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Clinical evaluation of a noninvasive estimation system for cardiac function

Research Project

Project/Area Number 18300167
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionTohoku University

Principal Investigator

YOSHIZAWA Makoto  Tohoku University, サイバ-サイエンスセンター, 教授 (60166931)

Co-Investigator(Kenkyū-buntansha) NITTA Shinichi  東北大学, 加齢医学研究所, 教授 (90101138)
YAMBE Tomoyuki  東北大学, 加齢医学研究所, 教授 (70241578)
SAIJO Yoshifumi  東北大学, 医工学研究科, 教授 (00292277)
TANAKA Akira  福島大学, 共生システム理工学類, 准教授 (10323057)
SHIRAISHI Yasuyuki  東北大学, 加齢医学研究所, 准教授 (00329137)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,100,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2006: ¥8,000,000 (Direct Cost: ¥8,000,000)
KeywordsEmax / 最大エラスタンス / 非侵襲的推定 / 最適制御 / 心機能 / 補助人工心臓 / 左心室 / パラメータ最適化法 / 一拍内推定法
Research Abstract

補助人工心臓装着患者の心機能推定は人工心臓離脱時期決定に重要である. 本研究では, われわれが提案した1拍内だけの情報に基づいて心機能の指標であるE_<max>を推定する方法であるパラメ-タ最適化法が, 補助人工心臓装着時循環系における心機能推定に対しても有効かどうかを検討した. ヤギを用いた動物実験により検討した結果, パラメータ最適化法は, ポンプの回転数に依存せず, 補助人工心臓装着時循環系における心機能の推定が可能であることが明らかとなった.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (29 results)

All 2008 2007 2006 Other

All Journal Article (14 results) (of which Peer Reviewed: 6 results) Presentation (10 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Detection and quantification of calcifications in intravascular ultrasound images by automatic thresholding2008

    • Author(s)
      E. Santos Filho, Y. Saijo, A. Tanaka, M. Yoshizawa
    • Journal Title

      Ultrasound in Medicine & Biology 34(1)

      Pages: 160-165

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Evaluation of Effects of Visually-Induced Motion Sickness Based on Causal Coherence Functions between Blood Pressure and Heart Rate2008

    • Author(s)
      Norihiro Sugita, Makoto Yoshizawa, Akira Tanaka, Ken-ichi Abe, Shigeru Chiba, Tomoyuki Yambe and Shin-ichi Nitta
    • Journal Title

      Displays 29

      Pages: 167-175

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 多変数制御装置としての循環中枢-心拍数調節と血管抵抗調節の役割分担-2008

    • Author(s)
      吉澤誠, 杉田典大, 阿部誠, 田中明, 山家智之, 仁田新一
    • Journal Title

      臨床脳波 36(7)

      Pages: 347-353

    • Related Report
      2008 Final Research Report
  • [Journal Article] 統合医療の医工学的評価と今後の展開-鍼が循環系に及ぼす影響の制御工学的解釈-2008

    • Author(s)
      吉澤誠, 関隆志, 杉田典大, 阿部誠, 田中明, 金野敏, 川田浩, 山家智之, 仁田新一
    • Journal Title

      日本統合医療学会会誌 1(1)

      Pages: 28-32

    • NAID

      40016193552

    • Related Report
      2008 Final Research Report
  • [Journal Article] Quantitative Evaluation of Effects of Visually-Induced Motion Sickness Based on Causal Coherence Functions between Blood Pressure and Heart Rate2008

    • Author(s)
      Norihiro Sugita
    • Journal Title

      Displays 29

      Pages: 167-175

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of adaptation to visually induced motion sickness based on the maximum cross-correlation between pulse transmission time and heart rate2007

    • Author(s)
      Norihiro Sugita, Makoto Yoshizawa, Makoto Abe, Akira Tanaka, Takashi Watanabe, Shigeru Chiba, Tomoyuki Yambe, Shin-ichi Nitta
    • Journal Title

      Journal of NeuroEngineering and Rehabilitation 4(35)

    • NAID

      120002338949

    • URL

      http://www.jneuroengrehab.com/content/4/1/35

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 工学的アプローチによる統合医療の評価-自律神経系指標ρ_<max>の適用例-2007

    • Author(s)
      吉澤誠, 関隆志, 杉田典大, 阿部誠, 田中明, 金野敏, 川田浩, 山家智之, 仁田新一
    • Journal Title

      統合医療 4(1/2)

      Pages: 60-64

    • Related Report
      2008 Final Research Report
  • [Journal Article] 相補・代替医療の研究(3)(医工学から)2007

    • Author(s)
      金野敏, 川田浩, 仁田新一, 杉田典大, 吉澤誠
    • Journal Title

      治療 89(3)

      Pages: 700-707

    • Related Report
      2008 Final Research Report
  • [Journal Article] Detection and quantification of calcifications in intravascular ultrasound images by automatic thresholding2007

    • Author(s)
      Esmeraldo Dos Santos Filho
    • Journal Title

      Ultrasound in Medicine & Biology 34

      Pages: 160-165

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Yukihiko Nose : Indirect flow measurement of the NEDO PI gyro pump for Chronic BVAD experiments2006

    • Author(s)
      Daisuke Ogawa, Makoto Yoshizawa, Akira Tanaka, Ken-ichi Abe, Paul Oregario, Tadashi Motomura, Hisashi Okubo, Takeshi Oda, Toshiya Okahisa, Steohen R. Igo
    • Journal Title

      ASAIO J 52(3)

      Pages: 266-271

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 定常流型補助人工心臓の循環制御は不要か?2006

    • Author(s)
      吉澤誠, 田中明, 小川大祐, 笠原孝一郎, ポール・オレガリオ, 白石泰之, 関根一光, 山家智之, 仁田新一
    • Journal Title

      循環制御 28(1)

      Pages: 4-11

    • NAID

      10018896138

    • Related Report
      2008 Final Research Report
  • [Journal Article] Indirect flow measurement of the NEDO PI gyro pump for Chronic BVAD experiments2006

    • Author(s)
      Daisuke Ogawa
    • Journal Title

      ASAIO J 52

      Pages: 266-271

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Intravascular two-dimensional tissue strain imaging2006

    • Author(s)
      Yoshifumi Saijo
    • Journal Title

      Ultrasonics 22・44

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 定常流型補助人工心臓の復環制御は不要か?2006

    • Author(s)
      吉澤 誠
    • Journal Title

      循環制御 28・1

      Pages: 4-11

    • Related Report
      2006 Annual Research Report
  • [Presentation] Estimation of Emax of Assisted Hearts using Single Beat Estimation Method2008

    • Author(s)
      T.K.Sugai, A.Tanaka, M.Yoshizawa, Y.Shiraishi, S. Nitta, T.Yambe and A.Baba
    • Organizer
      The 13th International Conference on Biomedical Engineering
    • Place of Presentation
      Singapore, Singapore
    • Year and Date
      2008-12-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Estimation of Cardiac Function with VAD based on Estimated Flow2008

    • Author(s)
      Telma Keiko Sugai
    • Organizer
      54th ASAIO Annual Conference
    • Place of Presentation
      San Francisco, U.S.A.
    • Year and Date
      2008-06-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Preliminary evaluation of some single-beat methods for assessment of the ventricular contractility during assistance with RBP2008

    • Author(s)
      T.K. Sugai, A. Tanaka, M. Yoshizawa, Y. Shiraishi, T. Yambe, S. Nitta, A. Baba
    • Organizer
      16th Congress of ISRBP, Houston
    • Place of Presentation
      USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Preliminary study on the estimation of Emax using single-beat methods during assistance with rotary blood pumps2008

    • Author(s)
      T.K. Sugai, A. Tanaka, M. Yoshizawa, Y. Shiraishi, T. Yambe, S. Nitta, A. Baba
    • Organizer
      30th Annual International Conference of the IEEE
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] S : Evaluation of Pump Control Based on Dynamic Property on Native Heart2008

    • Author(s)
      Tanaka A, Kasahara K, Yoshizawa M, Sugai TK, Shiraishi Y, Baba A, Yambe T, Nitta S
    • Organizer
      54th Annual Conference ASAIO, San Fransisco
    • Place of Presentation
      USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Estimation of Cardiac Function with VAD based on Estimated Flow2008

    • Author(s)
      T.K. Sugai, A. Tanaka, M. Yoshizawa, D. Ogawa, Y. Shiraishi, T. Yambe, S. Nitta, A. Baba
    • Organizer
      54th ASAIO Annual Conference
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Detection of cardiac function during rotary blood pump assistance2008

    • Author(s)
      T.K. Sugai, A. Tanaka, M. Yoshizawa, D. Ogawa, Y. Shiraishi, T. Yambe, S.Nitta
    • Organizer
      3rd International Symposium on Medical, Bio- and Nano-Electronics
    • Place of Presentation
      Sendai Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Evaluation of Emax Estimation Based on Motor Current and Rotational Speed2007

    • Author(s)
      Telma Keiko Sugai
    • Organizer
      15th Congress of International Society for the Rotary Blood Pump
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2007-11-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Control Strategy of Continuous-Flow Artificial Hearts2006

    • Author(s)
      Makoto Yoshizawa, Daisuke Ogawa, Paul Olegario, Kouichiro Kasahara, Akira Tanaka, Ken-ichi Abe, Yasuyuki Shiraishi, Tomoyuki Yambe, Sin-ichi Nitta
    • Organizer
      2^<nd> International Symposium on Bio- and Nano-Electronics
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2006-12-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Development of an algorithm for detection of fatal arrhythmias for implantable cardioverter-defibrillator using a self-organizing map2006

    • Author(s)
      Hiroyuki Kinoshita, Makoto Yoshizawa, Masashi Inagaki, Kazunori Uemura, Masaru Sugimachi, Kenji Sunagawa
    • Organizer
      Proc. of 28th Annual International conference IEEE Engineering in Medicine and Biology Sosiety
    • Place of Presentation
      New York, USA
    • Year and Date
      2006-09-01
    • Related Report
      2008 Final Research Report
  • [Book] システム制御工学2007

    • Author(s)
      阿部健一, 吉澤誠
    • Publisher
      朝倉書店
    • Related Report
      2008 Final Research Report
  • [Book] 循環器系人工臓器医用機器II(山形仁編)2006

    • Author(s)
      吉澤誠
    • Publisher
      コロナ社
    • Related Report
      2008 Final Research Report
  • [Book] 環器系人工臓器,山形 仁 編著 : 医用機器II,pp.145-1522006

    • Author(s)
      吉澤 誠
    • Total Pages
      167
    • Publisher
      コロナ社
    • Related Report
      2006 Annual Research Report
  • [Remarks]

    • URL

      http://www.yoshizawa.ecei.tohoku.ac.jp/wwwpub/EstEmax/

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 不整脈信号検出装置および除細動装置2007

    • Inventor(s)
      木下広幸, 吉澤 誠, 石橋純一, 清水一夫
    • Industrial Property Rights Holder
      東北大学
    • Industrial Property Number
      2007-036728
    • Filing Date
      2007-02-16
    • Related Report
      2006 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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