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A study of target recognition and axon branching m hanisms in the thalamomrocalpmjection

Research Project

Project/Area Number 18300105
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionOsaka University

Principal Investigator

YAMAMOTO Nobuhiko  Osaka University, Graduate School of Frontier Biosaenoes, Professor (00191429)

Co-Investigator(Kenkyū-buntansha) SUGO Noriyuki  Osaka University, Graduate School of Frontier Bioscienoes, Assistant Professor (20372625)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥16,790,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2007: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2006: ¥8,600,000 (Direct Cost: ¥8,600,000)
Keywordsneocorex / thalamus / axon branching / layer / neural activity / 層構造
Research Abstract

The thalamocortical (TC) projection in the mammalian brain is a well characterized system in terms of laminar specificity of neocortical circuits. To understand the mechanisms that underlie lamina-specific TC axon targeting, the role of extracellular and cell surface molecules which are expressed in the upper layers of the developing cortex was studied in vitro culture techniques. The result demonstrated that multiple upper layer molecules cooperated to produce stop behavior of TC axons in the target layer. Activity dependency of TC axon branching was also investigated in organotypic cocultures of the thalamus and cortex. TC axon branches were formed dynamically by addition and elimination during the second week in vitro, when spontaneous firing increased in thalamic and cortical cells. Pharmacological blockade of firing or synaptic activity reduced the remodeling process, in particular, branch addition in the target layer. Together, these findings suggest that TC axon targeting mechanisms involve the regulation with multiple lamina-specific molecules and modification of the molecular mechanisms via neural activity.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (16 results)

All 2008 2007 2006 Other

All Journal Article (10 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Cooperative activity of multiple upper layer proteins for thalamocortical axon growth thalamocortical axon targeting2008

    • Author(s)
      Maruyama T, Matsuura M, Suzuki K, Yamamoto N
    • Journal Title

      Develop Neurobiol 68

      Pages: 317-331

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cooperative activity of multiple upper layer proteins for thalamocortical axon growth2008

    • Author(s)
      Maruyama, T, Matsuura, M., Suzuki, K., Yamamoto, N
    • Journal Title

      Dev Neurobiol 68

      Pages: 317-331

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Molecular mechanisms of thalamocortical axon targeting2008

    • Author(s)
      Yamamoto, N., Maruyama, T., Uesaka, N., Hayano, Y., Takemoto, M., Yamada, A
    • Journal Title

      In : Cortical development : Genes and Genetic abnormalities G. Bock and J. Goode, eds. (John Wiley & Sons Ltd.)

      Pages: 199-211

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interplay between laminar specificity and activity-dependent mechanisms of thalamocortical axon branching2007

    • Author(s)
      Uesaka N, Hayano Y, Yamada A, Yamamoto N
    • Journal Title

      J Neurosci 27

      Pages: 5215-5223

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Interplay between laminar specificity and activity-dependent mechanisms of thalamocortical axon branching2007

    • Author(s)
      Uesaka, N., Hayano, Y., Yamada, A., Yamamoto, N
    • Journal Title

      J Neurosci 27

      Pages: 5215-5223

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interplay between laminar specificity and activity-dependent mechanisms of thalamocortical axon branching2007

    • Author(s)
      Uesaka N, Hayano Y, Yamada A, Yamamoto N.
    • Journal Title

      J Neurosci. 27

      Pages: 5215-5223

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of neural activity in cortical axon branching2006

    • Author(s)
      Uesaka N, Ruthazer ES, Yamamoto N
    • Journal Title

      Neuroscientist 12

      Pages: 102-106

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The role of neural activity in cortical axon branching2006

    • Author(s)
      Uesaka, N., Ruthazer, ES., Yamamoto, N
    • Journal Title

      Neuroscientist 12

      Pages: 102-106

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Activity-dependent regulation of cortical axon branching2006

    • Author(s)
      Uesaka N, Yamamoto N
    • Journal Title

      Neuroscientist 12

      Pages: 102-106

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Er8l is expressed in a subpopulation of layer 5 neurons in rodent and primate neocortices2006

    • Author(s)
      Yoneshima et al.
    • Journal Title

      Neuroscience 137

      Pages: 401-412

    • Related Report
      2006 Annual Research Report
  • [Presentation] 大脳皮質神経細胞におけるHDAC9の神経活動依存的な核・細胞質間移動による遺伝子発現と樹状突起形成の制御2007

    • Author(s)
      Sugo N, Oshiro H, Song W, Yamamoto N
    • Organizer
      第30回日本神経科学・第50回日本神経化学会・第17回日本神経回路学会大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Activity-independent and dependent mechanisms for the formation of the thalamocortical projection2007

    • Author(s)
      Yamamoto, N., Uesaka, N., Hayano, Y., Yamada, A
    • Organizer
      British Neuroscience Association
    • Place of Presentation
      Harrogate, UK
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanisms of thalamocortical axon targeting2007

    • Author(s)
      Yamamoto, N., Maruyama, T., Uesaka, N., Hayano, Y., Yamada, A
    • Organizer
      Novartis Foundation Symposium
    • Place of Presentation
      London
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Molecular mechanisms of thalamocortical axon targeting2007

    • Author(s)
      Yamamoto N, Maruyama T, Uesaka N, Hayano Y, Takemoto M, Yamada A
    • Publisher
      John Wiley & Sons Ltd
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.fbs.osaka-u.acJp/~neurobiol/index.html

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.fbs.osaka-u.ac.jp/~neurobiol/

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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