Signal transduction in the endometrium : novel viewpoint for understanding the physiology and pathology of the endometrium

• Project/Area Number: 18209051
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: TAKETANI Yuji The University of Tokyo, 医学部附属病院, 教授 (10114539)
• Co-Investigator(Kenkyū-buntansha): OSUGA Yutaka 東京大学, 医学部附属病院, 講師 (80260496) ; MOMOEDA Mikio 東京大学, 医学部附属病院, 講師 (50221627) ; YANO Tetsu 東京大学, 医学部附属病院, 准教授 (90251264) ; FUJII Tomoyuki 東京大学, 医学部附属病院, 准教授 (40209010)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥49,790,000 (Direct Cost: ¥38,300,000、Indirect Cost: ¥11,490,000); Fiscal Year 2008: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000); Fiscal Year 2007: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2006: ¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
• Keywords: 子宮内膜 / 子宮内膜症 / シグナル伝達 / proteinase-activated receptor / TGFβ / IL-6 / IL-17 / MAPキナーゼ / Th17 / IL-8 / AMPキナーゼ / メトホルミン / 着床 / 自然免疫

Research Abstract

子宮内膜とその関連疾患についてのシグナル伝達機構とその制御について臨床にフィードバックできる多くの貴重なデータを得ることができ、周辺の事項も含めて発展的に理解を深めることができた。子宮内膜症に関しては、発症機序について多くの新しい知見を得ることができ、さらに、アポトーシスやT細胞免疫に新たな分子標的を見出すことにより不妊症治療につながる新たな展開をもたらした。一方、正所性子宮内膜に関しては、月経周期にともなう組織学的変化を支える種々のシグナル伝達機構や、その制御異常による不妊症などについて多くの知見を得ることができた。

Research Products

• [Journal Article] Tunicamycin enhances tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-induced apoptosis in endometriotic stromal cells (2009)
  • Author(s): Hasegawa A, Osuga Y, Hirota Y, Hamasaki K, Kodama A, Harada M, Tajima T, Takemura Y, Hirata T, Yoshino O, Koga K, Yano T, Taketani Y.
  • Journal Title: Hum Reprod 24 Pages: 408-14
  • Peer Reviewed
• [Journal Article] IL-1{beta} stimulates migration and survival of first trimester villous cytotrophoblast cells through endometrial epithelial cell-derived IL-8 (2009)
  • Author(s): Hirota Y, Osuga Y, Hasegawa A, Kodama A, Tajima T, Hamasaki K, Koga K, Yoshino O, Hirata T, Harada M, Takemura Y, Yano T, Tsutsumi O, Taketani Y.
  • Journal Title: Endocrinology 150 Pages: 350-6
  • Peer Reviewed
• [Journal Article] Interleukin(IL)-1beta stimulates migration and survival of first-trimester villous cytotrophoblast cells through endometrial epithelial cell-derived IL-8 (2009)
  • Author(s): Hirota Y, Osuga Y, Hasegawa A, Kodama A, Tajima T, Hamasaki K, Koga K, Yoshino O, Hirata T, Harada M, Takemura Y, Yano T, Tsutsumi O, Taketani Y
  • Journal Title: Endocrinology 150 Pages: 350-356
  • Peer Reviewed
• [Journal Article] Conjoined twins in a triplet pregnancy after intracytoplasmic sperm injection and blastocyst transfer : case report and review of the literature (2009)
  • Author(s): Hirata T, Osuga Y, Fujimoto A, Oishi H, Hiroi H, Fujiwara T, Yano T, Taketani Y
  • Journal Title: Fertil Steril 91 Pages: 933-933
  • Peer Reviewed
• [Journal Article] Tunicamycin enhances the apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand in endometriotic stromal cells (2009)
  • Author(s): Hasegawa A, Osuga Y, Hirota Y, Hamasaki K, Kodama A, Harada M, Tajima T, Takemura Y, Hirata T, Yoshino O, Koga K, Yano T, Taketani Y.
  • Journal Title: Hum Reprod 24 Pages: 408-414
  • Peer Reviewed
• [Journal Article] Interleukin-4 stimulates proliferation of endometriotic stromal cells (2008)
  • Author(s): OuYang Z, Hirota Y, Osuga Y, Hamasaki K, Hasegawa A, Tajima T, Hirata T, Koga K, Yoshino O, Harada M, Takemura Y, Nose E, Yano T, Taketani Y.
  • Journal Title: Am J Pathol. 173 Pages: 463-9
  • Peer Reviewed
• [Journal Article] Androgen insensitivity syndrome with serous gonadal cyst (2008)
  • Author(s): Yanai Y, Hiroi H, Osuga Y, Fujimoto A, Momoeda M, Yano T, Taketani Y.
  • Journal Title: Fertil Steril 90 Pages: 2018-2018
  • Peer Reviewed
• [Journal Article] Deficiency of Immunophilin FKBP52 Promotes Endometriosis (2008)
  • Author(s): Hirota Y, Tranguch S, Daikoku T, Hasegawa A, Osuga Y, Taketani Y, Dey SK.
  • Journal Title: Am J Pathol 173 Pages: 1747-57
  • Peer Reviewed
• [Journal Article] Novel therapeutic strategies for endometriosis : a pathophysiological perspective (2008)
  • Author(s): Osuga Y.
  • Journal Title: Gynecol Obstet Invest 66
  • Peer Reviewed
• [Journal Article] Basic and translational research on proteinase-activated receptors : proteinase-activated receptors in female reproductive tissues and endometriosis (2008)
  • Author(s): Osuga Y, Hirota Y, Taketani Y.
  • Journal Title: J Pharmacol Sci Pages: 108422-5
  • NAID: 10025732567
  • Peer Reviewed
• [Journal Article] Interleukin (IL)-17A Stimulates IL-8 Secretion, Cyclooxygensase-2 Expression, and Cell Proliferation of Endometriotic Stromal Cells (2008)
  • Author(s): Hirata T, Osuga Y, Hamasaki K, Yoshino O, Ito M, Hasegawa A, Takemura Y, Hirota Y, Nose E, Morimoto C, Harada M, Koga K, Tajima T, Saito S, Yano T, Taketani Y.
  • Journal Title: Endocrinology 149 Pages: 1260-1267
  • Peer Reviewed
• [Journal Article] Dienogest inhibits BrdU uptake with G (0)/G (1) arrest in cultured endometriotic stromal cells (2008)
  • Author(s): Fu L, Osuga Y, Morimoto C, Hirata T, Hirota Y, Yano T, Taketani Y.
  • Journal Title: Fertil Steril. 89 Pages: 1344-7
  • Peer Reviewed
• [Journal Article] High soluble CD44 concentration in peritoneal fluid in endometriosis (2008)
  • Author(s): Hasegawa A, Yoshino O, Osuga Y, Hirata T, Yano T, Taketani Y.
  • Journal Title: Fertil Steril. 89 Pages: 1267-8
  • Peer Reviewed
• [Journal Article] A case of hydrosalpinx associated with the menstrual cycle (2008)
  • Author(s): Osuga Y, Koga K, Hirata T, Hiroi H, Taketani Y.
  • Journal Title: Fertil Steril. 90 Pages: 199-199
  • Peer Reviewed
• [Journal Article] Interleukin-4 stimulates proliferation of endometriotic stromal cells (2008)
  • Author(s): OuYang Z, Hirota Y, Osuga Y, Hamasaki K, Hasegawa A, Tajima T, Hirata T, Koga K, Yoshino O, Harada M, Takemura Y, Nose E, Yano T, Taketani Y
  • Journal Title: Am J Pathol 173 Pages: 463-469
  • Peer Reviewed
• [Journal Article] Deficiency of immunophilin FKBP52 promotes endometriosis (2008)
  • Author(s): Hirota Y, Tranguch S, Daikoku T, Hasegawa A, Osuga Y, Taketani Y, Dey SK.
  • Journal Title: Am J Pathol 173 Pages: 1747-1757
  • Peer Reviewed
• [Journal Article] Basic and translational research on proteinase-activated receptors : proteinase-activated receptors in female reproductive tissues and endometriosis (2008)
  • Author(s): Osuga Y, Hirota Y, Taketani Y.
  • Journal Title: J Pharmacol Sci 150 Pages: 422-425
  • NAID: 10025732567
  • Peer Reviewed
• [Journal Article] The presence of midkine and its possible implication in human ovarian follicles (2007)
  • Author(s): Hirota Y, Osuga Y, Nose E, Koga K, Yoshino O, Hirata T, Yano T, Tsutsumi O, Sakuma S, Muramatsu T, Taketani Y.
  • Journal Title: Am J Reprod Immunol. 58 Pages: 367-373
  • Peer Reviewed
• [Journal Article] Metformin suppresses interleukin (IL)-lbeta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells (2007)
  • Author(s): Takemura Y, Osuga Y, Yoshino O, Hasegawa A, Hirata T, Hirota Y, Nose E, Morimoto C, Harada M, Koga K, Tajima T, Yano T, Taketani Y.
  • Journal Title: J Clin Endocrinol Metab. 92 Pages: 3213-3218
  • Peer Reviewed
• [Journal Article] Expression of Toll-like receptors 2, 3, 4, and 9 genes in the human endometrium during the menstrual cycle (2007)
  • Author(s): Hirata T, Osuga Y, Hamasaki K, Hirota Y, Nose E, Morimoto C, Harada M, Takemura Y, Koga K, Yoshino O, Tajima T, Hasegawa A, Yano T, Taketani Y.
  • Journal Title: J Reprod Immunol. 74 Pages: 53-60
  • Peer Reviewed
• [Journal Article] Selective increase in high molecular weight adiponectin concentration in serum of women with preeclampsia (2007)
  • Author(s): Takemura Y, Osuga Y, Koga K, Tajima T, Hirota Y, Hirata T, Morimoto C, Harada M, Yano T, Taketani Y.
  • Journal Title: J Reprod Immunol. 73 Pages: 60-5
  • Peer Reviewed
• [Journal Article] Expression of toll-like receptors 2,3,4, and 9 genes in the human endometrium during the menstrual Cycle (2007)
  • Author(s): Hirata T, Osuga Y, Hamasaki K, Hirota Y, Nose E, Morimoto C, Harada M, Takemura Y, Koga Yoshino O, Tajima
  • Journal Title: J Reprod Immunol 74 Pages: 53-60
  • Peer Reviewed
• [Journal Article] Metformin suppresses interleukin(IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells (2007)
  • Author(s): Takemura Y, Osuga Y, Yoshino O, Hasegawa A, Hirata T, Hirota Y, Nose E, Morimoto C, Harada M, Koga K, Tajima
  • Journal Title: J Clin Endocrinol Metab 92 Pages: 3213-3218
  • Peer Reviewed
• [Journal Article] Interleukin(IL)-17A stimulates IL-8 secretion, cyclooxygensase-2 expression, and cell prolifbration of endometriotic stromal cells (2007)
  • Author(s): Hirata T, Osuga Y, Hamasaki K, Yoshino O, Ito M, Hasegawa A, Takemura Y, Hirota Y, Nose E, Morimoto C, Harada M.
  • Journal Title: Endocrinology 149 Pages: 1260-1267
  • Peer Reviewed
• [Journal Article] Selective increase in high molecular weight adiponectin concentration in serum of women with preeclampsia (2007)
  • Author(s): Takemura Y, Osuga Y, Koga K, Tajima T, Hirota Y, Hirata T, Morimoto C, Harada M, Yano T, Taketani Y
  • Journal Title: J Repord Immunol 73(1) Pages: 60-65
• [Journal Article] The expression and possible roles of chemokine CXCL11 and its receptor CXCR3 in the human endometrium (2006)
  • Author(s): Hirota Y, Osuga Y, Koga K, Yoshino O, Hirata T, Morimoto C, Harada M, Takemura Y, Nose E, Yano T, Tsutsumi O, Taketani Y.
  • Journal Title: J Immunol. 177 Pages: 8813-21
  • Peer Reviewed
• [Journal Article] Recurrence of ovarian endometrioma after laparoscopic excision (2006)
  • Author(s): Koga K, Takemura Y, Osuga Y, Yoshino O, Hirota Y, Hirata T, Morimoto C, Harada M, Yano T, Taketani Y.
  • Journal Title: Hum Reprod. 21 Pages: 2171-2174
  • Peer Reviewed
• [Journal Article] Expression of adiponectin receptors and its possible implication in the human endometrium (2006)
  • Author(s): Takemura Y, Osuga Y, Yamauchi T, Kobayashi M, Harada M, Hirata T, Morimoto C, Hirota Y, Yoshino O, Koga K, Yano T, Kadowaki T, Taketani Y.
  • Journal Title: Endocrinology 147 Pages: 3203-3210
  • Peer Reviewed
• [Journal Article] FR 167653, a p38 mitogen-activated protein kinase inhibitor, suppresses the development of endometriosis in a murine model (2006)
  • Author(s): Yoshino O, Osuga Y, Koga K, Hirota Y, Hirata T, Ruimeng X, Na L, Yano T, Tsutsumi O, Taketani Y.
  • Journal Title: J Reprod Immunol. 72 Pages: 85-93
  • Peer Reviewed
• [Journal Article] Elevated serum bisphenol A levels under hyperandrogenic conditions may be caused by decreased UDP-glucuronosyltransferase activity (2006)
  • Author(s): Takeuchi T, Tsutsumi O, Ikezuki Y, Kamei Y, Osuga Y, Fujiwara T, Takai Y, Momoeda M, Yano T, Taketani Y.
  • Journal Title: Endocr J. 53 Pages: 485-491
  • NAID: 10019269724
  • Peer Reviewed
• [Journal Article] Expression of adiponectin receptors and its possible implication in the human endometrium (2006)
  • Author(s): Takemura Y, Osuga Y, Yamauchi T, Kobayashi M, Harada M, Hirata T, Morimoto C, Hirota Y, Yoshino O, Koga K, Yano T, Kadowaki T, Taketani Y.
  • Journal Title: Endocrinology 147(7) Pages: 3203-3210
• [Journal Article] Recurrence of ovarian endometrioma after laparoscopic excision (2006)
  • Author(s): Koga K, Takemura Y, Osuga Y, Yoshino O, Hirota Y, Hirata T, Morimoto C, Harada M, Yano T, Taketani Y.
  • Journal Title: Hum Repord 21(8) Pages: 2171-2174
• [Journal Article] FR 167653, a p38 mitogen-activated protein kinase inhibitor, suppresses the development of endometriosis in a murine model (2006)
  • Author(s): Yoshino O, Osuga Y, Koga K, Hirota Y, Hirata T, Ruimeng X, Na L, Yano T, Tsutsumi O, Taketani Y.
  • Journal Title: J Reprod Immunol 72(I-2) Pages: 85-93
• [Journal Article] The expression and possible roles of chemokine CXCLII and its receptor CXCR3 in the human endometrium (2006)
  • Author(s): Hirota Y, Osuga Y, Koga K, Yoshino O, Hirata T, Morimoto C, Harada M, Takemura Y, Nose E, Yano T, Tsutsumi O, Taketani Y.
  • Journal Title: J Immunol 177(12) Pages: 8813-8821
• [Journal Article] Conjoined twins in a triplet pregnancy after ICSI and blastocyst transfer : Case report and review of the literature
  • Author(s): Hirata T, Osuga Y, Fujimoto A, Oishi H, Hiroi H, Fujiwara T, Yano T, Taketani Y.
  • Journal Title: Fertil Steril (in press)
  • Peer Reviewed
• [Journal Article] Expression and possible implication of GHRH receptor splice variant 1 (SV1) in endometriosis
  • Author(s): Fu L, Osuga Y, Yano T, Takemura Y, Morimoto C, Hirota Y, Schally AV, Taketani Y.
  • Journal Title: Fertil Steril (in press)
  • Peer Reviewed
• [Journal Article] Expression of toll-like receptors2, 3, 4, and 9 genes in the human endometrium during the menstrual cycle
  • Author(s): Hirata T, Osuga Y, Hamasaki K, Hirota Y, Nose E, Morimoto C, Harada M, Takemura Y, Koga K, Yoshino O, Tajima T, Hasegawa A, Yano T, Taketani Y.
  • Journal Title: J Reprod Immunol (In press)
• [Presentation] 子宮内膜症におけるTh2細胞とIL-4の意義について (2008)
  • Author(s): 欧陽卓, 廣田泰, 大須賀穣, 濱崎かほり, 長谷川亜希子, 田島敏樹, 平田哲也, 甲賀かをり, 吉野修, 原田美由紀, 竹村由里, 矢野哲, 武谷雄二
  • Organizer: 第53回日本生殖医学会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-10-23
• [Presentation] 40歳以上で不妊治療を開始した症例の成績と治療方針に関する検討 (2008)
  • Author(s): 藤本晃久, 大石元, 平田哲也, 原田美由紀, 廣井久彦, 大須賀穣, 矢野哲, 武谷雄二
  • Organizer: 第53回日本生殖医学会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-10-23
• [Presentation] 子宮内膜症の発症、進展におけるIL-17の意義 (2008)
  • Author(s): 平田哲也, 大須賀穣, 濱崎かほり, 吉野修, 伊藤実香, 長谷川亜希子, 竹村由里, 廣田泰, 能瀬栄美, 森本千恵子, 原田美由紀, 甲賀かをり, 斎藤滋, 矢野哲, 武谷雄二
  • Organizer: 第53回日本生殖医学会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-10-23
• [Presentation] ヒト卵巣における bonemorphogenetic protein (BMP)-6の発現と機能に関する検討 (2008)
  • Author(s): 吉野修, 施佳, 大須賀穣, 矢野哲, 西井修, 武谷雄二
  • Organizer: 第53回日本生殖医学会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-10-23
• [Presentation] Progress in the management of endometriosis (2008)
  • Author(s): Osuga Y
  • Organizer: 94th Annual Meeting of the Korean Society of Obstetrics and Gynecology
  • Place of Presentation: ソウル市
  • Year and Date: 2008-09-27
• [Presentation] Progress in the management of endometriosis (2008)
  • Author(s): Osuga Y
  • Organizer: 94^<th> Annual Meeting of the Korean Society of Obstetrics and Gynecology
  • Place of Presentation: Seoul 韓国
  • Year and Date: 2008-09-27
• [Presentation] Current understanding of the pathogenesis of endometriosis (2008)
  • Author(s): Osuga Y
  • Organizer: 13th Seoul International Symposium
  • Place of Presentation: ソウル市
  • Year and Date: 2008-09-25
• [Presentation] Current understanding of the pathogenesis of endometriosis (2008)
  • Author(s): Osuga Y
  • Organizer: 13^<th> Seoul International Symposium
  • Place of Presentation: Seoul 韓国
  • Year and Date: 2008-09-25
• [Presentation] 子宮内膜症の診断・治療における腹腔鏡の意義子宮内膜症合併不妊における腹腔鏡の適応と意義についての諸問題 (2008)
  • Author(s): 大須賀穣
  • Organizer: 第48回日本産科婦人科内視鏡学会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-08-02
• [Presentation] 子宮内膜症におけるTh17の発現とその意義 (2008)
  • Author(s): 平田哲也, 大須賀穣, 濱崎かほり, 吉野修, 原田美由紀, 長谷川亜希子, 田島敏樹, 児玉亜子, 伊藤実香, 斎藤滋, 矢野哲, 武谷雄二
  • Organizer: 第60回日本産科婦人科学会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-04-14
• [Presentation] 子宮内膜症 (2008)
  • Author(s): 大須賀穣
  • Organizer: 第60回日本産科婦人科学会、第60回日本産科婦人科学会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-04-14
• [Presentation] New aspects in the pathogenesis of endometriosis (2007)
  • Author(s): Yutaka Osuga
  • Organizer: International Symposium on Translational Research in Uterine Biology
  • Place of Presentation: 神戸市
  • Year and Date: 2007-11-29
• [Presentation] 子宮内膜症患者の腹腔内貯留液中における可溶型CD44についての検討 (2007)
  • Author(s): 長谷川亜希子, 大須賀穣, 平田哲也, 濱崎かほり, 廣田泰, 森本千恵子, 原田美由紀, 竹村由里, 田島敏樹, 矢野哲, 武谷雄二
  • Organizer: 第52回日本生殖医学会
  • Place of Presentation: 秋田市
  • Year and Date: 2007-10-26
• [Presentation] 子宮内膜および子宮内膜症細胞における小胞体ストレスマーカーsXBP1mRNAの発現 (2007)
  • Author(s): 長谷川亜希子, 大須賀穣, 吉野修, 広田泰, 平田哲也, 原田美由紀, 竹村由里, 田島敏樹, 濱崎かほり, 児玉亜子, 矢野哲, 武谷雄二
  • Organizer: 第12回日本生殖内分泌学会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-19
• [Presentation] ヒト子宮内膜におけるBMP7の発現および機能に関する検討 (2007)
  • Author(s): 児玉亜子, 大須賀穣, 吉野修, 濱崎かほり, 長谷川亜希子, 田島敏樹, 森本千恵子, 平田哲也, 矢野哲, 武谷雄二
  • Organizer: 第12回日本生殖内分泌学会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-19
• [Presentation] Implication of immunological and inflammatory mediators in the development of endometriosis (2007)
  • Author(s): Yutaka Osuga
  • Organizer: The 10th Korea-Japan Joint Conference of Obstetrics and Gynecology
  • Place of Presentation: 東京
  • Year and Date: 2007-09-21
• [Presentation] The expression and possible roles of chemokine CXCL 11 and its receptor CXCR3 in the human endometrium (2007)
  • Author(s): Osuga Y, Hirota Y, Hirata T, Koga K, Yoshino O, Morimoto C, Harada M, Takemura Y, Nose E, Yano T, Tsutsumi
  • Organizer: X International Congress of Reproductive Immunology
  • Place of Presentation: Opatija,Croatia
  • Year and Date: 2007-06-12
• [Presentation] 子宮内膜間質細胞 (ESC) におけるToll-like receptor (TLR) を介するサイトカイン産生能とそのIFNγによる制御についての検討 (2007)
  • Author(s): 平田哲也, 大須賀穣, 広田泰, 吉野修, 森本千恵子, 原田美由紀, 竹村由里, 長谷川亜希子, 田島敏樹, 濱崎かほり, 矢野哲, 武谷雄二
  • Organizer: 第59回日本産科婦人科学会
  • Place of Presentation: 京都市
  • Year and Date: 2007-04-16
• [Presentation] Metformin は、子宮内膜症細胞において、IL-8産生、細胞増殖、aromatase発現を抑制する (2007)
  • Author(s): 竹村由里, 大須賀穣, 平田哲也, 広田泰, 森本千恵子, 原田美由紀, 田島敏樹, 長谷川亜希子, 甲賀かをり, 吉野修, 矢野哲, 武谷雄二
  • Organizer: 第59回日本産科婦人科学会
  • Place of Presentation: 京都市
  • Year and Date: 2007-04-16
• [Presentation] 新規GHRH (growth hormone-releasing hormone) アンタゴニストMZ-5-156のヒト子宮内膜癌細胞株に対するアポトーシス誘導効果の検討 (2007)
  • Author(s): 趙琳, 矢野哲, 大須賀穣, 中川俊介, 大石元, 和田修, 久具宏司, 武谷雄二
  • Organizer: 第59回日本産科婦人科学会
  • Place of Presentation: 京都市
  • Year and Date: 2007-04-16
• [Presentation] 婦人科腹腔鏡下手術における予防的抗生剤投与の効果についての検討 (2006)
  • Author(s): 田島敏樹, 廣田泰, 濱崎かほり, 長谷川亜希子, 平田哲也, 森本千恵子, 原田美由紀, 大須賀穣, 矢野哲, 武谷雄二
  • Organizer: 第54回日本化学療法学会西日本支部総会
  • Place of Presentation: 福岡市
  • Year and Date: 2006-12-02
• [Presentation] 子宮内膜症および子宮内膜におけるアディポネクチンの意義についての検討 (2006)
  • Author(s): 竹村由里, 大須賀穣, 原田美由紀, 平田哲也, 森本千恵子, 広田泰, 田島敏樹, 長谷川亜希子, 矢野哲, 武谷雄二
  • Organizer: 第11回生殖内分泌学会
  • Place of Presentation: 東京
  • Year and Date: 2006-11-25
• [Presentation] 子宮筋の蠕動運動は、子宮内膜間質細胞の脱落膜化の制御を介して着床機序に関与している可能性がある (2006)
  • Author(s): 原田美由紀, 大須賀穣, 竹村由里, 吉野修, 甲賀かをり, 廣田泰, 平田哲也, 森本千恵子, 矢野哲, 武谷雄二
  • Organizer: 第51回日本生殖医学会
  • Place of Presentation: 大阪市
  • Year and Date: 2006-11-09
• [Presentation] 子宮内膜におけるTLR2, 3, 4, 9mRNAの発現と月経周期による局在の変化についての検討 (2006)
  • Author(s): 平田哲也, 大須賀穣, 廣田泰, 甲賀かをり, 吉野修, 原田美由紀, 森本千恵子, 竹村由里, 田島敏樹, 長谷川亜希子, 矢野哲, 武谷雄二
  • Organizer: 第51回日本生殖医学会
  • Place of Presentation: 大阪市
  • Year and Date: 2006-11-09
• [Presentation] 子宮筋腫合併不妊症例に対する腹腔鏡 (補助) 下子宮筋腫核出の意義 (2006)
  • Author(s): 北麻里子, 大須賀穣, 甲賀かをり, 廣田泰, 平田哲也, 森本千恵子, 原田美由紀, 竹村由里, 田島敏樹, 長谷川亜希子, 濱崎かほり
  • Organizer: 第51回日本生殖医学会
  • Place of Presentation: 大阪市
  • Year and Date: 2006-11-09
• [Presentation] 新規子宮内膜症治療薬ジェノゲストの子宮内膜症細胞に対する直接効果 (2006)
  • Author(s): 大須賀穣, 傅莉, 森本千恵子, 竹村由里, 原田美由紀, 平田哲也, 広田泰, 吉野修, 甲賀かをり, 矢野哲, 武谷雄二
  • Organizer: 第51回日本生殖医学会
  • Place of Presentation: 大阪市
  • Year and Date: 2006-11-09
• [Presentation] ケモカイン受容体CXCR3とそのリガンドがヒト胚の遊走・侵入に関与する (2006)
  • Author(s): 広田泰, 大須賀穣, 甲賀かをり, 吉野修, 平田哲也, 森本千恵子, 原田美由紀, 竹村由里, 長谷川亜希子, 田島敏樹, 濱崎かほり, 矢野哲, 堤治, 武谷雄二
  • Organizer: 第51回日本生殖医学会
  • Place of Presentation: 大阪市
  • Year and Date: 2006-11-09
• [Presentation] 子宮内膜症患者の腹水におけるCXCL16に関する検討 (2006)
  • Author(s): 平田哲也, 大須賀穣, 広田泰, 森本千恵子, 原田美由紀, 竹村由里, 矢野哲, 武谷雄二
  • Organizer: 第27回炎症再生学会
  • Place of Presentation: 東京
  • Year and Date: 2006-07-11
• [Presentation] 低用量HRTとビタミンKまたはビスフォスフォネートの併用療法が骨代謝に及ぼす効果 (2006)
  • Author(s): 中澤学, 大石元, 福島寛子, 藤原敏博, 大須賀穣, 百枝幹雄, 久具宏司, 竹内亨, 矢野哲, 武谷雄二
  • Organizer: 第58回日本産科婦人科学会
  • Place of Presentation: 横浜市
  • Year and Date: 2006-04-24
• [Presentation] Protease-activated receptor-2 (PAR2) が子宮内膜症の進展に関与する (2006)
  • Author(s): 大須賀穣, 広田泰, 甲賀かをり, 吉野修, 平田哲也, 森本千恵子, 原田美由紀, 竹村由里, 矢野哲, 堤治, 武谷雄二
  • Organizer: 第58回日本産科婦人科学会
  • Place of Presentation: 横浜市
  • Year and Date: 2006-04-24
• [Presentation] 子宮腺筋症がARTの成績に与える影響 (2006)
  • Author(s): 広田泰, 大須賀穣, 和田修, 藤原敏博, 甲賀かをり, 大石元, 矢野哲, 武谷雄二
  • Organizer: 第58回日本産科婦人科学会
  • Place of Presentation: 横浜市
  • Year and Date: 2006-04-24
• [Presentation] 生理的子宮収縮は子宮内膜の脱落膜化を調節している可能性がある : 着床機序への関与 (2006)
  • Author(s): 原田美由紀, 大須賀穣, 竹村由里, 吉野修, 甲賀かをり, 広田泰, 平田哲也, 森本千恵子, 矢野哲, 武谷雄二
  • Organizer: 第58回日本産科婦人科学会
  • Place of Presentation: 横浜市
  • Year and Date: 2006-04-24
• [Presentation] 子宮内膜における各種Toll-like Receptor (TLR) の発現についての検討 (2006)
  • Author(s): 平田哲也, 大須賀穣, 広田泰, 甲賀かをり, 吉野修, 原田美由紀, 森本千恵子, 矢野哲, 武谷雄二
  • Organizer: 第58回日本産科婦人科学会
  • Place of Presentation: 横浜市
  • Year and Date: 2006-04-24
• [Presentation] 子宮内膜における adiponectinreceptor の発現とその意義 (2006)
  • Author(s): 竹村由里, 大須賀穣, 平田哲也, 原田美由紀, 甲賀かをり, 広田泰, 森本千恵子, 吉野修, 田島敏樹, 長谷川亜希子, 矢野哲, 武谷雄二
  • Organizer: 第58回日本産科婦人科学会
  • Place of Presentation: 横浜市
  • Year and Date: 2006-04-24
• [Presentation] GnRH IIによるヒト子宮内膜癌細胞株におけるG2期停止に関する検討 (2006)
  • Author(s): 趙琳, 矢野哲, 中川俊介, 大須賀穣, 大石元, 和田修, 久具宏司, 武谷雄二
  • Organizer: 第58回日本産科婦人科学会
  • Place of Presentation: 横浜市
  • Year and Date: 2006-04-24