Newly Developed Image Analysis Method of Tumor Blood Flow : Separate Quantitative Analysis of Intranodular Arterial and Portal Blood Flow and Its Application to Research on Hepatocarcinogenesis

• Project/Area Number: 18300176
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Kinki University
• Principal Investigator: KUDO Masatoshi Kinki University, 医学部, 教授 (10298953)
• Co-Investigator(Kenkyū-buntansha): MURAKAMI Takamichi 近畿大学, 医学部, 教授 (20252653) ; MUNAKATA Hiroshi 近畿大学, 医学部, 教授 (90111294) ; 福永 豊和 近畿大学, 医学部, 講師 (90330315)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥15,110,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥1,110,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2006: ¥10,300,000 (Direct Cost: ¥10,300,000)
• Keywords: 肝細胞癌 / 造影ハーモニック法 / Sonazoid / Pure arterial phase imaging / 結節内動脈血流 / 結節内門脈血流 / 早期肝癌 / 前癌病変 / 肝腫瘍 / 純動脈相イメージング / 腺腫様過形成 / Levovist

Research Abstract

今回われわれはraw data保存を利用して動脈血流と門脈血流を分離評価できる方法を開発した。新規超音波造影剤Sonazoidを用いることにより、そのraw data保存から検査後に腫瘍ならびに腫瘍の外側の動脈や門脈に関心領域(ROI)をおき、その立ち上がりから純粋に動脈のみで栄養される数秒間を装置内でコンピューター解析で同定し、その時間だけのMIP画像を加算してaccumulation画像を作成すると動脈が栄養しているか否かを判定し得ることを明らかにした。また、その後の門脈と動脈の両方が入るmixed phaseにおいては両者の交じり合ったこのphaseで血流が認められれば、それは門脈血流が存在する結節であることが評価できる。

Research Products

• [Journal Article] Multicentric occurrence of HCC detected 3-4 yerars after AFP-L3 positivity. (2009)
  • Author(s): Kim SR
  • Journal Title: Internal Med (in press)
  • Peer Reviewed
• [Journal Article] Value of liver parenchymal phase imaging of contrast-enhanced ultrasonography to diagnose the premalignant/borderline lesions and overt HCC. (2009)
  • Author(s): Inoue T
  • Journal Title: AJR Am J Roentgenol (in press)
  • Peer Reviewed
• [Journal Article] Multistep human hepatocarcinogenesis : correlation of imaging with pathology. (2009)
  • Author(s): Kudo M
  • Journal Title: J Gastroenterol (in press)
  • NAID: 10025177447
  • Peer Reviewed
• [Journal Article] International consensus on the pathologic diagnosis of early hepatocellular carcinoma : A report of the international consensus group for hepatocellular neoplasia. (2009)
  • Author(s): Wanless I
  • Journal Title: Hepatology (in press)
  • Peer Reviewed
• [Journal Article] Crohn's disease with gastroduodenal mucosa lesions that are similar to the lesions caused by ulcerative colitis. (2009)
  • Author(s): Umehara Y
  • Journal Title: Inflamm Bowel Dis (in press)
  • Peer Reviewed
• [Journal Article] Campylobacter fetus meningitis in a patient with Crohn's disease. (2009)
  • Author(s): Umehara Y
  • Journal Title: Inflamm Bowel Dis (in press)
  • Peer Reviewed
• [Journal Article] Two cases of non-alcoholic steato-hepatitis developing from simple fatty liver. (2009)
  • Author(s): Kim SR
  • Journal Title: J Hepatol (in press)
  • Peer Reviewed
• [Journal Article] Pegylated interferon plus ribavirin combination therapy for chronic hepatitis C with high viral load of serum HCV RNA, genotype 1b, discontinued on attaining sustained virological response in week 16 after onset of acute pancreatitis. (2009)
  • Author(s): Kim SR
  • Journal Title: J Gastroint Liver Dis (in press)
  • Peer Reviewed
• [Journal Article] Small cell carcinoma of the pancreas : Role of EUS-FNA in its confirmation and subsequent effective chemotherapy using carbop latin and etoposide. (2009)
  • Author(s): Sakamoto H
  • Journal Title: J Gastroenterol (in press)
  • Peer Reviewed
• [Journal Article] Prospective comparative study of the EUS guided 25-gauge FNA needle with the 19-gauge Trucut needle and 22-gauge FNA needle in patients with solid pancreatic masses. (2009)
  • Author(s): Sakamoto H
  • Journal Title: J Gastroen Hepatol (in press)
  • Peer Reviewed
• [Journal Article] Comparison of an ecabet sodium and proton pump inhibitor(PPI) combination therapy with PPI alone in the treatment of endoscopic submucosal dissection(ESD)-induced ulcers in early gastric cancer : prospective randomized study. (2009)
  • Author(s): Asakuma Y
  • Journal Title: Hepatogastroenterol (in press)
  • Peer Reviewed
• [Journal Article] Association of genetic polymorphism with interferon-induced he matologic adverse effects in chronic hepatitis C patients. (2009)
  • Author(s): Wada M
  • Journal Title: J Viral Hepatitis (in press)
  • Peer Reviewed
• [Journal Article] Pegylated interferon plus ribavirin combination therapy for chronic hepatitis C with high viral load of serum HCV RNA, genotype 1b, discontinued on attaining sustained virological response in week 16 after onset of acute pancreatitis. (2009)
  • Author(s): Kim SR
  • Journal Title: Digestion (in press)
  • Peer Reviewed
• [Journal Article] Endoscopic findings of intestinal Behcet's disease complicated with toxic megacolon. (2009)
  • Author(s): Umehara Y
  • Journal Title: Endoscopy (in press)
  • Peer Reviewed
• [Journal Article] Hepatectomy versus radiofrequency ablation for early hepatocelullar carcinoma : Reply. (2009)
  • Author(s): Hasegawa K
  • Journal Title: J Hepatol (in press)
  • Peer Reviewed
• [Journal Article] Comparison of endoscopic ultrasound guided directional e-FLOW using microbubble contrast gent with power Doppler and color Doppler in solid pancreatic lesions. (2009)
  • Author(s): Das K
  • Journal Title: Ultrasound Med Biol (in press)
  • Peer Reviewed
• [Journal Article] Transarterial infusion chemotherapy alone versus transarterial chemoembolization for the treatment of hepatocellular carcinoma : Results of a multicenter randomized phase III trial. (2009)
  • Author(s): Okusaka T
  • Journal Title: Hepatology (in press)
  • Peer Reviewed
• [Journal Article] Angiotensin-II type 1 receptor blocker and angiotensin-converting enzyme inhibitor suppress pancreatitis and fibrosis : in vitro study with rat pancreatic stellate cells and in vivo study with Wistar Bonn/Kobori Rats. (2009)
  • Author(s): Fukuta N
  • Journal Title: Gastroenterology (in press)
  • Peer Reviewed
• [Journal Article] Radiofrequency ablation guided by Sonazoid-enhanced harmonic US for occult hepatic malignancies resolved poorly on B-mode US (2009)
  • Author(s): Minami Y
  • Journal Title: Radiology (in press)
  • Peer Reviewed
• [Journal Article] Colic intussusception in a patient with Cronkhite-Canada syndrome is relieved by colonscopic redution. (2009)
  • Author(s): Minami Y
  • Journal Title: Gastrointenst Endosc (in press)
  • Peer Reviewed
• [Journal Article] Hepatocellular carcinooma 2009 and beyond : from the surveillance to molecular targeted therapy (2008)
  • Author(s): Kudo M
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Epidemiology of hepatocellular carcinoma in Japan and Korea (2008)
  • Author(s): Kim SR, Kudo M, 他4名
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Impact of Interferon therapy after curative treatment of hepatocellular carcinoma (2008)
  • Author(s): Kudo M
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Sonazoid-enhanced ultrasonography for diagnosis of hepatic malignancies : comparison with contrast-enhanced CT (2008)
  • Author(s): Hatanaka K, Kudo M, 他2名
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Imaging of hepatocellular carcinoma : qualitative and quantitative analysis of post-vascular phase contrast-enhanced US with Sonazoid ; comparison with superparamagnetic ironoxide magnetic resonance images (2008)
  • Author(s): Inoue T, Kudo M, 他10名
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Intranodular blood supply correlates well with biological malignancy grade determined by tumor growth rate in pathologically proven hepatocellular carcinoma (2008)
  • Author(s): Kudo M, 他1名
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Validation of a new prognostic staging system for heptaocellular carcinoma : a comparison of the biomarker combined Japan integrated staging(JIS) score, the conventional JIS score and the BALAD score (2008)
  • Author(s): Kitai S, Kudo M, 他8名
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] PIVKA-II is the best prognostic predictor in patients with hepatocellular carcinoma after radio frequency ablation therapy (2008)
  • Author(s): Takahashi S, KudoM, 他9名
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Response evaluation of transcatheter arterial chemoembolizaion in hepatocellular carcinomas : the usefulness of Sonazoid-enhanced harmonic sonography (2008)
  • Author(s): Xia Y, Kudo M, 他13名
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Combination therapy with S-1 and pegylated interferon alpha for advanced hepatocellular carcinoma (2008)
  • Author(s): Ueshima K, Kudo M, 他8名
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Focal nodular hyperplasia-like lesion with venous washout in alcoholic liver cirrhosis (2008)
  • Author(s): Kim SR, KudoM, 他10名
  • Journal Title: Internal Med 47 Pages: 1899-1903
  • NAID: 130000079588
  • Peer Reviewed
• [Journal Article] Multistep progression from a hypovascular nodule to a nodule-in-nodule type hepatocellular carcinoma in hepatitis C-related cirrhosis (2008)
  • Author(s): Madan K, Kudo M, 他1名
  • Journal Title: Indian J Gastroenterol 27 Pages: 176-176
  • Peer Reviewed
• [Journal Article] Foreign body granuloma mimicking disseminated tumor reccurence after radiofrequency ablation for hepatocellular carcinoma (2008)
  • Author(s): Takahashi S, Kudo M, 他5名
  • Journal Title: Liver Int 28 Pages: 414-415
  • Peer Reviewed
• [Journal Article] Surgical resection vs. percutaneous ablation for hepatocellular carcinoma : a preliminary report of the Japanese nationwide survey (2008)
  • Author(s): Hasegawa K, Kudo M, 他13名
  • Journal Title: J Hepatol 49 Pages: 589-594
  • Peer Reviewed
• [Journal Article] Long-term follow-up of atypical progressive focal nodular hyperplasia increasing in size and number implicates its pathogenesis (2008)
  • Author(s): Kudo M, 他6名
  • Journal Title: Am J Gastroenterol 103 Pages: 2153-2155
  • Peer Reviewed
• [Journal Article] Tumor markers after radio frequency ablation therapy for hepatocellular carcinoma (2008)
  • Author(s): Ogawa C, Kudo M, 他3名
  • Journal Title: Hepato-Gastroenterol 55 Pages: 1454-1457
  • Peer Reviewed
• [Journal Article] Defect reperfusion imaing, a newly developed novel technology usine Sonazoid in the treatment of hepatocellular carcinoma (2008)
  • Author(s): Kudo M, 他2名
  • Journal Title: J Med Ultrasound 16 Pages: 169-175
  • Peer Reviewed
• [Journal Article] Prognostic value of pretreatment levels of tumor markers for hepatocellular carcinoma on survival after curative treatment of patients with HCC (2008)
  • Author(s): Toyoda H, Kudo M, 他11名
  • Journal Title: J Hepatol 49 Pages: 223-232
  • Peer Reviewed
• [Journal Article] Sonazoid-enhanced ultrasound in the diagnosis and treatment of hepatic tumors (2008)
  • Author(s): Kudo M, 他2名
  • Journal Title: J Med Ultrasound 16 Pages: 130-139
  • Peer Reviewed
• [Journal Article] A new prognostic staging system for hepatocellular carcinoma : value of the biomarker combined Japan integrated staging score (2008)
  • Author(s): Kitai S, Kudo M, 他15名
  • Journal Title: Intervirology 51
  • Peer Reviewed
• [Journal Article] Elevated serum ALT levels durinc pegylated interferon monotherapy may be caused by hepatic iron overload (2008)
  • Author(s): Nagashima M, Kudo M, 他5名
  • Journal Title: Intervirology 51
  • Peer Reviewed
• [Journal Article] Usefulness of a new immunoradiometric assay of HCV core antigen to predict virological response during PEG-IFN/RBV combination therapy for chronic hepatitis with high viral load of serum HCV RNA genotye 1b (2008)
  • Author(s): Sasase N, Kudo M, 他10名
  • Journal Title: Intervirology 51
  • Peer Reviewed
• [Journal Article] Differential diagnosis of hepatic tumors : value of contrast-enhanced harmonic sonography using the newly developed contrast agent, Sonazoid (2008)
  • Author(s): Hatanaka K, Kudo M, 他10名
  • Journal Title: Intervirology 52
  • Peer Reviewed
• [Journal Article] Noninvasive evaluation of hepatic fibrosis using serum fibrotic markers, transient elastography (FibroScan), and real-time tissue (2008)
  • Author(s): Tatsumi C, Kudo M, 他10名
  • Journal Title: Intervirology 51
  • Peer Reviewed
• [Journal Article] Diagnostic accuracy of imaging for liver cirrhosis compared to histologically proven liver cirrhosis (2008)
  • Author(s): Kudo M, 他13名
  • Journal Title: Intervirology 51
  • Peer Reviewed
• [Journal Article] Radiofrequency ablation of hepatocellular carcinoma : value of virtual CT sonography with magnetic navigation (2008)
  • Author(s): Minami Y, Kudo M, 他6名
  • Journal Title: AJR Am J Roentgenol 190
  • Peer Reviewed
• [Journal Article] Lone-term outcome of percutaneous ethanol injection therapy for minimum-sized hepatocellular carcinoma (2008)
  • Author(s): Taniguchi M, Kudo M, 他9名
  • Journal Title: World J Gastroenterol 14 Pages: 1997-2002
  • Peer Reviewed
• [Journal Article] Comparison of three current staging systems for hepatocellular carcinoma : Japan integrated staging score, new Barcelona clinic liver cancer staging classification, and Tokyo score (2008)
  • Author(s): Chung H, Kudo M, 他8名
  • Journal Title: J Gastroenterol Hepatol 23 Pages: 445-452
  • Peer Reviewed
• [Journal Article] Molecular mechanisms of portal vein tolerance (2008)
  • Author(s): Watanabe T, Kudo M, 他2名
  • Journal Title: Hepatol Res 38 Pages: 441-449
  • NAID: 10024148257
  • Peer Reviewed
• [Journal Article] Comparison of the outcomes between an anatomical subsegmentectomy and a non-anatomical minor hepatectomy for single hepatocellular carcinomas based on a Japanese nationwide survey (2008)
  • Author(s): Eguchi S, Kudo M, 他12名
  • Journal Title: Surgery 143 Pages: 469-475
  • Peer Reviewed
• [Journal Article] Preliminary study of contrast-enhanced harmonic endosonography with second-generation contrast agents (2008)
  • Author(s): Kitano M, Kudo M, 他8名
  • Journal Title: J Med Ultrasonics 35 Pages: 11-18
  • NAID: 10024142634
  • Peer Reviewed
• [Journal Article] Mixed intenstinal- and diffuse-type histology is a risk factor for lymph node metastasis of submucosal invasive gastric cancer (2008)
  • Author(s): Tsuji N, Kudo M, 他2名
  • Journal Title: Digest Endosc 20 Pages: 17-21
  • Peer Reviewed
• [Journal Article] A novel perfusion imaging technique of the pancreas : contrast-enhanced harmonic EUS (with video). (2008)
  • Author(s): Kitano M
  • Journal Title: Gastrointest Endscopy 67 Pages: 141-150
  • Peer Reviewed
• [Journal Article] Mixed intestinal- and diffuse-type histology is a risk factor for lymph node metastasis of submucosal invasive gastric cancer. (2008)
  • Author(s): Tsuji N
  • Journal Title: Digest Endosc 20 Pages: 17-21
  • Peer Reviewed
• [Journal Article] Usefulness of a new immunoradiometric assay of HCV core antigen to predict virological response during PEG-IFN/RBV combination therapy for chronic hepatitis with high viral load of serum HCV RNA genotye 1b. (2008)
  • Author(s): Sasase N
  • Journal Title: Intervirology 51
  • Peer Reviewed
• [Journal Article] Elevated serum ALT levels during pegylated interferon monotherapy may be caused by hepatic iron overload. (2008)
  • Author(s): Nagashima M
  • Journal Title: Intervirology 51
  • Peer Reviewed
• [Journal Article] Sonazoid-enhanced ultrasound in the diagnosis and treatment of hepatic tumors. (2008)
  • Author(s): Kudo M
  • Journal Title: J Med Ultrasound 16 Pages: 130-139
  • Peer Reviewed
• [Journal Article] Prognostic value of pretreatment levels of tumor markers for hepatocellular carcinoma on survival after curative treatment of patients with HCC. (2008)
  • Author(s): Toyoda H
  • Journal Title: J Hepatol 49 Pages: 223-232
  • Peer Reviewed
• [Journal Article] Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer : an open-label, randomised controlled trial. (2008)
  • Author(s): Fukase K
  • Journal Title: Lancet 372 Pages: 392-397
  • Peer Reviewed
• [Journal Article] Endoscopic findings can predict the efficacy of leukocytapheresis for steroid-naive patients with moderately active ulcerative colitis. (2008)
  • Author(s): Umehara Y
  • Journal Title: World J Gastroenterol 14 Pages: 5316-5321
  • Peer Reviewed
• [Journal Article] Defect reperfusion imaing, a newly developed novel technology using Sonazoid in the treatment of hepatocellular carcinoma. (2008)
  • Author(s): Kudo M
  • Journal Title: J Med Ultrasound 16 Pages: 169-176
  • Peer Reviewed
• [Journal Article] Long-term follow-up of atypical progressive focal nodular hyperplasia increasing in size and number implicates its pathogenesis. (2008)
  • Author(s): Kudo M
  • Journal Title: Am J Gastroenterol 103 Pages: 2153-2155
  • Peer Reviewed
• [Journal Article] Multistep progression from a hypovascular nodule to anodule-in-nodule type hepatocellular carcinoma in hepatitis C-related cirrhosis. (2008)
  • Author(s): Madan K
  • Journal Title: Indian J Gastroenterol 27 Pages: 176-176
  • Peer Reviewed
• [Journal Article] Intracystic hemorrhage in a patient of polycystic kidney with renocolic fistula diagnosed by contrast-enhanced ultrasonography. (2008)
  • Author(s): Ishikawa E
  • Journal Title: Internal Med 47 Pages: 1977-1979
  • Peer Reviewed
• [Journal Article] Hepatocellular ccarcinoma 2009 and beyond : from the surveillance to molecular targeted therapy. (2008)
  • Author(s): Kudo M
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Epidemiology of hepatocellular carcinoma in Japan and Korea. (2008)
  • Author(s): Kim SR
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Impact of interferon therapy after curative treatment of hepatocellular carcinoma. (2008)
  • Author(s): Kudo M
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Sonazoid-enhanced ultrasonography for diagnosis of hepatic malignancies : comparison with contrast-enhanced CT. (2008)
  • Author(s): Hatanaka K
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Imaging of hepatocellular carcinoma : qualitative and quantitative analysis of post-vascular phase contrast-enhanced US with Sonazoid ; comparison with superparamagnetic iron oxide magnetic resonance images. (2008)
  • Author(s): Inoue T
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Intranodular blood supply correlates well with biological malignancy grade determined by tumor growth rate in pathologically proven hepatocellular carcinoma. (2008)
  • Author(s): Kudo M
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Validation of a new prognostic staging system for heptaocellular carcinoma : a comparison of the biomarker combined Japan integrated staging (JIS) score, the conventional JIS score and the BALAD score. (2008)
  • Author(s): Kitai S
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] PIVKA-II is the best prognostic predictor in patients with hepatocellular carcinoma after radiofrequency ablation therapy. (2008)
  • Author(s): Takahashi S
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Response evaluation of transcatheter arterial chemoembolizaion in hepatocellular carcinomas : the usefulness of Sonazoid-enhanced harmonic sonography. (2008)
  • Author(s): Xia Y
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Combination therapy with S-1 and pegylated interferon alpha for advanced hepatocellular carcinoma. (2008)
  • Author(s): Ueshima K
  • Journal Title: Oncology 75
  • Peer Reviewed
• [Journal Article] Prognostic significance of intragastric pressure for the occurrence of aspiration pneumonia in the patients with percutaneous endoscopic gastrostomy(PEG). (2008)
  • Author(s): Kudo M
  • Journal Title: Hepato-Gastroenterol 55 Pages: 1935-1938
  • Peer Reviewed
• [Journal Article] Focal nodular hyperplasia-like lesion with venous washout in a lcoholic liver cirrhosis. (2008)
  • Author(s): Kim SR
  • Journal Title: Internal Med 47 Pages: 1899-1903
  • Peer Reviewed
• [Journal Article] Effects of decorin on the expression of alpha-smooth muscle actin in a human myofibroblast cell line. (2008)
  • Author(s): Nakatani T
  • Journal Title: Mol Cell Biochem (in press)
  • Peer Reviewed
• [Journal Article] Utility of contrast-enhanced endoscopic ultrasonography for diagnosis of small pancreatic carcinomas (2008)
  • Author(s): Sakamoto H
  • Journal Title: Ultrasound Med Biol (in press)
  • Peer Reviewed
• [Journal Article] Treatment of large and/or multiple hepatic malignancies:open surgical approaches of radiofrequency ablation (2008)
  • Author(s): Minami Y
  • Journal Title: Hepato-Gastroenterol (in press)
  • Peer Reviewed
• [Journal Article] Multicentric occurrence of HCC detected 3-4 yerars after AFP L3 positivity (2008)
  • Author(s): Kim SR
  • Journal Title: Internal Med (in press)
  • Peer Reviewed
• [Journal Article] Evaluation of therapeutic response to gemcitabine in pancreatic cancer:value of contrast-enhanced harmonic imaging (2008)
  • Author(s): Suetomi Y
  • Journal Title: Hepato-Gastroenterol (in press)
  • Peer Reviewed
• [Journal Article] Comparision of three current staging systems for hepatocellular carcinoma:JIS score, new Barcelona clinic liver cancer staging classification, and Tokyo score (2008)
  • Author(s): Chung H
  • Journal Title: J Gastroenterol Hepatol (in press)
  • Peer Reviewed
• [Journal Article] Tumor markers after radiofrequency ablation therapy for hepatocellular carcinoma (2008)
  • Author(s): Ogawa C
  • Journal Title: Hepato-Gastroenterol (in press)
  • Peer Reviewed
• [Journal Article] Foreign body granuloma mimicking disseminated tumor reccurence after radiofrequency ablation for hepatocellular carcinoma in a subcapsular location (2008)
  • Author(s): Takahashi S
  • Journal Title: Liver Int (in press)
  • Peer Reviewed
• [Journal Article] Molecular mechanisms of portal vein tolerance (2008)
  • Author(s): Watanabe T
  • Journal Title: Hepatol Res (in press)
  • Peer Reviewed
• [Journal Article] Preliminary study of cntrast-enhanced harmonic endosonography with second generation contrast agents (2008)
  • Author(s): Kitano M
  • Journal Title: J Med Ultrasonics (in press)
  • Peer Reviewed
• [Journal Article] Long-term outcome of percutaneous ethanol injection therapy for minimum-sized hepatocellular carcinoma (2008)
  • Author(s): Taniguchi M
  • Journal Title: World J Gastroenterol (in press)
  • Peer Reviewed
• [Journal Article] The clinical characteristics, endscopic treatment and prognosis for patients presenting with duodenal varices (2008)
  • Author(s): Matsui S
  • Journal Title: Hepato-Gastroenterol (in press)
  • Peer Reviewed
• [Journal Article] Comparison of outcome between anatomical subsegmentectomy and non-anatomical partial resection for single hepatocellular carcinomas using a Japanese nationwide survey (2008)
  • Author(s): Eguchi S
  • Journal Title: Annals of Surgery (in press)
  • Peer Reviewed
• [Journal Article] Surgical resection vs.percutaneous ablation for hepatocellular carcinoma:prospective Japanese nationwide survey (2008)
  • Author(s): Hasegawa K
  • Journal Title: J Hepatol (in press)
  • Peer Reviewed
• [Journal Article] Radiofrequency ablation of hepatocellular carcinoma:value of virtual CT sonography with magnetic navigation (2008)
  • Author(s): Minami Y
  • Journal Title: AJR Am J Roentgenol (in press)
  • Peer Reviewed
• [Journal Article] In situ carcinoma of pancreas diagnosed by EUS-FNA (2008)
  • Author(s): Sakamoto H
  • Journal Title: Endoscopy (in press)
  • Peer Reviewed
• [Journal Article] A new prognostic staging system for hepatocellular carcinoma:value of biomarker combined Japan Integrated Staging(bm-JIS)score (2008)
  • Author(s): Kitai S
  • Journal Title: Intervirology (in press)
  • Peer Reviewed
• [Journal Article] Diagnostic imaging accuracy of liver cirrhosis compared to information from a resected specimen:a multicenter collaborative study (2008)
  • Author(s): Kudo M
  • Journal Title: Intervirology (in press)
  • Peer Reviewed
• [Journal Article] Non-invasive method for liver fibrosis using transient elastography(FibroScan),real-time tissue elastography and serum fibrotic markers (2008)
  • Author(s): Tatsumi C
  • Journal Title: Intervirology (in press)
  • Peer Reviewed
• [Journal Article] Differential diagnosis of hepatic tumors:value of contrast-enhanced harmonic sonograpy using the newly developed contrast agent,Sonazoid (2008)
  • Author(s): Hatanaka K
  • Journal Title: Intervirology (in press)
  • Peer Reviewed
• [Journal Article] Utility and limitations of contrast-enhanced power Doppler endoscopic ultrasonography for diagnosis of pancreatic carcinomas (2008)
  • Author(s): Sakamoto H
  • Journal Title: Endoscopy (in press)
  • Peer Reviewed
• [Journal Article] Treatment of large and/or multiple hepatie malignancies:open surgical approaches of radiofrequency ablation (2008)
  • Author(s): Minami Y
  • Journal Title: Hepato-Gastroenterol (in press)
  • Peer Reviewed
• [Journal Article] Multicentric occurrence of HCC detected 3-4 yerars after AFP L3 positivity (2008)
  • Author(s): Kim SR
  • Journal Title: Internal Medieine (in press)
  • Peer Reviewed
• [Journal Article] Treatment of large and/or multiple hepatic malignancies : open surgical approaches of radio frequency ablation (2007)
  • Author(s): Minami Y, Kudo M, 他8名
  • Journal Title: Hepato-Gastroenterol 54 Pages: 2358-2360
  • Peer Reviewed
• [Journal Article] Combination therapy with PEG-IFN-alpha and 5-FU inhibits HepG2 tumor cell growth in nude mice by apoptosis of p53 (2007)
  • Author(s): Hagiwara S, Kudo M, Munakata H, 他6名
  • Journal Title: Brit J Cancer 97 Pages: 1532-1537
  • Peer Reviewed
• [Journal Article] Case of rapidly progressed sarcomatoid hepatocellular carcinoma in young female without risk factor (2007)
  • Author(s): InoueT, KudoM, 他4名
  • Journal Title: Liver Int 27 Pages: 1428-1430
  • Peer Reviewed
• [Journal Article] Long-term interferon maintenance therapy improves survival in patients with HCV-related hepatocellular carcinoma after curative radiofrequency ablation : a matched case-control study (2007)
  • Author(s): Kudo M, 他10名
  • Journal Title: Oncology 72
  • Peer Reviewed
• [Journal Article] Percutaneous radiofrequency ablation of sonographically unidentifiable liver tumors : Feasibility and usefulness of a novel guiding technique with an integrated system of computed tomography and sonographic images (2007)
  • Author(s): Minami Y, Kudo M, 他10名
  • Journal Title: Oncology 72
  • Peer Reviewed
• [Journal Article] Initial treatment response is essential to improve survival in patients with heptocellular carcinoma who underwent curative radiofrequency ablation therapy (2007)
  • Author(s): Takahashi S, Kudo M, 他9名
  • Journal Title: Oncology 72
  • Peer Reviewed
• [Journal Article] What is the best time to evaluate treatment response after radio frequency ablation of hepatocellular carcinoma using contrast-enhanced sonography? (2007)
  • Author(s): Zhou P, Kudo M, 他5名
  • Journal Title: Oncology 72
  • Peer Reviewed
• [Journal Article] Severe complications of radiofrequency ablation therapy for hepatocellular carcinoma : an analysis of 3,891 ablations in 2,614 patients (2007)
  • Author(s): Kasugai H, Kudo M, 他3名
  • Journal Title: Oncology 72
  • Peer Reviewed
• [Journal Article] Clinical characteristics of nonBnonC HCC:comparison with HBV and HCV related HCC. (2007)
  • Author(s): Hatanaka K
  • Journal Title: Intervirology 50 Pages: 24-31
  • Peer Reviewed
• [Journal Article] Endoscopic ultrasound-guided pancreatico-gastrostomy reconstruction (2007)
  • Author(s): Sakamoto H
  • Journal Title: Endoscopy 39
  • Peer Reviewed
• [Journal Article] Multistep hepatocarcinogenesis from dysplastic nodule to well-differentiated hepatocelllular carcinoma in patient with alcohol-related liver cirrhosis (2007)
  • Author(s): Kim SR
  • Journal Title: World J Gastroenterol 13 Pages: 1271-1274
  • Peer Reviewed
• [Journal Article] Report of the 17th follow-up survey of primary liver cancer in Japan (2007)
  • Author(s): Ikai I
  • Journal Title: Hepatol Res 37 Pages: 676-691
  • Peer Reviewed
• [Journal Article] Contrast harmonoc sonographic-guided radiofrequency ablation theraph for recurrent hepatocellular carcinoma poorly depicted by b-mode sonography:A prospective randomized ontrolled traial (2007)
  • Author(s): Minami Y
  • Journal Title: AJR 188 Pages: 489-494
  • Peer Reviewed
• [Journal Article] Antibody to hepatitis B core antigen and risk for hepatitis C-related hepatocellular carcinoma:a prospective study (2007)
  • Author(s): Ikeda K
  • Journal Title: Ann Intern Med 146 Pages: 649-656
  • Peer Reviewed
• [Journal Article] Radiofrequency ablation combined with reduction of hepatic blood flow:effect of lipiodol on coagulation diameter and ablation time in normal pig liver (2007)
  • Author(s): Chung H
  • Journal Title: Hepato-Gastroenterol 54 Pages: 701-704
  • Peer Reviewed
• [Journal Article] Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia:Bordeaux update (2007)
  • Author(s): Bioulac-Sage P
  • Journal Title: J Hepatol 46 Pages: 521-527
  • Peer Reviewed
• [Journal Article] Diagnosis of gallbladder diseases by contrast-enhanced phase-inversion harmonic ultrasonography (2007)
  • Author(s): Inoue T
  • Journal Title: Ultrasound In Medcine and Bilogy 33 Pages: 353-361
  • Peer Reviewed
• [Journal Article] Endoscopic ultrasonography with three miniature probes of different frequency is an accurate diagnostic tool for endoscopic submucosal dissection (2007)
  • Author(s): Ichikawa T
  • Journal Title: Hepato-Gastenterol 54 Pages: 325-328
  • Peer Reviewed
• [Journal Article] First attempt of boron neutron capture therapy (BNCT) for hepatocellular carcinoma (2007)
  • Author(s): Suzuki M
  • Journal Title: Jpn J Clin Oncol 37 Pages: 376-381
  • Peer Reviewed
• [Journal Article] Small hepatocellular carcinoma presenting with massive metastasis in the peritoneum,mimicking sarcomatous tumor (2007)
  • Author(s): Kim SR
  • Journal Title: Hepatol Res 37 Pages: 885-889
  • Peer Reviewed
• [Journal Article] Hepatocellular carcinoma:international consensus and controversies (2007)
  • Author(s): Kudo M
  • Journal Title: Hepatol Res 37 Pages: 83-87
  • Peer Reviewed
• [Journal Article] Role of tumor markers in assesment of tumor progression and prediction of outcomes in patients with hepatocellular carcinoma (2007)
  • Author(s): Toyoda H
  • Journal Title: Hepatol Res 37 Pages: 166-171
  • Peer Reviewed
• [Journal Article] New sonographic techniques for the diagnosis and treatment of hepatocellular carcinoma (2007)
  • Author(s): Kudo M
  • Journal Title: Hepatol Res 37 Pages: 193-199
  • NAID: 10019773126
  • Peer Reviewed
• [Journal Article] Review of current staging systems for hepatocellular carcinoma (2007)
  • Author(s): Chung H
  • Journal Title: Hepatol Res 37 Pages: 210-215
  • Peer Reviewed
• [Journal Article] International camparision of treatment outcomes based on staging systems (2007)
  • Author(s): Kudo M
  • Journal Title: Hepatol Res 37 Pages: 216-222
  • Peer Reviewed
• [Journal Article] Well-to moderately-differentiated HCC manifesting hyperattenuation on both CT during arteriography and arterial portography (2007)
  • Author(s): Kim S R
  • Journal Title: World J Gastroenterol 13 Pages: 5775-5778
  • Peer Reviewed
• [Journal Article] Outcomes of non-transplant potentially curative therapy for early-stage hepatocellular carinoma in Child-Pugh stage A cirrhosis is comparable with liver transplantation (2007)
  • Author(s): Takahashi S
  • Journal Title: Digest Dis 25 Pages: 303-309
  • Peer Reviewed
• [Journal Article] Management of heepatocellular carinoma in Japan:Consensus-based clinical practice manual proposed by the Japan Society of Hepatology(JSH) (2007)
  • Author(s): Kudo M
  • Journal Title: Oncology 72
  • Peer Reviewed
• [Journal Article] Natural course of small nodular lesions with intranodular preserved portal supply in cirrhotic liver (2007)
  • Author(s): Fukunaga T
  • Journal Title: Oncology 72
  • Peer Reviewed
• [Journal Article] Development of a novel assay to quantify serum human telomerase reverse transcriptase messenger RNA and its significance as a tumor marker for hepatocellular carcinoma (2007)
  • Author(s): Miura N
  • Journal Title: Oncology 72
  • Peer Reviewed
• [Journal Article] Superiority of CT arterioportal angiography to contrast-enhanced CT and MRI in the diagnosis of hepatocellular carcinoma in nodules smaller than 2cm (2007)
  • Author(s): Kim S R
  • Journal Title: Oncology 72
  • Peer Reviewed
• [Journal Article] Severe complications of radiofrequency ablation therapy for hepatocellular carcinoma:an analysis of 3,891 ablations in 2,614 patients (2007)
  • Author(s): Kasugai H
  • Journal Title: Oncology 72
  • Peer Reviewed
• [Journal Article] What is the best time to evaluate treatment response after radiofrequency ablation of hepatocellular carcinoma using contrast-enhanced sonography (2007)
  • Author(s): Zhou P
  • Journal Title: Oncology 72
  • Peer Reviewed
• [Journal Article] Initial treatment response is essential to improve survival in patients with heptocellular carcinoma who underwent curative radiofrequency ablation therapy (2007)
  • Author(s): Takahashi S
  • Journal Title: Oncology 72
  • Peer Reviewed
• [Journal Article] Percutaneous radiofrequency ablation of sonographically unidentifiable liver tumors:Feasibility and usefulness of a novel guiding technique with an integrated system of computed tomography and sonographic images (2007)
  • Author(s): Minami Y
  • Journal Title: Oncology 72
  • Peer Reviewed
• [Journal Article] Long-term interferon maintenance therapy improves survival in patients with HCV-related hepatocellular carcinoma after curative radiofrequency ablation:a matched case-control study (2007)
  • Author(s): Kudo M
  • Journal Title: Oncology 72
  • Peer Reviewed
• [Journal Article] Case of rapidly progressed sarcomatoid hepatocellular carcinoma in young female without risk factor (2007)
  • Author(s): Inoue T
  • Journal Title: Liver Int 27 Pages: 1428-1430
  • Peer Reviewed
• [Journal Article] Combination therapy with PEG-IFN-alpha and 5-FU inhibits HepG2 tumor cell growth in nude mice by apoptosis of p53 (2007)
  • Author(s): Hagiwara S
  • Journal Title: Brit J Cancer 97 Pages: 1532-537
  • Peer Reviewed
• [Journal Article] A novel perfusion imaging technique of the pancreas:contrast-enhanced harmonic EUS(with video) (2007)
  • Author(s): Kitano M
  • Journal Title: Gastrointest Endscopy 67 Pages: 141-150
  • Peer Reviewed
• [Journal Article] Clinical characteristics of nonBnonC HCC : comparison with HBV and HCV related HCC. (2007)
  • Author(s): Hatanaka K, Kudo M, Fukunaga T, et al.
  • Journal Title: Intervirology 50 Pages: 24-31
• [Journal Article] Endoscopic ultrasoud-guided pancreatico-gastrostomy reconstruction. (2007)
  • Author(s): Sakamoto H, Kitano M, Kudo M, et al.
  • Journal Title: Endoscopy 39
• [Journal Article] Multistep hepatocarcinogenesis from dysplastic nodule to well-differentiated hepatocelllular carcinoma in patient with alcohol-related liver cirrhosis. (2007)
  • Author(s): Kim SR, Ikawa H, Kudo M, et al.
  • Journal Title: World J Gastroenterol (in press)
• [Journal Article] Report of the 17^<th> follow-up survey of primary liver cancer in Japan. (2007)
  • Author(s): Ikai I, Arii S, Kudo M, et al.
  • Journal Title: Hepatol Res (in press)
• [Journal Article] EUS-guided pancreaticogastrostomy reconstruction. (2007)
  • Author(s): Sakamoto H, Kitano M, Kudo M, et al.
  • Journal Title: Endoscopy (in press)
• [Journal Article] Utility and limitations of contrast-enhanced power Doppler endoscopic ultrasonography for diagnosis of pancreatic carcinomas. (2007)
  • Author(s): Sakamoto H, Kitano M, Kudo M, et al.
  • Journal Title: Endoscopy (in press)
• [Journal Article] Contrast harmonoc sonographic-guided radiofrequency ablation theraph for recurrent hepatocellular carcinoma poorly depicted by b-mode sonography : A prospective randomized ontrolled traial. (2007)
  • Author(s): Minami Y, Kudo M
  • Journal Title: AJR (in press)
• [Journal Article] Hepatitis B core seropositivity is a risk for hepatitis C related hepatocellular carcinoma; a prospective study. (2007)
  • Author(s): Ikeda K, Marusawa H, Kudo M, et al.
  • Journal Title: Ann Intern Med (in press)
• [Journal Article] Treatment of large and/or multiole hepatic malignancies : open surgical approaches of radiofrequency ablation. (2007)
  • Author(s): Minami Y, Kawasaki T, Kudo M, et al.
  • Journal Title: Hepato-Gastroenterol (in press)
• [Journal Article] Case of adult genotype CHBV carrier after acute hepatitis B, losing HBsAg and acquiring HBsAb after IFN and lamivudine treatment. (2007)
  • Author(s): Kin SR, Imoto S, Kudo M, et al.
  • Journal Title: Hepatol Res (in press)
  • NAID: 10018640735
• [Journal Article] Radiofrequency ablation combined with reduction of hepatic blood flow : effect of lipiodol on coagulation diameter and ablation time in normal pig liver. (2007)
  • Author(s): Chung H, Kudo M, Kawasaki T, et al.
  • Journal Title: Hepato-Gastroenterol (in press)
• [Journal Article] Multicentric occurrence of HCC detected 3-4 yerars after AFP L3 positivity. (2007)
  • Author(s): Kim SR, Taniguchi M, Kudo M, et al.
  • Journal Title: Internal Medicine (in press)
• [Journal Article] Diagnosis of gallbladder diseases by contrast-enhanced ohase-inversion harmonic ultrasonography. (2007)
  • Author(s): Inoue T, Kitano M, Kudo M, et al.
  • Journal Title: Ultrasound In Medcine and Bilogy (in press)
• [Journal Article] Comparison of outcome between anatomical subsegmentectomy and non-anatomical partial resection for single hepatocellular carcinomas using a Japanese nationwide survey. (2007)
  • Author(s): Eguchi S, Kanematsu T, Kudo M, et al.
  • Journal Title: Annals of Surgery (in press)
• [Journal Article] Evaluation of therapeutic response to gemcitabine in pancreatic cancer : value of contrast-enhanced harmonic imaging. (2007)
  • Author(s): Suetomi Y, Kitano M, Kudo M, et al.
  • Journal Title: Hepato-Gastroenterol (in press)
• [Journal Article] Endoscopic ultrasonography with three miniature probes of different frequency is an accurate diagnostic tool for endoscopic submucosal dissection. (2007)
  • Author(s): Ichikawa T, Kudo M, Matsui S, et al.
  • Journal Title: Hepato-Gastenterol (in press)
• [Journal Article] First attempt of boron neutron capture therapy (BNCT) for hepatocellular carcinoma. (2007)
  • Author(s): Suzuki M, Sakurai Y, Kudo M, et al.
  • Journal Title: Jpn J Clin Oncol (in press)
• [Journal Article] A proposal of the modified liver damage classification for hepatocellular carcinoma. (2006)
  • Author(s): Chung H, Kudo M, Haji S, et al.
  • Journal Title: Hepatol Res 34 Pages: 124-129
  • NAID: 10020405920
• [Journal Article] Comparison of standard-dose and low-dose regimens of gemcitabine for patients with pancreatic adenocarcinoma : a preliminary prospective randomized trail. (2006)
  • Author(s): Sakamoto H, Kitano M, Kudo M, et al.
  • Journal Title: J Gastroenterol 41 Pages: 70-76
• [Journal Article] Cecal necrosis due to ischemic colitis mimicking an abscess on songraphy. (2006)
  • Author(s): Watanabe T, Tomita S, Kudo M, et al.
  • Journal Title: J Ultrasound Med 25 Pages: 393-396
• [Journal Article] Clinical significance of the genotype and core promoter/pre-core mutations in hepatitis B virus carriers. (2006)
  • Author(s): Hagiwara S, Kudo M, Minami Y, et al.
  • Journal Title: Intervirology 49 Pages: 200-206
• [Journal Article] What is the best staging system for hepatocellular carcionoma? (2006)
  • Author(s): Kudo M
  • Journal Title: J Gastroenterol 41 Pages: 290-291
• [Journal Article] Value of computed tomography for evaluating the injection site in endosonography-guided celiac plexue neurolysis. (2006)
  • Author(s): Sakamoto H, Kitano M, Kudo M, et al.
  • Journal Title: Digestive Endoscopy 18 Pages: 206-211
  • NAID: 10017137774
• [Journal Article] Wegener's granulomatosis complicated with aphthoid colitis : a case report. (2006)
  • Author(s): Umehara Y, Kudo M, Minami Y, et al.
  • Journal Title: Digestive Endoscopy 18 Pages: 221-224
• [Journal Article] Consensus on extra-hepatic portal vein obstruction. (2006)
  • Author(s): Sarin SK, Sollano JD, Kudo M, et al.
  • Journal Title: Liver Int 26 Pages: 512-519
• [Journal Article] Regulatory failure of serum prohepcidin levels in patients with hepatitis C. (2006)
  • Author(s): Nagashima M, Kudo M, Chung H, et al.
  • Journal Title: Hepatol Res 36 Pages: 288-293
  • NAID: 10018639789
• [Journal Article] Hepatocellular carcinoma metastasizing to the skull base involving multiple cranial nerves. (2006)
  • Author(s): Kim SR, Kanda F, Kudo M, et al.
  • Journal Title: World J Gastroenterol 12 Pages: 6727-6729
• [Journal Article] Serum proinflammatory cytokines and adhesion molecules in ulcerative colitis. (2006)
  • Author(s): Umehara Y, Kudo M, Nakaoka R, et al.
  • Journal Title: Hepato-Gastenterol 53 Pages: 879-882
• [Journal Article] Stagin hepatocellular carcinoma by a novel scoring system (BALAD Score) based on serum markers. (2006)
  • Author(s): Toyoda H, Kumada T, Kudo M, et al.
  • Journal Title: Clinical Gastroenterol and Hepatol 4 Pages: 1528-1536
• [Journal Article] Prognostic factors for portal venous invasion in patients with hepatocellular carcinoma. (2006)
  • Author(s): Hagiwars S, Kudo M, Kawasaki T, et al.
  • Journal Title: J Gastroenterol 41 Pages: 1214-1219
  • NAID: 10018541500
• [Journal Article] Multicentric occurrence of HCC detected 3-4 yerars after AFP-L3 positivity
  • Author(s): Kim SR, Kudo.M, 他12名
  • Journal Title: Internal Med 2009 (in press)
  • Peer Reviewed
• [Journal Article] Value of liver parenchymal phase imaging of contrast-enhanced ultrasonography to diagnose the premalignant/borderline lesions and overt HCC.
  • Author(s): Inoue T, Kudo M, 他5名
  • Journal Title: AJR Am J Roentgenol 2009 (in press)
  • Peer Reviewed
• [Journal Article] Multistep human hepatocarcinogenesis : correlation of imageing with pathology
  • Author(s): Kudo M
  • Journal Title: J Gastroenterol 2009 (in press)
  • NAID: 10025177447
  • Peer Reviewed
• [Journal Article] International consensus on the pathologic diagnosis of early hepatocellular carcinoma : A report of the international consensus group for hepatocellular neoplasia
  • Author(s): Wanless I, Kudo M, 他24名
  • Journal Title: Hepatology 2009 (in press)
  • Peer Reviewed
• [Journal Article] Two cases of non-alcoholic steato-hepatitis developing from simple fatty liver
  • Author(s): Kim SR, Kudo M, 他10名
  • Journal Title: J Hepatol 2009 (in press)
  • Peer Reviewed
• [Journal Article] Pegylated interferon plus ribavirin combination therapy for chronic hepatitis C with high viral load of serum HCV RNA, genotype 1b, discontinued on attaining sustained virological response in week 16 after onset of acute pancreatitis
  • Author(s): Kim SR, Kudo M, 他2名
  • Journal Title: J Gastroint Liver Dis 2009 (in press)
  • Peer Reviewed
• [Presentation] 肝細胞癌外科治療におけるソナゾイドを用いた術中造影エコーの有用性 (2009)
  • Author(s): 土師誠二
  • Organizer: 第11回関西肝癌局所療法研究会
  • Place of Presentation: 阪急電鉄本社ビル, 大阪
  • Year and Date: 2009-03-07
• [Presentation] RFA-safety marginの必要性とそのevidence. シンポジウム「肝細胞癌治療における局所再発の抑制とSafety/Surgical marginの必要性-画像による判定」 (2009)
  • Author(s): 工藤正俊
  • Organizer: 第15回肝血流動態イメージ研究会
  • Place of Presentation: パシフィコ横浜, 神奈川
• [Presentation] 自然退縮した肝細胞癌症例の画像所見と組織所見との比較. (2009)
  • Author(s): 矢田典久
  • Organizer: 第15回肝血流動態イメージ研究会
  • Place of Presentation: パシフィコ横浜, 神奈川
• [Presentation] Treatment of single HCC in 2-5cm : Debate on gray zone. Non-surgical treatment : Eastern experience (2008)
  • Author(s): Kudo M
  • Organizer: 6thInternational Meeting Hepatoce llular Carcinoma : Eastern and Western Experiences Current Issues of Hepatocellular Carcinoma
  • Place of Presentation: Korea
  • Year and Date: 2008-12-12
• [Presentation] 各種肝腫瘤のソナゾイド造影超音波による質的診断評価. パネルディスカッション「造影エコーの現状と未来-造影イメージから病態解明ヘ-」 (2008)
  • Author(s): 前川清
  • Organizer: 日本超音波医学会第35回関西地方会学術集会
  • Place of Presentation: 神戸国際会議場, 兵庫
  • Year and Date: 2008-12-06
• [Presentation] 振幅変調法によるソナゾイド造影超音波撮像法の使用経験. (2008)
  • Author(s): 前川清
  • Organizer: 日本超音波医学会第35回関西地方会学術集会
  • Place of Presentation: 神戸国際会議場, 兵庫
  • Year and Date: 2008-12-06
• [Presentation] 肝腫瘤におけるDefect Re-perfusion Imagingの有用性について. (2008)
  • Author(s): 畑中絹世
  • Organizer: 日本超音波医学会第35回関西地方会学術集会
  • Place of Presentation: 神戸国際会議場, 兵庫
  • Year and Date: 2008-12-06
• [Presentation] 肝血管筋脂肪腫の一例. (2008)
  • Author(s): 前野知子
  • Organizer: 日本超音波医学会第35回関西地方会学術集会
  • Place of Presentation: 神戸国際会議場, 兵庫
  • Year and Date: 2008-12-06
• [Presentation] Special Lecture "How to screen (2008)
  • Author(s): Kudo M
  • Organizer: APASL Consensus Development Meeting on Management of Hepatocellular Carcinooma
  • Place of Presentation: Grand Hyatt Hotel, Nusa Dua, Bali
  • Year and Date: 2008-11-04
• [Presentation] Special Lecture "Ultrasound (2008)
  • Author(s): Kudo M
  • Organizer: APASL Consensus Development Meeting on Management of Hepatocellular Carcinooma
  • Place of Presentation: Grand Hyatt Hotel, Nusa Dua, Bali
  • Year and Date: 2008-11-04
• [Presentation] Special Lecture "Diagnostic algorithm (2008)
  • Author(s): Kudo M
  • Organizer: APASL Consensus Development Meeting on Management of Hepatocellular Carcinooma
  • Place of Presentation: Grand Hyatt Hotel, Nusa Dua, Bali
  • Year and Date: 2008-11-04
• [Presentation] C型慢性肝炎に対するインターフェロン療法著効後に発症した肝細胞癌破裂の1例 (2008)
  • Author(s): 峯宏昌
  • Organizer: 日本消化器病学会近畿支部第89回例会
  • Place of Presentation: 大阪国際交流センター, 大阪
  • Year and Date: 2008-09-27
• [Presentation] 肝内胆管癌にTS-1を投与し著効した1例 (2008)
  • Author(s): 西尾健
  • Organizer: 日本消化器病学会近畿支部第89回例会
  • Place of Presentation: 大阪国際交流センター, 大阪
  • Year and Date: 2008-09-27
• [Presentation] 肝細胞癌におけるBiomarker Combined Japan Integrated Staging (bm-JIS) Scoreの有用性 (2008)
  • Author(s): 北井聡
  • Organizer: 日本消化器病学会近畿支部第89回例会
  • Place of Presentation: 大阪国際交流センター, 大阪
  • Year and Date: 2008-09-27
• [Presentation] 肝細胞癌非合併の硬変変症例におけるBCAA製剤投与による生存率への寄与 (2008)
  • Author(s): 早石宗右
  • Organizer: 日本消化器病学会近畿支部第89回例会
  • Place of Presentation: 大阪国際交流センター, 大阪
  • Year and Date: 2008-09-27
• [Presentation] Invited Lecture "Diffuse liver disease (2008)
  • Author(s): Kudo M
  • Organizer: WFUMB 2008 WORKSHOP
  • Place of Presentation: Ulaanbaatar, Mongolian
  • Year and Date: 2008-07-26
• [Presentation] Invited Lecture "Contrast-enhanced us of hepatic tumors with Sonazoid (2008)
  • Author(s): Kudo M
  • Organizer: WFUMB 2008 WORKSHOP
  • Place of Presentation: Ulaanbaatar, Mongolian
  • Year and Date: 2008-07-26
• [Presentation] Invited Lecture "Direct Re-perfusion Imaging with Sonazoid in the diagnosis and treatment of hepatic malignancies (2008)
  • Author(s): Kudo M
  • Organizer: WFUMB 2008 WORKSHOP
  • Place of Presentation: Ulaanbaatar, Mongolian
  • Year and Date: 2008-07-26
• [Presentation] ソナゾイド造影超音波による肝腫瘤の質的診断評価 (2008)
  • Author(s): 前川清
  • Organizer: 第8回関西肝血流動態イメージ研究会
  • Place of Presentation: オーバルホール, 兵庫
  • Year and Date: 2008-06-14
• [Presentation] ソナゾイド造影超音波による肝癌局所療法の効果判定『特にDefect-reinjection-testと支援画像表示』 (2008)
  • Author(s): 前川清
  • Organizer: 日本超音波医学会第81回学術集会
  • Place of Presentation: 神戸国際会議場, 兵庫
  • Year and Date: 2008-05-25
• [Presentation] Defect Re-inection imagingの有用性について (2008)
  • Author(s): 畑中絹世
  • Organizer: 日本超音波医学会第81回学術集会
  • Place of Presentation: 神戸国際会議場, 兵庫
  • Year and Date: 2008-05-25
• [Presentation] 肝臓エラストグラフィの定量化の試みと深部領域の感度の改善. パネルディスカッション「弾性の考え方と診断法 : 各領域における見方」 (2008)
  • Author(s): 藤本研治
  • Organizer: 日本超音波医学会第81回学術集会
  • Place of Presentation: 神戸国際会議場, 兵庫
  • Year and Date: 2008-05-23
• [Presentation] Defect Re-injection Testの有用性とRFA治療支援. シンポジウム「RFA-STATE of ARTS」 (2008)
  • Author(s): 畑中絹世
  • Organizer: 第44回日本肝癌研究会
  • Place of Presentation: 大阪国際会議場, 大阪
  • Year and Date: 2008-05-22
• [Presentation] 非B非C肝癌の臨床的特徴 : B型関連肝癌・C型関連肝癌との比較 (2008)
  • Author(s): 畑中絹世
  • Organizer: 第44回日本肝癌研究会
  • Place of Presentation: 大阪国際会議場, 大阪
  • Year and Date: 2008-05-22
• [Presentation] MDCT、MRI画像診断によるHCCのRFA治療効果判定 (2008)
  • Author(s): 岡田真広
  • Organizer: 第44回日本肝癌研究会
  • Place of Presentation: 大阪国際会議場, 大阪
  • Year and Date: 2008-05-22
• [Presentation] 進行肝細胞に対するS-1,ペグインターフェロン併用療法 (2008)
  • Author(s): 上嶋一臣
  • Organizer: 第49回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-09
• [Presentation] 進行肝細胞癌に対するS-1、ペグインターフェロン併用療法 (2008)
  • Author(s): 上嶋一臣
  • Organizer: 第49回日本消化器病学会総会
  • Place of Presentation: 福岡国際会議場, 福岡
  • Year and Date: 2008-05-09
• [Presentation] Defect Re-injection Testの有用性について (2008)
  • Author(s): 畑中絹世
  • Organizer: 第49回日本消化器病学会総会
  • Place of Presentation: 福岡国際会議場, 福岡
  • Year and Date: 2008-05-09
• [Presentation] Multistep hepatocecarcinogenesis : Correlation of imaging with pathology. Session : Basic Aspects (2008)
  • Author(s): Kudo M
  • Organizer: The 94^<th> Annual Meeting of the Japanese Society of Gastroenterology 1^<st> International Forum
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2008-05-09
• [Presentation] HCV Core抗原、NS3蛋白によるTLR2を介するCross Torelanceの誘導シンポジウム「ウイルス肝炎・肝癌に対する生体防御」 (2008)
  • Author(s): 鄭浩柄
  • Organizer: 第49回日本消化器病学会総会
  • Place of Presentation: 福岡サンパレスホテル&ルーム, 福岡
  • Year and Date: 2008-05-08
• [Presentation] Sonazoid^r造影超音波によるRFA治療の効果判定 : 特にDefect-reinjection-test (D-RIT)と支援画像表示 (2008)
  • Author(s): 前川清
  • Organizer: 第21回日本腹部造影エコー・ドプラ診断研究会
  • Place of Presentation: 秋葉原コンベンションホール, 東京
  • Year and Date: 2008-04-12
• [Presentation] Sonazoid^rを用いた造影超音波ガイド下ラジオ波焼灼術の有用性 (2008)
  • Author(s): 南康範
  • Organizer: 第21回日本腹部造影エコー・ドプラ診断研究会
  • Place of Presentation: 秋葉原コンベンションホール, 東京
  • Year and Date: 2008-04-12
• [Presentation] 難治性C型慢性肝炎(I型高ウイルス量)に対するPEG-IFN α2b/Ribavirin併用療法の長期投与成績と安全性について (2008)
  • Author(s): 石川恵美
  • Organizer: 第49回日本消化器病学会総会
  • Place of Presentation: マリンメッセ福岡, 福岡
• [Presentation] Special Lecture "Treatment of single HCC in 2-5cm : Debate on gray zone. Non-surgical treatment : Eastern experience. (2008)
  • Author(s): Kudo M
  • Organizer: 6^<th> International Meeting Hepatocellular Carcinoma : Eastern and Western Experiences Current Issues of Hepatocellular Carcinoma
  • Place of Presentation: Asian Medical Center, Seoul, Korea
• [Presentation] Special Lecture "Sonazoid-enhanced US for liver tumors : Present status and future perspective. (2008)
  • Author(s): Kudo M
  • Organizer: 10^<th>International Symposium on Ultrasound Contrast Imaging, Tokyo Medical Hospital
  • Place of Presentation: Tokyo, Japan
• [Presentation] 日本肝癌研究会全国原発追跡調査の現状と課題 (2008)
  • Author(s): 猪飼伊知夫
  • Organizer: 第63回消化器外科学会定期学術総会 シンポジウム
  • Place of Presentation: ロイトン札幌, 北海道
• [Presentation] 進行肝細胞癌に対するソラフェニブの使用経験. シンポジウム「肝癌の分子標的治療」 (2008)
  • Author(s): 上嶋一臣
  • Organizer: 第12回日本肝臓学会大会
  • Place of Presentation: グランドプリンスホテル新高輪, 東京
• [Presentation] 肝細胞癌根治後C型肝癌に対するIFN少量長期維持療法の生命予後改善効果に関する検討. シンポジウム「肝細胞癌治療後の抗ウイルス療法は予後を改善するか」 (2008)
  • Author(s): 上田泰輔
  • Organizer: 第12回日本肝臓学会大会
  • Place of Presentation: グランドプリンスホテル新高輪, 東京
• [Presentation] 肝予備能良好かつ単発の肝細胞癌患者に対するラジオ波焼灼療法治療成績. パネルディスカッション「肝癌の病態別推奨治療 : コンセンサス形成を目指す異分野間衆議」 (2008)
  • Author(s): 鄭浩柄
  • Organizer: 第50回日本消化器病学会大会
  • Place of Presentation: グランドプリンスホテル新高輪, 東京
• [Presentation] Sonazoidを用いた造影超音波ガイド下ラジオ波焼灼術の有用性 (2008)
  • Author(s): 南康範
  • Organizer: 第12回日本肝臓学会大会
  • Place of Presentation: グランドプリンスホテル新高輪, 東京
• [Presentation] 肝腫瘍の診断におけるDefect Re-perfusion Imagingの有用性について. ワークショップ「新生代超音波造影剤導入による肝癌診断・治療の変革」 (2008)
  • Author(s): 畑中絹世
  • Organizer: 第12回日本肝臓学会大会
  • Place of Presentation: グランドプリンスホテル新高輪, 東京
• [Presentation] ソナゾイド造影超音波検査におけるpost vascular phase imagingとSPIO-MRIとの比較 (2008)
  • Author(s): 井上達夫
  • Organizer: 第12回日本肝臓学会大会
  • Place of Presentation: グランドプリンスホテル新高輪, 東京
• [Presentation] 難治性C型慢性肝炎に対する治療戦略-後期陰性化症例における検討-. シンポジウム「C型肝炎 ; PEG-Riba治療のコンセンサス」 (2008)
  • Author(s): 上田泰輔
  • Organizer: 第50回日本消化器病学会大会
  • Place of Presentation: グランドプリンスホテル新高輪, 東京
• [Presentation] Child-Pugh C型肝硬変に合併した肝癌は治療すべきか? その是非と治療法選択に関するRetrospectivee多施設共同研究. パネルディスカッション「肝癌の病態別推奨治療 : コンセンサス形成を目指す異分野間衆議」 (2008)
  • Author(s): 大崎往夫
  • Organizer: 第12回日本肝臓学会大会
  • Place of Presentation: グランドプリンスホテル新高輪, 東京
• [Presentation] Superiority of atrerioportal angiography to contrast-enhanced CT and MRI in the diagnosis of hepatocellular carcinoma in nodules smaller than 2cm. (2008)
  • Author(s): Kim SR
  • Organizer: The 43^<rd> Annual Meeting of the Europian Association for the Study of the Liver
  • Place of Presentation: Milan, Italy
• [Presentation] Contrast enhanced sonography for hepatic malignancies : value of Defect Re-injection Test. (2008)
  • Author(s): Hatanaka K
  • Organizer: DDW (Digestive Disease Week) 2008
  • Place of Presentation: San Diego, USA
• [Presentation] Usefulness of virtual CT Sonography using magnetic navigation. (2008)
  • Author(s): Kitai S
  • Organizer: DDW (Digestive Disease Week) 2008
  • Place of Presentation: San Diego, USA
• [Presentation] Phase I/II study of S-1 in patients (pts) with advanced hepatocellular carcinoma (HCC) : Results of the pgase II part. (2008)
  • Author(s): Okusaka T
  • Organizer: 2008 Annual Meeting, AMERICAN SOCIETY OF CLINICAL ONCOLOGY
  • Place of Presentation: Chicago, USA
• [Presentation] Separate analysis of intranodular blood supply in nodular lesions associated with liver cirrhosis : a novel ultrasound technique "pure arterial phase imaging (2008)
  • Author(s): Kudo M
  • Organizer: 2^<nd> International Liver Cancer Association (ILCA) 2008 Annual Conference
  • Place of Presentation: Chicago, USA
• [Presentation] A proposal of novel treatment-assist technique in the Sonazoid-en hanced ultrasonography : value of defect re-perfusion imaging. (2008)
  • Author(s): Kudo M
  • Organizer: 2^<nd> International Liver Cancer Association (ILCA) 2008 Annual Conference
  • Place of Presentation: Chicago, USA
• [Presentation] Phase I/II study of the efficacy and safety of S-1 in patients (PTS) with advanced hepatocellular carcinoma(HCC). (2008)
  • Author(s): Kudo M
  • Organizer: 2^<nd> International Liver Cancer Association (LCA)2008 Annual Conference
  • Place of Presentation: Chicago, USA
• [Presentation] Qualitative and quantitative analysis of liver-parenchymal phase contrast-enhanced US with Sonazoid in detecting HCC ; Comparison with SPIO-MRI. (2008)
  • Author(s): Inoue T
  • Organizer: 16^<th> United Europian Gastroenterology Week (UEGW)
  • Place of Presentation: Vienna, Austria
• [Presentation] Value of liver parenchymal phase imaging of contrast-enhanced ultrasonography to diagnose the premalignant/borderline lesions and overt HCC. (2008)
  • Author(s): Inoue T
  • Organizer: 16^<th> United Europian Gastroenterology Week (UEGW)
  • Place of Presentation: Vienna, Austria
• [Presentation] Evaluation of the effectiveness of radiofrequency ablation for hepatic malignancies : Usefulness of virtual CT Sonography using magnetic navigation. (2008)
  • Author(s): Kitai S
  • Organizer: 16^<th> United Europian Gastroenterology Week (UEGW)
  • Place of Presentation: Vienna Asutria
• [Presentation] Surgical resection vs. percutaneous ablation for hepatocellular carcinoma : a preliminary report of the Japanese nationwide survey. Copenhagen (2008)
  • Author(s): Hasegawa K
  • Organizer: The 44^<th> Annual Meeting of the European Association for the Study of the liver
  • Place of Presentation: Denmark
• [Presentation] Invited Lecture "Hepatocellular carcinoma : current topics in the diagnosis and treatment (2008)
  • Author(s): Kudo M
  • Organizer: LAENNEC SOCIETY : SUMMER MEETING
  • Place of Presentation: Padova, Italy.
• [Presentation] Invited Lecture "Contrast-enhanced US with new contrast agent, Sonazoid for liver tumors" Australasian Society for Ultrasound in Medicine (2008)
  • Author(s): Kudo M
  • Organizer: 38^<th> Annual Scientific Meeting
  • Place of Presentation: New Zealand
• [Presentation] Special Lecture "Impact of primovist on current diagnostic and therapeutic algorithm in HCC (2008)
  • Author(s): Kudo M
  • Organizer: The 2^<nd> International Forum for Liver MRI 2008
  • Place of Presentation: Kyoto, Japan
• [Presentation] Special Lecture "U/s & EUS in diagnosis of pancreatic tumors (2008)
  • Author(s): Kudo M
  • Organizer: 6^<th> AFSUMB Workshop Delhi
  • Place of Presentation: New Delhi, India
• [Presentation] Special Lecture "Is adjuvant therapy necessary after curative treatment of HCC? Low-dose, long-term maintenance interferon therapy after curative RFA increases survival in patients with hepatitis C-related HCC. (2008)
  • Author(s): Kudo M
  • Organizer: 6^<th> International Meeting Hepatocellular Carcinoma : Eastern and Western Experiences Current Issues of Hepatocellular Carcinoma
  • Place of Presentation: Asian Medical Center, Seoul, Korea
• [Presentation] Non-invasive methods for the assessment of liver fibrosis:comparision of transient elastography(Fibroscan), real-time tissue elastography and serum fibrotic markers (2007)
  • Author(s): Tatsumi C
  • Organizer: The 4th Korea-Japan Liver Synposium
  • Place of Presentation: Seoul,Korea
  • Year and Date: 2007-09-08
• [Presentation] Diagnosis of gallbladder diseases by contrast-enhanced phase-inversion harmonic ultrasonography (2007)
  • Author(s): Inoue T
  • Organizer: DDW(Digestive Disease Week) and the 108th Annual Meeting of the AGA
  • Place of Presentation: Washington,DC,USA
• [Presentation] Multicentric recurrence of hepatocellular careinoma and CD-34 expression in baekground liver (2007)
  • Author(s): Tsuji N
  • Organizer: DDW(Digestive Disease Week) and the 108th Annual Meeting of the AGA
  • Place of Presentation: Washington,DC,USA
• [Presentation] Regulatory failure of serum prohepcidin levels in patients with hepatitis C (2007)
  • Author(s): Nagashima M
  • Organizer: DDW(Digestive Disease Week) and the 108th Annual Meeting of the AGA
  • Place of Presentation: Washington,DC,USA
• [Presentation] Clinical application of contrast-enhanced harmonic imaging to endosonography (2007)
  • Author(s): Kitano M
  • Organizer: DDW(Digestive Disease Week) and ASGE
  • Place of Presentation: Washington,DC,USA
• [Presentation] Transarterial infusion chemotherapy alone versus transarterial chemoembolization for the treatment of hepatocellular carcinoma:Results of a multicenter randomized ohase III traial (2007)
  • Author(s): Okusaka T
  • Organizer: American Society of Clinical Oncology
  • Place of Presentation: Chicago,USA
• [Presentation] Expression in noncancerous liver tissue predicts multicentric recurrence of hepatocellular carcinoma (2007)
  • Author(s): Tsuji N
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Kobe,Japan
• [Presentation] Radiofrequency ablation of hepatocellular carcinoma:usefulness of real-time virtual CT sonography (2007)
  • Author(s): Minami Y
  • Organizer: 15th United European Gastroenterology Week(UEGW)
  • Place of Presentation: Paris,France
• [Presentation] A proposal of novel treatment-assist technique in the Sonazoid-enhanced ultrasonography:value of defect re-perfusion imaging (2007)
  • Author(s): Kudo M
  • Organizer: American Association for the Study of liver Diseases (AASLD)
  • Place of Presentation: Boston,USA
• [Presentation] Separate analysis of intranodular blood supply in nodular lesions associated with liver cirrhosis:a novel ultrasound technique"Pure arterial phase imaging (2007)
  • Author(s): Kudo M
  • Organizer: American Association for the Study of liver Diseases (AASLD)
  • Place of Presentation: Boston,USA
• [Presentation] Contrast enhanced sonography for hepatic malignancies:Value of defect re-injectjon test (2007)
  • Author(s): Hatanaka K
  • Organizer: Asian Federation of Societies for Ultrasound in Medieine and Biology The 8th Congress AFSUMB Thailand
  • Place of Presentation: Bangkok,Thailand
• [Presentation] Experimental and early clinical studies of S-1, a novel oral DPD inhibitor, chemotherapy for advanced hepatocellular carcinoma.
  • Author(s): Yamashita T
  • Organizer: The 59^<th> Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • Place of Presentation: San Francisco, USA
• [Presentation] Patterns of local recurrence of hepatocellular carcinoma and liver metastasisafter radiofrequency.
  • Author(s): Okada M
  • Organizer: 2008 Annual Meeting, Radiological Society of North America (RSNA)
  • Place of Presentation: Chicago, USA
• [Presentation] How to use liver-specific contrast agents on MRI and sonography : Enhancement patterns of Kupffer, Sinusoid and Hepatocyte using superparamagnetic iron oxide, Gd-EOB-DTPA, galactosepalmitic acid and NC100100.
  • Author(s): Okada M
  • Organizer: 2008 Annual Meeting, Radiological Society of North America (RSNA)
  • Place of Presentation: Chicago, USA