Dynamic and Multinuclear NMR Studies of Molecular Transport and Distribution in Biomembrane

• Project/Area Number: 18350004
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Physical chemistry
• Research Institution: Kyoto University
• Principal Investigator: NAKAHARA Masaru Kyoto University, 化学研究所, 教授 (20025480)
• Co-Investigator(Kenkyū-buntansha): MATUBAYASI Nobuyuki 京都大学, 化学研究所, 准教授 (20281107) ; OKAMURA Emiko 姫路獨協大学, 薬学部, 教授 (00160705) ; WAKAI Chihiro 京都大学, 化学研究所, 助教M (40293948)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥12,920,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥1,920,000); Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2007: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2006: ¥4,600,000 (Direct Cost: ¥4,600,000)
• Keywords: NMR / 膜 / 拡散定数 / NOESY / コレステロール / DPPC / DMPC / 分子シミュレーション / 緩和時間 / 曲率 / イオン透過

Research Abstract

脂質膜は、生体組織の「内」と「外」を分け、呼吸・栄養補給・代謝に必要な物質の輸送と分配を司る.本研究では、生体膜およびモデル膜における物質透過・分布の非侵襲的なその場測定の方法論を確立した.動的多核NMR 法によって物質の捕獲・透過のダイナミクスを実時間で計測し、コレステロールの膜内および溶液中での溶存状態を明らかにした.

Research Products

• [Journal Article] Water as an In-situ NMR Indicator for Impurity Acids in Ionic Liquids (2009)
  • Author(s): Y. Yasaka, C. Wakai, N. Matubayasid, M. Nakahara
  • Journal Title: Analytical Chemistry 81 Pages: 400-407
  • Peer Reviewed
• [Journal Article] Self-diffusion coefficients for water and organic solvents in extremely low-density supercritical states (2009)
  • Author(s): K Yoshida, N. Matubayasi, M. Nakahara
  • Journal Title: J. Mol. Liq.
  • Peer Reviewed
• [Journal Article] Self-diffusion coefficients for water and organic solvents at high-temperatures along the coexistence curve (2008)
  • Author(s): K. Yoshida, N. Matubayasi and M. Nakahara
  • Journal Title: J. Chem. Phys 129, 214501
• [Journal Article] Free-energy analysis of the molecular binding into lipid membrane with the method of energy representation (2008)
  • Author(s): N. Matubayasi, W. Shinoda, and M. Nakahara
  • Journal Title: J. Chem. Phys 128, 195107 Pages: 13-13
• [Journal Article] Cholesterol Location and Orientation inAqueous Suspension of Large UnilamellarVesicles of Phospholipid Revealed byIntermolecular Nuclear Overhauser Effect (2008)
  • Author(s): Giordani, C. Wakai, K. Yoshida, E. Okamura,N. Matubayasi, and M. Nakahara
  • Journal Title: J. Phys.Chem B 112 Pages: 2622-2628
• [Journal Article] Cholesterol Location and Orientation in Aqueous Suspension of Large Unilamellar Vesicles of Phospholipid Revealed by Intermolecular Nuclear Overhauser Effect (2008)
  • Author(s): C. Giordani, C. Wakai, K. Yoshida, E. Okamura, N. Matubayasi, M. Nakahara
  • Journal Title: J. Phys. Chem. B 112 Pages: 2622-2628
  • Peer Reviewed
• [Journal Article] Investigation of the dominant hydration structures among the ionic species in aqueous solution : Novel quantum mechanics/molecular mechanics simulations combined with the theory of energy representation (2008)
  • Author(s): H. Takahashi, H. Ohno, T. Yamauchi, R. Kishi, S. Furukawa, M. Nakano, N. Matubayasi
  • Journal Title: J. Chem. Phys 128 Pages: 64507-64507
  • Peer Reviewed
• [Journal Article] Partial Pair Correlation Functions of Low-Density Supercritical Water Determined by Neutron Diffraction with the H/D Isotopic Substitution Method (2008)
  • Author(s): T. Otomo, H. Iwase, Y. Kameda, N. Matubayasi, K. Itoh, S. Ikeda, M. Nakahara
  • Journal Title: J. Phys. Chem. B 112 Pages: 4687-4693
  • Peer Reviewed
• [Journal Article] Computation of the reduction free energy of coenzyme in aqueous solution by the QM/MM-ER method (2008)
  • Author(s): H. Takahashi, H. Ohno, R. Kishi, M. Nakano, N. Matubayasi
  • Journal Title: Chem. Phys. Lett. 456 Pages: 176-180
  • Peer Reviewed
• [Journal Article] Free-energy analysis of the molecular binding into lipid membrane with the method of energy representation (2008)
  • Author(s): N. Matubayasi, W. Shinoda, M. Nakahara
  • Journal Title: T. Chem. Phys 128 Pages: 195107-195107
  • Peer Reviewed
• [Journal Article] Hydrothermal C-C Bond Formation and Disproportionation of Acetaldehyde with Formic Acid (2008)
  • Author(s): S. Morooka, N. Matubayasi, M. Nakahara
  • Journal Title: J. Phys. Chem. A 112 Pages: 6950-6959
  • Peer Reviewed
• [Journal Article] Free-Energy Change of Inserting Halothane into Different Depths of a Hydrated DMPC Bilayer (2008)
  • Author(s): P. L. Chau, K. M. Tu, K. K. Liang, S. L. Chan, N. Matubayasi
  • Journal Title: Chem. Phys. Lett. 462 Pages: 112-115
  • Peer Reviewed
• [Journal Article] Computation of the free energy change associated with one-electron reduction of coenzyme immersed in water : A novel approach with in the framework of the quantum mechanical/molecular mechanical method combined with the theory of energy representation (2008)
  • Author(s): H. Takahashi, H. Ohno, R. Kishi, M. Nakano, N. Matubayasi
  • Journal Title: J. Chem. Phys 128 Pages: 205103-205103
  • Peer Reviewed
• [Journal Article] Self-diffusion coefficients for water and organic solvents at high-temperatures along the coexistence curve (2008)
  • Author(s): K. Yoshida, N. Matubayasi, M. Nakahara
  • Journal Title: J. Chem. Phys 128 Pages: 21450-21450
  • Peer Reviewed
• [Journal Article] Solvation shell dynamics studied bymolecular dynamics simulation in relation tothe translational and rotational dynamics ofsupercritical water and benzene (2007)
  • Author(s): K. Yoshida,N. Matubayasi, and M. Nakahara, J
  • Journal Title: Chem.Phys 127, 174509
• [Journal Article] Slowdown of H/D Exchange Reaction Rateand Water Dynamics in Ionic Liquids : Deactivation of Solitary Water Solvated bySmall Anions in1-Butyl-3-Methylimidazolium Chloride (2007)
  • Author(s): Y.Yasaka, C. Wakai, N. Matubayasi, and M.Nakahara, J
  • Journal Title: Phys. Chem. A 111 Pages: 541-543
• [Journal Article] Slowdown of H/D Exchange Reaction Rate and Water Dynamics in Ionic Liquids: Deactivation of Solitary Water Solvated by Small Anions in 1-Buty1-3-Methylimidazolium Chloride. (2007)
  • Author(s): Yasaka, Y., Wakai, C., Matubayasi, N. & Nakahara, M.
  • Journal Title: J. Phys. Chem. A 111 Pages: 541-543
  • Peer Reviewed
• [Journal Article] Kinetic Study on Disproportionations of Cl Aldehydes in Supercritical Water: Methanol from Formaldehyde and Formic Acid (2007)
  • Author(s): Morooka, S., Matubayasi, N. & Nakahara, M.
  • Journal Title: J. Phys. Chem. A 111 Pages: 2697-2705
  • Peer Reviewed
• [Journal Article] Chemical equilibrium of formaldehyde and methanediol in hot water: Free-energy analysis of the solvent effect. (2007)
  • Author(s): Matubayasi, N., Morooka, S., Nakahara, M. & Takahashi, H
  • Journal Title: J. Mol. Liq. 134 Pages: 58-63
  • Peer Reviewed
• [Journal Article] High-sensitivity Raman Spectroscopy of Supercritical Water and Methanol over a Wide Range of Density (2007)
  • Author(s): Yasaka, Y., Kubo, M., Matubayasi, N. & Nakahara, M
  • Journal Title: Bull. Chem. Soc. Japan 80 Pages: 1764-1769
  • NAID: 10019847192
  • Peer Reviewed
• [Journal Article] Rotational dynamics of water and benzene controlled by anion field in ionicliquids: 1-butyl-3-methylimidazolium chloride and hexafluorophosphate. (2007)
  • Author(s): Yasaka, Y., Wakai, C., Matubayasi, N. & Nakahara, M
  • Journal Title: J. Chem. Phys 127
  • Peer Reviewed
• [Journal Article] Solvation shell dynamics studied by molecular dynamics simulation in relation to the translational and rotational dynamics of supercritical water and benzene (2007)
  • Author(s): Yoshida, K., Matubayasi, N. & Nakahara, M
  • Journal Title: J. Chem. Phys 127
  • Peer Reviewed
• [Journal Article] Hydration Free Energy of Hard-Sphere Solute over a Wide Range of Size Studied by Various Types of Solution Theories. (2007)
  • Author(s): Matubayasi, N., Kinoshita, M. & Nakahara, M
  • Journal Title: Condensed Matter Physics 10 Pages: 471-480
  • Peer Reviewed
• [Journal Article] A New High Temperature Multinuclear Magnetic Resonance Probe for Structure, Dynamics, and Reaction in Supercritical Water. (2007)
  • Author(s): Yoshida, K., Matubayasi, N., Nakahara, M., Ikeda, T. & Anai, T.
  • Journal Title: JEOL News 42 Pages: 16-20
  • Peer Reviewed
• [Journal Article] 高温多核拡散NMRプローブ開発と超臨界水中の構造・ダイナミクス・反応研究への応用 (2007)
  • Author(s): 吉田 健、松林 伸幸、中原 勝、池田 武義、穴井 孝弘
  • Journal Title: 日本電子News 39 Pages: 1-7
  • Peer Reviewed
• [Journal Article] 高温多核拡散NMRプローブ開発と超臨界水中の構造・ダイナミクス・反応研究への応用 (2007)
  • Author(s): 中原 勝、松林 伸幸、八坂 能郎
  • Journal Title: 化学 62 Pages: 12-16
  • Peer Reviewed
• [Journal Article] Cholesterol Location and Orientation in Aqueous Suspension of Large Unilamellar Vesicles of Phospholipid Revealed by Intermolecular Nuclear Overhauser Effect (2007)
  • Author(s): Giordani, C., Wakai, C., Yoshida, K., Okamura, E., Matubayasi, N. & Nakahara, M
  • Journal Title: J. Phys. Chem. B 111 Pages: 2622-2628
  • Peer Reviewed
• [Journal Article] Slowdown of H/D Exchange Reaction Rate and Water Dynamics in Ionic Liquids : Deactivation of Solitary Water Solvated by Small Anions in 1-Butyl-3-Methylimidazolium Chloride (2007)
  • Author(s): Y.Yasaka, C.Wakai, N.Matubayasi, M.Nakahara
  • Journal Title: J. Phys. Chem. A 111 Pages: 541-543
• [Journal Article] Kinetic Study on Disproportionations of C1 Aldehydes in Supercritical Water : Methanol from Formaldehyde and Formic Acid (2007)
  • Author(s): S.Morooka, N.Matubayasi, M.Nakahara
  • Journal Title: J. Phys. Chem. A 111(印刷中)
• [Journal Article] Chemical Equilibrium of Formaldehyde and Methanediol in Hot Water : Free-energy Analysis of the Solvent Effect (2007)
  • Author(s): N.Matubayasi, S.Morooka, M.Nakahara, H.Takahashi
  • Journal Title: J. Mol. Liq. 121(印刷中)
• [Journal Article] Kinetic and Equilibrium Study on FormicAcid Decomposition in Relation to theWater-Gas-Shift Reaction (2006)
  • Author(s): Y. Yasaka, K.Yoshida, C. Wakai, N. Matubayasi, and M.Nakahara
  • Journal Title: J. Phys. Chem. A 110 Pages: 11082-11090
• [Journal Article] Free-energy analysis of solubilization in micelle (2006)
  • Author(s): N. Matubayasi, K. K. Liang, and M. Nakahara
  • Journal Title: J. Chem. Phys 124, 154908
• [Journal Article] Dynamic and 2D NMR Studies onHydrogen-Bonding Aggregates of Cholesterolin Low-Polarity Organic Solvents (2006)
  • Author(s): C.Giordani, C. Wakai, E. Okamura, N.Matubayasi, and M. Nakahara, J
  • Journal Title: Phys. Chem B 110 Pages: 15205-15211
• [Journal Article] Pair-correlation entropy of hydrophobic hydration : Decomposition into translational and orientational contributions and analysis of solute-size effects (2006)
  • Author(s): M.Kinoshita, N.Matubayasi, Y.Harano, M.Nakahara
  • Journal Title: J. Chem. Phys. 124
• [Journal Article] Synthesis of Bis(germacyclopropa)benzenes and Structures of Their Annealed Benzene Rings (2006)
  • Author(s): T.Tajima, T.Sasamori, N.Takeda, N.Tokitoh, K.Yoshida, M.Nakahara
  • Journal Title: Organometallics. 25 Pages: 230-235
• [Journal Article] Free-energy analysis of solubilization in micelle (2006)
  • Author(s): N.Matubayasi, K.K.Liang, M.Nakahara
  • Journal Title: J. Chem. Phys. 124
• [Journal Article] Self-diffusion of supercritical water in extremely low-density region (2006)
  • Author(s): K.Yoshida, N.Matubayasi, M.Nakahara
  • Journal Title: J. Chem. Phys. 124
• [Journal Article] Kinetic and Equilibrium Study on Formic Acid Decomposition in Relation to the Water-Gas-Shift Reaction (2006)
  • Author(s): Y.Yasaka, K.Yoshida, C.Wakai, N.Matubayasi, M.Nakahara
  • Journal Title: J. Phys. Chem. A 110 Pages: 11082-11090
• [Journal Article] Dynamic and 2D NMR Studies on Hydrogen-Bonding Aggregates of Cholesterol in Low-Polarity Organic Solvents (2006)
  • Author(s): C.Giordani, C.Wakai, E.Okamura, N.Matubayasi, M.Nakahara
  • Journal Title: J. Phys. Chem. B 110 Pages: 15205-15211
• [Journal Article] Intermolecular proton transfer from formaldehyde intermediate to anisole in noncatalytic pyrolysis : Phenol produced without hydrolysis (2006)
  • Author(s): Y.Tsujino, C.Wakai, N.Matubayasi, M.Nakahara
  • Journal Title: Chem. Lett 35 Pages: 1334-1335
  • NAID: 10020134281
• [Presentation] エネルギー表法による機能性分子系の自由エネルギー解析 (2009)
  • Author(s): 松林伸幸
  • Organizer: 文部科学省「最先端・高性能スーパーコンピュータの開発利用」プロジェクト 次世代ナノ統合シミュレーションソフトウェアの研究開発 次世代ナノ統合シミュレーションソフトウェア説明会
  • Place of Presentation: 岡崎
  • Year and Date: 2009-03-11
• [Presentation] エネルギー表不法による機能性分子系の自由エネルギー解析 (2009)
  • Author(s): 松林伸幸
  • Organizer: 東レ計算科学要素技術連絡会
  • Place of Presentation: 大津
  • Year and Date: 2009-02-12
• [Presentation] 分子シミュレーションと溶液理論の融合による脂質膜系の自由エネルギー解析 (2009)
  • Author(s): 松林伸幸
  • Organizer: 次世代スパコン「ナノ統合拠点」連続研究会「膜、ミセル(ソフト複雑系の分子科学)」
  • Place of Presentation: 法華クラブ京都
  • Year and Date: 2009-02-10
• [Presentation] ミセルおよび脂質膜系への分子結合の自由エネルギー解析 (2009)
  • Author(s): 松林伸幸
  • Organizer: 次世代スパコン「ナノ統合拠点」連続研究会 「DDSナノキャリヤー-ミセル、脂質膜、タンパク質複合体を中心として-」
  • Place of Presentation: 東京女子医科大学
  • Year and Date: 2009-01-29
• [Presentation] エネルギー表示法による溶媒効果の自由エネルギー解析- (2009)
  • Author(s): 松林伸幸
  • Organizer: 第8回化学・材料研究セミナー
  • Place of Presentation: 九州大学国際ホール
  • Year and Date: 2009-01-24
• [Presentation] エネルギー表不法による機能性分子の脂質膜結合の自由エネルギー解析 (2009)
  • Author(s): Acep PURQON, 松林伸幸, 中原勝
  • Organizer: 文部科学省「最先端・高性能スーパーコンピュータの開発利用」プロジェクト 次世代ナノ統合シミュレーションソフトウェアの研究開発第3回公開シンポジウム
  • Place of Presentation: 岡崎
• [Presentation] NMRを用いた単糖の熱分解挙動の解析 (2009)
  • Author(s): 木村浩, 松林伸幸, 中原勝
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋
• [Presentation] 溶液NMRによる脂質膜中のドラッグ分子の運動性を支配する相互作用因子の検討 (2009)
  • Author(s): 新谷恵, 林伸幸, 中原勝
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋
• [Presentation] イオン液体中でのアルデヒド不均化反応 (2009)
  • Author(s): 伊能博臣, 八坂能郎, 若井千尋, 松林伸幸, 中原勝
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋
• [Presentation] 溶液内のナノスケール構造体の自由エネルギー解析 (2009)
  • Author(s): 松林伸幸
  • Organizer: 電気化学会第76回大会
  • Place of Presentation: 京都
• [Presentation] 溶液化学の現状と将来の展望 (2009)
  • Author(s): 中原勝
  • Organizer: 電気化学会第76回大会
  • Place of Presentation: 京都
• [Presentation] High-TemperatureMultinuclear-Magnetic-Resonance Probe forthe Analysis of Structure, Dynamics, andChemical Reactions in Supercritical Water (2008)
  • Author(s): T. Ikeda, T. Anai, K. Yoshida, N. Matubayasi and M. Nakahara
  • Organizer: The 15th International Conference on the Properties of Water and Steam, Berlin
  • Year and Date: 2008-08-07
• [Presentation] エネルギー表示法による溶媒効果の自由エネルギー解析 (2008)
  • Author(s): 松林伸幸
  • Organizer: 第7回九州溶液化学懇談会
  • Place of Presentation: 九州大学
  • Year and Date: 2008-07-23
• [Presentation] エネルギー表示法による溶媒効果の自由エネルギー解析 (2008)
  • Author(s): 松林伸幸
  • Organizer: 富士通計算化学ユーザーフォーラム2008
  • Place of Presentation: 富士通幕張システムフボラトリ
  • Year and Date: 2008-06-11
• [Presentation] Free-Energy Analysis of Functional, Self-Organizing Systems in Solution (2008)
  • Author(s): N. Matubayasi, W. Shinoda, M. Nakahara
  • Organizer: The 1st International Conference of the Grand Challenge to Next-Generation Integrated Nanoscience
  • Place of Presentation: Tokyo Academic Park
• [Presentation] MD Simulation on the Slow Rotational Dynamics in Ionic Liquids (2008)
  • Author(s): Y. Yasaka, C. Wakai, N. Matubayasi, M. Nakahara
  • Organizer: The 1st International Conference of the Grand Challenge to Next-Generation Integrated Nanoscience
  • Place of Presentation: Tokyo Academic Park
• [Presentation] The 1st International Conference of the Grand Challenge to Next-Generation Integrated Nanoscience (2008)
  • Author(s): Y. Andon, N. Yoshii, K. Yoshida, N. Matubayasi, M. Nakahara, S. Okazaki
  • Organizer: The 1st International Conference of the Grand Challenge to Next-Generation Integrated Nanoscience
  • Place of Presentation: Tokyo Academic Park
• [Presentation] Free-Energy Analysis of Nano-Organized Systems in Solution (2008)
  • Author(s): N. Matubayasi
  • Organizer: The 2nd International Symposium on "Molecular Theory for Real Systems"
  • Place of Presentation: 岡崎
• [Presentation] Molecular dynamics study on molecular origin of 1H-NMR spectrum of cholesterol in lipid bilayer (2008)
  • Author(s): Yoshimichi Andoh, Noriyuki Yoshii, Ken Yoshida, Nobuyuki Matsubayashi, Masaru Nakahara, Susumu Okazaki
  • Organizer: EMLG/TMLG Annual Meeting 2008
  • Place of Presentation: リスボン
• [Presentation] Diffusion Dynamics of Supercritical Water Studied by NMR and MD (2008)
  • Author(s): Nobuyuki Matubayasi, Ken Yoshida, M. Nakahara
  • Organizer: The 15th International Conference on the Properties of Water and Steam
  • Place of Presentation: ベルリン
• [Presentation] Kinetics and Equilibrium of the Reversible Formic Acid Decomposition in Hot Water (2008)
  • Author(s): Yoshiro Yasaka, Ken Yoshida, Chihiro Wakai, N. Matubayasi, M. Nakahara
  • Organizer: The 15th International Conference on the Properties of Water and Steam
  • Place of Presentation: ベルリン
• [Presentation] High-Temperature Multinuclear-Magnetic-Resonance Probe for the Analysis of Structure, Dynamics, and Chemical Reactionsin Supercritical Water (2008)
  • Author(s): T. Ikeda, T. Anai, K. Yoshida, N. Matubayasi, M. Nakahara
  • Organizer: The 15th International Conference on the Properties of Water and Steam
  • Place of Presentation: ベルリン
• [Presentation] Molecular dynamics study on molecular origin of 1H-NMR spectrum of cholesterol in lipid bilayer (2008)
  • Author(s): Y. Andoh, N. Yoshii, Ken Yoshida, N. Matsubayashi, M. Nakahara, S. Okazaki
  • Organizer: The 15th International Conference on the Properties of Water and Steam
  • Place of Presentation: ベルリン
• [Presentation] Free-energy change of Inserting Halothane in to Different Depths of a DMPC Membrane (2008)
  • Author(s): P. -L. Chau, K. M. Tu, K. K. Liang, S. L. Chan, Nobuyuki Matubayasi
  • Organizer: CCP5 Annual Meeting Surfaces and Interfaces
  • Place of Presentation: ロンドン
• [Presentation] エネルギー表示法によるタンパク質への基質結合の自由エネルギー解析 (2008)
  • Author(s): 松林伸幸, 中原勝
  • Organizer: 第31回溶液化学シンポジウム
  • Place of Presentation: 近畿大学
• [Presentation] NMRによるイオン液体中の酸性不純物の微量分析 (2008)
  • Author(s): 八坂能郎, 若井千尋, 松林伸幸, 中原勝
  • Organizer: 第31回溶液化学シンポジウム
  • Place of Presentation: 近畿大学
• [Presentation] リン脂質二分子膜中に取り込まれたドラッグのNMR観測 (2008)
  • Author(s): 新谷恵, 松林伸幸, 中原勝
  • Organizer: 第31回溶液化学シンポジウム
  • Place of Presentation: 近畿大学
• [Presentation] 単糖・二糖の燃焼分解挙動のNMR観察 (2008)
  • Author(s): 木村浩, 松林伸幸, 中原勝
  • Organizer: 第31回溶液化学シンポジウム
  • Place of Presentation: 近畿大学
• [Presentation] 回転運動方程式の解法および溶液理論に基づく自由エネルギー計算法の新規開発と応用 (2008)
  • Author(s): 松林伸幸
  • Organizer: 第22回分子シミュレーション討論会
  • Place of Presentation: 岡山大学
• [Presentation] エネルギー表示法によるタンパク質への基質結合の自由エネルギー解析 (2008)
  • Author(s): 松林伸幸, 中原勝
  • Organizer: 第22回分子シミュレーション討論会
  • Place of Presentation: 岡山大学
• [Presentation] エネルギー表示法による溶液中での接触イオン対生成の自由エネルギー(その2) (2008)
  • Author(s): 竹内宗孝, 松林伸幸, 梅林泰宏, 石黒慎一
  • Organizer: 第22回分子シミュレーション討論会
  • Place of Presentation: 岡山大学
• [Presentation] 水和自由エネルギー計算はどこまできたか? -精度と規模、現状とブレークスルー (2008)
  • Author(s): 松林伸幸
  • Organizer: 第46回日本生物物理学会
  • Place of Presentation: 博多
• [Presentation] 溶媒和殻概念から見た超臨界水のダイナミクスのMDによる研究 (2008)
  • Author(s): 中原 勝、吉田 健、松林 伸幸
  • Organizer: 文部科学省「最先端・高性能スーパーコンピュータの開発利用」プロジェクト 次世代ナノ統合シミュレーションソフトウェアの研究開発 第2回公開シンポジウム
  • Place of Presentation: 岡崎
• [Presentation] 重水素化イオン液体中におけるイミダゾリウムカチオンの立体構造及び液体構造の過渡的1HNOE法による解析 (2008)
  • Author(s): 若井 千尋、八坂 能郎、松林 伸幸、中原 勝
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 東京
• [Presentation] イミダゾリウム系およびアルキルアンモニウム系イオン液体中での水およびベンゼンの回転ダイナミクスのNMRによる解析 (2008)
  • Author(s): 木村 浩、八坂 能郎、若井 千尋、松林 伸幸、中原 勝
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 東京
• [Presentation] リン脂質二分子膜における分子間相互作用のNOE観測:ベシクルサイズ効果と温度効果 (2008)
  • Author(s): 新谷 恵、吉田 健、松林 伸幸、中原 勝
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 東京
• [Presentation] Free energy of solvation in the energetic perspective (2007)
  • Author(s): N. Matubayasi
  • Organizer: Multiscale Dynamics of Biomolecules
  • Place of Presentation: Tapei(Taiwan)
• [Presentation] Difffusion and 2DNMR studies on cholesterol aggregates formed in low-polarity organic solvents mimicking the hydrophobic core of lipid bilayer (2007)
  • Author(s): Cristiano Giordani、若井千尋、岡村恵美子、松林伸幸、中原勝
  • Organizer: 日本化学会第87 春季年会
  • Place of Presentation: 吹田
• [Presentation] Anion-field Effect on Rotational Dynamics of Water and Benzene in Ionic Liquids: 1-Butyl-3-methylimidazolium Chloride and Hexafluorophosphate (2007)
  • Author(s): Chihiro Wakai, Yoshiro Yasaka, Nobuyuki Matubayasi, and Masaru Nakahara
  • Organizer: The 2nd International Congress on Ionic Liquids (COIL-2)
  • Place of Presentation: 横浜
• [Presentation] 高温高圧水中におけるギ酸を用いたC-C結合生成反応:アセトアルデヒドから乳酸への化学進化 (2007)
  • Author(s): 諸岡 紗以子、松林 伸幸、中原 勝
  • Organizer: 第48回高圧討論会
  • Place of Presentation: 倉吉パークスクエア
• [Presentation] Free-Energy Analysis of Binding into Nanoscale Structures in Solution with the Method of Energy Representation (2007)
  • Author(s): Nobuyuki Matubayasi, Wataru Shinoda, Masaru Nakahara
  • Organizer: Joint Conference of JMLG/EMLG Meeting 2007 and 30th Symposium on Solution Chemistry of Japan
  • Place of Presentation: Fukuoka University, Fukuoka
• [Presentation] Hydrothermal C-C Bond Formation with Formic Acid from C2 to C3 Compounds: Lactic Acid from Acetaldehyde (2007)
  • Author(s): Saiko Morooka, Nobuyuki Matubayasi, Masaru Nakahara
  • Organizer: Joint Conference of JMLG/EMLG Meeting 2007 and 30th Symposium on Solution Chemistry of Japan
  • Place of Presentation: Fukuoka University, Fukuoka
• [Presentation] Self-diffusion and rotation in supercritical water and benzene and their dependencies on the solvation shell state and lifetime (2007)
  • Author(s): Ken Yoshida, Nobuyuki Matubayasi, and Masaru Nakahara
  • Organizer: Joint Conference of JML G/EMLG Meeting 2007 and 30th Symposium on Solution Chemistry of Japan
  • Place of Presentation: Fukuoka University, Fukuoka
• [Presentation] Rotaional Dynamics of Water in Imidazolium Ionic Liquids Controlled by Anion Field: Cl-and PF_6- (2007)
  • Author(s): Yoshiro Yasaka, Chihiro Wakai, Nobuyuki Matubayasi, Masaru Nakahara
  • Organizer: Joint Conference of JMLG/EMLG Meeting 2007 and 30th Symposium on Solution Chemistry of Japan
  • Place of Presentation: Fukuoka University, Fukuoka
• [Presentation] Comparative Free-Energy Analysis of Aromatic Compounds Solvated in Octanol and Water (2007)
  • Author(s): Jianyi Wang, Nobuyuki Matubayasi, and Masaru Nakahara
  • Organizer: Joint Conference of JMLG/EMLG Meeting 2007 and 30th Symposium on Solution Chemistry of Japan
  • Place of Presentation: Fukuoka University, Fukuoka
• [Presentation] NMR NOE study on vertical fluctuation and orientational relaxation of intermolecular correlation in lipid bilayer (2007)
  • Author(s): Ken Yoshida, Megumi Shintani, Nobuyuki Matubayasi, and Masaru Nakahara
  • Organizer: Joint Conference of JMLG/EMLG Meeting 2007 and 30th Symposium on Solution Chemistry of Japan
  • Place of Presentation: Fukuoka University, Fukuoka
• [Presentation] Dynamics of Solvation of Water and Benzene in Imidazolium-Based and Pyrrolidinium-Based Ionic Liquids: The Effects of Local Electric Field (2007)
  • Author(s): Yoshiro Yasaka, Hiroshi Kimura, Chihiro Wakai, Nobuyuki Matubayasi, Masaru Nakahara
  • Organizer: Joint Conference of JMLG/EMLG Meeting 2007 and 30th Symposium on Solution Chemistry of Japan
  • Place of Presentation: Fukuoka University, Fukuoka
• [Presentation] 生体モデル膜への物質結合の自由エネルギー解析 (2007)
  • Author(s): 松林 伸幸、篠田 渉、中原 勝
  • Organizer: 第21回分子シミュレーション討論会
  • Place of Presentation: 金沢
• [Presentation] 分子動力学計算による脂質二重層膜内コレステロールNMRスペクトルの分子機構の研究 (2007)
  • Author(s): 安藤 嘉倫、吉井範行、吉田健、松林伸幸、中原 勝、岡崎 進
  • Organizer: 第21回分子シミュレーション討論会
  • Place of Presentation: 金沢
• [Presentation] In-situ NMR Spectroscopic Studies on Human JurkatCells (2006)
  • Author(s): M. Nakahara
  • Organizer: 9th Eurasia Conference on Chemical Science
  • Place of Presentation: Antalya(Turkey)
• [Book] 集合体の熱力学・統計熱力学 (2007)
  • Author(s): 中原勝
  • Total Pages: 189
  • Publisher: 岩波書店
• [Book] 集合体の熱力学・統計熱力学 (2007)
  • Author(s): 中原 勝
  • Total Pages: 189
  • Publisher: 岩波書店
• [Book] 高圧力の科学と技術 広い密度・圧力領域における超臨界流体に対する精密密度測定の新しい方法 (2006)
  • Author(s): 吉田 健, 松林 伸幸, 中原 勝
  • Total Pages: 2
  • Publisher: 日本高圧力学会
• [Patent(Industrial Property Rights)] 細胞・微生物のNMR測定方法およびNMR用プローブ並びにNMR制御装置 (2008)
  • Inventor(s): 池田武義、中原勝、松林伸幸、若井千尋
  • Industrial Property Rights Holder: 池田武義、中原勝、松林伸幸、若井千尋
  • Filing Date: 2008-08-31
• [Patent(Industrial Property Rights)] 細胞・微生物のNMR測定方法およびNMR用プローブ並びにNMR制御装置 (2006)
  • Inventor(s): 池田武義, 中原勝, 松林伸幸, 若井千尋
  • Industrial Property Number: 2006-235082
  • Filing Date: 2006-08-31