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Molecular bases of hypoglycemc index diet which prevents metabolic syndrome

Research Project

Project/Area Number 18300232
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionThe University of Tokushima

Principal Investigator

TAKEDA Eiji  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (00144973)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Hironori  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (60314861)
ARAI Hidekazu  静岡県立大学, 食品栄養科学部, 准教授 (60325256)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,400,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2006: ¥9,600,000 (Direct Cost: ¥9,600,000)
Keywordsメタボリック症候群 / グリセミック・インデックス / パラチノース / オレイン酸 / リノール酸 / キシリトール / 遺伝子発現 / 組み合わせ食 / めかぶ / 大麦 / デスアシルグレリン / 白血球遺伝子 / シュクロース / 糖毒性 / 脂肪毒性 / 脂肪組織炎症性反応
Research Abstract

1) 低グリセミック・インデックス(GI)食のメタボリック症候群予防効果に関するラットを用いた分子機構として、門脈内グルコース濃度上昇に応答する早期インスリン分泌能の解明、パラチノースとオレイン酸の組合せ食および長期キシリトールの糖質・脂質代謝改善効果、苦瓜の食後高血糖抑制機序、糖質調整流動食の長期投与による内臓脂肪蓄積予防、2) 低GI食のメタボリック症候群予防効果に関するヒトによる評価では、粘性食品の食後高血糖予防効果、糖質調整流動食のメタボリック症候群予防効果、大麦および糖質調整流動食Inslowのメタボリック症候群予防効果、3) メタボリック症候群の予防に関与するヒト末梢血白血球遺伝子としてpyxuvate dehydrogenase kinase, isozyme 4(PDK4)、calnitine palmitoyltransferase 1A(liver)(CPTIA)を同定した。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (51 results)

All 2009 2008 2007 2006 Other

All Journal Article (36 results) (of which Peer Reviewed: 29 results) Presentation (5 results) Book (5 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] Fermented ginseng improves the first-night effect in humans2009

    • Author(s)
      Kitaoka K, Uchida K, Okamoto N, Chikahisa S, Miyazaki T, Takeda E, Hiroyoshi Sei H
    • Journal Title

      SLEEP 32

      Pages: 413-421

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Does-dependent Effects of Barley Cooked with White Rice on postprandial Glucose and Desacyl Ghrelin Levels2009

    • Author(s)
      Sakuma M, Yamanaka-Okumura H, Naniwa N, Matsumoto D, Tsunematsu M, Yamamoto H, Taketani Y, Takeda E
    • Journal Title

      J Clin Biochem Nutr 44

      Pages: 1-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of glucose metabolism in patients with impaired glucose tolerance or diabetes by long-term administration of a palatinose-based liquid formula as a part of breakfast2009

    • Author(s)
      Sakuma M, Arai H, Mizuno A, Fukaya M, Matsuura M, Sasaki H, Yamanaka-Okumura H, Yamamoto H, Taketani Y, Doi T, Takeda E
    • Journal Title

      J Clin Biochem Nutr 44

      Pages: 151-159

    • NAID

      130004466575

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Docs-dependent Effccts of Barley Cooked with White Rice on postprandial Glucose and Desacyl Ghrelin Levels.2009

    • Author(s)
      Sakuma M, et al
    • Journal Title

      J Clin Binochem Nutr 44

      Pages: 1-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diurnal amplitudes of arterial pressure and heart rate are dampened in Clock mutant mice and adrenalectomized mice2008

    • Author(s)
      Sei H, Oishi K, Chikahisa S, Kitaoka K, Takeda E, Ishida N
    • Journal Title

      Endocrinology 149

      Pages: 3576-3580

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natto and viscous vegetables in a Japanese style meal suppress postprandial glucose and insulin responses2008

    • Author(s)
      Taniguchi A, Yamanaka-Okumura H, Nishida Y, Yamamoto H, Taketani Y, Takeda E
    • Journal Title

      Asia Pacific J Clin Nutr 17

      Pages: 663-668

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats2008

    • Author(s)
      Sato K, Arai H, Miyazawa Y, Fukaya M, Uebanso T, Koganei M, Sasaki H, Sato T, Yamamoto H, Taketani Y, Takeda E
    • Journal Title

      J Med Invest 55(3-4)

      Pages: 183-95

    • NAID

      130004465140

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Palalinose and olcic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats.2008

    • Author(s)
      Sato K, et al
    • Journal Title

      J Med Invest 55

      Pages: 183-195

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natto and viscous vegetables in a Japanese style meal suppress postprandial glucose and insulin responses.2008

    • Author(s)
      Taniguchi A, et al
    • Journal Title

      Asia Pacific J Clin Nutr 17

      Pages: 663-668

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of palatinose-based liquid diet (Inslow) on glycemic control and the second-meal effect in healthy men2007

    • Author(s)
      Arai H, Mizuno A, Sakuma M, Fukaya M, Matsuo K, Muto K, Sasaki H, Matsuura M, Okumura H, Yamamoto H, Taketani Y, Doi T, Takeda E
    • Journal Title

      Metabolism Clinical and Experimental 56

      Pages: 15-121

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphate Restriction in Diet Therapy, Nutrition and Kidney Disease2007

    • Author(s)
      Takeda E, Yamamoto H, Nishida Y, Sato T, Sawada N, Taketani Y
    • Journal Title

      A New Era. Contrib Nephrol. Basel, Karger Vol 155

      Pages: 113-124

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early-phase insulin secretion is disturbed in obese subjects with glucose intolerance2007

    • Author(s)
      Mizuno A, Arai H, Fukaya M, Sato M, Yamanaka-Okumura H, Takeda E, Doi T
    • Journal Title

      Metabolism Clinical and Experimental 56

      Pages: 856-862

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Anti-Obesity Effect of the Palatinose-Based Formula Inslow is Likely due to an Increase in the Hepatic PPAR α and Adipocyte PPAR γ・Gene Expressions2007

    • Author(s)
      Matsuo K, Arai H, Muto K, Fukaya M, Sato T, Mizuno A, Sakuma M, Yamanaka-Okumura H, Sasaki H, Yamamoto H, Taketani Y, Doi T, Takeda E
    • Journal Title

      J Clin Biochem Nutr 40

      Pages: 234-241

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene Expression in Low Glycemic IndexDiet-Impact on Metabolic Control, Tai ES, Gillies PJ (eds)2007

    • Author(s)
      Takeda E, Arai H, Muto K, Matsuo K, Sakuma M, Fukaya M, Yamanaka-Okumura H, Yamamoto H, Taketani Y
    • Journal Title

      Nutrigenomics- Opportunities in Asia. Forum Nutr Basel, Karger 160

      Pages: 127-139

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of rapid-phase insulin response to elevation of portal glucose concentration2007

    • Author(s)
      Fukaya M, Mizuno A, Arai H, Muto K, Uebanso T, Matsuo K, Yamamoto H, Taketani Y, Doi T, Takeda E
    • Journal Title

      Am J Physiol Endocrinol Metab 293

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary Palatinose and Oleic Acid Ameliorate Disorders of Glucose and Lipid Metabolism in Zucker Fatty Rats2007

    • Author(s)
      Sato K, Arai H, Mizuno A, Fukaya M, Sato T, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Doi T, Takeda E
    • Journal Title

      J Nutr 137

      Pages: 1908-1915

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Water extract of Cordyceps sinensis(WECS)inhibits the RANKL-induced osteoclast differentiation2007

    • Author(s)
      Mizuha Y, Yamamoto H, Sato T, Tsuji M, Masuda M, Uchida H, Sakai K, Taketani Y, Yasutomo K, Sasaki H, Takeda E
    • Journal Title

      BioFactors 30

      Pages: 105-116

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extracts of Momordica charantia Suppress Postprandial Hyperglycemia in Rats2007

    • Author(s)
      Uebanso T, Arai H, Taketani Y, Fukaya M, Yamamoto H, Mizuno A, Uryu K, Hada T, Takeda E
    • Journal Title

      J Nutr Sci Vitamino 1.53

      Pages: 482-488

    • NAID

      110006531867

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a palatinose-based liquid diet (Inslow) on glycemic control and the second-meal effect in healthy men2007

    • Author(s)
      Arai H, Mizuno A, Sakuma M, M Fukaya M, Matsuo K, Muto K, Sasaki H, Matsuura H, Okumura H, Yamamoto H, Taketani Y, Doi T, Takeda E
    • Journal Title

      Metabolism 56

      Pages: 115-121

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early-phase insulin secretion is disturbed in obese subjects with glucose intolerance2007

    • Author(s)
      Mizuno A
    • Journal Title

      Metabolism 56

      Pages: 856-862

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The anti-obesity effect of the palatinose-based formula Inslow is likely due to an imcrease in the hepatic PPAR-α and adipocyte PPAR-γgene expressions2007

    • Author(s)
      Matsuo K
    • Journal Title

      J Clin Biochem Nutr 40

      Pages: 234-241

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nutritional treatment of a patient with hepatic cirrhosis with the novel low glycemic index liquid food(Inslow)2007

    • Author(s)
      Matsumoto D
    • Journal Title

      J Med Invest 54

      Pages: 375-380

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of rapid-phase insulin response to elevation of portal glucodse concentration2007

    • Author(s)
      Fukaya M
    • Journal Title

      Am J Physiol Endocrinol Metab 293

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A combination of dietary palatinose and oleic acid ameliorates disorders of glucose and lipid metabolism in Zucker Fatty rats2007

    • Author(s)
      Sato K
    • Journal Title

      J Nutr 139

      Pages: 1908-1915

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nutrigenomics-Opportunities2007

    • Author(s)
      Takeda E
    • Journal Title

      Asia.Forum Nutr, Karger,Basel

      Pages: 127-139

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Effects of a palatinose-based liquid diet (Inslow) on glycemic control and the second meal effect in healthy men.2007

    • Author(s)
      Arai Hidekazu
    • Journal Title

      Metabolism 56

      Pages: 115-121

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of late evening snack with rice ball on energy metabolism in liver cirrhosis2006

    • Author(s)
      Yamanaka-Okumura H, Nakamura T, Takeuchi H, Miyake H, Katayama T, Arai H, Taketani Y, Fujii M, Shimada H, Takeda E
    • Journal Title

      European Journal of Clinical Nutrition 60

      Pages: 1067-1072

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute sffect of oral phosphate loading on serum fibroblast groeth factor 23 levels in healthy men2006

    • Author(s)
      Nishida Y, Taketani Y, Yamanaka-Okumura H, Imamura F, Tanigichi A, Sato T, Shuto E, Nashiki K, Arai H, Yamamoto H, Takeda E
    • Journal Title

      Kidney International 70

      Pages: 2141-2147

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate contransporter gene2006

    • Author(s)
      Yamamoto H, Tani Y, Kobayashi K, Taketani Y, Sato T, Arai H, Morita K, Miyamoto K, Pike JW, Kato S, Takeda E
    • Journal Title

      Biochim Biophys Acta 1732

      Pages: 43-52

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immobilization decreases duodenal calcium absorption through a 1, 25-dihydroxyvitamin D-dependent pathway2006

    • Author(s)
      Sato T, Yamamoto H, Sawada N, Nashiki K, Tsuji M, Nikawa T, Arai H, Morita K, Taketani Y, Takeda E
    • Journal Title

      J Bone Miner Metab 24

      Pages: 291-299

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of late evening snack with rice ball on energy metabolism in liver cirrhosis.2006

    • Author(s)
      Yamanaka-Okumura Hisami
    • Journal Title

      Eur J Clin Nutr 60

      Pages: 1067-1072

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Restraint stress alters the duodenal expression of genes important for lipid metabolism in rat.2006

    • Author(s)
      Sato Tadatoshi
    • Journal Title

      Toxicology 227

      Pages: 248-261

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Estimation of the total daily energy expenditure and its components by monitoring the heart rate in Japanese endurance athletes.2006

    • Author(s)
      Motonaga Keiko
    • Journal Title

      J Nutr Sci Vitaminol 52

      Pages: 360-367

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men.2006

    • Author(s)
      Nishida Yuka
    • Journal Title

      Kidney Int 70

      Pages: 2141-2147

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel function of phosphate-mediated intracellular signal transduction pathways.2006

    • Author(s)
      Takeda Eiji
    • Journal Title

      Adv Enzyme Regul. 46

      Pages: 154-161

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Acute effect of elevation of serum phosphorus on endothelial function with reference to oxidative stress and NO production

    • Author(s)
      Shuto E, Taketani Y, Tanaka R, Harada N, Isshiki M, Sato M, Nashiki K, Amo K, Yamamoto H, Higashi Y, Nakaya Y, Takeda E
    • Journal Title

      J Amer Soo Nephrol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 長期キシリトール投与による糖質・脂質代謝改善効果2008

    • Author(s)
      阿望 幾久子
    • Organizer
      第11回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-01-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of long-term intake of xylitol on visceral fat accumulation in rats fed high-fat diet2008

    • Author(s)
      Amo K, Arai H, Uebanso T, Fukaya M, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Takeda E
    • Organizer
      American Diabetes Association's 68th Scientific Sessions
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of long-term intake of xylitol on visceral fat accumulation in rats fed high-fat diet.2008

    • Author(s)
      Amo K, et al
    • Organizer
      第68回米国糖尿病学会
    • Place of Presentation
      サンフランシスコ
    • Related Report
      2008 Annual Research Report
  • [Presentation] Combination of food and nutrients for metabolic syndrome2007

    • Author(s)
      Takeda E
    • Organizer
      International Conference on Food Factors for Health Promotzon -IcoFF2007-
    • Place of Presentation
      京都
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 食後高血糖抑制効果を有する麦の配合割合の検討2007

    • Author(s)
      佐久間 理英
    • Organizer
      第61回日本栄養・食糧学会大会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-20
    • Related Report
      2007 Annual Research Report
  • [Book] 食品技術総合事典・食品の機能性の評価手法 ・ヒト試験による機能性評価2008

    • Author(s)
      武田英二, 奥村仙示
    • Publisher
      朝倉書店
    • Related Report
      2008 Annual Research Report
  • [Book] Nutrigenomics-Opportunities in Asia.Forum Nutr2007

    • Author(s)
      Takeda E
    • Publisher
      Karger, Base1
    • Related Report
      2007 Annual Research Report
  • [Book] 機能性食品の事典2007

    • Author(s)
      武田 英二
    • Publisher
      朝倉書店
    • Related Report
      2007 Annual Research Report
  • [Book] Nutrition and Kidney Diseases : A New Era, Contrib Nephrol. (Basel, Suzuki H, Kimmel PL (eds), Karger, vol 155)2007

    • Author(s)
      Takeda Eiji
    • Total Pages
      12
    • Publisher
      Phosphate restriction in diet therapy.
    • Related Report
      2006 Annual Research Report
  • [Book] メタボリックシンドローム、栄養評価と治療

    • Author(s)
      武田英二、阿望幾久子、上番増喬
    • Publisher
      メディカルレビュー社
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] GABA作動性ニューロン賦活剤2007

    • Inventor(s)
      武田英二、寺尾純二、勢井宏義、柳原啓之、北岡和義、宮崎寿次、北島智恵子
    • Industrial Property Number
      2007-164115
    • Filing Date
      2007-06-21
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 抗不安抗うつ剤2007

    • Inventor(s)
      武田英二、寺尾純二、勢井宏義、柳原啓之、北岡和義、宮崎寿次、北島智恵子
    • Industrial Property Number
      2007-164183
    • Filing Date
      2007-06-21
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 抗不安抗うつ剤2007

    • Inventor(s)
      武田英二、寺尾純二、勢井宏義、柳原啓之、北岡和義、宮崎寿次、北島智恵子
    • Industrial Property Number
      2007-164034
    • Filing Date
      2007-06-21
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 血中デスアシルグレリン濃度による血糖値・血中インスリン濃度の予測方法2007

    • Inventor(s)
      武田英二、奥村仙示、佐久間理英
    • Industrial Property Number
      2007-248241
    • Filing Date
      2007-09-25
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 血中デスアシルグレリン濃度による血糖値・血中インスリン濃度の予測方法2007

    • Inventor(s)
      武田 英二、奥村 仙示、佐久間 理英
    • Industrial Property Rights Holder
      徳島大学
    • Industrial Property Number
      2007-248241
    • Filing Date
      2007-09-25
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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