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A puncture method of flexible thin needle mimicked blood sucking mosquito

Research Project

Project/Area Number 18300148
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SAITO Hirokazu  Tokyo Medical and Dental University, 生体材料工学研究所, 助教 (00205668)

Co-Investigator(Kenkyū-buntansha) TOGAWA Tatsuo  早稲田大学, 人間科学部, 教授 (40013859)
MITSUBAYASHI Kohji  東京医科歯科大学, 生体材料工学研究所, 教授 (40307236)
OTSUKA Kimio  東京医科歯科大学, 生体材料工学研究所, 准教授 (00211798)
KUDO Kudo  東京医科歯科大学, 生体材料工学研究所, 講師 (70329118)
MIYAJIMA Kumiko  東京医科歯科大学, 生体材料工学研究所, 技術職員 (10516298)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥8,970,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2006: ¥3,900,000 (Direct Cost: ¥3,900,000)
Keywords無痛採血 / 微細針 / 蚊の吸血 / 穿刺 / スパッタ / 蚊 / スパッタリング
Research Abstract

無痛採血を目的とした外径200μm以下の微細な針を座屈することなく対象血管を確実に穿刺するため, 蚊の口束針を模擬した多重針を開発した。樹脂を基材とした三重複合針は外針に支えられた内針は弾性膜を座屈することなく穿刺できることが確認された。また円筒曲面の樹脂基材にPtをスパッタリングする技術を開発し, 針先で血液成分を検出するための電極形成が可能となった。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (26 results)

All 2008 2007 2006

All Journal Article (8 results) (of which Peer Reviewed: 5 results) Presentation (15 results) Book (3 results)

  • [Journal Article] Glucose sensor using phospholipid polymer-based enzyme immobilization method2008

    • Author(s)
      Kudo H, Yagi T, Chu MX, Saito H, Morimoto M, Iwasaki Y, Akiyoshi K, Mitsubayashi K
    • Journal Title

      Anal Bioanal Chem 391(IF2.591)

      Pages: 1269-1274

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A biochemical sniffer-chip for convenient analysis of gaseous formaldehyde from timber material2008

    • Author(s)
      Mitsubayashi K, Nishio G, Sawai M, Kazawa E, Yoshida H, Saito T, Kudo H, Otsuka K, Takao M, Saito H
    • Journal Title

      Microchimica Acta 160(IF1.159)

      Pages: 427-433

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glucose sensor using phospholipid polymer-based enzyme immobilization method2008

    • Author(s)
      Kudo H, Yagi T, Chu MX, Saito H, Morimoto M, Iwasaki Y, Akiyoshi K, Mitsubayashi K
    • Journal Title

      Anal Bioanal Chem 391

      Pages: 1269-1274

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An optic pharyngeal manometric sensor for deglutition analysis2007

    • Author(s)
      Takeuchi S, Tohara H, Kudo H, Otsuka K, Saito H, Uematsu H, Mitsubayashi K
    • Journal Title

      Biomedical Microdevices 9(IF2.551)

      Pages: 893-899

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A thin-type wearable oxygen sensor for transcutaneous measurement2006

    • Author(s)
      Iguchi S, Kudo H, Saito H, Otsuka K. Mitsubayashi K
    • Journal Title

      ICAS-2006(International Congress on Analytical Sciences)Proceedings 636

    • Related Report
      2008 Final Research Report
  • [Journal Article] 運動時呼吸代謝計測のための対数負荷法と微量採血法の検討2006

    • Author(s)
      斉藤浩一, 三林浩二, 戸川達男
    • Journal Title

      第21回生体・生理工学シンポジウム論文集

      Pages: 333-334

    • Related Report
      2008 Final Research Report 2006 Annual Research Report
  • [Journal Article] Detection of needle puncture to blood vessel by using electric conductivity of blood for automatic blood sampling2006

    • Author(s)
      Saito H, Mitsubayashi K, Togawa T
    • Journal Title

      Sensors and Actuators A : Physical 125(2)(IF1.434)

      Pages: 446-450

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A thin-type wearable oxygen sensor for transcutaneous measurement,2006

    • Author(s)
      Iguchi S., Kudo H., Saito H., Otsuka K., Mitsubayashi K.
    • Journal Title

      ICAS-2006 (International Congress on Analytical Sciences) Proceedings

      Pages: 636-636

    • Related Report
      2006 Annual Research Report
  • [Presentation] Computer controlled needle puncture system for automatic blood sampling2008

    • Author(s)
      Hirokazu Saito
    • Organizer
      The 34th Congress on Science and Technology of Thailand
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2008-11-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] An automatic venepuncture system for blood test2008

    • Author(s)
      Hirokazu Saito
    • Organizer
      PRiME (Pacific RIM Meeting) 2008
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2008-10-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] A fiber-optic biosensor with a UV-LED based excitation system2008

    • Author(s)
      Hiroyuki Kudo
    • Organizer
      EUROSENSORS XXII
    • Place of Presentation
      Dresden, German
    • Year and Date
      2008-10-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Computer controlled needle puncture system for automatic blood sampling2008

    • Author(s)
      Saito H, Miyajima K, Kudo H, Mitsubayashi K
    • Organizer
      34th Congress on Science and Technology of Thailand(STT34)
    • Place of Presentation
      Bangkok
    • Related Report
      2008 Final Research Report
  • [Presentation] Development of a flexible glucose sensor for continuous biomonitoring on eye site2008

    • Author(s)
      Kudo H, Iguchi S, Miyajima K, Saito H, Mitsubayashi K
    • Organizer
      34th Congress on Science and Technology of Thailand(STT34)
    • Place of Presentation
      Bangkok
    • Related Report
      2008 Final Research Report
  • [Presentation] A flexible biosensor for continuous glucose monitoring on eye site2008

    • Author(s)
      Kudo H, Iguchi S, Miyajima K, Saito H, Mitsubayashi K
    • Organizer
      214th Meeting of ECS-The Electrochemical Society
    • Place of Presentation
      Honolulu
    • Related Report
      2008 Final Research Report
  • [Presentation] An automatic venepuncture system for blood test2008

    • Author(s)
      Saito H, Miyajima K, Kudo H, Mitsubayashi K
    • Organizer
      214th Meeting of ECS-The Electrochemical Society
    • Place of Presentation
      Honolulu
    • Related Report
      2008 Final Research Report
  • [Presentation] A fiber-optic biosensor with a UV-LED based excitation system2008

    • Author(s)
      Kudo H, Koshida T, Sawai M, Miyajima K, Gessei T, Saito H, Yano K, Mitsubayashi K
    • Organizer
      Eurosensors XXII
    • Place of Presentation
      Dresden
    • Related Report
      2008 Final Research Report
  • [Presentation] Fiber optic bio-sniffer(biochemical gas sensor)for dimethyl sulfide vapor2008

    • Author(s)
      Saito H, Wang X, Suzuki Y, Hashimoto Y, Minamide T, Kudo H, Mitsubayashi K
    • Organizer
      12^<th> International Meeting on Chemical Sensors
    • Place of Presentation
      Ohio
    • Related Report
      2008 Final Research Report
  • [Presentation] Intelligent kinetic biosensors with active pressure system2007

    • Author(s)
      三林 浩二
    • Organizer
      5th Intelligent Conference on Instrumental Methods of Analysis Modern trends and Applications
    • Place of Presentation
      Rio Patras, Greece
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Bioelectronic sniffer with monoamine oxidase for halitosis monitoring2007

    • Author(s)
      齊藤 浩一
    • Organizer
      12th Asian Chemical Congress
    • Place of Presentation
      Kuala Rumpur, Malaysia
    • Year and Date
      2007-08-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Bioelectronic sniffer with monoamine oxidase for halitosis monitoring2007

    • Author(s)
      Saito H, Minamide T, Kozuka M, Sawai M, Kudo H, Otsuka K, Mitsubayashi K
    • Organizer
      12th Asian Chemical Congress(12ACC)2007
    • Place of Presentation
      Kuala Lumpur
    • Related Report
      2008 Final Research Report
  • [Presentation] Breath analysis with bio-sniffers(biochemical gas sensors)for ethanol and acetaldehyde after drinking2007

    • Author(s)
      Matsunaga H, Saito H, Kudo H, Mitsubayashi K
    • Organizer
      The 5th International Conference "Instrumental Methods of Analysis-IMA"
    • Place of Presentation
      Rio Patras
    • Related Report
      2008 Final Research Report
  • [Presentation] A stick-type bio-sniffer(gas-phase biosensor)for formaldehyde vapor2006

    • Author(s)
      Mitsubayashi K, Nishio G, Sawai M, Saito T, Kudo H, Otsuka K, Jaffrezic-Renault N, Saito H
    • Organizer
      The 11th International Meeting on Chemical Sensors
    • Place of Presentation
      Brescia
    • Related Report
      2008 Final Research Report
  • [Presentation] 運動時呼吸代謝計測のための対数負荷法と微量採血2006

    • Author(s)
      齊藤浩一, 戸川達男, 三林浩二
    • Organizer
      第21回生体・生理工学シンポジウム
    • Place of Presentation
      鹿児島
    • Related Report
      2008 Final Research Report
  • [Book] 血液検査の完全自動化のための血管穿刺制御2007

    • Author(s)
      齊藤浩一, 工藤寛之, 大塚公雄, 三林浩二
    • Publisher
      生体材料工学研究所年報
    • Related Report
      2008 Final Research Report
  • [Book] 蚊の吸血メカニズムに倣った自動採血システム, ユビキタス・バイオセンシング-健康モニタリング&日常ケアのための計測技術-2006

    • Author(s)
      齊藤浩一
    • Publisher
      三林浩二監修, CMC出版, 東京
    • Related Report
      2008 Final Research Report
  • [Book] ユビキタス・バイオセンシング-健康モニタリング&日常ケアのための計測技術-(三林浩二 監修)2006

    • Author(s)
      斉藤浩一
    • Total Pages
      291
    • Publisher
      CMC出版(東京)
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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