの機能解析 (2007)
  • Author(s): 浜本周造
  • Organizer: 日本尿路結石症学会第17回学術集会
  • Place of Presentation: 久留米市、福岡県
  • Year and Date: 2007-08-25
• [Presentation] オステオポンチン一塩基多型(SNPs)による尿路結石発症リスクの解析と予防への応用 (2007)
  • Author(s): 安井孝周
  • Organizer: 第16回日本腎泌尿器疾患予防医学研究会
  • Place of Presentation: 豊中市、大阪府
  • Year and Date: 2007-07-13
• [Presentation] Examination of alpha 1 adrenoceptor subtypes in the human ureter (2007)
  • Author(s): Yasunori Itoh
  • Organizer: 5th eULIS Symposium
  • Place of Presentation: Cascais, Portugal
  • Year and Date: 2007-07-05
• [Presentation] ビスフォスフォネート製剤による尿路結石予防効果 (2007)
  • Author(s): 安井孝周
  • Organizer: 第50回日本腎臓学会総会
  • Place of Presentation: 浜松市、静岡県
  • Year and Date: 2007-05-27
• [Presentation] 尿路結石形成における腎尿細管細胞障害とオステオポンチンの関係 (2007)
  • Author(s): 広瀬真仁
  • Organizer: 第50回日本腎臓学会総会
  • Place of Presentation: 浜松市、静岡県
  • Year and Date: 2007-05-27
• [Presentation] Bisphosphonate prevents calcium phosphate stones in patients with osteoporosis (2007)
  • Author(s): Takahiro Yasui
  • Organizer: 2007(102st)Annual Meeting of American Urological Association
  • Place of Presentation: Anaheim, California, USA
  • Year and Date: 2007-05-22
• [Presentation] Morphorogical conversion of calcium oxalate crystals into stones is regulated by the presence of osteopontin in hyperoxaluric mouse kidney (2007)
  • Author(s): Atsushi Okada
  • Organizer: 2007(102st)Annual Meeting of American Urological Association
  • Place of Presentation: Anaheim, California, USA
  • Year and Date: 2007-05-22
• [Presentation] 尿路結石患者におけるoxidative statusの検討 (2007)
  • Author(s): 伊藤恭典
  • Organizer: 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸市
  • Year and Date: 2007-04-16
• [Presentation] 尿路結石形成に関わるオステオポンチン一塩基多型(SNPs)の同定とその機能解析 (2007)
  • Author(s): 高兵
  • Organizer: 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸市
  • Year and Date: 2007-04-15
• [Presentation] アンチセンス発現尿路上皮細胞およびノックアウトマウスを用いた腎結石形成におけるオステオポンチンの役割 (2007)
  • Author(s): 岡田淳志
  • Organizer: 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸市
  • Year and Date: 2007-04-15
• [Presentation] 腎尿細管細胞障害を誘因とした尿路結石形成機序の解明 (2007)
  • Author(s): 広瀬真仁
  • Organizer: 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸市
  • Year and Date: 2007-04-15
• [Book] 尿路結石の疫学. 尿路結石症のすべて. I総説4. 尿路結石の疫学(編集・発行 : 日本尿路結石症学会郡健二郎) (2008)
  • Author(s): 井口正典、安井孝周、郡健二郎
  • Publisher: 医学書院(東京)
• [Book] 結石成分別にみた特徴. 尿路結石症のすべて. II診断7. 結石成分別に見た特徴(編集・発行 : 日本尿路結石症学会 郡健二郎) (2008)
  • Author(s): 安井孝周、小林隆宏、浜本周造
  • Publisher: 医学書院(東京)
• [Book] 新しい尿路結石治療薬の可能性. 尿路結石症のすべて. III治療6. 再発予防法. (1) 内服療法. d.新しい尿路結石治療薬の可能性(編集・発行 : 日本尿路結石症学会 郡健二郎、発売) (2008)
  • Author(s): 安井孝周
  • Publisher: 医学書院(東京)
• [Book] ビタミンD負荷. 尿路結石症のすべて. VI尿路結石モデル動物 2.ビタミンD 負荷(編集・発行 : 日本尿路結石症学会 郡健二郎) (2008)
  • Author(s): 安井孝周、伊藤恭典、郡健二郎
  • Publisher: 医学書院(東京)
• [Book] 尿路結石症とアディポネクチン. アディポネクチンとその受容体-抗生活習慣病ホルモンの全貌-編集 : 門脇孝 (2008)
  • Author(s): 伊藤恭典、安井孝周、吉村麦、戸澤啓一、郡健二郎
  • Publisher: 有限会社フジメディカル出版
• [Book] 尿路結石症.『ガイドライン外来診療2008』(2008年3月31日発行、編集主幹泉孝英)腎・泌尿器疾患33. 尿路結石症 (2008)
  • Author(s): 安井孝周、郡健二郎
  • Publisher: 日経メディカル開発
• [Book] 下部尿路結石.『最新 泌尿器科診療指針』編集 : 村井勝、塚本泰司、小川修、発行者 : 松浦三男 (2008)
  • Author(s): 戸澤啓一、安井孝周、郡健二郎
  • Publisher: 永井書店
• [Book] 尿路結石症(総論).最新泌尿器科診療指針(平成20年2月10日第1版発行、編集 : 村井勝、塚本泰司、小川修) (2008)
  • Author(s): 安井孝周、郡健二郎
  • Publisher: 永井書店(大阪市)
• [Book] メタボリックシンドロームと腎臓. Annual Review 腎臓. 編集 : 御手洗哲也、東原英二、秋澤忠男、五十嵐隆、金井好克 (2008)
  • Author(s): 伊藤恭典、安井孝周、郡健二郎
  • Publisher: 中外医薬社、東京
• [Book] メタボリックシンドロームと尿路結石. やさしい尿路結石の自己管理(2007年3月30日発行編集 : 郡健二郎) (2008)
  • Author(s): 安井孝周
  • Publisher: 医薬ジャーナル社(東京)
• [Book] 尿路結石症のすべて (2008)
  • Author(s): 郡健二郎
  • Total Pages: 217
  • Publisher: 医学書院
• [Book] Annual Review腎臓 (2008)
  • Author(s): 伊藤恭典
  • Publisher: メタボリックシンドロームと腎臓
• [Book] 最新泌尿器科診療指針 (2008)
  • Author(s): 安井孝周
  • Publisher: 永井書店
• [Book] 宇宙医学と尿路結石. やさしい尿路結石の自己管理(2007年3月30日発行編集 : 郡健二郎) (2007)
  • Author(s): 伊藤恭典、安井孝周、郡健二郎
  • Publisher: 医薬ジャーナル社(東京)
• [Book] 骨粗鬆症と尿路結石. やさしい尿路結石の自己管理)(2007年3月30日発行編集 : 郡健二郎) (2007)
  • Author(s): 安井孝周
  • Publisher: 医薬ジャーナル社(東京)
• [Book] 尿路結石の遺伝子解析.泌尿器疾患治療の新しいストラテジー(編集主幹 : 村井勝、奥山明彦、内藤誠二、発行者 : 浅原実郎)II.泌尿器科疾患の最新治療尿路結石の最新治療戦略 (2007)
  • Author(s): 安井孝周、岡田淳志、伊藤恭典、戸澤啓一、郡健二郎
  • Publisher: メジカルビュー社(東京)
• [Patent(Industrial Property Rights)] 尿路結石症の発症リスク判定方法、及び発症リスク判定用キット (2006)
  • Inventor(s): 郡健二郎、高兵、安井孝周
  • Industrial Property Rights Holder: 郡健二郎、高兵、安井孝周
  • Industrial Property Number: 2006-174573
  • Filing Date: 2006-06-23