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The effect of Okinawan gr en and yellow vegetables on the anti-oxidant vitamin levels and oxidative stress markers in a randomized human trial

Research Project

Project/Area Number 18300254
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionUniversity of the Ryukyus

Principal Investigator

TODORIKI Hidemi  University of the Ryukyus, 医学部, 准教授 (60175479)

Co-Investigator(Kenkyū-buntansha) TEI Keijo  国立大学法人琉球大学, 医学部, 助教 (90315466)
OHYA Yusuke  国立大学法人琉球大学, 医学部, 准教授 (30240964)
SASAKI Satoshi  国立大学法人東京大学, 大学院・医学系研究科, 教授 (70275121)
D・CRAIG Willcox  沖縄国際大学, 総合文化学部, 准教授 (70316214)
Co-Investigator(Renkei-kenkyūsha) TEI Keijo  琉球大学, 医学部, 助教 (90315466)
OHYA Yusuke  琉球大学, 医学部, 准教授 (30240964)
SASAKI Satoshi  国立大学法人東京大学, 大学院・医学系研究科, 教授 (70275121)
D・CRAIG Willcox  沖縄国際大学, 総合文化学部, 准教授 (70316214)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,610,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2007: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2006: ¥6,300,000 (Direct Cost: ¥6,300,000)
Keywords食事介入 / 無作為化割付比較試験 / 沖縄伝統的食事パターン / 沖縄野菜 / 高血圧予防 / 抗酸化栄養素 / 血圧降下 / 栄養疫学 / 沖縄型食事 / ヒト介入試験 / 沖縄伝統的食事 / 沖縄特産野菜 / 無作為割付比較試験 / 米国人 / 介入研究 / ヒト対象研究 / 酸化ストレスマーカー / 生体指標 / 緑黄色野菜
Research Abstract

沖縄野菜を主体とした沖縄型食事介入による無作為割付比較試験を行った。対象者は沖縄在住20-60歳代の女性、夫婦、米国人男女、横浜東京在住40-60歳代夫婦、合計700名であった。1)沖縄野菜を豊富に取り入れた伝統的沖縄型食事は、血圧予防に有効である可能性と、2)欧米型DASH食と異なる沖縄の伝統的食事が、同様の効果を示した。3)生活習慣病の予防や治療において、食事パターンへの介入が有効な戦略となりうる。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (50 results)

All 2009 2008 2007 2006 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (32 results) Remarks (6 results)

  • [Journal Article] Dietary intervention with Okinawan vegetables increased circulating endothelial progenitor cells in healthy young women2009

    • Author(s)
      Mano R、Ishida A、Ohya Y、Todoriki H、Takishita S
    • Journal Title

      Atherosclerosis 204

      Pages: 544-548

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 伝統的沖縄型食事介入による地域における健康改善は可能か?2008

    • Author(s)
      等々力英美
    • Journal Title

      -チャンプルースタディの結果から-、九州農誌 17

      Pages: 2-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary intervention with Okinawan vegetables increased circulating endothelial progenitor cells in healthy young women.2008

    • Author(s)
      Mano R, Ishida A, Ohya Y, Todoriki H, Takishita S.
    • Journal Title

      Atherosclerosis 電子媒体

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 伝統的沖縄型食事介入による地域における健康改善は可能か? -チャンプルースタディの結果から-2008

    • Author(s)
      等々力英美
    • Journal Title

      九州農誌 17

      Pages: 2-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 沖縄の異文化接触による食変化と長寿性2007

    • Author(s)
      等々力英美
    • Journal Title

      老年歯科医学 21

      Pages: 373-378

    • NAID

      10020174750

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] energy balance and healthy aging in Okinawans and Americans : Biomarker differences in septuagenarinas2007

    • Author(s)
      Willcox BJ、 Willcox DC、Todoriki H、Caloric Restriction
    • Journal Title

      The Okinawan J. American Studies 4

      Pages: 62-71

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caloric Restriction, the Traditional Okinawan Diet, and Healthy Aging The Diet of the World's Longest-Lived People and Its Potential Impact on Morbidity and Life Span2007

    • Author(s)
      Willcox BJ、Willcox DC、Todoriki H
    • Journal Title

      Ann. N.Y.Acad. Sci 1114

      Pages: 434-455

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caloric Restriction, the Traditional Okinawan Diet, and Healthy Aging The Diet of the World's Longest-Lived People and Its Potential Impact on Morbidity and Life Span2007

    • Author(s)
      Willcox BJ, Willcox DC, Todoriki H
    • Journal Title

      Ann. N.Y. Acad. Sci. 1114

      Pages: 434-455

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caloric Restriction, energy balance and healthy aging in Okinawans and Americans: Biomarker differences in septuagenarinas.2007

    • Author(s)
      Willcox BJ, Willcox DC, Todoriki H
    • Journal Title

      The Okinawan J. American Studies 4

      Pages: 62-74

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caloric restriction and human longevity : What can we learn from the Okinawans?2006

    • Author(s)
      Willcox DC、Willcox BJ、Todoriki H、Curb JD、Suzuki M
    • Journal Title

      Biogerontology 7

      Pages: 173-177

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potassium Excretion in Healthy Japanese Women was Increased by a DietaryIntervention Utilizing Home-Parcel Delivery of Okinawan Vegetables2006

    • Author(s)
      Tuekpe MKN、Todoriki H、Sasaki S、Zheng KC、Ariizumi M
    • Journal Title

      Hypertens Res 29

      Pages: 389-396

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potassium Excretion in Healthy Japanese Women was Increased by a Dietary Intervention Utilizing Home-Parcel Delivery of Okinawan Vegetables.2006

    • Author(s)
      Mellet Korsi-Ntumi Tuekpe
    • Journal Title

      Hypertens Res 29

      Pages: 389-396

    • Related Report
      2006 Annual Research Report
  • [Presentation] 沖縄における長寿再生を目指した一次予防戦略は可能か?2008

    • Author(s)
      等々力英美
    • Organizer
      第40回沖縄県公衆衛生学会学会長講演
    • Place of Presentation
      沖縄県南城市
    • Year and Date
      2008-11-14
    • Related Report
      2008 Final Research Report
  • [Presentation] クレイグ・ウィルコックス、沖縄伝統的食事の食事パターン介入による無作為割付比較試験(チャンプルースタディ)-DASH(Dietary Approaches to StopHypertension)食との類似性-2008

    • Author(s)
      等々力英美、比嘉郁乃、大屋祐輔、勝亦百合子、東上里康司、佐々木敏
    • Organizer
      第40回沖縄県公衆衛生学会
    • Place of Presentation
      沖縄県南城市
    • Year and Date
      2008-11-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 沖縄伝統的食事の食事パターン介入による無作為割け比較試験(チャンプルースタディ) -DASH (Dietary Approaches to Stop Hypertension) 食との類似性-2008

    • Author(s)
      等々力英美, 比嘉郁乃, 大屋祐輔, 勝亦百合子, 東上里康司, クレイグ・ウィルコックス, 佐々木敏
    • Organizer
      第40回沖繩県公衆衛生学会
    • Place of Presentation
      沖縄県南城市シュガーホール
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] A Community-based Randomized Intervention Trial Utilizing Traditional Okinawa Vegetable Diet-Importance of the Descriptive Data on Nutrition Transition in Post-War Okinawa-2008

    • Author(s)
      Todoriki H
    • Organizer
      International Symposium on Medical and Dental Research Field Symposium for Education Program Development of Public Health Experts on Island and Community Medicine with a Focus on Islands Countries
    • Place of Presentation
      Kagoshima
    • Year and Date
      2008-03-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 伝統的沖縄野菜料理は高血圧予防に有効か-チャンプルースタディによる科学的検証-2008

    • Author(s)
      等々力英美
    • Organizer
      第3回沖縄産官学連携推進フォーラム(新産業創出に向けたシーズ発表会)
    • Place of Presentation
      那覇市
    • Year and Date
      2008-02-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Could the intervention of an Okinawan vegetable-based diet changestone-risk parameters in healthy subjects in Okinawa?2008

    • Author(s)
      Ogawa Y、Hossain RZ、Todoriki H、Machida N、Naka H、Hokama S、Sugaya K
    • Organizer
      11th International Symposium on Urolithiasis
    • Place of Presentation
      Nice, France、Urol Res
    • Related Report
      2008 Final Research Report
  • [Presentation] DASH食類似の伝統的沖縄食の摂取は血圧を低下させる : 無作為割付による食事介入研究(チャンプルースタディ)2008

    • Author(s)
      等々力英美、大屋祐輔、勝亦百合子、東上里康司、クレイグ・ウィルコックス、佐々木敏
    • Organizer
      第31回日本高血圧学会総会
    • Place of Presentation
      北海道札幌市
    • Related Report
      2008 Final Research Report
  • [Presentation] 各種だし素材使用量と野菜摂取量との相関 : 40-60歳代の沖縄県住民を対象とした栄養疫学研究2008

    • Author(s)
      黒田素央、等々力英美、佐々木敏
    • Organizer
      第54回日本栄養改善学会
    • Place of Presentation
      長崎県長崎市
    • Related Report
      2008 Final Research Report
  • [Presentation] Dietary intervention with Okinawan vegetables through home-parcel delivery increased circulating endothelial progenitor cells in healthy young women、22nd Scientific Meeting International Society of Hypertension2008

    • Author(s)
      Mano R、Ishida A、Ohya Y、Todoriki H、Takishita S
    • Organizer
      Internationales Congress Centrum Berlin(ICC)
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2008 Final Research Report
  • [Presentation] A Clinical Trial of the Effects of the Traditional Okinawa Diet on Blood Pressure and other Health Indicators : Can DASH-like Results be Achieved?2008

    • Author(s)
      Todoriki H、Katsumata Y、Ohya Y、Willcox DC、Zheng KC、Sasaki S
    • Organizer
      22nd Scientific Meeting International Society of Hypertension、 Internationales Congress Centrum Berlin(ICC)
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2008 Final Research Report
  • [Presentation] 健全な食生活の実践にむけてー島野菜摂取促進から長寿再生へー2008

    • Author(s)
      等々力英美
    • Organizer
      徳島県食生活改善フォーラム
    • Related Report
      2008 Final Research Report
  • [Presentation] 生活習慣病の予防的戦略をどう考えるかー沖縄野菜による高血圧予防(チャンプルースタディー)を中心にー2008

    • Author(s)
      等々力英美
    • Organizer
      那覇市医師会学術・生涯教育講演会
    • Related Report
      2008 Final Research Report
  • [Presentation] 沖縄の長寿の危機と長寿再生は可能か?2008

    • Author(s)
      等々力英美
    • Organizer
      福井県立大学健康長寿研究会招待講演
    • Related Report
      2008 Final Research Report
  • [Presentation] A Clinical Trial of the Effects of the Traditional Okinawa Diet on Blood Pressure and other Health Indicalors : Can DASH-like Results be Achieved?2008

    • Author(s)
      Todoriki H., Katsumata Y., Ohya Y., Willcox D. C., Zheng K., Sasaki S.
    • Organizer
      22nd Scientific Meeting International Socicty of llypertension
    • Place of Presentation
      Internationales Congress Contrum Herlin (ICC), Berlin, Germany
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dietary intervention with Okinawnn vegetables through home-parcel delivery increased circulating endothelial progenitor cells in healthy young women2008

    • Author(s)
      Mano R, lshida A, Ohya Y, Todoriki H, Takishita S
    • Organizer
      22nd Seientific Meeting International Societyof Hypertension
    • Place of Presentation
      Internationales Congress Centrum Berlin (ICC), Berlin, Germany
    • Related Report
      2008 Annual Research Report
  • [Presentation] DASH食類似の伝統的冲縄食の摂取は血圧を低下させる : 無作為割付による食事介入研究(チャンプルースタディ)2008

    • Author(s)
      等々力英美, 大屋祐輔, 勝亦百合子, 東上里康司, クレイグ・ウィルコックス, 佐々木敏
    • Organizer
      第31回日本高血圧学会総会
    • Place of Presentation
      北海道札幌市ロイトン札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] 各種だし素材使用量と野菜摂収量との相関 : 40-60歳代の冲縄県住民を対象とした衆養疫学研究2008

    • Author(s)
      黒田素央, 等々力英美, 佐々木敏
    • Organizer
      第54回日本栄養改善学会
    • Place of Presentation
      長崎県長崎市ブリックホール
    • Related Report
      2008 Annual Research Report
  • [Presentation] 食事介入と高血圧予防-沖縄型食事と沖縄野菜の組み合わせによる食事介入研究(チャンプルースタディ)2007

    • Author(s)
      等々力英美
    • Organizer
      第30回日本高血圧学会総会シンポジウム「栄養と高血圧」
    • Place of Presentation
      那覇市
    • Year and Date
      2007-10-27
    • Related Report
      2008 Final Research Report
  • [Presentation] 沖縄野菜と沖縄型食事から健康長寿へ2007

    • Author(s)
      等々力英美
    • Organizer
      第17回九州農村医学会学会長講演
    • Place of Presentation
      那覇市
    • Year and Date
      2007-06-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Correlation between the consumption of materials for soup stock(dashi)and vegetables with respect to intake of electrolytes : Nutritional & epidemiological study of the Okinawan residents aged 40-69 years2007

    • Author(s)
      Kuroda M、Todoriki H、Ohya Y、Sasaki S
    • Organizer
      The 6th Asian-Pacific Congress of Hypertension
    • Place of Presentation
      Beijing, China
    • Related Report
      2008 Final Research Report
  • [Presentation] Radial Augmentation Index とPulse Wave Velocityとの相関は弱い(30、292)2007

    • Author(s)
      太田千亜紀、金城民子、根路銘国政、東上里康司、等々力英美、大屋祐輔
    • Organizer
      日本高血圧学会総会プログラム・抄録集
    • Related Report
      2008 Final Research Report
  • [Presentation] 沖縄野菜摂取の血管内皮前駆細胞(EPC)に及ぼす影響(無作為割付研究)(30、266)2007

    • Author(s)
      真野理恵子、石田明夫、大屋祐輔、等々力英美、瀧下修一
    • Organizer
      日本高血圧学会総会プログラム・抄録集
    • Related Report
      2008 Final Research Report
  • [Presentation] 各種だし素材使用量と野菜摂取量および摂取電解質(Na、K)量との相関40-60歳代の沖縄県住民を対象とした栄養疫学研究(30、265)2007

    • Author(s)
      黒田素央、等々力英美、大屋祐輔、佐々木敏
    • Organizer
      日本高血圧学会総会プログラム・抄録集
    • Related Report
      2008 Final Research Report
  • [Presentation] 沖縄の伝統的野菜によるヒト介入研究(56-2)(73-74)2007

    • Author(s)
      等々力英美、鄭奎城、佐々木敏、大屋祐輔
    • Organizer
      日本農村医学会雑誌
    • Related Report
      2008 Final Research Report
  • [Presentation] Correlation between the consumption of materials for soup stock (dashi) and vegetables with respect to intake of electrolytes: Nutritional & epidemiological study of the Okinawan residents aged 40-69 years.2007

    • Author(s)
      Kuroda M, Todoriki H, Ohya Y, Sasaki S
    • Organizer
      The 6th Asian-Pacific Congress of Hypertension
    • Place of Presentation
      Beijing, China
    • Related Report
      2007 Annual Research Report
  • [Presentation] 沖縄特産野菜が抗酸化ビタミンおよび酸化ストレスマーカーに与える影響 : 若年女性を対象とした無作為化割付介入試験(チャンプルースタディ1)2006

    • Author(s)
      等々力英美、鄭奎城、勝亦百合子、Tuekpe MKN、佐々木敏
    • Organizer
      第71回日本民族衛生学会
    • Place of Presentation
      沖縄
    • Year and Date
      2006-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] 沖縄の異文化接触による食変化と長寿性、シンポジウム「長寿と現在歯数(8020 の人がほんとうに長寿か)」2006

    • Author(s)
      等々力英美
    • Organizer
      第17回日本老年歯科医学会総会・学術大会
    • Place of Presentation
      沖縄県宜野湾市
    • Year and Date
      2006-06-02
    • Related Report
      2008 Final Research Report
  • [Presentation] 沖縄伝統的野菜と沖縄型食事で健康になれるか?無作為化割付によるヒト介入試験 チャンプルースタディ12006

    • Author(s)
      等々力英美
    • Organizer
      第1回沖縄産官学連携推進フォーラム、産業支援センター
    • Place of Presentation
      那覇市
    • Year and Date
      2006-03-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 沖縄伝統的野菜を中心とした無作為化割付比較によるヒト介入試験チャンプルー研究(973)2006

    • Author(s)
      Tuekpe MKN、等々力英美、佐々木敏
    • Organizer
      日本公衆衛生学会総会抄録集
    • Related Report
      2008 Final Research Report
  • [Presentation] 摂取エネルギーの制限は人間の死亡と罹患のリスクを減らすことが出来るか?(996)2006

    • Author(s)
      Willcox DC、等々力英美、Willcox BJ
    • Organizer
      日本公衆衛生学会総会抄録集
    • Related Report
      2008 Final Research Report
  • [Presentation] Can We Improve the Health of the Publicthrough Community-basedNutrition Intervention ProgramsUtilizing Traditional OkinawanVegetables? -Exploring the Potentialof the Chample Study-2006

    • Author(s)
      Todoriki H、Zheng KC、Ohya Y、 Willcox DC、Tuekpe MKN、Sasaki S
    • Organizer
      The 1st World Congress on Ningen Dock
    • Place of Presentation
      Okinawa
    • Related Report
      2008 Final Research Report
  • [Presentation] Ariizumi M、Potassium Excretion of Healthy Japanese Women in a Randomized Controlled Dietary Intervention Study Utilizing Typical Okinawan Vegetables : The Chample Study2006

    • Author(s)
      Todoriki H、Tuekpe MKN、Sasaki S、Zheng KC
    • Organizer
      17th Japan-China-Korea Joint Conference on Occupational Health Jeju City、Jejudo
    • Place of Presentation
      Korea
    • Related Report
      2008 Final Research Report
  • [Remarks] 神奈川新聞(朝刊1面)、「沖縄野菜健康効果は?」、2008.01.14

    • Related Report
      2008 Final Research Report
  • [Remarks] 朝日新聞(全国版朝刊1面)、Be on Sunday「沖縄野菜の健康パワー」、2007.12.12

    • Related Report
      2008 Final Research Report
  • [Remarks] 沖縄タイムス、「減塩で高血圧改善を -沖縄の伝統食が有効-」、2007.11.2

    • Related Report
      2008 Final Research Report
  • [Remarks] 日経メディカルオンライン、「沖縄の伝統食が高血圧予防に有効である可能性-チャンプルースタディより-」、2007.10.30

    • Related Report
      2008 Final Research Report
  • [Remarks] 琉球新報、「沖縄食が高血圧予防」、2007.10.27

    • Related Report
      2008 Final Research Report
  • [Remarks] Stars and Stripes、'150 Americans in Okinawa study to weight diet's effect on longevity'、2007.01.26

    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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