Screening of cancer cell surface markers and molecular targeting in vivo with bio-nanocapsule

• Project/Area Number: 18300164
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Okayama University
• Principal Investigator: SENO Masaharu Okayama University, 大学院・自然科学研究科, 教授 (90243493)
• Co-Investigator(Kenkyū-buntansha): TADA Hiroko 岡山大学, 大学院・自然科学研究科, 助教 (60271061)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,930,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥2,730,000); Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2007: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2006: ¥6,100,000 (Direct Cost: ¥6,100,000)
• Keywords: がん細胞 / 細胞表面マーカー / DNAマイクロアレイ / 球面自己組織化マップ / 脳腫瘍 / 乳がん / 分子標的 / ErbB2

Research Abstract

独自に開発している細胞表面マーカーDNAマイクロアレイを用いてマウス神経系腫瘍細胞株、ヒトグリオーマ細胞株、ヒト乳がん細胞株の遺伝子発現プロフィールを作成し、球面自己組織化マップを応用して遺伝子のクラスタリング解析を行った結果、それぞれの腫瘍に特異的なマーカー遺伝子の抽出に効率よく成功した。また、乳がん等で高発現が認められるErbB2に対して高親和性を示すペプチドを用いてin vitroおよびin vivoにおいて分子標的能力を示すことができた。

Research Products

• [Journal Article] Delivery of sodium borocaptate to glioma cells using immunoliposome conjugated with anti-EGFR antibodies by ZZ-His (2009)
  • Author(s): Feng B, Tomizawa K, Michiue H, Miyatake S, Han XJ, Fujimura A, Seno M, Kirihata M, Matsui H.
  • Journal Title: Biomaterials 30 Pages: 1746-1755
  • Peer Reviewed
• [Journal Article] Identifi cation of TM9SF2 as a Candidate of the Cell Surface Marker Common to Breast Carcinoma Cells (2009)
  • Author(s): Abou-Sharieha S, Sugii Y, Tuoya, Yu D, Chen L, Tokutaka H, Seno M.
  • Journal Title: Clin Oncol Cancer Res 6 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Abou-Sharieha S, Sugii Y, Tuoya, Yu D, Chen L, Tokutaka H, Seno, M. Identifi cation of TM9SF2 as a Candidate of the Cell Surface Marker Common to Breast Carcinoma Cells. (2009)
  • Author(s): Abou-Sharieha S, Sugii Y, Tuoya, Yu D, Chen L, Tokutaka H, Seno, M.
  • Journal Title: Clin Oncol Cancer Res. 6 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Delivery of sodium borocaptate to glioma cells using immunoliposome conjugated with anti-EGFR antibodies by ZZ-His. (2009)
  • Author(s): Feng B, Tomizawa K, Michiue H, Miyatake s, Han XJ, Fujimura A, Seno M, Kirihata M, Matsui H.
  • Journal Title: Biomaterials 30 Pages: 1746-1755
  • Peer Reviewed
• [Journal Article] Spherical self-organizing map as a helpful tool to identify category-specific cell surface markers (2008)
  • Author(s): Tuoya, Sugii Y, Satoh H, Yu D, Matsuura Y, Tokutaka H, Seno M
  • Journal Title: Biochem Biophys Res Commun 376 Pages: 414-418
  • Peer Reviewed
• [Journal Article] Reversal of streptozotocin-induced hyperglycemia by continuous supply of betacellulin in mice (2008)
  • Author(s): Yamamoto Y, Yamada S, Kodera T, Hara A, Motoyoshi K, Tanaka Y, Nagaoka T, Seno M, Kojima I
  • Journal Title: Growth Factors 26 Pages: 173-179
  • Peer Reviewed
• [Journal Article] Intracellular Delivery of Glutathione S-Transferase-fused Proteins into Mammalian Cells by Polyethylenimine-Glutathione Conjugates (2008)
  • Author(s): Murata H, Futami J, Kitazoe M, Yonehara T, Nakanishi H, Kosaka M, Tada H, Sakaguchi M, Yagi Y, Seno M, Huh NH, Yamada H
  • Journal Title: J Biochem 144 Pages: 447-455
  • NAID: 10024912690
  • Peer Reviewed
• [Journal Article] Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300 (2008)
  • Author(s): Hirota M, Watanabe K, Hamada S, Sun Y, Strizzi L, Mancino M, Nagaoka T, Gonzales M, Seno M, Bianco C, Salomon DS
  • Journal Title: Cell Signal 20 Pages: 1632-1641
  • Peer Reviewed
• [Journal Article] betacellulin mutant promotes differentiation of pancreatic acinar AR42J cells into insulin-producing cells with low affinity of binding to ErbB1 (2008)
  • Author(s): Nagaoka T, Fukuda T, Hashizume T, Nishiyama T, Tada H, Yamada H, Salomon DS, Yamada S, Kojima I, Seno M. A
  • Journal Title: J Mol Biol 380 Pages: 83-94
  • Peer Reviewed
• [Journal Article] A simple method to induce differentiation of murine bone marrow mesenchymal cells to insulin-producing cells using conophylline and betacellulin-delta4 (2008)
  • Author(s): Hisanaga E, Park KY, Yamada S, Hashimoto H, Takeuchi T, Mori M, Seno M, Umezawa K, Takei I, Kojima I
  • Journal Title: Endocr J 55 Pages: 535-543
  • Peer Reviewed
• [Journal Article] Cell type dependent endocytic internalization of ErbB2 with an artificial peptide ligand that binds to ErbB2 (2008)
  • Author(s): Hashizume T, Fukuda T, Nagaoka T, Tada H, Yamada H, Watanabe K, Salomon DS, Seno M
  • Journal Title: Cell Biol Int 32 Pages: 814-826
  • Peer Reviewed
• [Journal Article] Transient cell proliferation with polyethylenimine-cationized N-terminal domain of simian virus 40 large T-antigen (2008)
  • Author(s): Murata H, Futami J, Kitazoe M, Kosaka M, Tada H, Seno M, Yamada H.
  • Journal Title: J Biosci Bioeng 105 Pages: 34-38
  • NAID: 110006570773
  • Peer Reviewed
• [Journal Article] Involvement of MAPK signaling molecules and Runx2 in the NELL1-induced osteoblastic differentiation (2008)
  • Author(s): Bokui N, Otani T, Igarashi K, Kaku J, Oda M, Nagaoka T, Seno M, Tatematsu K, Okajima T, Matsuzaki T, Ting K, Tanizawa K, Kuroda S.
  • Journal Title: FEBS Lett 582 Pages: 365-371
  • Peer Reviewed
• [Journal Article] Involvement of MAPK signaling molecules and Runx2 in the NELL1-induced osteoblastic differentiation (2008)
  • Author(s): Bokui N, Otani T, Igarashi K, Kaku J, Oda M, Nagaoka T, Seno M, Tatematsu K, Okajima T, Matsuzaki T, Ting K, Tanizawa K, Kuroda S
  • Journal Title: FEBS Lett 582 Pages: 365-371
  • Peer Reviewed
• [Journal Article] Transient cell proliferation with polyethylenimine-cationized N-terminaldomain of simian virus 40 large T-antigen (2008)
  • Author(s): Murata H, Futami J, Kitazoe M, Kosaka M, Tada H, Seno M, Yam ad a H
  • Journal Title: J Biosci Bioeng 105 Pages: 34-38
  • Peer Reviewed
• [Journal Article] Cell type dependent endocytic internalization of ErbB2 with an artificial peptide ligand that binds to ErbB2. (2008)
  • Author(s): Hashizume T, Fukuda T, Nagaoka T, Tada H, Yamada H, Watanabe K, Salomon DS, Seno M
  • Journal Title: Cell Biol Int. 32 Pages: 814-826
  • Peer Reviewed
• [Journal Article] A simple method to induce differentiation of murine bonemarrow mesenchymal cells to insulin-producing cells using conophyllineand betacellulin-delta4. (2008)
  • Author(s): Hisanaga E, Park KY, Yamada S, Hashimoto H, Takeuchi T, Mori M, Seno M, Umezawa K, Takei I, Kojima I.
  • Journal Title: Endocr J. 55 Pages: 535-543
  • Peer Reviewed
• [Journal Article] A betacellulin mutant promotes differentiation of pancreatic acinar AR42J cells into insulin-producing cells with low affinity of binding to ErbB1. (2008)
  • Author(s): Nagaoka T, Fukuda T, Hashizume T, Nishiyama T, Tada H, Yam ad a H, Salomon DS, Yamada S, Kojima I, Seno M.
  • Journal Title: J Mol Biol. 380 Pages: 83-94
  • Peer Reviewed
• [Journal Article] Smad2 functions as a co-activator of canonical Wnt/beta-cateninsignaling pathway independent of Smad4 through histone acetyltransferaseactivity of p300. (2008)
  • Author(s): Hirota M, Watanabe K, Hamada s, Sun Y, Strizzi L, Mancino M, Nagaoka T, Gonzales M, Seno M, Bianco c, Salomon DS.
  • Journal Title: Cell Signal. 20 Pages: 1632-1641
  • Peer Reviewed
• [Journal Article] Intracellular Delivery of Glutathione S-Transferase-fused Proteins into Mammalian Cells by Polyethylenimine-Glutathione Conjugates. (2008)
  • Author(s): Murata H, Futami J, Kitazoe M, Yonehara T, Nakanishi H, Kosaka M, Tada H, Sakaguchi M, Yagi Y, Seno M, Huh NH, Yamada H.
  • Journal Title: J Biochem. 144 Pages: 447-455
  • NAID: 10024912690
  • Peer Reviewed
• [Journal Article] Reversal of streptozotocin-induced hyperglycemia by continuous supply of betacellulin in mice. (2008)
  • Author(s): Yamamoto Y, Yamada S, Kodera T, Hara A, Motoyoshi K, Tanaka Y, Nagaoka T, Seno M, Kojima I.
  • Journal Title: Growth Factors 26 Pages: 173-179
  • Peer Reviewed
• [Journal Article] Spherical self-organizing map as a helpful tool to identify category-specific cell surface markers. (2008)
  • Author(s): Tuoya, Sugii Y, Satoh H, Yu D, Matsuura Y, Tokutaka H, Seno M.
  • Journal Title: Biochem Biophys Res Commun. 376 Pages: 414-418
  • Peer Reviewed
• [Journal Article] Conophylline and Betacellulin-delta4 : an Effective Combination of Differentiation Factors for Pancreatic beta Cells (2007)
  • Author(s): Kitamura RI, Ogata T, Tanaka Y, Motoyoshi K, Seno M, Takei I, Umezawa K, Kojima I
  • Journal Title: Endocr J 54 Pages: 255-264
  • Peer Reviewed
• [Journal Article] Characteristics of hollow microtubes consisting of amorphous iron oxide nanoparticles produced by iron oxidizing bacteria (2007)
  • Author(s): Hashimoto H, Yokoyama S, Asaoka H, Kusano Y, Ikeda Y, Seno M, TakadaJ, Fujii T, Nakanishi M and Murakami R.
  • Journal Title: Leptothrix ochracea. J Magnetism Magnetic Materials 310 Pages: 2405-2407
  • Peer Reviewed
• [Journal Article] Characterization of bio-nanocapsule as a transfer vector targeting human hepatocyte carcinoma by disulfide linkage modification (2007)
  • Author(s): Nagaoka T, Fukuda T, Yoshida S, Nishimura H, Yu D, Kuroda S, Tanizawa K, Kondo A, Ueda M, Yamada H, Tada H, Seno M.
  • Journal Title: J Control Release 118 Pages: 248-356
  • Peer Reviewed
• [Journal Article] 'Crystal lattice engineering, an approach to engineer protein crystal contacts by creating intermolecular symmetry : Crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines (2007)
  • Author(s): Yamada H, Tamada T, Kosaka M, Miyata K, Fujiki S, Tano M, Moriya M, Yamanishi M, Honjo E, Tada H, Ino T, Yamaguchi H, Futami J, Seno M, Nomoto T, Hirata T, Yoshimura M, Kuroki R.
  • Journal Title: Protein Sci. 16 Pages: 1389-1397
  • Peer Reviewed
• [Journal Article] Development of bionanocapsules targeting brain tumors (2007)
  • Author(s): Tsutsui Y, Tomizawa K, Nagita M, Michiue H, Nishiki T, Ohmori I, Seno M, Matsui H
  • Journal Title: J Control Release 122 Pages: 159-164
  • NAID: 130005448930
  • Peer Reviewed
• [Journal Article] Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phosphol ipase D and enhancement of endothelial cell migration (2007)
  • Author(s): Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS
  • Journal Title: J Biol Chem 282 Pages: 31643-31655
  • Peer Reviewed
• [Journal Article] Gene therapy of liver tumors with human liver-specific nanoparticles (2007)
  • Author(s): Iwasaki Y, Ueda M, Yamada T, Kondo A, Seno M, Tanizawa K, Kuroda S, Sakamoto M, Kitajima M.
  • Journal Title: Cancer Gene Ther 14 Pages: 74-81
  • Peer Reviewed
• [Journal Article] バイオナノキャリアの開発とがん遺伝子治療への応用 (2007)
  • Author(s): 近藤昭彦, 黒田俊一, 谷澤克行, 妹尾昌治, 上田政和
  • Journal Title: バイオテクノロジージャーナル 7 Pages: 41-47
• [Journal Article] Growth factor induction of Cripto-l shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. (2007)
  • Author(s): Watanabe K. Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS
  • Journal Title: J Biol Chem 282 Pages: 31643-31655
  • Peer Reviewed
• [Journal Article] Development of bionanocapsules targeting brain tumors. (2007)
  • Author(s): Tsutsui Y, Tomizawa K, Nagita M, Michiue H, Nishiki T, Ohmori I, Seno M, Matsui H.
  • Journal Title: J Control Release 122 Pages: 159-164
  • NAID: 130005448930
  • Peer Reviewed
• [Journal Article] 'Crystal lattice engineering,' an approach to engineer protein crystal contacts by creating intermolecular symmetry: Crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines. (2007)
  • Author(s): Yamada H, Tamada T, Kosaka M, Miyata K, Fujiki S, Tano M, Moriya M, Yamanishi M, Honjo E, Tada H, Ino T, Yamaguchi H, Futami J, Seno M, Nomoto T, Hirata T, Yoshimura M, Kuroki R.
  • Journal Title: Protein Sci. 16 Pages: 1389-1397
  • Peer Reviewed
• [Journal Article] Characterization of bio-nanocapsule as a transfer vector targeting human hepatocyte carcinoma by disulfide linkage modification. (2007)
  • Author(s): Nagaoka T, Fukuda T, Yoshida S, Nishimura H, Yu D, Kuroda S, Tanizawa K, Kondo A, Ueda M, Yamada H, Tada H, Seno M.
  • Journal Title: J Control Release 118 Pages: 348-356
  • Peer Reviewed
• [Journal Article] Characteristics of hollow microtubes consisting of amorphous iron oxide nanoparticles produced by iron oxidizing bacteria, Leptothrix ochracea (2007)
  • Author(s): Hashimoto H, Yokoyama S, Asaoka H, Kusano Y, Ikeda Y, Seno M, TakadaJ, Fujii T, Nakanishi M and Murakami R.
  • Journal Title: Journal of Magnetism and Magnetic Materials 310 Pages: 2405-2407
  • Peer Reviewed
• [Journal Article] Conophylline and Betacellulin-delta4: an Effective Combination of Differentiation Factors for Pancreatic beta Cells. (2007)
  • Author(s): Kitamura RI, Ogata T, Tanaka Y, Motoyoshi K, Seno M, Takei I, Umezawa K, Kojima I.
  • Journal Title: Endocr J. 54 Pages: 255-264
  • Peer Reviewed
• [Journal Article] バイオナノキャリアの開発とがん遺伝子治療への応用 (2007)
  • Author(s): 近藤昭彦, 黒田俊一, 谷澤克行, 妹尾昌治, 上田政和
  • Journal Title: バイオテクノロジージャーナル 7・1 Pages: 41-47
• [Journal Article] Gene therapy of liver tumors with human liver-specific nanoparticles. (2007)
  • Author(s): Iwasaki Y, Ueda M, Yamada T, Kondo A, Seno M, Tanizawa K, Kuroda S, Sakamoto M, Kitajima M
  • Journal Title: Cancer Gene Ther. 14・1 Pages: 74-81
• [Journal Article] Secretory production system of bionanocapsules using a stably transfected insect cell line (2006)
  • Author(s): Shishido T, Muraoka M, Ueda M, Seno M, Tanizawa K, Kuroda S, Fukuda H, Kondo A.
  • Journal Title: Appl Microbiol Biotechnol 73 Pages: 505-511
  • Peer Reviewed
• [Journal Article] Secretory production system of bionanocapsules using a stably transfected insect cell line. (2006)
  • Author(s): Shishido T, Muraoka M, Ueda M, Seno M, Tanizawa K, Kuroda S, Fukuda H, Kondo A
  • Journal Title: Appl Microbiol Biotechnol. 73・3 Pages: 505-511
• [Presentation] シスプラチン内包シアリルルイスX 修飾リポソームによる腫瘍選択的標的と副作用の低減化 (2008)
  • Author(s): 平井政彦
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] 中空ナノ粒子形成に対するHBV エンベロープ蛋白質粒子内部領域の影響 (2008)
  • Author(s): 栗木政徳
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] シスプラチン内包シアリルルイスX修飾リボソームによる腫瘍選択的標的と副作用の低減化 (2008)
  • Author(s): 平井政彦, 北川寛之, 平松由衣, 大家一典, 五十嵐貢一, 千熊正彦, 妹尾昌治
  • Organizer: 第31回日本分子生物学会年会・第8-1回日本生化学会大会合同大会(BMB2008).
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] 中空ナノ粒子形成に対するHBVエンベロープ蛋白質粒子内部領域の影響 (2008)
  • Author(s): 栗木政徳, 多田宏子, 遠部圭佑, 小坂 恵, 二見淳一郎, 妹尾昌治, 山田秀徳
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] TM9SF2 is upregulated in breast cancer and is a potential molecular target for breast cancer gene therapy (2008)
  • Author(s): Abou-Sharieha S
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] がん細胞内在化能を有する抗体に結合したリポソームを用いる腫瘍イメージング (2008)
  • Author(s): 大谷敬亨
  • Organizer: 第31回日本分子生物学会年会・第81 回日本生化学会大会合同大会(BMB2008)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] がん細胞内在化能を有する抗体に結合したリボソームを用いる腫瘍イメージング (2008)
  • Author(s): 大谷敬亨, 平井政彦, 峯松秀希, 岩下真輝, 田中淳, 平松由衣, 北川寛之, 大家一典, 妹尾昌治, 五十嵐貢一
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] B型肝炎ウィルスエンベロープ蛋白質によるウィルス様粒子形成にTM1ヘリックスは不必要である (2008)
  • Author(s): 遠部圭佑
  • Organizer: 第8回日本蛋白質科学会年会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-10
• [Presentation] B型肝炎ウィルスエンベロープ蛋白質によるウィルス様粒子形成にTM1ヘリックスは不必要である。 (2008)
  • Author(s): 遠部圭佑, 多田宏子, 栗木政徳, 小坂恵, 二見淳一郎, 妹尾昌治, 山田秀徳
  • Organizer: 第8回日本蛋白質科学会年会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-10
• [Presentation] 好酸球塩基性顆粒に由来するタンパク質は心筋細胞の分化を促進する (2008)
  • Author(s): 大谷敬亨
  • Organizer: 第7回日本再生医療学会総会
  • Place of Presentation: 名古屋
• [Presentation] コノフィリンとベータセルリンδ4はGKラットの耐糖能を改善する (2008)
  • Author(s): 小寺力
  • Organizer: 第50回日本糖尿病学会年次学術集会
  • Place of Presentation: 仙台
• [Presentation] ベータセルリン(BTC)のβ細胞分化誘導シグナル経路の解明 (2008)
  • Author(s): 山田聡子
  • Organizer: 第50回日本糖尿病学会年次学術集会
  • Place of Presentation: 仙台
• [Presentation] 持続的なベータセルリン供給は2型糖尿病モデルの病態を改善する (2008)
  • Author(s): 山本頼綱
  • Organizer: 第50回日本糖尿病学会年次学術集
  • Place of Presentation: 仙台
• [Presentation] 腫瘍マーカーの探索と能動的ターゲッティング (2008)
  • Author(s): 妹尾昌治
  • Organizer: 高度医療都市を創出する未来技術シンポジウム
  • Place of Presentation: 岡山
• [Presentation] Searching for cell surface markers common and specific to tumors by spherical self-organizing maps (2008)
  • Author(s): Tuoya
  • Organizer: 2008年日本バイオインフォマティクス学会年会
  • Place of Presentation: 大阪
• [Presentation] S.TM9SF2, a novel cell surface potential target in breast cancer. Second JCA-AACR Special Joint Conferences (2008)
  • Author(s): Abou-Sharieha S
  • Organizer: The Latest Advances in Breast Cancer Research
  • Place of Presentation: 兵庫
• [Presentation] TM9SF2, a novel cell surface potential target in breast cancer (2008)
  • Author(s): Abou-Sharieha S
  • Organizer: 2008 NCRI Cancer Conference
  • Place of Presentation: Birmingham, UK
• [Presentation] TM9SF2, a novel cell surface potential target in breast cancer (2008)
  • Author(s): Abou-Sharieha S
  • Organizer: 20th EORTC-NCI-AACR symposium on " Molecular Targets and Cancer therapeutics "
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Y. Cell Surface Marker Candidate in Brain Tumors Identified by an Oligonucleotide Microarray Coupled with spherical Self-Organizing Map (2008)
  • Author(s): Sugii Y
  • Organizer: The 1st World Congress of Industrial Biotechnology, ibio2008
  • Place of Presentation: Hangzhou, China
• [Presentation] Screening of Cell Surface Marker Candidates with Microarray Coupled with Self-Organizing Map (2008)
  • Author(s): Seno M
  • Organizer: The 1st World Congress of Industrial Biotechnology, ibio2008
  • Place of Presentation: Hangzhou, China
• [Presentation] Cell Surface Marker Screening and Mapping Carcinoma Cells (2008)
  • Author(s): Seno M.
  • Organizer: 2008 Tianjin International Breast Cancer Symposium : Individualized Clinical Pathological Evaluation and Treatment
  • Place of Presentation: Tianjin, China
• [Presentation] The active targeting liposome encupsulated high-density colloidal gold (2008)
  • Author(s): Otani T.
  • Organizer: 11th Liposome Research Days Conference
  • Place of Presentation: Yokohama
• [Presentation] コノフィリンとベータセルリンδ4はGKラツトの耐糖能を改善する (2008)
  • Author(s): 小寺力, 山本頼綱, 原朱美, 山田聡子, 田中祐司. 拓亜, 妹尾昌治, 梅渫一夫, 武井泉. 小島至
  • Organizer: 第50回 日本糖尿病学会年次学術集会
  • Place of Presentation: 仙台
• [Presentation] ベータセルリン(BTC)のβ細胞分化誘導シグナル経路の解明 (2008)
  • Author(s): 山田聡子, 石山延吉, 山本頼綱, 原朱美, 小寺力. 永岡唯宏, 拓亜, 妹尾昌治, 小島至
  • Organizer: 第50回 日本糖尿病学会年次学術集会
  • Place of Presentation: 仙台
• [Presentation] 持続的なベータセルリン供給は2型糖尿病モデルの病態を改善する (2008)
  • Author(s): 山本頼綱, 山田聡子, 小寺力, 原朱美, 田中佑司, 本吉和夫, 妹尾昌治, 小島至
  • Organizer: 第50回 日本糖尿病学会年次学術集会
  • Place of Presentation: 仙台
• [Presentation] Searching for eell surface markers common and specific to tumors by spherical self-organizing maps (2008)
  • Author(s): Tuoya, Yuh Sugii, Hitomi Satoh, Dongwei Yu, Yasaburo Matsuura, Heizo Tokutaka, Masaharu Seno
  • Organizer: 2008年日本バイオインフォマティクス学会年会
  • Place of Presentation: 大阪
• [Presentation] TM9SF2, a novel cell surface potential target in breastcancer. (2008)
  • Author(s): Abou-Sharieha S, Sugii Y, Tada H, Seno M.
  • Organizer: Second JCA-AACE Special Joint Conferences : The Latest Advances in Breast Cancer Research.
  • Place of Presentation: 兵庫
• [Presentation] TM9SF2, a novel cell surface potential target in breastcancer. (2008)
  • Author(s): Abou-Sharieha S. Sugii Y. Tada H, Seno M.
  • Organizer: 2008 NCRI Cancer Conference.
  • Place of Presentation: Birmingham, UK
• [Presentation] TM9SF2, a novel cell surface potential target in breast cancer. (2008)
  • Author(s): Abou-Sharieha S, Sugii Y. Tada H, Seno M
  • Organizer: 20th EORTC-NCI-AACR symposium on "MolecularTargets and Cancer therapeutics".
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Cell Surface Marker Candidate in Brain Tumors Identified by an Oligonucleotide Microarray Coupled with spherical Self-Organizing Map (2008)
  • Author(s): Yuh Sugii, Tuoya, Samah Abou-Sharieha, Hiroko Tada, Hidenori Yamada, Heizo Tokutaka, Masaharu Seno
  • Organizer: The lst World Congress of Industrial Biotechnology, ibio2008
  • Place of Presentation: Hangzhou, China
• [Presentation] Screening of Cell Surface Marker Candidates with Microarray Coupled with Self-Organizing Map (2008)
  • Author(s): Seno M
  • Organizer: The lst World Congress of Industrial Biotechnology, ibio2008
  • Place of Presentation: Hangzhou, China
• [Presentation] Cell surface marker candidates in brain tumors identified by an oligonucleotide microarray coupled with spherical SOM (2007)
  • Author(s): Sugii Y.
  • Organizer: 2007年度日本バイオインフォマティクス学会年会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-19
• [Presentation] Cell surface marker candidates in brain tumors identified by an oligonucleotide microarray coupled with spherical SOM. (2007)
  • Author(s): Yuh Sugii, Tuoya, Samah Abou-Sharieha, Hiroko Tada, Hidenori Yamada. Heizo Tokutaka, Masaharu Seno
  • Organizer: 2007年度日本バイオインフォマティクス学会年会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-19
• [Presentation] Androgen依存性前立腺癌細胞におけるTomoregulin2の機能解析 (2007)
  • Author(s): 藤橋豊人
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会(BMB2007)
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] Cell surface marker candidates in brain tumors (2007)
  • Author(s): Sugii Y
  • Organizer: 47th Annual Meeting The American Society for Cell Bioligy
  • Place of Presentation: Wash DC (USA)
  • Year and Date: 2007-12-05
• [Presentation] Differentiation of AR42J Cells is Not Dependent on ErbB1 Stimulation (2007)
  • Author(s): Nagaoka T.
  • Organizer: 47th Annual Meeting, American Society for Cell Bioligy
  • Place of Presentation: Wash DC (USA)
  • Year and Date: 2007-12-05
• [Presentation] Cell surface marker candidates in brain tumors. (2007)
  • Author(s): Yuh Sugii, Tuoya, Samah A. Abou-Sharieha, Hiroko Tada, Hidenori Yamada. Heizo Tokutaka^*, Masaharu Seno
  • Organizer: 47th Annual Meeting, The American Society for Cell Bioligy
  • Place of Presentation: Wash DC (USA)
  • Year and Date: 2007-12-05
• [Presentation] Differentiation of AR42J Cells is Not Dependent on ErbBl Stimulation. (2007)
  • Author(s): Nagaoka T, Fukuda T, Hashizume T, Tada H, Yamada H, Yamada S, KojimaI, Seno M
  • Organizer: 47th Annual Meeting, The American Society for Cell Bioligy
  • Place of Presentation: Wash DC (USA)
  • Year and Date: 2007-12-05
• [Presentation] Identification of cell surface marker candidates in breast cancer using an oligonucleotide-based microarray system (2007)
  • Author(s): Abou-Sharieha S.
  • Organizer: 第66回日本癌学会学術総
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] Cell type dependent internalization of ErbB (2007)
  • Author(s): 橋爪敏浩
  • Organizer: 第66回日本癌学会学術総
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] Identification of cell surface marker candidates in breast cancer using an oligonucleotide-based microarray system. (2007)
  • Author(s): Abou-Sharieha S, Sugii Y, Tada H, Seno M
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] Cell type dependent internalization of ErbB2 (2007)
  • Author(s): 橋爪敏浩, 多田宏子, 妹尾昌治
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] Continuous Delivery of Betacellulin Reverses Hyperglycemia Induced by Streptozotocin in Mice (2007)
  • Author(s): Yamamoto Y.
  • Organizer: Endocrine Society's 89th Annual Meeting
  • Place of Presentation: Toronto, Canada
• [Book] 自己組織化マップとそのツール (2008)
  • Author(s): 妹尾昌治、杉井裕、拓亜、アボウ・シャリエハサマー、徳高平蔵 シュプリンガー・ジャパン
  • Total Pages: 216
  • Publisher: 大北正昭、徳高平蔵、藤村喜久郎、植田英功編
• [Book] 自己組織化マップとそのツール、大北正昭、徳高平蔵、藤村喜久郎、植田英功編 (2008)
  • Author(s): 妹尾昌治, 杉井裕, 拓亜, アボウ・シャリェハ サマー, 徳高平蔵
  • Total Pages: 216
  • Publisher: シュプリンガー・ジャパン
• [Book] 自己組織化マップとその応用 (2007)
  • Author(s): 妹尾昌治、松浦弥三郎、拓亜、徳高平蔵、大北正昭、藤村喜久郎(編))
  • Total Pages: 314
  • Publisher: シュプリンガー・ジャパン
• [Book] Bioinformatics-a practical approach- ed.Shui Qing Ye, Mathematical and Computational Biology Series (2007)
  • Author(s): Jun Wada, Hiroko Tada, Masaharu Seno
  • Total Pages: 618
  • Publisher: Chapman & Hall/CRC
• [Book] 自己組織化マップとその応用、徳高平蔵、大北正昭、藤村喜久郎編 (2007)
  • Author(s): 妹尾昌治、松浦弥三郎、拓亜、徳高平蔵、大北正昭
  • Total Pages: 314
  • Publisher: シュプリンガー・ジャパン
• [Book] Bioinformatics-a practical approach-ed. shui Qing Ye, (Mathematical and Computational Biology Series) (2007)
  • Author(s): Jun Wada, Hiroko Tada, Masaharu Seno
  • Total Pages: 618
  • Publisher: Chapman & Hall/CRC
• [Remarks] 山陽放送 1月21日(水)18時15分-イブニングニュース
• [Remarks]
  • URL: http://www.cyber.biotech.okayama-u.ac.jp/senolab/
• [Remarks]
  • URL: http://www.cyber.biotech.okayama-u.ac.jp/senolab/index.html
• [Patent(Industrial Property Rights)] ヒトおよびラットの細胞表面マーカー遺伝子を結合したDNAアレイとその用途 (2007)
  • Inventor(s): 妹尾昌治
  • Industrial Property Rights Holder: 国立大学法人岡山大学
  • Industrial Property Number: 2007-218030
  • Filing Date: 2007-08-24