| Budget Amount *help |
¥18,220,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2007: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2006: ¥6,000,000 (Direct Cost: ¥6,000,000)
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| Research Abstract |
Proliferation of malaria parasites in the host is mainly controlled by an erythrocytic factor that maps to the Pymr region on mouse Chr.9. We found a convincing candidate gene, which was indirectly related to cerebral malaria and malaria nephrosis, but had no effect on dermatitis. Other genetic loci concerning cerebral malaria (Cmr1, Cmr2) and parasite exclusion (Pymr2) had an influence on dermatitis. A few key genes of the immune system, such as Il12rb and Il27ra1, are present in the Pymr2 region on Chr.8, and there were some nonsynonymous mutations in these genes in the NC mice. They may have function as common genetic factors in the susceptibility to allergy and infectious diseases.
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