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Study of molecular basis for T cell-mediated recognition of antigens in subjects with HLA-A3 super type

Research Project

Project/Area Number 18310147
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionKurume University

Principal Investigator

ITOH Kyogo  Kurume University, Sch. Med, Dep. Immunol., Professor (50125499)

Co-Investigator(Kenkyū-buntansha) YAMADA Akira  Kurume University, Research Center for Innovative Cancer Therapy, Professor (50158177)
YUTANI Shigeru  Kurume University, Sch. Med, Associate Professor (20279160)
NOGUCHI Masanori  Kurume University, Sch. Med, Assistant Professor (10140691)
SAKAMOTO Kikuo  Kurume University, Sch. Med, Assistant Professor (70279222)
SHIICHIJO Shigeki  Kurume University, Sch. Med, Associate Professor (30080592)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥18,310,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2007: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2006: ¥8,300,000 (Direct Cost: ¥8,300,000)
Keywordscancer / virus / allergy / biotechnology / immunology
Research Abstract

1. Cancer associated antigen-derived peptides: We have identified new peptides from SART3 and Lck antigens that are recognized by HLA-A3 super family-restricted cytotoxic T lymphocytes (CTL) (Minami, et. Al., Cancer Immunol. Immunoth.: Naito, et. Al., Brit.J.Can. 2007).
2. Exogenous antigen-derived peptides: We have identified new peptides from hepatitis C virus sequences that are recognized by HLA-A3 super family-restricted CTL (Matsueda, et. Al., Cancer Immunol Immunotherapy, 2007). Furthermore, we found that measurement of lgG antibodies specific to core region of hepatitis C virus at positions 35-44 (C35-44) is a possible new diagnostic tool of hepatitis C virus infection (Takao, et. Al., Med. Mirobiol. Immunol., 2007).
3. Self antigen-derived peptides: We have identified new peptides from self antigens that are recognized by HLA-A3 super family-restricted CTL (Matsueda, et. Al., J. Immunotherpy 2007).
4. Summary: We have obtained new evidence during the past two years with regard to molecular basis of T cell-mediated recognition of antigens in both healthy donors and cancer patients belonging to HLA-A3 super type (HLA-A3,-A 11, -A31, and-A33). The binding motifs of these newly identified peptides to HLA-class IA alleles of HLA-A3 super type were mostly unpredictable from the currently available database of MHC binding peptides predicting the binding of peptides to HLA-class IA alleles of A3 super type. These results indicate that the binding motifs of CTL epitopes to HLA-class IA alleles of HLA-A3 super type are different form those expected in the past. The results created in this grant shall facilitate to better understanding of host responses to cancer cells as well as viral antigens in subjects of HLA-A3 super type, and may contribute to development of new database of MHC binding peptides.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (43 results)

All 2007 2006

All Journal Article (32 results) (of which Peer Reviewed: 13 results) Presentation (5 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 2 results)

  • [Journal Article] Combination therapy of personalized peptide vaccination with low-dose estramustine phosphate for metastatic hormone refractory prostate cancer patients:an analysis of prognostic factors in the treatment2007

    • Author(s)
      Noguchi M, Itoh K, et. al.
    • Journal Title

      Oncol Res 16

      Pages: 341-349

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Phase I clinical study of a personalized peptide vaccination for patients infected with hepatitis C virus(HCV)1b who failed to respond to interferon-based therapy2007

    • Author(s)
      Yutani S, Itoh K, et. al.
    • Journal Title

      Vaccine 25

      Pages: 7429-35

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of SART3-derived peptides having the potential to induce cancer-reactive cytotoxic T lymphocytes from prostate cancer patients with HLA-A3 supertype alleles2007

    • Author(s)
      Minami T, Itoh K, et. al.
    • Journal Title

      Cancer Immunol Immunother 56

      Pages: 689-698

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Serum levels of IgG to the peptide of HCV1b core at positions 35-44 correlated with persistent infection,while levels of IgG to the peptide of NS5A at positions 2132-2140 correlated with better prognosis in HCV-infected patients2007

    • Author(s)
      Takao Y, Itoh K, et. al.
    • Journal Title

      Med Microbiol Immunol 196

      Pages: 157-164

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A new epitope peptide derived from hepatitis C virus 1b possessing the capacity to induce cytotoxic T-lymphocytes in HCV1b-infected patients with HLA-A11,-A31 and -A332007

    • Author(s)
      Matsueda S, Itoh K, et. al.
    • Journal Title

      Cancer Immunol Immunother 56

      Pages: 1359-66

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] New peptide vaccine candidates for epithelial cancer patients with HLA-A3 supertype alleles2007

    • Author(s)
      Matsueda S, Itoh K, et. al.
    • Journal Title

      J Immunother 30

      Pages: 274-281

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of Lck-derived peptides applicable to anti-cancer vaccine for patients with human leukocyte antigen-A3 supertype alleles2007

    • Author(s)
      Naito M, Itoh K, et. al.
    • Journal Title

      British J Cancer 97

      Pages: 1648-1654

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Combination therapy of personalized peptide vaccination with low-dose estramustine phosphate for metastatic hormone refractory prostate cancer patients : an analysis of prognostic factors in the treatment.2007

    • Author(s)
      Noguchi M, Mine T, Yamada A, Obata Y, Yoshida K, Mizoguchi J, Harada M, Suekane S, Itoh K, Matuoka K
    • Journal Title

      Oncol Res 16

      Pages: 341-349

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of SART3-derived peptides having the potential to induce cancer-reactive cytotoxic T lymphocytes from prostate cancer patients with HLA-A3 supertype alleles.2007

    • Author(s)
      Minami T, Matsueda S, Takedatsu H, Tanaka M, Noguchi M, Uemura H, Itoh K, Harada M
    • Journal Title

      Cancer Immunol Immunother. 56

      Pages: 689-698

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Serum levels of IgG to the peptide of HCVlb core at positions 35-44 correlated with persistent infection, while levels of IgG to the peptide of NS5A at positions 2132-2140 correlated with better prognosis in HCV-infected patients.2007

    • Author(s)
      Takao Y, Yamada A, Yutani S, Ono T, Nagao Y, Ando E, Ide T, Itoh K, Sata M
    • Journal Title

      Med Microbiol Immunol. 196

      Pages: 157-164

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A new epitope peptide derived from hepatitis C virus lb possessing the capacity to induce cytotoxic T-lymphocytes in HCVlb-infected patients with HLA-A11, -A31 and -A33.2007

    • Author(s)
      Matsueda S, Yamada A, Takao Y, Tamura M, Komatsu N, Yutani S, Ide T, Sata M, Itoh K
    • Journal Title

      Cancer Immunol Immunother. 56

      Pages: 1359-66

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Phase I clinical study of a personalized peptide vaccination for patients infected with hepatitis C virus(HCV) lb who failed to respond to interferon-based therapy.2007

    • Author(s)
      Yutani S, Yamada A, Yoshida K, Takao Y, Tamura M, Komatsu N, Ide T, Tanaka M, Sata M, Itoh K
    • Journal Title

      Vaccine 25

      Pages: 7429-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] New peptide vaccine candidates for epithelial cancer patients with HLA-A3 supertype alleles.2007

    • Author(s)
      Matsueda S, Takedatsu H, Sasada T, Azuma K, Ishihara Y, Komohara Y, Noguchi M, Shichijo S, Itoh K, Harada M
    • Journal Title

      J Immunother 30

      Pages: 274-281

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of Lek-derived peptides applicable to anti-cancer vaccine for patients with human leukocyte antigen-A3 supertype alleles.2007

    • Author(s)
      Naito M, Komohara Y, Ishihara Y, Noguchi M, Yamashita Y, Shirakusa T, Yamada A, Itoh K, Harada M
    • Journal Title

      British J Cancer 97

      Pages: 1648-1654

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Personalized peptide vaccination for cancer patient.2007

    • Author(s)
      Itoh K, Noguti M, Yamanaka R, Yamada A, Shichijo S
    • Journal Title

      The 27th General Assembly of the Japan Medical Congress.(Osaka) 4/6-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of a peptide derived from HCV inducing cellular responses with various HLA class I -A alleles.2007

    • Author(s)
      Shichijo S, Komohara Y, Matsueda S, Yutani S, Komatsu N, Sata M, Yamada A, Itoh K
    • Journal Title

      The 66th Annual Meeting of the Japanese Cancer Association.(Yokohama) 10/3-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Combination therapy of personalized peptide vaccination with low-doseestramustine phosphate for metastatic hormone refractory prostate cancer patients: an analsis of pronostic factors in the treatment2007

    • Author(s)
      Noguchi M, Itoh K, et. al.
    • Journal Title

      Oncol Res 16

      Pages: 341-349

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I clinical study of a presonalized peptide vaccination for patients infected with hepatitis C virus (HCV) 1b who failed to respond to interferon-based therapy2007

    • Author(s)
      Yutani S, Itoh K, et. al.
    • Journal Title

      Vaccine 25

      Pages: 7429-7435

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of SART3-dehved peptides having the potential to induce cancer-reactive cytotoxic T lymphocytes from prostate cancer patients with HLA-A3 supertype alleles2007

    • Author(s)
      Minami T, Itoh K, et. al.
    • Journal Title

      Cancer Immunol Immunother 56

      Pages: 689-698

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] tionSerum levels of IgG to the peptide of HCV 1b core at positions 35-44 correlated with persistent infecyion, while levels of IgG to the peptide of NS5A at posi 2132-2140 correlated with better prognosis in HCV-inferected patients2007

    • Author(s)
      Takao Y, Itoh K, et. al.
    • Journal Title

      Med Microbiol Immunol 196

      Pages: 157-164

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new epitope peptide derived from hepatitis C virus 1b possessing the capacity to induce cytotoxic T-lymphocytes in HCV1b-infected patioents with HLA-All, -A31 and -A332007

    • Author(s)
      Matsueda S, Itoh K, et. al.
    • Journal Title

      Cancer Immunol Immunother 56

      Pages: 1359-1366

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Lck-derived peptides applicable to anti-cancer vaccine-for patients with human leukogyte antigen-A3 supertype alleles2007

    • Author(s)
      Naito M, Itoh K, et. al.
    • Journal Title

      British J Cancer 97

      Pages: 1648-1654

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of SART3-derived peptides having the potential to induse cancer-reactive Cytotoxic T Lymphocytes from prostate cancer patients with HLA-A3 super type alleles.2007

    • Author(s)
      Minami T, Itoh K, et al.
    • Journal Title

      Cancer Immunol Immunother. (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Serum levels of IgG to the peptide of HCV-1b core at positions 35-44 correlated with persistent infection, while levels of IgG to the peptide of NS5A at position 2132-2140 correlated with better prognosis in HCV-infected patients.2007

    • Author(s)
      Takao Y, Itoh K, et al.
    • Journal Title

      Medical Microbiol.Immunol. (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of new immunogenic peptides in conserved regions of hepatitis C virus (HCV) 1b that can induce both cellular and humoral immunity in HCV1b+HLA-A24+ patients.2007

    • Author(s)
      Takao Y, Itoh K, et al.
    • Journal Title

      Hepatology Research (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nonmutated self-antigen-derived cancer vaccine peptides elicit an IgE-independent but mast cell-dependent immediate-type skin reaction without systemic anaphylaxis.2006

    • Author(s)
      Yamada A, Yano H, Takao Y, Ono T, Matsumoto T, Itoh K
    • Journal Title

      J Immunol 176

      Pages: 857-863

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Antitumor effects of systemic and local immunization with a CTL-directed peptide in combination with a local injection of OK-432.2006

    • Author(s)
      Ono T, Harada M, Yamada A, Tanaka M, Takao Y, Tanaka Y, Mine T, Sakamoto K, Nakashima T, Itoh K
    • Journal Title

      Clin Cancer Res 12

      Pages: 1325-1332

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of hepatitis C virus(HCV) 2a-derived epitope peptides having the capacity to induce cytotoxic T lymphocytes in human leukocyte antigen-A24+ and HCV2a-infected patients.2006

    • Author(s)
      Wang Y, Takao Y, Harada M, Komatsu N, Ono T, Sata M, Itoh, K, Yamada A
    • Journal Title

      Cell Immunol 241

      Pages: 38-46

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] New epitope peptides derived from hepatitis C virus(HCV) 2a which have the capacity to induce cytotoxic T lymphocytes in HLA-A2+ HCV-infected patients.2006

    • Author(s)
      Wang Y, Takao Y, Harada M, Yutani S, Ide T, Sata M, Itoh K, Yamada A
    • Journal Title

      Microbiol Immunol 50

      Pages: 857-865

    • NAID

      10018398215

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Nonmutated self-antigen-derived cancer vaccine peptides elicit an IgE-independent but mast cell-dependent immediate-type skin reaction without systemic anaphylaxis.2006

    • Author(s)
      Yamada A., Itoh K., et al.
    • Journal Title

      J Immunol. 176

      Pages: 857-863

    • Related Report
      2006 Annual Research Report
  • [Journal Article] New epitope peptides derived from hepatitis C virus (HCV) 2a which have the capacity to induce cytotoxic T lymphocytes in HLA-A2+ HCV-infected patients.2006

    • Author(s)
      Wang Y, Itoh K, et al.
    • Journal Title

      Microbiol Immunol. 50

      Pages: 857-865

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of hepatitis C virus (HCV) 2a-derived epitope peptides having the capacity to induce cytotoxic T lymphocytes in human leukocyte anitigen-A24+and HCV2a-infected patients.2006

    • Author(s)
      Wang Y, Itoh K, et al.
    • Journal Title

      Cell Immunol. 241

      Pages: 38-46

    • Related Report
      2006 Annual Research Report
  • [Presentation] テーラーメイド癌ペプチドワクチン開発の現状と展望2007

    • Author(s)
      伊東 恭悟, 他4名
    • Organizer
      第27回日本医学会総会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Identification of a peptide derived from HCV inducing cellular responses with various HLA class I-A alleles2007

    • Author(s)
      Shichijo S, Itoh K, et. al.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Personalized peptide vaccination for cancer patient.2007

    • Author(s)
      Itoh K, Noguti M, Yamanaka R, Yamada A, Shichijo S
    • Organizer
      The 27th General Assembly of the Japan Medical Congress.
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of a peptide derived from HCV inducing cellular responses with various HLA class I -A alleles.2007

    • Author(s)
      Shichijo S, Komohara Y, Matsueda S, Yutani S, Komatsu N, Sata M, Yamada A, Itoh K
    • Organizer
      The 66th Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of apeptide derived ffom HCV inducing cellular responses with various HLA clalss I-A alleles2007

    • Author(s)
      Shichljo S, Itoh K, et. al.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] HLA-A3スーパータイプアレル陽性前立腺癌患者に対する癌ワクチン療法に有用なSART3由来ペプチド2007

    • Inventor(s)
      伊東 恭悟, 原田 守
    • Industrial Property Rights Holder
      学校法人久留米大学
    • Filing Date
      2007-07-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Overseas
  • [Patent(Industrial Property Rights)] HLA-A3スーパータイプの患者に対するがんワクチンのためのLck-由来ペプチドの同定2007

    • Inventor(s)
      伊東 恭悟, 野口 正典, 原田 守
    • Industrial Property Rights Holder
      学校法人久留米大学
    • Industrial Property Number
      2007-212179
    • Filing Date
      2007-08-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] HLA-A3スーパータイプァレル陽性前立腺癌患者に対する癌ワクチン療法に有用なSART3由来ペプチド2007

    • Inventor(s)
      伊東 恭悟、原田 守
    • Industrial Property Rights Holder
      学校法人久留米大学
    • Filing Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] HLA-A3スーパータイプの患者に対するがんワクチンのためのLck-由来ペプチドの同定2007

    • Inventor(s)
      伊東 恭悟、野口 正典、原田 守
    • Industrial Property Rights Holder
      学校法人久留米大学
    • Industrial Property Number
      2007-212179
    • Filing Date
      2007-08-16
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] HLA-A3スーパータイプアレル分子陽性前立腺癌患者に対する癌ワクチン候補となる前立腺関連蛋白由来ペプチド2006

    • Inventor(s)
      伊藤恭悟, 原田 守, 野口正典
    • Industrial Property Rights Holder
      学校法人久留米大学
    • Filing Date
      2006-06-22
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] HLA-A3スーパータイプアレル陽性前立腺癌患者に対する癌ワクチン療法に有用なSART3由来ペプチド2006

    • Inventor(s)
      伊藤恭悟, 原田 守
    • Industrial Property Rights Holder
      学校法人久留米大学
    • Industrial Property Number
      2006-190276
    • Filing Date
      2006-07-11
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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