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Chewing-induced activation and regeneration of neuronal circuits in human brain

Research Project

Project/Area Number 18209058
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionKanagawa Dental College

Principal Investigator

ONOZUKA Minoru  Kanagawa Dental College, Dentistry, Professor (90084780)

Co-Investigator(Kenkyū-buntansha) SATO Sadao  Kanagawa Dental College, Dentistry, Professor (00084799)
UEMATSU Hiroshi  Tokyo Medical and Dental University, Dentistry, Professor (80100957)
KANEMATSU Masayuki  Gifu University Hospital, Faculty of Medicine, Associate professor (40252134)
WATANABE Kazuko  Seijo University, Rehabilitation, Professor (40158621)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥40,430,000 (Direct Cost: ¥31,100,000、Indirect Cost: ¥9,330,000)
Fiscal Year 2007: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2006: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
KeywordsMemory / Chewing / Denture / Implant / Hippocampus / Prefrontal cortex / Cognition / Dementia / 咬合咀嚼 / 義歯装着 / ガムチューイング / 連合野
Research Abstract

The goal of this project is to elucidate the crosstalk mechanism(s) between the masticatory organs and the higher brain including the cerebral and the hippocampus. Especially, we focused on the preventive effect of Chewing stimulus on memory processes in aged humans, using the functional magnetic resonance imaging (fMRI) technique and the behavioral method. In the first experiment, using fMRI during rhythmic gum-chewing and no chewing, we examined the effect of aging on brain regional activity during chewing in young adult, middle-aged, and aged intact humans. In all subjects, chewing resulted in a bilateral increase in the BOLD signals in the sensorimotor cortex, cerebellum, thalamus, supplementary motor area, and insula, and a unilateral increase in the right prefrontal area. In the first three regions, the signal increases were attenuated in an age-dependent manner, whereas, in the right prefrontal area, the converse was seen. The remaining two regions showed no significant differences with ages.
We did another fMRI experiment, in which we examined the effect of chewing on the hippocampal activities, by employing a task using photographs containing spatial cognitive function. As a result, the hippocampus in young subjects was strongly activated, but no significant difference was seen between before and after chewing. In contrast, activation in the elderly was quite small in comparison with the young subjects. However, the activation area and the intensity of fMRI signals increased by chewing. Furthermore, according to the results from the recall test, aged subjects showed a significant increase in memory acquisition after chewing.
Furthermore, increases in hippocampal activities and memory acquisition were recognized after denture wearing. These results strongly suggest that, in the elderly, chewing causes an enhancement and/or maintaining in hippocampus-dependent cognitive memory.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (42 results)

All 2008 2007 2006 Other

All Journal Article (38 results) (of which Peer Reviewed: 2 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Depolarization-induced differentiation of PC12 cells is mediated by phospholipase D2 through the transcription factor CREB pathway2008

    • Author(s)
      Bannno Y, et. al.
    • Journal Title

      J Neurochem 104

      Pages: 1372-86

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dynorphin-A immuno9reactive terminals on the neuronal somata of rat mesencephalic trigeminal culceus2008

    • Author(s)
      Yamada K, et. al.
    • Journal Title

      Neurosci Lett 438

      Pages: 150-4

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of chewing in working memory processin2008

    • Author(s)
      Hirano Y, et. al.
    • Journal Title

      Neurosci Lett 436

      Pages: 186-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Depolarization-induced differentiation of PC 12 cells is mediated by phospholipase D2 through the transcription factor CREB pathway2008

    • Author(s)
      Bannno Y
    • Journal Title

      J Neurochem 104

      Pages: 1372-86

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dynorphin-A immuno 9 reactive terminals on the neuronal somata of rat mesencephalic trigeminal culceus2008

    • Author(s)
      Yamada K
    • Journal Title

      Neurosci Lett 438

      Pages: 150-4

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] effects of chewing in working memory processing2008

    • Author(s)
      Hirano Y
    • Journal Title

      Neurosci Lett 436

      Pages: 186-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Multdetector row CT of the kidney:optimizing scan delays for bolus tracking techniques of arterial,corticomedullary,and nephrographicpases2007

    • Author(s)
      Goshima S, et. al.
    • Journal Title

      Eur J Radiol 63

      Pages: 420-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] MDCT of the pancreas:optimizing scanning delay with a bolus-tracking technique for pancreatic,peripancreatic vascular,and hepatic contrast enhancement2007

    • Author(s)
      Kondo H, et. al.
    • Journal Title

      Am J Roentgenol 188

      Pages: 751-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gadolinium-enhanced multiphasic 3D MRI of the liver with prospective adaptive navigator correction:phantom study and preliminary clinical evaluation2007

    • Author(s)
      Kanematsu M, et. al.
    • Journal Title

      Am J Roentgenol 188

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tyrosine hydoxylase(TH)- and aromatic-L-amino acid decarboxylase (AADC)-immunoreactive neurons of the common marmoset(Callithrix jacchus)brain:an immunohistochemical analysis2007

    • Author(s)
      Karasawa N, et. al.
    • Journal Title

      Acta Histochem Cytochem 40

      Pages: 83-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Occlusal disharmony attenuates glucocortical negative feedback in aged SAMP8 mice2007

    • Author(s)
      Ichihashi Y, et. al.
    • Journal Title

      Neurosci Lett 427

      Pages: 71-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Occlusal disharmony induces spatial memory impairment and hippocampal neuron degeneration via stress in SAMP8 mice2007

    • Author(s)
      Kubo K, et. al.
    • Journal Title

      Neurosci Lett 414

      Pages: 188-91

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Stimulation of music for prolonged disturbance of consciousness patients in early rehabilitation2007

    • Author(s)
      Aoki T, et. al.
    • Journal Title

      J Saitama Kenou Rehabi 7

      Pages: 50-3

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of biting on elevation of blood pressure and other physiological responses to stress in rats:Biting may reduce allostatic load2007

    • Author(s)
      Okada S, et. al.
    • Journal Title

      Brain Res 1185

      Pages: 189-94

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] よく噛む人はボケにくい2007

    • Author(s)
      渡邊 和子、小野 塚実
    • Journal Title

      綜合臨床 56

      Pages: 2823-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Multdetector row CT of the kidney : optimizing scan delays for bolus tracking techniques of arterial, corticomedullary, and nephrographic pases2007

    • Author(s)
      Goshima S
    • Journal Title

      Eur J Radiol 63

      Pages: 420-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] MDCT of the pancreas : optimizing scanning delay with a bolus-tracking technique for pancreatic, peripancreatic vascular, and hepatic contrast enhancement2007

    • Author(s)
      Kondo H
    • Journal Title

      Am J Roentgenol 188

      Pages: 751-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gadolinium-enhanced multiphasic 3D MRI of the liver with prospective adaptive navigator correction : phantom study and preliminary clinical evaluation2007

    • Author(s)
      Kanematsu M
    • Journal Title

      Am J Roentgenol 188

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tyrosine hydoxylase(TH)-and aromatic-L-amino acid decarboxylase(AADC)-immunoreactive neurons of the common marmoset(Callithrix jacchus) brain : an immunohistochemical analysis2007

    • Author(s)
      Karasawa N
    • Journal Title

      Acta Histochem Cytochem 40

      Pages: 83-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Occlusal disharmony attenuates glucocortical negative feedback in aged SAMP8 mice2007

    • Author(s)
      Ichihashi Y
    • Journal Title

      Neurosci Lett 427

      Pages: 71-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Occlusal disharmony induces spatial memory impairment and hippocampal neuron degeneration via stress in SAMP8 mice2007

    • Author(s)
      Kubo K
    • Journal Title

      Neurosci Lett 414

      Pages: 188-91

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Stimulation of music for prolonged disturbance of consciousness patients in early rehabilitation2007

    • Author(s)
      Aoki T
    • Journal Title

      J Saitama Kenou Rehabil 7

      Pages: 50-3

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of biting on elevation of blood pressure and other physiological responses to stress in rats : Biting may reduce allostatic load2007

    • Author(s)
      Okada S
    • Journal Title

      Brain Res 1185

      Pages: 189-94

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] よく噛む人はボケにくい2007

    • Author(s)
      渡邊 和子、小野塚 実
    • Journal Title

      綜合臨床 56

      Pages: 2823-6

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Occlusal disharmony attenuates glucocorticoid negative feed back in Aged SAMP8 mice2007

    • Author(s)
      Ichihashi Y, et. al.
    • Journal Title

      Neurosci Lett 427

      Pages: 71-6

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occlusal disharmony induces spatial memory impairment and hippocampal neuron degeneration via stress in SAMP8 mice2007

    • Author(s)
      Kubo, et. al.
    • Journal Title

      Neurosci Lett 414

      Pages: 188-91

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occlusal disharmony induces spatial memory impairment and hippocampal neuron degeneration via stress in SAMP8 mice2007

    • Author(s)
      Kubo K, et al.
    • Journal Title

      Neuroscience Letters 414

      Pages: 188-191

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gadolinium-enhanced multiphasic 3D MRI of the live with prospective adaptive navigator correction : phantom study and preliminary clinical evaluation2007

    • Author(s)
      Kanematsu M, et al.
    • Journal Title

      Gastorointestinal Imaging 188

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Double hepatic arterial phase MRI of the liver with switching of reversed centric and centric K space recorderin2006

    • Author(s)
      Kanematsu M, et. al.
    • Journal Title

      Am J Roentgenol 187

      Pages: 464-472

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effect of unpleasant loud noise on hippocampal activities during picture encoding:an fMRI study2006

    • Author(s)
      Hirano Y, et. al.
    • Journal Title

      Brain Cognit 61

      Pages: 280-285

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Optimal scan delay for contrast-enhanced multi-detector row CT12006

    • Author(s)
      Goshima S, et. al.
    • Journal Title

      Radiology 241

      Pages: 167-174

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Projections of glutamate decaboxylase positive and negative cerebellar neurons to the pretectum in the cat2006

    • Author(s)
      Nakamura H, et. al.
    • Journal Title

      Neurosci Lett 403

      Pages: 30-34

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comparison of callose plug structrure between dicotyledon and monocotyledon germinated in vitro2006

    • Author(s)
      Miyamoto M, et. al.
    • Journal Title

      Grana 45

      Pages: 249-56

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Double hepatic arterial phase MRI of the liver with switching of reversed centric and centric K space recorderin2006

    • Author(s)
      Kanematsu M
    • Journal Title

      Am J Roentgenol 187

      Pages: 464-472

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effect of unpleasant loud noise on hippocampal activities during picture encoding : an fMRI study2006

    • Author(s)
      Hirano Y
    • Journal Title

      Brain Cognit 61

      Pages: 280-285

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Optimal scan delay for contrast-enhanced multi-detector row CT12006

    • Author(s)
      Goshima S
    • Journal Title

      Radiology 241

      Pages: 167-174

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Projections of glutamate decaboxylase positive and negative cerebellar neurons to the pretectum in the cat2006

    • Author(s)
      Nakamura H
    • Journal Title

      Neurosci Lett 403

      Pages: 30-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comparison of callose plug structrure between dicotyledon and monocotyledon germinated in vitro2006

    • Author(s)
      Miyamoto M
    • Journal Title

      Grana 45

      Pages: 249-56

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Novel Trends in Brain Science2008

    • Author(s)
      M Onozuka & CT Yen
    • Total Pages
      237
    • Publisher
      Springer
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Novel Trends in Brain Science2008

    • Author(s)
      M Onozuka, CT Yen(eds)
    • Publisher
      Springer, Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Novel Trends in Brain Science2008

    • Author(s)
      M Onozuka and C-T Yen
    • Total Pages
      254
    • Publisher
      Springer(Tokyo)
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.kdcnet.ac.jp/college/HPD/index.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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