Identification of Regulation Targets and Analysis of Regulation Modes by Uncharacterized Transcription Factors from Escherichia coli

• Project/Area Number: 18310133
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 基礎ゲノム科学
• Research Institution: Hosei University
• Principal Investigator: ISHIHAMA Akira Hosei University, 生命科学部, 教授 (80019869)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,240,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥2,940,000); Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2007: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2006: ¥5,500,000 (Direct Cost: ¥5,500,000)
• Keywords: ゲノム調節 / 転写 / 遺伝子 / 細菌 / 発現制御 / 転写因子 / 転写包括制御 / RNAポリメラーゼ / プロモーター / 転写制御ネットワーク / GENOMIC SELEX / 大腸菌 / 環境応答 / 転写制御 / 転写調節ネットワーク / GENONIC SELEX

Research Abstract

転写酵素RNAポリメラーゼの転写対象遺伝子群の選択は、転写因子との相互作用によって決定される。約300種類の大腸菌転写因子のうち、約100種は制御機能未知である。本研究では、機能未知転写因子が認識する配列から制御機能を同定するGenomic SELEX法を開発した。純化転写因子を利用した解析から、各転写因子の制御対象遺伝子群の同定に成功したことで、ゲノム転写包括制御の全貌解明の展望が開けた。

Research Products

• [Journal Article] Involvement of leucine-reponse transcription factor LeuO in regulation of the genes for sulfa-drug efflux (2009)
  • Author(s): Shimada, T., Yamamoto, K. and Ishihama, A.
  • Journal Title: J. Bacterlol 191(in press)
  • Peer Reviewed
• [Journal Article] Characterization of CitA-CitB signal transduction activating genes involved in anaerobic citrate catabolism in Escherichia coli. (2009)
  • Author(s): Yamamoto, K., Matsumoto, F., Minagawa, S., Oshima, T., Fujita, N., Ogasawara, N., Ishihama, A.
  • Journal Title: Biosci. Biotechnol. Biochem. 133 Pages: 6080-6084
  • NAID: 10027537345
  • Peer Reviewed
• [Journal Article] A11R is the Allantoin/Glyoxylate-Sensing Master Regulator of the Genes for Degradation and Reutilization of Purines (2008)
  • Author(s): Hasegawa, A., Ogasawara, H., Kori, A. and Ishihama, A.
  • Journal Title: Microbiology 154 Pages: 3366-3378
  • Peer Reviewed
• [Journal Article] Involvement of RNA binding protein Hfq in the post-tanscriptional regulation of invE gene expression in Shigella sonnei (2008)
  • Author(s): Mitobe, J., Ishihara, T., Ishihama, A. and Watanabe, H.
  • Journal Title: J. Biol. Chem 283 Pages: 5738-5747
  • Peer Reviewed
• [Journal Article] The Escherichia coli RutR transcription factor binds at targets within genes as well as intergenic regions (2008)
  • Author(s): Shimada, T., Ishihama, A., Busby, S.J.W. and Grainger, D.C.
  • Journal Title: Nucleic Acids Res. 36 Pages: 3950-3955
  • Peer Reviewed
• [Journal Article] The uncharacterized YdhM is the regulator of the nemA gene, coding for N-ethylmaleimide reductase (2008)
  • Author(s): Umezawa, Y., Ogasawara, H., Shimada, T., Kori, A. and Ishihama, A.
  • Journal Title: J. Bacteriol 190 Pages: 5890-5897
  • Peer Reviewed
• [Journal Article] Involvement of multiple transcription factors for metal-induced spy gene expression in Escherichia coli (2008)
  • Author(s): Yamamoto, K., Ogasawara, H. and Ishihama, A.
  • Journal Title: J. Biotechnol 133(16) Pages: 6080-6084
  • Peer Reviewed
• [Journal Article] AIIR is the allantoin/glyoxylate-sensing master regulator of the genes for degradation and reutilization of purines. (2008)
  • Author(s): Hasegawa, A., Ogasawara, H., Kori, A., Ishihama, A.
  • Journal Title: Microbiology 154 Pages: 3366-3378
  • Peer Reviewed
• [Journal Article] Involvement of RNA binding protein Hfq in the post-tanscriptional regulation of invE gene expression in Shigella sonnei. (2008)
  • Author(s): Mitobe, J., Ishihara, T., Ishihama, A., Watanabe, H.
  • Journal Title: J. Biol. Chem. 283 Pages: 5738-5747
  • Peer Reviewed
• [Journal Article] The Escherichia coli RutR transcription factor binds at targets within genes as well as intergenic regions. (2008)
  • Author(s): Shimada, T., Ishihama, A., Busby, S. J. W, Grainger, D. C.
  • Journal Title: Nucleic Acids Res. 36 Pages: 3950-3955
  • Peer Reviewed
• [Journal Article] Single live-bacterial cell assay of promoter activity and regulation. (2008)
  • Author(s): Teramoto, J., Hasegawa, A., Kori, A., Magdy, E-S., Nakajima, M., Lin, Y-C., Yamanshi, Y., Arai, F., Fukuda, T., Ishihama, A.
  • Journal Title: Micro-Nano Mechatronics and Human Science 2008 Pages: 301-306
  • Peer Reviewed
• [Journal Article] The uncharacterized YdhM is the regulator of the nemA gene, coding for N-ethylmaleimide reductase. (2008)
  • Author(s): Umezawa, Y., Ogasawara, H., Shimada, T., Kori, A., Ishihama, A.
  • Journal Title: J. Bacteriol. 190 Pages: 5890-5897
  • Peer Reviewed
• [Journal Article] Anaerobic regulation of citrate fermentation by CitAB in Escherichia coli. (2008)
  • Author(s): Yamamoto, K., Matsumoto, F, Oshima, T., Fujita, N., Ogasawara, N., Ishihama, A.
  • Journal Title: Biosci. Biotechnol. Biochem. 72 Pages: 3011-3014
  • NAID: 10027534304
  • Peer Reviewed
• [Journal Article] Involvement of multiple transcription factors for metal-induced spygene expression in Escherichia coli. (2008)
  • Author(s): Yamamoto, K., Ogasawara, H., Ishihama, A.
  • Journal Title: J. Biotechnol. 133 Pages: 6080-6084
  • Peer Reviewed
• [Journal Article] Comprehensive analysis of the recognition sequences of DNA-binding transcription factors within the Esherichia coli genome using a newly developed‘Promoter Chip" (2008)
  • Author(s): Yamamoto, K., Shimada, T., Ishihama, A.
  • Journal Title: Micro-Nano Mechatronics and Human Science 2008 Pages: 307-310
  • Peer Reviewed
• [Journal Article] On-chip temperature sensing and control for cell immobilization and culture system (2008)
  • Author(s): Yamanishi, Y., Chow, E., Teramoto, J., Magariyama, Y., Ishihama, A., Fukuda, T., Arai, F
  • Journal Title: Micro-Nano Mechatronics and Human Science 2008 Pages: 295-300
  • Peer Reviewed
• [Journal Article] Involvement of RNA binding protein Hfq in the post-tanscriptional regulation of invE gene expressio in Shigella sonnei (2008)
  • Author(s): Mitobe, J., Ishihara, T., Ishihama, A. and Watanbe, H.
  • Journal Title: J. Biol. Chem. 283 Pages: 5738-5747
  • Peer Reviewed
• [Journal Article] The Escherishia coli RutR transcription factor binds at targets within genes as well as intergenic regions (2008)
  • Author(s): Shimada, T., Ishihama, A., Busby, S.J.W. and Grainger, D.C
  • Journal Title: Nucleic Acids Res. (In press)
  • Peer Reviewed
• [Journal Article] Genomic SELEX search for target genes under the control of PhoQP-RstBA signal relay cascade (2007)
  • Author(s): Ogasawara, H., Hasegawa, A., Kanda, E., Miki, T., Yamamoto, K. and Ishihama, A.
  • Journal Title: J. Bacteriol 189 Pages: 4791-4799
  • Peer Reviewed
• [Journal Article] PdhR(pyruvate dehydrogenase complex regulator) controls the respiratory electron transport system in Escherichia coll (2007)
  • Author(s): Ogasawara, H., Ishida, Y., Yamada, K., Yamamoto, K. and Ishihama, A.
  • Journal Title: J. Bacteriol 189 Pages: 5534-5541
  • Peer Reviewed
• [Journal Article] RutR is the uracil/thymine-sensing master regulator of a set of genes for synthesis and degradation of pyrimdines (2007)
  • Author(s): Shimada, T., Hirao, K., Kori, A., Yamamoto, K. and Ishihama, A.
  • Journal Title: Mol. Microbic 66 Pages: 744-779
  • Peer Reviewed
• [Journal Article] The role of omega subunit of RNA polymerase in expression of the relA gene in Escherichia coli (2007)
  • Author(s): Chatterji, D., Ozoline, O., Ogawa, Y. Shimada, T. and Ishiama, A.
  • Journal Title: REMS Microbiol. Lett. 267 Pages: 51-55
  • Peer Reviewed
• [Journal Article] Host tactor Ebp1: Selective inhibitor of influenza virus RNA polymerase (2007)
  • Author(s): Honda, A., Okamoto, T. and Ishihama, A
  • Journal Title: Genes Cells 12 Pages: 133-142
  • Peer Reviewed
• [Journal Article] Multi-scale genetics towards understanding the ragulatory reles of all 300 transcription tactors from a single organism Escherichia coli (2007)
  • Author(s): Ishihama, A.,Ogasawara, H., Teramoto, J., Shimada, T., Hasegawa, A., Umezawa, Y., Yabuki, K., Ishida, Y., Inaba, T., Kori, A., Yamada, K., Kitai, Y., Kobayashi, N., Kato, D. and Yamamoto, K
  • Journal Title: Micro-Nano Mechatronics and Human Science 2007 Pages: 35-37
• [Journal Article] Genomic SELEX search for target genes under the control of PhoQP-RstBA signal realy cascade (2007)
  • Author(s): Ogasawara, H., Hasegawa, A., Kanda, E., Miki, T., Yamamoto, K. and Ishihama, A.
  • Journal Title: J. Beacteriol. 189 Pages: 4791-4799
  • Peer Reviewed
• [Journal Article] PdhR (pyuvate dehydrogenase complex regulator) controls the respiratory electron transport system in Eschrichia coli (2007)
  • Author(s): Ogasawara, H., Ishida, Y., Yamada, K., Yamamoto, K. and Ishihama, A.
  • Journal Title: J. Bacteriol. 189 Pages: 5534-5541
  • Peer Reviewed
• [Journal Article] Prepartion and preliminary X-ray diffraction anaiysis of crytals of bacterial flagellar sigma factor o^<28> in complex with the o^<28>-binding region of its anti-sigma factor FlgM (2007)
  • Author(s): Okuda, K., Ichihara, H., Takahashi, H., Fujita, N., Ishihama, A. and Hakoshima, T.
  • Journal Title: Acta Crystallgr F63 Pages: 196-199
  • Peer Reviewed
• [Journal Article] RutR is the uracil/thymine-sensing master regulator of a set of genes for synthesis and degradation of pyrimdines (2007)
  • Author(s): Shimada, T., Hirao, K., Kori, A., Yamamoto, K. and Ishihama, A.
  • Journal Title: Mol. Microbiol. 66 Pages: 744-749
  • Peer Reviewed
• [Journal Article] Enhancement of the synthesis of RpoN, Cra and H-NS by polyamines at the level of tranlastion Escherichia coΛ cultured with glucose and glutamate (2007)
  • Author(s): Terui, Y., Higashi, K., Taniguchi, S., Shigemasa, A., Nishimura, K., Kashiwagi, K., Yamamoto, K., Ishihama, A. and lgarashi, K.
  • Journal Title: J. Bactereiol. 189 Pages: 2359-2368
  • Peer Reviewed
• [Journal Article] Construction of 'Promoter Chip' for microarrary analysis of regulation tragets of transcription factors (2007)
  • Author(s): Yamamoto, K. and Ishihama, A.
  • Journal Title: Micro-Nano Mechatroics and Human Science 2007 Pages: 35-40
  • Peer Reviewed
• [Journal Article] Involvement of multiple transcriptio factors for metal-induced spygene expressio in Esherichia coll (2007)
  • Author(s): Yamamoto, K., Ogaswara, H. and Ishihama, A.
  • Journal Title: J. Biotechnol. 133 Pages: 6080-6084
  • Peer Reviewed
• [Journal Article] folA a new member of the TyrR regulon in Escherichia coli K-12 (2007)
  • Author(s): Yang, J., Ogawa, Y., Camakaris, H., Shimada, T., Ishihama, A. and Pittard, A.J.,
  • Journal Title: J. Bacteriol. 189 Pages: 6080-8084
  • NAID: 120000993292
  • Peer Reviewed
• [Journal Article] 代謝系を統合的に制御する包括転写因子-ひとつの生物の全ての転写因子の調節機能同定を目指して- (2007)
  • Author(s): 石浜 明
  • Journal Title: 遺伝 21 Pages: 322-332
• [Journal Article] 大腸菌ゲノム発現カスケード-「細胞個性学」事始め- (2007)
  • Author(s): 石浜 明
  • Journal Title: 日本ロボット学会誌 25 Pages: 32-35
  • NAID: 10018869516
• [Journal Article] 大腸菌ゲノムの転写包括制御-ひとつの生物の全ての転写因子の調節機能同定をめざして- (2007)
  • Author(s): 石浜 明
  • Journal Title: 実験医学 25 Pages: 1531-1538
• [Journal Article] The role of omega subunit of RNA Polymerase in expression of the relA gene in Escherichia coil. (2007)
  • Author(s): Chatterji, D, Ozoline, O, Ogawa, Y, Shimada, T, Ishihama,A.
  • Journal Title: FEMS Microbiol.Lett. 267 Pages: 51-55
• [Journal Article] Host factor Ebql : Selective inhibitor ob influenza virus RNA polymerase. (2007)
  • Author(s): Honda, A, Okamoto, T, Ishihama, A.
  • Journal Title: Genes Cells 12 Pages: 132-142
• [Journal Article] Enhancement of the synthesis of RpoN, Cra and H-NS by polyamines at the level of translation Escherichia coil cultures with glucose and glutamate. (2007)
  • Author(s): Terui, Y, Higashi, K, Taniguchi, S, Shigemasa, A, Nishimura, K, Kashiwagi, K, Yamamoto, K, Ishihara, A, Igarashi,K.
  • Journal Title: J.Bacteriol., 189 Pages: 2359-2368
• [Journal Article] Genomic SELEX search for target genes under the control of PhoQP-RstBA signal relay cascade. (2007)
  • Author(s): Ogasawara, H, Hasegawa, A, Kanda, E, Miki, T, Yamamoto, K, Ishihama,A.
  • Journal Title: J.Bacteriol. 189(in press)
• [Journal Article] PdhR (pyruvate dehydrogenase complex regulator) controls the respiratory electron transport system in Escherichia coli. (2007)
  • Author(s): Ogasawara, H, Ishida, Y, Yamada, K, Yamamoto, K, Ishihama,A.
  • Journal Title: J.Bacteriol. 189(in press)
• [Journal Article] Anaerobic regulation of citrate metabolism by CitAB two-components signal transduction in Escherichia coli. (2007)
  • Author(s): Yamamoto, K, Matsumoto, F, Oshima, T, Fujita, N, Ogasawara, N, Ishihama,A.
  • Journal Title: J.Bacteriol. 130(in press)
• [Journal Article] 大腸菌における金属ホメオスタシス (2007)
  • Author(s): 山本兼由, 石浜 明
  • Journal Title: バイオサイエンスとバイオインダストリー 64 Pages: 151-154
  • NAID: 10017315807
• [Journal Article] 代謝系を統合的に制御する包括転写因子-ひとつの生物に全ての転写因子の調節機能同定を目指して- (2007)
  • Author(s): 石浜 明
  • Journal Title: 生物の科学 遺伝 別冊21
• [Journal Article] 大腸菌ゲノムの転写包括制御-ひとつの生物の全ての転写因子の調節機能同定をめざして- (2007)
  • Author(s): 石浜 明
  • Journal Title: 実験医学 増刊号「転写因子をモデルとしたグローバル制御へのアプローチ」 (印刷中)
• [Journal Article] The dynamic state of DNA topology is essential for genome condensation in bacteria (2006)
  • Author(s): Ohniwa, R. L. , Mirikawa, K., Kim, J., Ohta, T., Ishihama, A., Wada, C. and Takeyasu, K.
  • Journal Title: EMBO J. 25 Pages: 5591-5602
  • Peer Reviewed
• [Journal Article] Enhancement of +1 frameshift by polyamines during translation of polypeptide release factor 2 in Escherichia coli. (2006)
  • Author(s): Higashi, K, Kashiwagi, K, Taniguchi, S, Terui, Y, Yamamoto, K, Ishihama, A, Igarashi,K.
  • Journal Title: J.Biol.Chem. 281 Pages: 9527-9537
• [Journal Article] The dynamic state of DNA topology is essential of genome condensation in bacteria. (2006)
  • Author(s): Ohniwa, R.L, Mirikawa, K, Kim, J, Ohta, T, Ishihama, A, Wada, C, Takeyasu,K.
  • Journal Title: EMBO J. 25 Pages: 5591-5602
• [Journal Article] Characterization of copper-inducible promoters regulated by CpxA/CpxR in Escherichia coil. (2006)
  • Author(s): Yamamoto, K, Ishihama, A.
  • Journal Title: Biosci.Biotechnol.Biochem. 70 Pages: 1688-1695
• [Journal Article] Multi-scale genetics towards understanding the hierarchy of transcription factor network in genome regulation. (2006)
  • Author(s): Ishihama, A, Ogasawara, H, Shimada, T, Teramoto, J, Hasegawa, A, Umezawa, Y, Yabuki, K, Ishida, Y, Inaba, T, Matsui, M, Kori, A, Yamada, K, Hirao, K, Yamamoto,K.
  • Journal Title: Micro-Nano Mechatronics Human Sci. 2006(in press)
• [Journal Article] 大腸菌細胞文化の遺伝子発現カスケード : 「細胞個性学」の幕開け (2006)
  • Author(s): 石浜 明
  • Journal Title: 蛋白質核酸酵素 51 Pages: 958-965
• [Presentation] Genomic SELEX search for regulation targets by 100 species of uncharacterized transcription factors from E. coll. (2009)
  • Author(s): Ishihama, A.
  • Organizer: 12^<th> Transcription Assembly
  • Place of Presentation: Chandigarh, India
• [Presentation] 大腸菌ゲノム転写の包括制御 (2009)
  • Author(s): 石浜明
  • Organizer: 2008年度「べん毛研究交流会」
  • Place of Presentation: 仙台、宮城
• [Presentation] Genomic SELEX search for regulation targets by 100 species of uncharacterized transcription factors from E. coli (2009)
  • Author(s): Ishihama, A.
  • Organizer: 12^<th> Transcription Assembly
  • Place of Presentation: Chandigarh, India
• [Presentation] Comprehensive analysis for the recognition sequences of DNA-binding transcription factors within the E. coli genome using the newly developed‘Promoter Chip' (2009)
  • Author(s): Yamamoto, K., Shimada, T., Ishlhama, A.
  • Organizer: 21st RNA Polymerase Workshop
  • Place of Presentation: Bristol, UK
• [Presentation] 嫌気条件で誘導される大腸菌新規核様体タンパク質 (2009)
  • Author(s): 寺本 潤, 吉村成弘, 竹安邦夫, 石浜 明
  • Organizer: 定領域研究「バイオ操作」第7回公開シンポジウム
  • Place of Presentation: エレクトローンホール宮城・仙台
• [Presentation] 大腸菌転写因子YpdB支配下制御遺伝子群の同定と制御機構の解明 (2009)
  • Author(s): 稲葉 達也, 山田佳代子, 郡 彩子, 石浜 明
  • Organizer: 日本ゲノム微生物学会第3回年会
  • Place of Presentation: 中央大学・東京
• [Presentation] Quorum Sensing転写因子QseAの調節機能の解析 (2009)
  • Author(s): 小林尚貴, 寺本 潤, 石浜 明
  • Organizer: 日本ゲノム微生物学会第3回年会
  • Place of Presentation: 中央大学・東京
• [Presentation] Genomic SELEXを用いた大腸菌転写因子LeuOの転写制御機構解析 (2009)
  • Author(s): 島田友裕, 山本兼由, 石浜明
  • Organizer: 日本ゲノム微生物学会第3回年会
  • Place of Presentation: 中央大学・東京
• [Presentation] 大腸菌ゲノム転写の包括制御 (2009)
  • Author(s): 石浜 明
  • Organizer: 定領域研究「バイオ操作」第7回公開シンポジウム
  • Place of Presentation: エレクトローンホール宮城・仙台
• [Presentation] 多因子が関与する大腸菌Curli線毛発現制御機構の解明 (2009)
  • Author(s): 小笠原寛 郡彩子 山田佳代子山本兼由石浜明
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 国際会議場・福岡
• [Presentation] ウラシル/チミンを感知する転写因子RutRによるピリミジン合成/分解経路に関与する遺伝子群の制御機構の解析 (2009)
  • Author(s): 島田友裕, 平尾貴世, 郡彩子, 山本兼由, 石浜 明
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 国際会議場・福岡
• [Presentation] 新規ゲノム研究資材を用いたゲノム機能解析 (2008)
  • Author(s): 山本兼由, 石浜 明
  • Organizer: 日本農芸化学会2008年関東支部大会
  • Place of Presentation: 山梨大学・甲府
  • Year and Date: 2008-10-11
• [Presentation] 大腸菌における全リボソーム蛋白質遺伝子の発現解析 (2008)
  • Author(s): 梅林 章, 片寄純也, 石浜明, 前田理久
  • Organizer: 日本農芸化学会2008年関東支部大会
  • Place of Presentation: 山梨大学・甲府
  • Year and Date: 2008-10-11
• [Presentation] Multi-Scale Genetics towards Understanding the Regulatory Roles of All Transcription Factors from a Single Organism Escherichia coll. Asian Conference on Transcription (ACT) (2008)
  • Author(s): Ishihama, A.
  • Organizer: 10^<th> Meeting
  • Place of Presentation: Bangalore, India
• [Presentation] 20 years of progress with RNA polymerase (2008)
  • Author(s): Ishihama, A.
  • Organizer: 20^<th> RNA Polymerase Workshop
  • Place of Presentation: York, UK
• [Presentation] Multi-factor promoters and multi-factor networks (2008)
  • Author(s): Ishihama, A. et.al.
  • Organizer: 20^<th> RNA Polymerase Workshop
  • Place of Presentation: York, UK
• [Presentation] 細菌の金属ストレスに対する転写応答の包括的な制御機構 (2008)
  • Author(s): 山本兼由、石浜明
  • Organizer: 日本農芸化学会大会
  • Place of Presentation: 名城大学・名古屋
• [Presentation] Multi-factor promoters and multi-factor networks. (2008)
  • Author(s): Ishihama, A., Ogasawara, H., Shimada, T., Teramoto, J., Hasegawa, A., Umezawa, Y., Kori, A., Yamada, K., Yamamoto, K.
  • Organizer: 20^<th> RNA Polymerase Workshop
  • Place of Presentation: York, UK
• [Presentation] Single live-cell assay of promoter activity and regulation. (2008)
  • Author(s): Teramoto, J., Hasegawa, A., Shohata, E., Kori, A., Magdy, E-S. H. Nakajima, M., Lin, Y-C., Yamanishi, Y., Magariyama, Y., Arai, F., Fukuda, T., Ishihama, A.
  • Organizer: Micro-Nano Mechatronics Human Sci. Symp.
  • Place of Presentation: Nagoya, Japan
• [Presentation] Distribution of a DNA-binding Protein using the Novel‘Promoter Chip' (2008)
  • Author(s): Yamamoto, K., Ishihama, A.
  • Organizer: Micro-Nano Mechatronics Human Sci. Symp.
  • Place of Presentation: Nagoya, Japan
• [Presentation] On-chip temperature sensing and control for cell immobilization and culture system (2008)
  • Author(s): Yamanishi, Y., Chow, E., Teramoto, J., Magariyama, Y., Ishihama, A., Fukuda, T., Arai, F.
  • Organizer: Micro-Nano Mechatronics Human Sci. Symp.
  • Place of Presentation: Nagoya, Japan
• [Presentation] Global regulation of genome transcription : Multi-factor promoters and multi-factor networks (2008)
  • Author(s): Ishihama, A.
  • Organizer: 2008 Asian Academic Seminar(AAS)
  • Place of Presentation: Bangalore, India
• [Presentation] 単一細胞観測系による大腸菌遺伝子プロモーター強度測定 (2008)
  • Author(s): 寺本 潤, 長谷川明子, E-S. H. Magdy, 郡 彩子, 中島正博, 林育菁, 小笠原 寛, 曲山幸生, 新井史人, 福田敏男, 石浜 明
  • Organizer: 特定領域研究「バイオ操作」第6回公開シンポジウム
  • Place of Presentation: キャンパスプラザ・京都
• [Presentation] 大腸菌転写因子AscGの制御機能の解明 (2008)
  • Author(s): 石田雄士, 郡 彩子, 石浜 明
  • Organizer: 2008年日本ゲノム微生物学会若手の会
  • Place of Presentation: 大学セミナーハウス・八王子
• [Presentation] 大腸菌csgDプロモーターの制御 : 原核生物の多因子支配プロモーター (2008)
  • Author(s): 小笠原寛, 郡 彩子, 山田佳代子, 山本兼由, 石浜 明
  • Organizer: 2008年日本ゲノム微生物学会若手の会
  • Place of Presentation: 大学セミナーハウス・八王子
• [Presentation] Genomic SELEXとChIP-chip法による大腸菌機能未知転写因子YcdCのゲノム上結合領域の同定 (2008)
  • Author(s): 島田友裕, Grainger, D., Busby, S. J. W., 山本兼由, 石浜 明
  • Organizer: 2008年日本ゲノム微生物学会若手の会
  • Place of Presentation: 大学セミナーハウス・八王子
• [Presentation] ポリマー製マイクロブリッジを用いた細胞固定培養システム (2008)
  • Author(s): 山西陽子, 寺本 潤, 曲山幸生, 石浜 明, 福田敏男, 新井史人
  • Organizer: 第18回化学とマイクロ・ナノシステム研究会
  • Place of Presentation: 京都大学・京都
• [Presentation] 植物由来の配糖体取り込み系を制御する大腸菌転写因子AscGの機能解明 (2008)
  • Author(s): 石田雄士, 郡 彩子, 石浜明
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会
  • Place of Presentation: 国際展示場・神戸
• [Presentation] 大腸菌転写因子YpdBによる制御遺伝子の同定と制御機構の解明 (2008)
  • Author(s): 稲葉達也, 山田佳代子, 郡 彩子, 石浜 明
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会
  • Place of Presentation: 国際展示場・神戸
• [Presentation] 多因子が関与するCurii織毛発現調節の分子機構の解明 (2008)
  • Author(s): 小笠原寛, 山田佳代子, 郡 彩子, 山本兼由, 石浜 明
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会
  • Place of Presentation: 国際展示場・神戸
• [Presentation] Quorum Sensing転写因子QseAの調節機能の解析 (2008)
  • Author(s): 小林尚貴, 寺本 潤, 山田佳代子, 石浜 明
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会
  • Place of Presentation: 国際展示場・神戸
• [Presentation] ChIP-chip法による大腸菌転写因子RutRのゲノム上結合領域の同定 (2008)
  • Author(s): 島田友裕, 石浜 明, Busby, S. J. W., Grainger, D.
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会
  • Place of Presentation: 国際展示場・神戸
• [Presentation] 大腸菌の嫌気条件下発現新規核様体蛋白質の同定と特性解析 (2008)
  • Author(s): 寺本潤, 吉村成弘, 郡 彩子, 竹安邦夫, 石浜 明
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会
  • Place of Presentation: 国際展示場・神戸
• [Presentation] 定常期におけるポリアミンの大腸菌の生存率維持に果たす役割 (2008)
  • Author(s): 照井祐介, 東恭平, 田部井譲, 秋山真律子. 富取秀行, 山本兼由, 石浜明, 五十嵐一衛, 柏木敬子
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会
  • Place of Presentation: 国際展示場・神戸
• [Presentation] Multi-Scale Genetics towards Understanding the Regulatory Roles of All Ttansoription Factors from a Single Organism Escherchia coli (2008)
  • Author(s): A, Ishihama
  • Organizer: 10th Asian Conference on Transcription
  • Place of Presentation: Bangalore,Indla
• [Presentation] Identification of a Novei Nucleoid Proteh(NNP)with Enhancing Actvity of Nucease Sensitivty in Escherichia coli Growm under Anaerobic Conditions (2008)
  • Author(s): J.Teramoto, N.Kobayashi, A.Kori and A.Ishihama
  • Organizer: 10th Asian Conference on Transcription
  • Place of Presentation: Bangalore,India
• [Presentation] RutR is the Uracil/Thymine Sensing Master Regulator of a Set of Genes for Snthesis and Deradation of Primidines (2008)
  • Author(s): Shimada, T.,Hirao, K.,Kori, A.,Yamamoto, K.and Ishihama,A.
  • Organizer: 10th Asian Conference on Transcription
  • Place of Presentation: Bangalore,India
• [Presentation] Transcriptionai Response of Escherichia coli to Extemal Metais (2008)
  • Author(s): K.Yamamoto and A, ishihama
  • Organizer: 10th Asian Conference on Transcription
  • Place of Presentation: Bangalore,India
• [Presentation] 20 years of prgress with RNA polymerase (2008)
  • Author(s): A.Ishihama
  • Organizer: 20th RNA Polymerase Workshop
  • Place of Presentation: York,UK
• [Presentation] Multi-factor promoters and multi-factor networks (2008)
  • Author(s): Ishihama, A., Ogasawara, H., Shimada, T., Teramto, J., Hasegawa, A., Umezawa, Y., Yabuki, K., Ishida, Y., Inaba, T., Kori, A., Yamada, K.and Yamamoto,K
  • Organizer: 20th RNA Polymerase Workshop
  • Place of Presentation: York,UK
• [Presentation] 大腸菌金属感知転写因子群のGenomic SELEX法による機能解折 (2008)
  • Author(s): 小笠原 寛、渡邊 智行、跡部 裕之、片山 泰徳、出田 佳代子、郡 彩子、山本 兼由、石浜 明
  • Organizer: 第二回日本ゲノム微生物学会年会
  • Place of Presentation: 大阪大学、大阪
• [Presentation] ウラシル/チミンを感知する転写因子RutRによるピリミジン合成/分解経路に関与する遺伝子群の制御機構の解析 (2008)
  • Author(s): 島田 友裕、平尾 貴世、郡 彩子、山本 兼由、石浜 明
  • Organizer: 第二回日本ゲノム微生物学会年会
  • Place of Presentation: 大阪大学、大阪
• [Presentation] 細菌の金属ストレスに対する転写応答の包括的な制御機構 (2008)
  • Author(s): 山本 兼由、石浜 明
  • Organizer: 日本農芸化学会大会
  • Place of Presentation: 名城大学、名古屋
• [Presentation] RutR is the uracil/thymine sensing regulator of a set of genes for synthesis and degradation of pyrimidines (2007)
  • Author(s): Shimada, T., Hirao, K., Kori, A., Yamamoto, K., Grainger, D. C. , Busby, S.J.W. and Ishihama, A.
  • Organizer: RNA Polymerase Workshop
  • Place of Presentation: London, UK
• [Presentation] Multi-Scale Genetics of Transcription Network : Understanding the Regulatory Roles of All 300 Transcription Factors from a Single Organism (2007)
  • Author(s): Ishihama, A., et.al.
  • Organizer: Escherichia coll
  • Place of Presentation: Nagoya, Japan
• [Presentation] ゲノムの転写制禦 : ひとつの生物のすべての転写因子の調節機能同定の試み (2007)
  • Author(s): 石浜明
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会マスターズレクチャー
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] 細菌の環境金属応答の転写包括制御 (2007)
  • Author(s): 石浜明・山本兼由・小笠原寛・島田友裕・寺本潤
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会ワークショップ「金属イオンのChemical Bio10gy」
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] Involvement of RNA binding protein Hfq in the post-transcriptional regulation of invE gene expression in Shigella sonnei (2007)
  • Author(s): J.Mitobe, T.Morita-Ishihara, A.Ishihama and H.Watanabe
  • Organizer: US-Japan Conference on Pathogenic Bacteria
  • Place of Presentation: Washington,USA
• [Presentation] Multi-Scale Genetics of Transcription Netwoek:Understanding the Regulatory Roles of All 300 Transcription Factors from a Single Organism Escherichia coll (2007)
  • Author(s): A.Ishihama, H.Ogasaawra, J.Teramoto, T.Shimada, A.Hasegawa, Y.Umezawa, K.Yabuki, Y.Ishida, T.Inaba, A.Kori, K.Yamada, Y.Kitai, N.Kobayashi, D.Kato and K.Yamamoto
  • Organizer: 2007Micro-Nano Mechatroncs and Human Science Symp
  • Place of Presentation: Nagoya,Japan
• [Presentation] Construction of a Novei 'Promoter Chip 'for DNA Microarray (2007)
  • Author(s): K.Yamamoto and A.ishihama
  • Organizer: 2007Micro-Nano Mechatronics and Human Science Symp
  • Place of Presentation: Nagoya,Japan
• [Presentation] ビルヒン酸応答転写制御因子PdhRの転写抱括制御機能 (2007)
  • Author(s): 小笠原 寛, 石田 雄司, 山田 佳代子, 山本 兼由, 石浜 明
  • Organizer: 第4回大腸菌研究会
  • Place of Presentation: 藤枝エミナース、静岡
• [Presentation] ウラシルノチミンを感知する転写因子RUtRによるピリミジン合成/分解経路に関与する遺伝子群の制御機構の解析 (2007)
  • Author(s): 島田 友裕・平尾 貴世・郡 彩子・山本 兼由・石浜 明
  • Organizer: 第4回大腸菌研究会
  • Place of Presentation: 藤枝エミナース、静岡
• [Presentation] 大腸菌革一細胞観測系の構築とプロモーター強度測定 (2007)
  • Author(s): 長谷川 明子、寺本 潤、曲山 幸生、新井 史人、福田 敏男、石浜 明
  • Organizer: 特定領域研究「バイオ操作」女性シンポジウム
  • Place of Presentation: 法政大学、東京
• [Presentation] Genomic SELEX法による大腸菌転写因子標的プロモーターの探索 (2007)
  • Author(s): 小笠原 寛、島田 友祐、寺本 潤、長谷川 明子、梅澤 喜正、矢吹 光史郎、石田 雄士、稲葉 達也、鍛代 悠一、加藤 大策、小林 尚貴、山田 佳代子、郡 彩子、山本 兼由、石浜 明
  • Organizer: 2007年日本ゲノム微生物生物学会若手の会
  • Place of Presentation: 八王子セミナーハウス・東京
• [Presentation] ゲノムの転写制禦:ひとつの生物のすべての転写因子の調節機能同定の試み (2007)
  • Author(s): 石浜 明
  • Organizer: 第30回日本分子生物学会・第89回日本生化学会マスターズレクチャー
  • Place of Presentation: みなとみらい、横浜
• [Presentation] 細菌の環境金属応答の転写包括制御 (2007)
  • Author(s): 石浜 明、山本 兼由、小笠原 寛、島田 友裕、寺本 潤
  • Organizer: 第30回日本生物学会・第80回日本生化学会ワークショップ「金属イオンのChermical Biology」
  • Place of Presentation: みなとみらい、横浜
• [Presentation] 大腸菌転写因子TorRの新規標的遺伝子群の探索と制御機構 (2007)
  • Author(s): 稲葉 達也、寺本 潤、三本 健良、石浜 明
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会
  • Place of Presentation: みなとみらい、横浜
• [Presentation] 大腸菌機能未知転写因子YdhMの転写調節機能の解明 (2007)
  • Author(s): 梅澤 喜正、小笠原 寛、山田 佳代子、三木 健良、石浜 明
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会
  • Place of Presentation: みなとみらい、横浜
• [Presentation] 大腸菌核様体構造蛋白質H-NSのゲノム包括制御における役割 (2007)
  • Author(s): 矢吹 光史郎、島田 友裕、三木 健良、石浜 明
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会
  • Place of Presentation: みなとみらい、横浜
• [Presentation] 大腸菌新規核様体タンパク質の同定 (2007)
  • Author(s): 寺本 潤、吉村 成弘、郡 彩子、竹安 邦夫、石浜 明
  • Organizer: 第30回日本分子生物学会・第80回日本生物学会
  • Place of Presentation: みなとみらい、横浜
• [Presentation] Curli織毛発現調節の分子機構の解明 (2007)
  • Author(s): 小笠原 寛、山田 佳代子、郡 彩子、山本 兼由、石浜 明
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会
  • Place of Presentation: みなとみらい、横浜
• [Presentation] 大腸菌単一細胞観測系の構築とプロモーター強度測定 (2007)
  • Author(s): 長谷川 明子、寺本 潤、郡 彩子、曲山 幸生、Ei-Shimy H.Magciy, 、中島 正博、林 青菁、新井 史人、福田 敏男、石浜 明
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会
  • Place of Presentation: みなとみらい、横浜
• [Presentation] ウラシル/チミンを感知する転写因子RutRによるピリミジン合成/分解経路に関与する遺伝子群の制御機構の解析 (2007)
  • Author(s): 島田 友裕、平尾 貴世、郡 彩子、山本 兼由、石浜 明
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会
  • Place of Presentation: みなとみらい、横浜
• [Presentation] RNAポリメラーゼ : ゲノム転写の包括制御機構 (2006)
  • Author(s): 石浜明
  • Organizer: シンポジウム"The Origins of Trendy RNAs"
  • Place of Presentation: 北里大学、東京
  • Year and Date: 2006-07-15
• [Presentation] マルチスケール遺伝学 : 大腸菌全転写因子の機能同定 (2006)
  • Author(s): 石浜明、小笠原寛、島田友裕、寺本潤、郡彩子、山田佳代子、平尾貴世、長谷川明子、梅澤喜正、矢吹光史郎、石田雄司、稲葉達也、松井勝、鍛代悠一、加藤大策
  • Organizer: シンポジウム「マルチスケール操作によるシステム細胞工学」
  • Place of Presentation: 名古屋大学野依学術交流館、名古屋
  • Year and Date: 2006-06-30
• [Presentation] The bacterial nucleoid (2006)
  • Author(s): Ishihama, A.
  • Organizer: The 1^<st> Symp Nuclear Architecture : Chromosome-Chromatin Dynamics
  • Place of Presentation: Bangalrore, India
• [Presentation] Systemacic search for regulatory roles of putative transcription factors with unidentified functions (2006)
  • Author(s): Ishihama, A.
  • Organizer: The 10^<th> Transcription Assembly
  • Place of Presentation: Kolkata, India
• [Presentation] 大腸菌機能未知転写因子の機能解析 : 制御標的遺伝子の探索 (2006)
  • Author(s): 石浜明、小笠原寛、島田友裕、寺本潤、郡彩子、山田佳代子、平尾貴世、長谷川明子、梅澤喜正、矢吹光史郎、成瀬みなみ、石田雄司、稲葉達也、松井勝、鍛代悠一、田中邦貴
  • Organizer: 第6回日本蛋白質科学会年会
  • Place of Presentation: 京都
• [Book] The nucleoid : an overview. In : Escherichia coil and Salmonella (Neidhardt, F.C., eds.) (2009)
  • Author(s): Ishihama, A.
  • Publisher: American Society of Microbiology Washington, USA
• [Book] Escherichia coli and Salmonella (2009)
  • Author(s): Ishihama, A.
  • Total Pages: 1050
  • Publisher: American Society for Microbiology (ASM), Washington, USA
• [Book] Escherichia coli and Salmonella (2008)
  • Author(s): A.Ishihama and S.Adhya
  • Total Pages: 1561
  • Publisher: American Society of Microbiology
• [Book] Multi-scale genetics towards understanding the regulatory roles of all 300 transcription factors from a single organism Escherichia coli (2007)
  • Author(s): Ishihama, A. et.al
  • Publisher: In : Micro Uano Mechatronics and Human Science (Fukuda, T. eds.)
• [Book] Escherichia coil and Salmonella Cellular and Molecular Biology (2007)
  • Author(s): Ishihama, A.
  • Publisher: American Society for Microbiology Press, Washington,DC (in press)
• [Book] バイオインフォマティクス事典 (2007)
  • Author(s): 石浜 明
  • Publisher: 共立出版 東京
• [Book] タンパク質の事典 (2007)
  • Author(s): 石浜 明
  • Publisher: 朝倉書店
• [Book] タンパク質化学 (2007)
  • Author(s): 石浜 明
  • Publisher: 広川書店、東京
• [Remarks]
  • URL: http://www.k.hosei.ac.jp/ceng/fb/teacher/ishihama.html