Effects of exercise and genetic background on unloaded shortening velocity of muscle : A study with 'slack test'

• Project/Area Number: 18300217
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: The University of Tokyo
• Principal Investigator: ISHII Naokata The University of Tokyo, 大学院・総合文化研究科, 教授 (20151326)
• Co-Investigator(Kenkyū-buntansha): NAKAZATO Kouichi 日本体育大学, 体育学部, 准教授 (00307993)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,050,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥2,550,000); Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2007: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2006: ¥6,000,000 (Direct Cost: ¥6,000,000)
• Keywords: スラックテスト / 無負荷短縮速度 / 運動トレーニング / 筋線維組成 / 遺伝子多型 / スラックテスト法 / 無負荷最大速度 / 運動・トレーニング / 運動、トレーニング / 筋繊維組成

Research Abstract

運動・トレーニング、加齢、性差、遺伝子多型などの環境的要因が、筋の無負荷短縮速度(Vo)と筋線維動員パターンに及ぼす効果を調べるため、スラックテスト法(Sasaki & Ishii, 2005)およびその変法(「新スラックテスト法」)、単収縮の強縮後増強効果(PTP)を利用した方法を主に用いて研究を行った。その結果、1)生体内での筋収縮におけるVoは、動員されている運動単位のうち最も速度の速いもののVoを反映していること、2)加齢はVoおよび筋線維の動員パターンに有意な影響を及ぼさないが、筋線維の動員パターンには性差があること、3)長期的な筋力トレーニングの実施により筋力および筋サイズの増加が起こっても、Voおよび筋線維の動員パターンには変化が起こらないこと、4)α-アクチニン3遺伝子(ACTN3)の多型は、Voの初期値には影響しないが、高強度筋運動後の筋力回復過程に影響を及ぼし、同時にVoの一時的な低下にも関連する可能性のあること、などが判明した。

Research Products

• [Journal Article] Ageing related differences in maximum force, unloaded velocity and power of human leg multi-joint movement (2010)
  • Author(s): Yamauchi, J., Mishima, C., Nakayama, S., Ishii, N.
  • Journal Title: Gerontology 56 Pages: 167-174
  • Peer Reviewed
• [Journal Article] Elevation of myostatin and FOXOs in prolonged muscular impairment induced by eccentric contractions in rat medial gastrocnemius muscle (2010)
  • Author(s): Ochi, E., Hirose, T., Hiranuma, K., Min, S., Ishii N., Nakazato K.
  • Journal Title: J. Appl. Physiol. 108 Pages: 306-313
  • Peer Reviewed
• [Journal Article] Peripheral venous occlusion causing cardiac hypertrophy and changes in biological parameters in rats (2009)
  • Author(s): Kawada, S., Ishii, N.
  • Journal Title: Eur. J. Appl. Physiol. 105 Pages: 909-917
  • Peer Reviewed
• [Journal Article] Force-velocity, force-power relationships of bilateral and unilateral leg multi-joint movements in young and elderly women (2009)
  • Author(s): Yamauchi, J., Mishima, C., Nakayama, S., Ishii, N.
  • Journal Title: J. Biomech. 41 Pages: 2151-2157
  • Peer Reviewed
• [Journal Article] Effects of body weight based exercise training on muscle functions of leg multi-joint movement in elderly individuals (2009)
  • Author(s): Yamauchi, J., Nakayama, S., Ishii, N.
  • Journal Title: Geriatrics and Gerontology Int. 9 Pages: 262-269
  • Peer Reviewed
• [Journal Article] Hemodynamic responses to simulated weightlessness of 24 h head-down bed rest and KAATSU blood flow restriction. (2009)
  • Author(s): Nakajima, T., Ishii, N., Abe, T. 他
  • Journal Title: Eur. J. Appl. Physiol. (印刷中 掲載確定)
  • Peer Reviewed
• [Journal Article] Changes in muscle activation and force generation patterns during cycling movements due to low-intensity squat training with slow movement and tonic force generation (LST). (2009)
  • Author(s): Tanimoto. M., Miyachi, M. and Ishii, N.
  • Journal Title: Str. Conditon. Res. (印刷中 掲載確定)
  • Peer Reviewed
• [Journal Article] Low-intensity resistance training with slow movement and tonic force generation (LST) increases basal limb blood flow. (2009)
  • Author(s): Tanimoto. M., Kawano, H., Gando, Y., Sanada, K., Yamamoto, K, Ishii, N., Tabata I. and Mivachi. M.
  • Journal Title: Clinical Physiology and Functional Imaging (印刷中 掲載確定)
  • Peer Reviewed
• [Journal Article] Significant roles of microtubules in mature striated muscle deduced from the correlation between tubulin and its molecular chaperone alphaB-crystallin in rat muscles. (2009)
  • Author(s): Chi, H., Sakurai, T., Kawada, S., Ishii, N. and Atomi, Y.
  • Journal Title: J. Physiol. Sci. (印刷中 掲載確定)
  • Peer Reviewed
• [Journal Article] Peripheral venous occlusion causing cardiac hypertrophy and changes in biological parameters in rats. (2009)
  • Author(s): Kawada, S. and Ishii, N.
  • Journal Title: Eur. J. Appl. Physiol. (印刷中 掲載確定)
  • Peer Reviewed
• [Journal Article] Ageing related differences in maximum force, unloaded velocity and power of human leg multi-joint movement (2009)
  • Author(s): Yamauchi, J., Mishima, C., Nakayama, S. and Ishii. N.
  • Journal Title: Gerontology (印刷中 掲載確定)
  • Peer Reviewed
• [Journal Article] Effects of body weight based exercise training on muscle functions of leg multi-joint movement in elderly individuals. (2009)
  • Author(s): Yamauchi, J., Mishima, C., Nakayama, S. and Ishii. N.
  • Journal Title: Geriatrics and Gerontology International (印刷中 掲載確定)
  • Peer Reviewed
• [Journal Article] Force-velocity, force-power relationships of bilateral and unilateral leg multi-joint movements in young and elderly women. (2009)
  • Author(s): Yamauchi, J., Mishima, C., Nakayama, S. and Ishii. N.
  • Journal Title: J. Biomech. (印刷中 掲載確定)
  • Peer Reviewed
• [Journal Article] Hormonal and metabolic responses to slow movement resistance exercise with different durations of concentric and eccentric actions. (2009)
  • Author(s): Goto, K., Ishii, N., Kizuka, T., Kraemer, RR., Honda, Y. and Takamatsu, K.
  • Journal Title: Eur. J. Appl. Physiol. (印刷中 掲載確定)
  • Peer Reviewed
• [Journal Article] Changes in Skeletal Muscle Size and Fiber-Type Composition after Chronic Restriction of Venous Blood Flow in Rats (2008)
  • Author(s): Kawada, S., Ishii N.
  • Journal Title: Acta Physiol. Scand. 192 Pages: 541-549
  • Peer Reviewed
• [Journal Article] TGF-betal and TNF- alpha is involved in the transcription of type I collagen alpha 2 gene in soleus muscle atrophied by mechanical unloading (2008)
  • Author(s): Hirose, T., Nakazato, K., Song, H., Ishii, N.
  • Journal Title: J. Appl. Physiol. 104 Pages: 170-177
  • Peer Reviewed
• [Journal Article] Blood pressure response to force-velocity properties of the knee-hip extension movement (2008)
  • Author(s): Yamauchi, J., Nakayama, S., Ishii, N.
  • Journal Title: Eur. J. Appl. Physiol. 102 Pages: 569-575
  • Peer Reviewed
• [Journal Article] Ultrasonographic measurement of tendon displacement caused by active force generation in the psoas major muscle (2008)
  • Author(s): Matsubayashi, T., Kubo, J., Matsuo, A., Kobayashi, K., Ishii, N.
  • Journal Title: J. Physiol. Sci. 58 Pages: 323-332
  • NAID: 10023966705
  • Peer Reviewed
• [Journal Article] Changes in Skeletal Muscle Size andFiber-Type Composition after Chronic Restriction of Venous Blood Flow in Rats. (2008)
  • Author(s): Kawada, S. and Ishii, N.
  • Journal Title: Acta Physiol. Scand. 192 Pages: 541-549
  • Peer Reviewed
• [Journal Article] Cross-transfer effects of resistance training with blood flow restriction. (2008)
  • Author(s): Madarame, H., Neya, M., Ochi, E., Nakazato, K., Sato, Y. and Ishii, N.
  • Journal Title: Med. Sci. Sports Exerc. 40 Pages: 258-263
  • Peer Reviewed
• [Journal Article] TGF-betal and TNF-alpha is involved in the transcription of type I collagen alpha 2 gene in soleus muscle atrophied by mechanical unloading. (2008)
  • Author(s): Hirose, T., Nakazato, K., Song, H. and Ishii, N.
  • Journal Title: J. Appl. Physiol. 104 Pages: 170-177
  • Peer Reviewed
• [Journal Article] Blood pressure response to force-velocity properties of the knee-hip extension movement. (2008)
  • Author(s): Yamauchi, J., Nakayama, S. and Ishii, N.
  • Journal Title: Eur. J. Appl. Physiol. 102 Pages: 569-575
  • Peer Reviewed
• [Journal Article] Ultrasonographic measurement of tendon displacement caused by active force generation in the psoas major muscle. (2008)
  • Author(s): Matsubayashi, T., Kubo, J., Matsuo, A., Kobayashi, K. and Ishii, N.
  • Journal Title: J. Physiol. Sci. 58 Pages: 323-332
  • NAID: 10023966705
  • Peer Reviewed
• [Journal Article] Resistance exercise combined with KAATSU during simulated weightlessness. (2008)
  • Author(s): N. Kubota, N. Ishii, T. Abe, T. Nakajima. 他
  • Journal Title: Int. J. Kaatsu Tr. Res. 4 Pages: 9-15
  • Peer Reviewed
• [Journal Article] Effects of whole-body low-intensity resistance training with slow movement and tonic force generation (LST) on muscular size and strength in young men. (2008)
  • Author(s): Tanimoto, M., K. Sanada, K. Yamamoto, H. Kawano, Y. Gando, I. Tabata, N. Ishii, M. Miyachi.
  • Journal Title: J. Str. Condition. Res. 22 Pages: 1926-1938
  • Peer Reviewed
• [Journal Article] Changes in skeletal muscle size and fiber-type composition after chronic resriction of venous blood flow in rats (2008)
  • Author(s): Kawada, S. and Ishii, N.
  • Journal Title: Acta Physiol.Scand. 192 Pages: 541-549
  • Peer Reviewed
• [Journal Article] Cross-transfer effects of resistance training with blood flow restriction (2008)
  • Author(s): Madarame, H., Neya, M., Ochi, E., Nakazato, K., Sato, Y. and Ishii, N
  • Journal Title: Med.Sci.Spoits Exererc 40 Pages: 258-263
  • Peer Reviewed
• [Journal Article] Blood pressure response to force-velocity properties of the knee-hip extension movement (2008)
  • Author(s): Yamauchi, J., Nakayama, S. and Ishii, N.
  • Journal Title: Eur.J.Appl.Physiol 102 Pages: 569-575
  • Peer Reviewed
• [Journal Article] TGF-betal and TNF-alpha is involved in the transcription of type I collagen alpha 2 gene in soleusmuscle atrophied by mechanical unloading (2008)
  • Author(s): Hiirose, T., Nakazato, K., Song, H. and Ishii, N.
  • Journal Title: J.Appl.Physiol (掲載確定)
  • Peer Reviewed
• [Journal Article] Relations between force-velocity characteristics of the knee-hip extension movement and vertical jump performance (2007)
  • Author(s): Yamauchi, J., Ishii N.
  • Journal Title: J. Str. Condition. Res. 21 Pages: 703-709
  • NAID: 40016135058
  • Peer Reviewed
• [Journal Article] Steady-state force-velocity relation in human multi-joint movement determined with force clamp analysis (2007)
  • Author(s): Yamauchi, J., Mishima, C., Fujiwara, M., Nakayama, S., Ishii, N.
  • Journal Title: J. Biomech. 40 Pages: 1433-1442
  • Peer Reviewed
• [Journal Article] Effects of eccentric exercise on joint stiffness and muscle connectin (titin) isoform in the rat hindlimb (2007)
  • Author(s): Ochi, E., Nakazato, K., Ishii, N.
  • Journal Title: J. Physiol. Sci. 57 Pages: 1-6
  • NAID: 10022595913
  • Peer Reviewed
• [Journal Article] Enhancement of fat metabolism by repeated bouts of moderate endurance exercise (2007)
  • Author(s): Goto, K., Ishii, N., Mizuno, A., Takamatsu, K.
  • Journal Title: J. Appl. Physiol. 102 Pages: 2158-2164
  • Peer Reviewed
• [Journal Article] Effects of acute eccentric contraction on rat ankle-joint stiffness (2007)
  • Author(s): Ochi. E., Ishii, N., Nakazato, K.
  • Journal Title: J. Sports Sci. Med. 6 Pages: 543-548
  • Peer Reviewed
• [Journal Article] Steady-state force-velocity relation in human multi-joint movement determined with force clampanalysis (2007)
  • Author(s): Yamauchi, J., Mishima, C., Fujiwara, M., Nakayama, S. and Ishii, N.
  • Journal Title: J.Biomech 40 Pages: 1433-1442
  • Peer Reviewed
• [Journal Article] Effects of acute eccentric contraction on rat ankle-joit stiffness (2007)
  • Author(s): Ochi.E., Ishii, N.and Nakazato, K.
  • Journal Title: J.Sports Sci.Med 6 Pages: 543-548
  • Peer Reviewed
• [Journal Article] Attenuated growth hormone response to resistance exercise with prior sprint exercise (2007)
  • Author(s): Goto, K., Ishii, N., Kurokawa, K. and Takamatsu, K.
  • Journal Title: Med.Sci.Sports Exerc 39 Pages: 108-115
  • Peer Reviewed
• [Journal Article] Relations between force-velocity characteristics of the knee-hip extension movement and vertical jump performance (2007)
  • Author(s): Yamauchi, J. and Ishii, N.
  • Journal Title: J.Str.Condition.Res. 21 Pages: 703-709
  • NAID: 40016135058
  • Peer Reviewed
• [Journal Article] Effects of resistance exercise on lipolysis during subsequent submaximal exercise (2007)
  • Author(s): Goto, K., Ishii, N., Sugiura, S., Yoshioka, T. and Takamatsu, K.
  • Journal Title: Med.Sci.Sports Exerc 39 Pages: 308-315
  • Peer Reviewed
• [Journal Article] Effects of eccentric exercise on joint stiffness and muscle connecti(titin)isoform in the rathindlimb (2007)
  • Author(s): Ochi, E., Nakazato, K. and Ishii, N.
  • Journal Title: J.Physiol.Sci 57 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Enhancement of fat metabolism by repeated bouts of moderate endurance exercise (2007)
  • Author(s): Goto, K., Ishii, N., Mizuno, A. and Takamatsu, K.
  • Journal Title: J.AppL.Phylsiol 102 Pages: 2158-2164
  • Peer Reviewed
• [Journal Article] Effects of KAATSU training on haemostasis in healthy subjects (2007)
  • Author(s): Nakajima, T., Takano, H., Kurano, M., lida, H., Kubota, N., Yasuda, T., Kato, M., Meguro, K., Sato, Y., Yamazaki, Y., Kawashima, S., Ohshima, H., Tachibana, S., Nagata, T. Abe, T., Ishii, N., and Morita, T
  • Journal Title: Int.J.Kaatsu Tr.Res 3 Pages: 11-20
  • Peer Reviewed
• [Journal Article] Attenuated growth hormone response to resistance exercise with prior sprint exercise. (2007)
  • Author(s): Goto, K., Ishii, N., Kurokawa, K., Takamatsu, K.
  • Journal Title: Med. Sci. Sports Exerc. 39 Pages: 108-115
• [Journal Article] Effects of eccentric exercise on joint stiffness and muscle connectin (titin) isoform in the rat hindlimb. (2007)
  • Author(s): Ochi, E., Nakazato, K., Ishii, N.
  • Journal Title: J. Physiol. Sci. 57 Pages: 1-6
  • NAID: 10022595913
• [Journal Article] Steady-state force-velocity relation in human multi-joint movement determined with force clamp analysis. (2007)
  • Author(s): Yamauchi, J., Mishima, C., Fujiwara, M., Nakayama, S., Ishii, N.
  • Journal Title: J. Biomech. 40 Pages: 1433-1442
• [Journal Article] Effects of low-intensity resistance exercise with slow movement and tonic force generation on muscular function in young men. (2006)
  • Author(s): Tanimoto, M., Ishii, N.
  • Journal Title: J. Appl. Physiol. 100 Pages: 1150-1157
  • Peer Reviewed
• [Journal Article] Effects of low-intensity resistance exercise with slow movement and tonic force generation on muscular function in young men. (2006)
  • Author(s): Tanimoto, M., Ishii, N.:
  • Journal Title: J. Appl. Physiol. 100 Pages: 1150-1157
• [Journal Article] Testosterone causes decrease in the content of muscle myostatin. (2006)
  • Author(s): Kawada, S., Okuno, M., Ishii, N.
  • Journal Title: Jut. J. Sport Health Sci. 4 Pages: 44-48
• [Journal Article] Effects of low-load resistance training with vascular occlusion on the mechanical properties of muscle and tendon. (2006)
  • Author(s): Kubo, K., Komuro, T., Ishiguro, N., Tsunoda, N., Sato, Y., Ishii, N., Kanehisa, H., Fukunaga, T.
  • Journal Title: J. Appl. Biomech. 22 Pages: 112-119
• [Presentation] Relationship between torque and angular velocity of human dorsiflexors in vivo. (2008)
  • Author(s): Sasaki, K., Matsubayashi, K. and Ishii, N.
  • Organizer: American College of Sport Medicine
  • Place of Presentation: シアトル(アメリカ合衆国)
• [Presentation] Effects of unilateral resistance exercise with vascular occlusion on muscular function of trained and untrained limbs (2007)
  • Author(s): Madarame, H., Sasaki, K., Ochi, E., Nakazato, K., Ishii, N.
  • Organizer: 12th Annual Congress of the European College of Sport Science
• [Presentation] Effects of unilateral resistance exercise with vascular occlusion on muscular function of trained and untrained limbs (2007)
  • Author(s): Hadarame, H., Sasaki, K., Ochi, E., Nakazato, K., Ishii, N.
  • Organizer: 12th Annual Congress of the European College of Sport Science
  • Place of Presentation: Finland
• [Presentation] 筋の抗加齢策としての加圧トレーニングとその応用 (2007)
  • Author(s): 石井 直方
  • Organizer: 第7回日本抗加齢医学会大会・シンポジウム
  • Place of Presentation: 京都
• [Presentation] 筋力と姿勢 (2007)
  • Author(s): 石井 直方
  • Organizer: 第12回日本咬合学会大会・特別講演
  • Place of Presentation: 東京
• [Presentation] ヒト前脛骨筋の形状・機能とACTN3遺伝子型との関連性 (2007)
  • Author(s): 佐々木 一茂、松林 武生、石井 直方
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田
• [Presentation] 筋運動の全均牲効果:加圧トレーニングによる内分泌活性化とそのメカニズムを中心に (2007)
  • Author(s): 石井 直方
  • Organizer: 第62回日本体力医学会大会・シンポジウム
  • Place of Presentation: 秋田
• [Presentation] 大腰筋の力-長さ関係 (2007)
  • Author(s): 松林 武生、久保 潤二郎、松尾 彰文、渡會 公治、小林 寛道、石井 直方
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田
• [Presentation] 尾部懸垂がラット筋内のTGF-βsの発現に与える影響 (2007)
  • Author(s): 廣瀬 立朗、越智 英輔、中里 浩一、石井 直方
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田
• [Presentation] 血流制限下のレジスタンストレーニングに対する内分泌応答:上肢運動と下肢運動の比較 (2007)
  • Author(s): 班目 春彦、石井 直方
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田
• [Presentation] 繰り返しの筋運動がラット骨格筋のAKT/mTOR/p70S6Kシグナル伝達経路の活性化に及ぼす影響 (2007)
  • Author(s): 越智 英輔、中里 浩一、廣瀬 立朗、木村 直人、石井 直方
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田
• [Presentation] 負荷重量の違いがスクワット運動における床反力の左右差に及ぼす影響 (2007)
  • Author(s): 小林雄志、久保潤二郎、松林武生、松尾彰文、小林寛道、石井直方
  • Organizer: 第62回躰体力医学会大会
  • Place of Presentation: 秋田
• [Book] 一生太らない体のつくり方 (2008)
  • Author(s): 石井直方
  • Total Pages: 190
  • Publisher: エクスナレッジ(東京)
• [Book] 一生太らない体のつくり方 (2008)
  • Author(s): 石井 直方
  • Total Pages: 190
  • Publisher: エクスナレッジ
• [Book] 加圧トレーニングの骨格筋に対する効果とそのメカニズム.加圧トレーニングの理論と実践(佐藤 嘉昭, 石井 直方, 中島 敏明, 安部 孝 編) (2007)
  • Author(s): 石井 直方
  • Total Pages: 179
  • Publisher: 講談社サイエンティフィック
• [Book] 究極のトレーニング (2007)
  • Author(s): 石井 直方
  • Total Pages: 301
  • Publisher: 講談社
• [Book] 筋肉の大研究 (2007)
  • Author(s): 石井 直方
  • Total Pages: 79
  • Publisher: PHP研究所
• [Book] 中高年から足腰力をつける本 (2007)
  • Author(s): 石井 直方, 工藤 麻衣子
  • Total Pages: 127
  • Publisher: 主婦と生活社
• [Book] 筋肉まるわかり大事典(第2巻) (2007)
  • Author(s): 石井 直方
  • Total Pages: 122
  • Publisher: ベースボールマガジン社
• [Book] 使える筋肉・使えない筋肉(実技編) (2006)
  • Author(s): 谷本道哉, 石井直方
  • Total Pages: 223
  • Publisher: 高橋書店(東京)