Study of the mechanism of GABAergic neurotransmission using glutamate decarboxylase knockout mice

• Project/Area Number: 18300102
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Gunma University
• Principal Investigator: YANAGAWA Yuchio Gunma University, 大学院・医学系研究科, 教授 (90202366)
• Co-Investigator(Kenkyū-buntansha): KAKIZAKI Toshikazu 群馬大学, 大学院・医学系研究科, 助教 (50375531)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥16,790,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥2,490,000); Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2007: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2006: ¥6,000,000 (Direct Cost: ¥6,000,000)
• Keywords: GABA / グルタミン酸脱炭酸酵素 / ノックアウトマウス / 誘導型ノックアウトマウス / GAD67 / GAD65 / 口蓋裂 / 臍帯ヘルニア

Research Abstract

GABAは、グルタミン酸脱炭酸酵素(GAD65とGAD67の2型存在)により合成される。出生日以降のGAD67分子の役割を明らかにする目的でGAD67誘導型ノックアウトマウスの作製を目指し、テトラサイクリントランスアクチベーターシステムについて検討し、GAD67-tTA2ノックインマウスを作製した。また、小脳皮質特異的GAD67ノックアウトマウス、GAD67とGAD65の完全型ノックアウトマウスについて解析した

Research Products

• [Journal Article] Altered responses to propofol, but not ketamine (2009)
  • Author(s): Kubo K, Nishikawa K, Yamada MH, Ishizeki J, Yanagawa Y, Saito S
  • Journal Title: in mice deficient in the 65-kDa isoform of glutamate decarboxylase. J Pharmacol Exp Ther 329 Pages: 592-599
• [Journal Article] Random walk behavior of migrating cortical interneurons in the marginal zone : time-lapse analysis in flat-mount cortex (2009)
  • Author(s): Tanaka DH, Yanagida M, Zhu Y, Mikami S, Nagasawa T, Miyazaki J, Yanagawa Y, Obata K, Murakami F
  • Journal Title: J Neurosci 29 Pages: 1300-11
• [Journal Article] Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor (2009)
  • Author(s): Pan B-X, Dong Y, Ito W, Yanagawa Y, Shigemoto R, Morozov A
  • Journal Title: Neuron 61 Pages: 917-929
• [Journal Article] Distinct Roles of Neuropilin 1 Signaling for Radial and Tangential Extension of Callosal Axons (2009)
  • Author(s): Hatanaka Y, Matsumoto T, Yanagawa Y, Fujisawa H, Murakami F, Masu M
  • Journal Title: J Comp Neurol 514 Pages: 215-225
• [Journal Article] Transfer of small interfering RNA by single-cell electroporation in cerebellar cell cultures (2009)
  • Author(s): Tanaka M, Yanagawa Y, Hirashima N
  • Journal Title: J Neurosci Methods 178 Pages: 80-86
• [Journal Article] The p21-activated kinase is required for neuronal migration in the cerebral cortex (2009)
  • Author(s): Causeret F, Terao M, Jacobs T, Nishimura YV, Yanagawa Y, Obata K, Hoshino M, Nikolic M
  • Journal Title: Cereb Cortex 19 Pages: 861-875
• [Journal Article] Altered response to propofo1, but not ketamine, in mice deficient in the 65-kDa isoform of glutamate decarboxylase. (2009)
  • Author(s): Kubo K, Yanagawa Y et aL.
  • Journal Title: J Pharmacol Exp Ther. (in press)
  • Peer Reviewed
• [Journal Article] Postnatal differentiation of basket cells from slow to fast signaling devices (2008)
  • Author(s): Doischer D, Hosp J, Yanagawa Y, Obata K, Jonas P, Vida I, Bartos M
  • Journal Title: J Neurosci 28 Pages: 12956-12968
• [Journal Article] The role of the t-SNARE SNAP-25 in action potential-dependent calcium signaling and expression in GABAergic and glutamatergic neurons (2008)
  • Author(s): Tafoya LCR, Shuttleworth WC, Yanagawa Y, Obata K, Wilson MC
  • Journal Title: BMC Neurosci 9 Pages: 105-105
• [Journal Article] Noradrenergic excitation of a subpopulation of GABAergic cells in the basolateral amygdala via both activation of nonselective cationic conductance and suppression of resting K^+ conductance : A study using glutamate decarboxylase 67-green fluorescent protein knock-in mice (2008)
  • Author(s): Kaneko K, Tamamaki N, Owada H, Kakizaki T, Kume N, Totsuka M, Yamamoto T, Yawo H, Yagi T, Obata K, Yanagawa Y
  • Journal Title: Neuroscience 157 Pages: 781-797
• [Journal Article] Nigral inhibition of GABAergic neurons in mouse superior colliculus (2008)
  • Author(s): Kaneda K, Isa K, Yanagawa Y, Isa T
  • Journal Title: J Neurosci 28 Pages: 11071-11078
• [Journal Article] The effects of cutting solutions on the viability of GABAergic interneurons in cerebral cortical slices of adult mice (2008)
  • Author(s): Tanaka Y, Tanaka Y, Furuta T, Yanagawa Y, Kaneko T
  • Journal Title: J Neurosci Methods 171 Pages: 118-125
• [Journal Article] Production and histological application of affinity-purified antibodies to heat-denatured GFP (2008)
  • Author(s): Nakamura KC, Kameda H, Koshimizu Y, Yanagawa Y, Kaneko T
  • Journal Title: J Histochem Cytochem 56 Pages: 647-657
• [Journal Article] GABA and synaptic inhibition of mouse cerebellum lacking glutamate decarboxylase 67 (2008)
  • Author(s): Obata K, Hirono M, Kume N, Kawaguchi Y, Itohara S, Yanagawa Y
  • Journal Title: Biochem Biophys Res Commun 370 Pages: 429-433
• [Journal Article] Quantitative chemical composition of cortical GABAergic neurons revealed in transgenic Venus-expressing rats (2008)
  • Author(s): Uematsu M, Hirai Y, Karube F, Ebihara S, Kato M, Abe K, Obata K, Yoshida S, Hirabayashi M, Yanagawa Y, Kawaguchi Y
  • Journal Title: Cereb Cortex 18 Pages: 315-330
• [Journal Article] Regulation of burst activity through pre- and postsynaptic GABAB receptors in mouse superior colliculus (2008)
  • Author(s): Kaneda K, Phongphanphanee P, Katoh T, Isa K, Yanagawa Y, Obata K, Isa T
  • Journal Title: J Neurosci 28 Pages: 816-827
• [Journal Article] Characterization of GABAergic neurons in rapid-eye-movement(REM) sleep controlling regions of the brainstem reticular formation in GAD67-GFP knock-in mice (2008)
  • Author(s): Brown RE, McKenna JT, Winston S, Basheer R, Yanagawa Y, Thakkar MM, McCarley RW
  • Journal Title: Eur J Neurosci 27 Pages: 352-363
• [Journal Article] Cortical-like functional organization of the pheromone-processing circuits in the medial amygdala (2008)
  • Author(s): Bian X, Yanagawa Y, Chen WR, Luo M
  • Journal Title: J Neurophysiol 99 Pages: 77-86
• [Journal Article] Quantification of GABA-ergic amacrine cells in the retina of GAD67-GFP knock-in mice (2008)
  • Author(s): May CA, Nakamura K, Fujiyama F, Yanagawa Y
  • Journal Title: Acta Ophthalmol Scand 86 Pages: 395-400
• [Journal Article] Noradrenergic excitation of a subpopulation of GABAergic cells in the basolateral amygdala via both activation of nonselective cationic conductance and suppression of resting K+ conductance: A study using glutamate decarboxylase 67-green fluorescent protein knock-in mice. (2008)
  • Author(s): Kaneko K, Yanagawa Y et al.
  • Journal Title: Netlroscience 157 Pages: 781-797
  • Peer Reviewed
• [Journal Article] The role of the t-SNARE SNAP-25 in action potential-dependent calciumsignaling and expression in GABAergic and glutamatergic neurons. (2008)
  • Author(s): Tafoya LCR, Yanagawa Y et al.
  • Journal Title: BMC Neurosci 9 Pages: 105-105
  • Peer Reviewed
• [Journal Article] Regulation of burst activity through pre- and postsynaptic GABAB receptors in mouSe superior colliculus. (2008)
  • Author(s): Kaneda, K., Yanagawa, Y, et. al.
  • Journal Title: J.Neurosci. 28 Pages: 816-827
  • Peer Reviewed
• [Journal Article] GABA and synaptic inhibition of mouse cerebellum lackng glutamate decarboxvlase67. (2008)
  • Author(s): Obata, K., Yanagawa, Y, et. al.
  • Journal Title: Biochem.Biophys.Res.Commun (in press)
  • Peer Reviewed
• [Journal Article] RGS2 modulates coupling between GABA_B receptors and GIRK channels in dopamine neurons of the ventral tegmental area (2007)
  • Author(s): Labouebe G, Lomazzi M, Cruz HG, Creton C, Lujan R, Li M, Yanagawa Y, Obata K, Watanabe M, Wickman K, Boyer SB, Slesinger PA, Luscher, C
  • Journal Title: Nat Neurosci 10 Pages: 1559-1568
• [Journal Article] The Neurochemically Diverse Intermedius Nucleus of the Medulla as a Source of Excitatory and Inhibitory Synaptic Input to the Nucleus Tractus Solitarii (2007)
  • Author(s): Edwards I J, Dallas ML, Milligan CJ, Yanagawa Y, Szabo G, Erdelyi F, Deuchars SA, Deuchars J
  • Journal Title: J Neurosci 27 Pages: 8324-8333
• [Journal Article] Hardwiring the brain : Endocannabinoids shape neuronal connectivity (2007)
  • Author(s): Berghuis P, Rajnicek AM, Morozov YM, Ross RA, Mulder J, Urban GM, Monory K, Marsicano G, Matteoli M, Canty A, Irving AJ, Katona I, Yanagawa Y, Rakic P, Lutz B, Mackie K, Harkany T
  • Journal Title: Science 316 Pages: 1212-1216
• [Journal Article] Nav11 localizes to axons of parvalbumin-positive inhibitory interneurons : a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation (2007)
  • Author(s): Ogiwara I, Miyamoto H, Morita N, Atapour N, Mazaki E, Inoue I, Takeuchi T, Itohara S, Yanagawa Y, Obata K, Furuichi T, Hensch TK, Yamakawa K
  • Journal Title: J Neurosci 27 Pages: 5903-5914
• [Journal Article] Glial Na_x channels control lactate signaling to neurons for brain [Na^+] sensing (2007)
  • Author(s): Shimizu H, Watanabe E, Hiyama T, Nagakura A, Fujikawa A, Okado H, Yanagawa Y, Obata K, Noda M
  • Journal Title: Neuron 54 Pages: 59-72
• [Journal Article] Respiratory activity in brainstem of fetal mice lacking glutamate decarboxylase 65/67 and vesicular GABA transporter (2007)
  • Author(s): Fujii M, Arata A, Kanbara-Kume N, Saito K, Yanagawa Y, Obata K
  • Journal Title: Neuroscience 146 Pages: 1044-52
• [Journal Article] GABAergic phenotype of periglomerular cells in the rodent olfactory bulb (2007)
  • Author(s): Panzanelli P, Fritchy JM, Yanagawa Y, Obata K, Sassoe-Pognetto M
  • Journal Title: J Comp Neurol 502 Pages: 990-1002
• [Journal Article] Calcium-dependent NMDA-induced dendric injury and MAP2 loss in acute hippocampal slices (2007)
  • Author(s): Hoskison MM, Yanagawa Y, Obata K, Shuttleworth WC
  • Journal Title: Neuroscience 145 Pages: 66-79
• [Journal Article] Homozygous GAD65 and heterozygous GAD67 knock-out mice reveal normal retinal development and maintenance despite reduced amounts of GABA (2007)
  • Author(s): May CA, Nakamura K, Fujiyama F, Komatsu Y, Yanagawa Y
  • Journal Title: Acta Neuropathologica 113 Pages: 101-103
• [Journal Article] Nav1.1 localizes to axons of parvalbumin-positive inhibitory intemeurons: a chcuit basis fbr epiIeptic seizures in mice carrying an ScnIagene mutatlon。 (2007)
  • Author(s): Ogiwara, I., Yanagawa, Y, et. al.
  • Journal Title: J.Neurosci. 27 Pages: 5903-5914
  • Peer Reviewed
• [Journal Article] Hardwiring the brain: Endocannabinoids shape neuronal comectivity. (2007)
  • Author(s): Berghuis, P ., Yanagawa, Y, et. al.
  • Journal Title: Science 316 Pages: 1212-1216
  • Peer Reviewed
• [Journal Article] RGS2 modulates coupling between GABA_B receptors and GIRK channels in dopamine neurons of the ventral tegmental area. (2007)
  • Author(s): Labouebe, G, Yanagawa, Y, et. al.
  • Journal Title: Nat. Neurosci. 10 Pages: 1559-1568
  • Peer Reviewed
• [Journal Article] Homozygous GAD65 and heterozygous GAD67 knock-out mice reveal normal retinal development and maintenance despite reduced amounts of GABA. (2007)
  • Author(s): May, C.A., Yanagawa, Y.et al.
  • Journal Title: Acta Neuropathologica 113 Pages: 101-103
• [Journal Article] Calcium-dependent NMDA-induced dendric injury and MAP2 loss in acute hippocampal slices. (2007)
  • Author(s): Hoskison, M.M., Yanagawa, Y.et al.
  • Journal Title: Neuroscience 145 Pages: 66-79
• [Journal Article] GABAergic phenotype of periglomerular cells in the rodent olfactory bulb. (2007)
  • Author(s): Panzanelli, P., Yanagawa, Y.ey al.
  • Journal Title: J. Comp. Neurol. (in press)
• [Journal Article] Major effects of sensory experiences on the neocortical inhibitory circuits (2006)
  • Author(s): Jiao Y, Zhang C, Yanagawa Y, Sun Q-Q
  • Journal Title: J Neurosci 26 Pages: 8691-8701
• [Journal Article] Major effects of sensory experience on the neocortical inhibitory circuits. (2006)
  • Author(s): Jiao, Y., Yanagawa, Y.et al.
  • Journal Title: J. Neurosci. 26 Pages: 8691-8701
• [Journal Article] Cortical interneurons require p35/Cdk5 for their migration and laminar organization
  • Author(s): Rakic S, Yanagawa Y, Obata K, Parnavelas JG, Nicolic M
  • Journal Title: Cereb Cortex in press
• [Presentation] Cleft palate and omphalocele in fetal mice lacking glutamate decarboxylase 65/67 and vesicular GABA transporter. (2008)
  • Author(s): Yanagawa Y, Kakizaki T, Saito K, Kayakabe M.
  • Organizer: 6th Annual Forum of European Neuroscience
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2008-07-14
• [Presentation] Real-time monitoring of effects of small interfering RNA transferred by single-cell electroporation in cerebellar cell cultures (2008)
  • Author(s): Tanaka M, Yanagawa Y, Hirashima N
  • Organizer: 38^<th> Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, DC
• [Presentation] Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor (2008)
  • Author(s): Pan B, Dong Y, Ito W, Yanagawa Y, Shigemoto R, Morozov AY
  • Organizer: 38^<th> Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, DC
• [Presentation] Hardwiring the brain : endocannabinoids regulate neuronal specification and axon patternin (2008)
  • Author(s): 3.Keimpema E.Mulder J, Aguado T, Barabas K , Monory K , Marsicano G , Yanagawa Y , Di Marzo V , Hurd YL , Lutz B, Lu HC, Guzman M, Galve-Roperh I , Mackie K, Harkany T
  • Organizer: 38^<th> Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, DC
• [Presentation] Cocaine exerts cell-intrinsic and extrinsic effects on GABA neuron migration from the embryonic striatum to the cerebral cortex (2008)
  • Author(s): McCarthy DM, Sims JR, Yanagawa Y, Bhide PG
  • Organizer: 38^<th> Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, DC
• [Presentation] Strength of GABA_A receptor-mediated transmission is crucial for the late phase of climbing fiber synapse elimination during postnatal cerebellar development (2008)
  • Author(s): Nakayama H, Hashimoto K, Miyazaki T, Yanagawa Y, Obata K, Watanabe M, Kano M
  • Organizer: 38^<th> Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, DC
• [Presentation] Feedforward inhibition by local GABAergic neurons regulates activity of wide-field vertical cells in mouse superior colliculus (2008)
  • Author(s): Kaneda K, Yanagawa Y, Isa T
  • Organizer: 38^<th> Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, DC
• [Presentation] Cleft palate and omphalocele in fetal mice lacking glutamate decarboxylase 65/67 and vesicular GABA transporter (2008)
  • Author(s): Yanagawa Y, Kakizaki T, Saito K, Kayakabe, M
  • Organizer: 6th Annual Forum of European Neuroscience
  • Place of Presentation: Geneva, Switzerland
• [Presentation] GABA signaling during mouse lens development (2008)
  • Author(s): Kwakowsky A, Schwirtlich M, Katarova Z, Yanagawa Y, Szabo G
  • Organizer: 6th Annual Forum of European Neuroscience
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Role of transient neurons and Semaphorin3C in guiding callosal axons (2008)
  • Author(s): Niquille M, Garel S, Mann F, Hornung JP, Otsmane B, Parras C, Guillemot F, Gaspar P, Galliot E, Chevalley S, Yanagawa Y, Obata K, Raper JA, Lebrand C
  • Organizer: 6th Annual Forum of European Neuroscience
  • Place of Presentation: Geneva, Switzerland
• [Presentation] GAD67-GFP knock inマウスを用いた母体ストレス動物の作成 (2008)
  • Author(s): 内田琢、古川智範、沖隆、柳川右千夫、福田敦夫
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] マウスバレル皮質4層細胞への視床及び皮質細胞からの入力に対するノルアドレナリンの制御 (2008)
  • Author(s): 大島稔、小幡邦彦、柳川右千夫、木村文隆
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 大脳皮質におけるGABA作動性介在ニューロンと皮質脊髄路ニューロングループの結合関係の解析 (2008)
  • Author(s): 田中康代、田中康裕、古田貴寛、柳川右千夫、川口泰雄、金子武嗣
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] Ca^<2+>/カルモジュリン依存性プロテインキナーゼII活性による学習・記憶の制御 (2008)
  • Author(s): 山肩葉子, 柳川右千夫, 井本敬二
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] マウス上丘局所GABA作動性ニューロンによるwide-field vertical cellの活動制御機構 (2008)
  • Author(s): 金田勝幸、柳川右千夫、小幡邦彦、伊佐正
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] GABA作動性ニューロンのシナプス後部におけるアクチン細胞骨格系の構築 (2008)
  • Author(s): 花村健次、柳川右千夫、白尾智明
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 嗅内皮質局所のVGATノックアウトにより生じた海馬内免疫組織学的変化 (2008)
  • Author(s): 棚平千代子、斉藤憲史、柳川右千夫、玉巻伸章
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] Reduced long-term potentiation at visual cortical inhibitory synapses in dark-reared and GAD65 knockout mice (2008)
  • Author(s): Reza F, Begum T, Yoshimura Y, Yanagawa Y, Y Komatsu Y
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 小脳細胞培養系における単一細胞エレクトロポレーションによるsiRNAの導入 (2008)
  • Author(s): 田中正彦、柳川右千夫、平嶋尚英
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 抑制性ニューロンにVenus蛍光タンパク質を発現させたトランスジェニックマウス (2008)
  • Author(s): 王英、柿崎利和、斉藤憲史、海老原利枝、阪上洋行、加藤めぐみ、平林真澄、柳川右千夫
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] VGATノックアウトマウスにおける脊髄運動神経回路の発達 (2008)
  • Author(s): 西丸広史、斉藤憲史、柳川右千夫
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 線条体小胞型GABAトランスポーター欠損による運動失調 (2008)
  • Author(s): 斉藤憲史、柿崎利和、籾山俊彦、片岡宏隆、三品昌美、柳川右千
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 胎生期におけるGABAおよびグリシン作動性神経伝達系の役割 (2008)
  • Author(s): 柿崎利和、加家壁美樹子、斉藤憲史、柳川右千夫
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 大脳皮質交連線維伸長におけるニューロピリン1の機能解析 (2008)
  • Author(s): 畠中由美子、松本智子、柳川右千夫、藤澤肇、村上富士夫、桝正幸
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] GABA神経前駆細胞は神経細胞マーカー分子と細胞分裂マーカー分子の共発現により特徴付けられる (2008)
  • Author(s): 玉巻伸章、武勝昔、江角重行、渡辺啓介、柳川右千夫
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] Nav1.1 predominantly localizes to axons in the developing mouse brain (2007)
  • Author(s): Ogiwara I, Miyamoto H, Morita N, Atapour N, Mazaki E, Inoue I, Itohara S, Yanagawa Y, Obata K, Furuichi T, Hensch TK, Yamakawa K
  • Organizer: 37^<th> Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego
• [Presentation] GABA_B receptor-mediated inhibition of burst activities in mouse superior colliculus in vitro (2007)
  • Author(s): Kaneda K, Phongphanphanee P, Yanagawa Y, Obata K, Isa T
  • Organizer: 37^<th> Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego
• [Presentation] Direct nigral inhibitory inputs to GABAergic neurons in mouse superior colliculus (2007)
  • Author(s): Yanagawa Y, Kaneda K, Isa K, Obata K, Isa T
  • Organizer: 37^<th> Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego
• [Presentation] VGATノックアウトマウスに見られる運動機能の変容 (2007)
  • Author(s): 斉藤憲史、西丸広史、柿崎利和、中里洋一、林遼太郎、福本学、柳川右千夫
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Ca^<2+>/カルモジュリン依存性プロテインキナーゼII・ノックアウトマウス脳と不活性型ノックインマウス脳の生化学的比較解析 (2007)
  • Author(s): 山肩葉子、柳川右千夫、井本敬二
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] 腹側体壁形成における抑制性神経伝達の役割 (2007)
  • Author(s): 柿崎利和、加家壁美樹子、斉藤憲史、柳川右千夫
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] マウス上丘でのGABAB受容体によるバースト発火の制御機構 (2007)
  • Author(s): 金田勝幸、Penphimon Phongphanphanee、柳川右千夫、小幡邦彦、伊佐正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] 黒質網様部から上丘中間層GABA作動性ニューロンへの抑制性入力 (2007)
  • Author(s): 伊佐かおる、金田勝幸、柳川右千夫、小幡邦彦、伊佐正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] 発達期小脳の神経回路形成過程における登上線維シナプス除去へのGABA作動性シナプス伝達の関与 (2007)
  • Author(s): 中山寿子、橋本浩一、宮崎太輔、柳川右千夫、小幡邦彦、渡辺雅彦、狩野方伸
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Nav1.1欠損マウスにおけるパルブアルブミン陽性インターニューロンの異常とてんかん (2007)
  • Author(s): 荻原郁夫、宮本浩行、森田規之、N Atapour、真崎恵美、井上育代、柳川右千夫、小幡邦彦、古市貞一、ヘンシュ貴雄、山川和広
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] CXCR4-dependent "wering period" of migrating cortical interneurons (2007)
  • Author(s): 田中大介、柳田光俊、山崎絵海、Yan Zhu、三上栄、長澤丘司、柳川右千夫、小幡邦彦、村上富士夫
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Cleft palate and omphalocele in vesicular GABA transporter knockout mice and glutamate decarboxylase 67 knockout mice (2007)
  • Author(s): Yanagawa Y, Saito K, Kakizaki T, Nakamura K, Obata K
  • Organizer: 7^<th> IBRO World Congress of Neuroscience
  • Place of Presentation: Melbourne
• [Presentation] Thalamic activation of GABAergic neurons leads to activation of excitatory neurons within a single barrel in the mouse thalamocortical system (2007)
  • Author(s): Kimura F, Itami C, Obata K, Yanagawa Y, Ohshima M
  • Organizer: 7^<th> IBRO World Congress of Neuroscience
  • Place of Presentation: Melbourne
• [Presentation] 扁桃体GABA作動性抑制神経系による情動学習関連神経回路の調節機構 (2006)
  • Author(s): 兼子幸一、柳川右千夫、小幡邦彦
  • Organizer: 第29回日本神経科学学会大会
  • Place of Presentation: 京都
• [Presentation] 体壁形成におけるGABA作動性シグナル伝達系の役割 (2006)
  • Author(s): 柿崎利和、斉藤憲史、柳川右千夫
  • Organizer: 第29回日本神経科学学会大会
  • Place of Presentation: 京都
• [Presentation] 小胞型GABAトランスポーター遺伝子欠損マウスの作成と解析 (2006)
  • Author(s): 斉藤憲史、中村健司、柿崎利和、海老原利枝、上松正和、高森茂雄、横山峯介、小西史朗、三品昌美、宮崎純一、小幡邦彦、柳川右千夫
  • Organizer: 第29回日本神経科学学会大会
  • Place of Presentation: 京都
• [Remarks]
  • URL: http://www.med.gunma-u.ac.jp/genbehavneuro/