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Eye movement control system in three dimensions - convergent eye movement system -

Research Project

Project/Area Number 18300133
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SHINODA Yoshikazu  医科歯科大 (60010104)

Co-Investigator(Kenkyū-buntansha) 杉内 友理子  東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (30251523)
伊澤 佳子  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (40372453)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥16,920,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2006: ¥4,700,000 (Direct Cost: ¥4,700,000)
Keywords運動系神経生理学 / 脳・神経 / 運動制御 / 眼球運動 / 前庭系 / 神経生理学
Research Abstract

本研究は, 三次元眼球運動制御系を理解するため, 垂直サッケード生成機構と輻輳性眼球運動系に関して, 前頭眼野から水平, 垂直系眼球運動ニューロンに至る出力系を訓練した慢性サル及び急性のサル・ネコの in vivo の標本で神経生理学的・解剖学的方法を用いて解析する。具体的には, 垂直サッケード生成機構と輻輳性眼球運動出力系を, 前頭眼野-上丘-眼球運動ニューロン系で上丘を中心としてその中枢神経機構を明らかにしたい。上丘頭側部と尾側部の機能分化の問題は, 現在眼球運動の研究者の間で大きな論争になっている。尾側部がサッケードを担う点は意見の一致を見ているが, 頭側部に固視領野が存在するか否かで見解が分かれ, 同様に, 頭側部に輻輳眼球運動を担う領野が存在するかに関しても意見の一致を見ていない。本研究においては, 上丘が輻輳眼球運動に関与するか否かを明らかにしたい。
視標が急にある点から別の点に三次元空間でジャンプした時, サッケードとともに輻輳運動が起こるが, この両方の系はシステムの時定数が大きく異なっている。その為, 三次元の視標の動きに対して, まず早いサッケードが起こり, その後に輻輳運動がゆっくり起こる。しかしながら, 最近の研究では, この三次元の早い視標のジャンプに対する眼球運動の時には, 輻輳運動の時定数はかなりサッケードに近づき(オランダCollewijn), 繰り返し練習による学習効果で, 輻輳運動の時定数が短くなることが示されている。このようなサッケードの発現にあったっては, 固視からの抑制解除が必要であるが, ゆっくり動く視標を注視して追う滑動性や輻輳性眼球運動の際には,サッケードを抑制する必要があり, 恐らく固視による抑制系が働いているであろう。そこで, サル, ネコの上丘に於いて, これまで我々が行ってきた上丘尾側部のサッケード系, 上丘頭側部の固視系の解析を対比しながら, 上丘頭側部の輻輳領域を同定し, そこからの出力とそこへの入力の中枢神経機構, さらには固視系, サッケード系, 輻輳系の相互の結合関係を明らかにし, 輻輳眼球運動系の三次元眼球運動制御系に於ける中枢神経機構を明らかにしたい。

Report

(4 results)
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (35 results)

All 2008 2007 2006

All Journal Article (15 results) (of which Peer Reviewed: 11 results) Presentation (20 results)

  • [Journal Article] Neural circuits for triggering saccades in the brainstem2008

    • Author(s)
      Shinoda Y, Sugiuchi Y, Izawa Y, Takahashi M
    • Journal Title

      Progress in Brain Research 17

      Pages: 79-85

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Commissural mirror-symmetric excitation and reciprocal inhibition between the two superior colliculi and their roles in vertical and horizontal eye movements2007

    • Author(s)
      Takahashi M, Sugiuchi Y, Shinoda Y
    • Journal Title

      J Neurophysiol 98

      Pages: 2664-2682

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Morecular, topographic, and functional organization of the cerebellar nuclei : Analysis by three-dimensional mapping of the olivonuclear projection and aldolase C labeling2007

    • Author(s)
      Sugihara I and Shinoda Y
    • Journal Title

      J Neurosci 27

      Pages: 9696-9710

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] ontroversy on "Fixation zone" of the Superior Colliculus2007

    • Author(s)
      Sugiuchi Y, Izawa Y, Takahashi M, Na J, Shinoda Y
    • Journal Title

      Neuro-Ophthalmology 31

      Pages: 147-155

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Neural pathways for vertical saccades : from the superior colliculus to trochlear motoneurons2007

    • Author(s)
      Izawa Y, Sugiuchi Y, Shinoda Y
    • Journal Title

      Neuro-Ophthalmology 31

      Pages: 141-146

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Neural organization of the pathways from the superior colliculus to trochelear motoneurons2007

    • Author(s)
      Izawa Y, Sugiuchi Y, Shinoda Y
    • Journal Title

      J Neurophysiol 97

      Pages: 3696-3712

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Neural organization of the pathways from the superior colliculus to trochlear motoneurons2007

    • Author(s)
      Izawa Y
    • Journal Title

      Journal of Neurophysiology 97

      Pages: 3696-3712

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular, topographic, and functional organization of the cerebellar nuclei: Analysis by three-dimensional mapping of the olivonuclear projection and aldolase C labeling.2007

    • Author(s)
      Sugihara I
    • Journal Title

      Journal of Neuroscience 27

      Pages: 9696-9710

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Commissural mirror-symmetric excitation and reciprocal inhibition between the two superior colliculi and their roles in vertical and horizontal eye movements2007

    • Author(s)
      Takahashi M
    • Journal Title

      Journal of Neurophysiology 98

      Pages: 2664-2682

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural pathways for vertical saccades: from the superior colliculus to trochlear motoneurons.2007

    • Author(s)
      Izawa Y
    • Journal Title

      Neuro-Ophthalmology 31

      Pages: 141-146

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Controversy on "Fixation zone" of the Superior Colliculus2007

    • Author(s)
      Sugiuchi Y
    • Journal Title

      Neuro-Ophthalmology 31

      Pages: 147-155

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural organization of the pathways from the superior colliculus to trochlear motoneurons2007

    • Author(s)
      Izawa, Y
    • Journal Title

      Journal of Neurophysiology (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Controversy on "Fixation zone" of the superior colliculus2007

    • Author(s)
      Sugiuchi, Y
    • Journal Title

      Neuro-Opthalmology (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neural pathways for vertical saccades : from the superior colliculus to trochlear motoneurons2007

    • Author(s)
      Izawa, Y
    • Journal Title

      Neuro-Opthalmology (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Long descending motor tract axons and their control of neck and axial muscles.2006

    • Author(s)
      Shinoda, Y.
    • Journal Title

      Progress in Brain Research 151

      Pages: 533-569

    • Related Report
      2006 Annual Research Report
  • [Presentation] Neural network that subserves vertical saccadic eye movements2008

    • Author(s)
      Izawa Y, Sugiuchi Y, Shinoda Y
    • Organizer
      The XXV Barany Society Meeting
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      2008-04-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] The interstitial nucleus of Cajal and its functional roles in generation of vertical saccades and the vestibulo-ocular reflex2008

    • Author(s)
      Sugiuchi Y, Izawa Y, Takahashi M, Shinoda Y
    • Organizer
      The XXV Barany Society Meeting
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      2008-04-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Functional roles of commissural mirror-symmetric excitatory and reciprocal inhibitory connections between the superior colliculi for control of vertical saccades2008

    • Author(s)
      Takahashi M, Sugiuchi Y, Shinoda Y
    • Organizer
      The XXV Baray Society Meeting
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      2008-04-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neural circuits of the saccadic and vestibulooculomotor systems in the brainstem2008

    • Author(s)
      Shinoda Y
    • Organizer
      The XXV Barany Society Meeting
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      2008-04-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neural circuits of the saccadic and vestibulooculomotor systems in the brainstem2008

    • Author(s)
      Shinoda Y
    • Organizer
      The XXV Baray Society Meeting
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Excitatory and inhibitory pathways from the superior colliculus to vertical ocular motoneurons.2008

    • Author(s)
      Izawa Y, Sugiuchi Y, Shinoda Y
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Functional roles of commissural excitation and inhibition between The superior colliculi for control of saccadic eye movement2008

    • Author(s)
      Takahashi M, Sugiuchi Y, Shinoda Y
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neural circuit for generation of saccades in the brainstem2008

    • Author(s)
      Shinoda Y
    • Organizer
      How the brain moves the eyes and the head : Neural Mechanisms of Oculomotor and Vestibular Function
    • Place of Presentation
      Medford, OR (USA)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neural mechanism for triggering saccades2007

    • Author(s)
      Y. Shinoda, Y. Sugiuchi, Y. Izawa, M. Takahashi
    • Organizer
      The Gordon Research Conference 2007 on Oculomotor System Bology
    • Place of Presentation
      Lewiston, Maine, USA
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Neural circuit for triggering saccades in the brainstem2007

    • Author(s)
      Shinoda Y, Sugiuchi Y, Izawa Y, Takahashi M
    • Organizer
      The 17th Meeting of The Neural Control of Movement Society
    • Place of Presentation
      Seville, Spain
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Neural circuits for triggering saccades in the brainstem2007

    • Author(s)
      Shinoda Y
    • Organizer
      "Using eye movements as an experimental probe of brain function", A synopsium in Honour of Jean Buttner-Ennever
    • Place of Presentation
      London, UK
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Neural circuits for triggering saccades in the brainstem2007

    • Author(s)
      Shinoda Y
    • Organizer
      "Using eye movements as an expermental probe of brain function", A symposium in Honor of Jean Biittner-Ennever,
    • Place of Presentation
      Imperial College London, London, UK
    • Related Report
      2007 Annual Research Report
  • [Presentation] Neural mechanism for triggering saccades2007

    • Author(s)
      Shinoda Y
    • Organizer
      The Gordon Research Conference 2007 on Oculomotor System Biology,
    • Place of Presentation
      Bates College, Lewiston, Maine, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Neural pathways mediating excitation and inhibition from the superior colliculus to vertical ocular motoneurons,2007

    • Author(s)
      Izawa Y
    • Organizer
      The Gordon Research Conference 2007 on Oculomotor System Biology
    • Place of Presentation
      Bates College, Lewiston, Maine, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Differential neural connections of the rostral and caudal superior colliculi with inhibitory burst neurons and omnipause neurons in the brainstem2007

    • Author(s)
      Sugiuchi Y
    • Organizer
      The Gordon Kesearch Conference 2007 on Oculomotor System Biology
    • Place of Presentation
      Bates College, Lewiston, Maine, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Functional roles of point-to-point commissural connections between the superior colliculi for control of suppression and generation of saccades2007

    • Author(s)
      Takahashi Y
    • Organizer
      The Gordon Research Conference 2007 on Oculomotor System Biology
    • Place of Presentation
      Bates College, Lewiston, Maine, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] 水平性サッケードと垂直性サッケードの出力神経機構2007

    • Author(s)
      伊澤佳子
    • Organizer
      第66回日本めまい平衡医学会
    • Place of Presentation
      大阪国際交流センター、大阪市
    • Related Report
      2007 Annual Research Report
  • [Presentation] 垂直性・水平性サッケードにおける両側上丘間の交連性興奮・抑制の役割2007

    • Author(s)
      高橋真有
    • Organizer
      第66回日本めまい平衡医学会
    • Place of Presentation
      大阪国際交流センター、大阪市
    • Related Report
      2007 Annual Research Report
  • [Presentation] 前頭眼野近傍の滑動性眼球運動への入力経路2007

    • Author(s)
      杉内友理子
    • Organizer
      第66回日本めまい平衡医学会
    • Place of Presentation
      大阪国際交流センター、大阪市
    • Related Report
      2007 Annual Research Report
  • [Presentation] Fixation and Gaze Control"-Conflicting Operations of the Same Network2006

    • Author(s)
      Shinoda Y
    • Organizer
      The 16th Annual Meeting of Neural Control of Movements
    • Place of Presentation
      Miami (Key Biscayne), Florida, USA.
    • Related Report
      2008 Self-evaluation Report

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Published: 2006-04-01   Modified: 2016-04-21  

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