Dynamic and Multinuclear NMR Studies of Molecular Transport and Distribution in Biomembrane
| Project/Area Number |
18350004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
NAKAHARA Masaru Kyoto University, 化学研究所, 教授 (20025480)
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| Co-Investigator(Kenkyū-buntansha) |
MATUBAYASI Nobuyuki 京都大学, 化学研究所, 准教授 (20281107)
OKAMURA Emiko 姫路獨協大学, 薬学部, 教授 (00160705)
WAKAI Chihiro 京都大学, 化学研究所, 助教M (40293948)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥12,920,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2006: ¥4,600,000 (Direct Cost: ¥4,600,000)
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| Keywords | NMR / 膜 / 拡散定数 / NOESY / コレステロール / DPPC / DMPC / 分子シミュレーション / 緩和時間 / 曲率 / イオン透過 |
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| Research Abstract |
脂質膜は、生体組織の「内」と「外」を分け、呼吸・栄養補給・代謝に必要な物質の輸送と分配を司る.本研究では、生体膜およびモデル膜における物質透過・分布の非侵襲的なその場測定の方法論を確立した.動的多核NMR 法によって物質の捕獲・透過のダイナミクスを実時間で計測し、コレステロールの膜内および溶液中での溶存状態を明らかにした.
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Report
(4 results)
Research Products
(95 results)
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[Journal Article] A New High Temperature Multinuclear Magnetic Resonance Probe for Structure, Dynamics, and Reaction in Supercritical Water.2007
Author(s)
Yoshida, K., Matubayasi, N., Nakahara, M., Ikeda, T. & Anai, T.
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Journal Title
JEOL News 42
Pages: 16-20
Related Report
Peer Reviewed
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[Journal Article] Cholesterol Location and Orientation in Aqueous Suspension of Large Unilamellar Vesicles of Phospholipid Revealed by Intermolecular Nuclear Overhauser Effect2007
Author(s)
Giordani, C., Wakai, C., Yoshida, K., Okamura, E., Matubayasi, N. & Nakahara, M
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Journal Title
J. Phys. Chem. B 111
Pages: 2622-2628
Related Report
Peer Reviewed
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