Histological analysis of brain injury with two-photon microscopy
| Project/Area Number |
18300121
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Mie University |
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Principal Investigator |
MIZOGUCHI Akira Mie University, Graduate school of Medicine, Professor (90181916)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Saburo Mie University, Graduate school of Medicine, part-time lecturer (70024635)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥15,170,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2007: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2006: ¥7,500,000 (Direct Cost: ¥7,500,000)
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| Keywords | Stroke / Thrombosis / Glia cells / Two photon microscopy / GFP Green mouse / Synapse formation / Cell Adhesion / Wiring Specificity |
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| Research Abstract |
We have succeeded in rescuing placental dysplasia caused by deletion of genes, Est2, Mapk14, and Mapkl through placenta-specific gene transfer (Nature Biotechnol). We have also demonstrated that a prototype cadherin, Arcadrin, is involved in control of dendritic spine number (Neuron). By aggregation assav, we have shown hemophilic cell adhesion activity mediated by water channel aquaporin 4.1
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Report
(3 results)
Research Products
(50 results)
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[Journal Article] Activity-induced protocadherin arcadlin regulates dendriticspine number by triggering N-cadherin endocytosis viaTAO2beta and p38 MAP kinases.2007
Author(s)
Yasuda S, Tanaka H, Sugiura H, Okamura K, Sakaguchi T, Tran U, Takemiya T, Mizoguchi A, Yagita Y, Sakurai T, DeRobertis EM, Yamagata K.
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Journal Title
Neuron. 56
Pages: 456-471
Related Report
Peer Reviewed
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[Journal Article] A nuclearfactor-kappaB inhibitor pyrrolidined ithiocarbamateameliorates pulmonary hypertension in rats.2007
Author(s)
Sawada H, Mitani Y, Maruyama J, Jiang BH, Ikeyama Y, Dida FA, Yamamoto H, Imanaka Yoshida K, Shimpo H, Mizoguchi A, Maruyama K, Komada Y.
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Journal Title
Chest. 132
Pages: 1265-1274
Related Report
Peer Reviewed
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[Journal Article] Synaptic scaffolding molecule alphaf is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA actication in dendrites.2007
Author(s)
lisa J, lshizaki H, Okamoto-Tanaka M, Kawata A, Sumita K, Ohgake S, Sato Y, Yorifuji H, Nukina N, Ohashi K, Mizuno K, Tautsumi T, Mizoguchi A, Miyoshi J, Takai Y, Hata Y.
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Journal Title
Mol Cell Biol. 27
Pages: 4388-4405
Related Report
Peer Reviewed
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[Journal Article] Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in meurotrophin release2007
Author(s)
Sadakata T, Kakegawa W, Mizoguchi A, Washida M, Katoh-Semba R, Shutoh F, Okamoto T, Nakashima H, Kimura K, Tanaka M, Sekine Y, Itohara S, Yuzaki M, Nagao S. Fururchi T.
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Journal Title
J Neurosci. 27
Pages: 2472-2482
Related Report
Peer Reviewed
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[Journal Article] Complementation of placental defects and embryonic lethalityby trophoblast-specific lentiviral genet ransfer.2007
Author(s)
Okada Y, Ueshin Y, Isotani A, Saito-Fujita T, Nakashima H, Kimura K, Mizoquchi A, Oh-flora M, MoriY, Ogata M, Oshima RG, Okabe M, Ikawa M.
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Journal Title
Nature Biotechnology 25(2)
Pages: 233-237
Related Report
Peer Reviewed
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[Journal Article] Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer.2007
Author(s)
Okada Y, Ueshin Y, Isotani A, Saito-Fujita T, Nakashima H, Kimura K, Mizoguchi A, Oh-Hora M, Mori Y, Ogata M, Oshima RG, Okabe M, Ikawa M
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Journal Title
Related Report
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[Journal Article] RGS2 promotes formation of neurites by stimulating microtubule polymerization.2006
Author(s)
Heo K, Ha SH, Chae YC, Lee S, Oh YS, Kim YH, Kim SH, Kim JH, Mizoguchi A, Itoh TJ, Kwon HM, Ryu SH, Suh PG
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Journal Title
Cell Signal. 18・12
Pages: 2182-2192
Related Report
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[Journal Article] Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart.2006
Author(s)
Okamoto R, Kato T, Mizoguchi A, Takahashi N, Nakakuki T, Mizutani H, Isaka N, Imanaka-Yoshida K, Kaibuchi K, Lu Z, Mabuchi K, Tao T, Hartshorne DJ, Nakano T, Ito M
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Journal Title
Cell Signal. 18・9
Pages: 1408-1416
Related Report
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[Journal Article] Implications of the Aquaporin-4 Structure on Array Formation and Cell Adhesion.2006
Author(s)
Hiroaki Y, Tani K, Kamegawa A, Gyobu N, Nishikawa K, Suzuki H, Walz T, Sasaki S, Mitsuoka K, Kimura K, Mizoguchi A, Fujiyoshi Y
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Journal Title
J Mol Biol. 355・4
Pages: 628-639
Related Report
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[Journal Article] Involvement of nectins in the formation of puncta adherentia junctions and the mossy fiber trajectory in the mouse hippocampus.2006
Author(s)
Honda T, Sakisaka T, Yamada T, Kumazawa N, Hoshino T, Kajita M, Kayahara T, Ishizaki H, Tanaka-Okamoto M, Mizoguchi A, Manabe T, Miyoshi J, Takai Y
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Journal Title
Mol Cell Neurosci. 31・2
Pages: 315-325
Related Report
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