Multi-component coupling reactions based on the additions of cation pools to carbon-carbon multiple bonds
| Project/Area Number |
18350020
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Okayama University (2008)
Kyoto University (2006-2007) |
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Principal Investigator |
SUGA Seiji Okayama University, 大学院・自然科学研究科, 教授 (50291430)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥16,060,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2006: ¥10,600,000 (Direct Cost: ¥10,600,000)
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| Keywords | 炭素カチオン / 多成分反応 / 有機電子移動反応 / カチオンプール法 / 立体選択的 / 三成分反応 / エナミン / N-アシルイミニウムイオン / 炭素-炭素多重結合 / マイクロ反応システム / アルケン / テトラヒドロフラン環 / 環化反応 / 立体選択的反応 / γ-ラクトン / N-アシルイミニウムイン / endo / exo選択性 |
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| Research Abstract |
Multi-component coupling reactions, especially three-component reactions based on the sequential additions of nucleophiles and electrophiles to carbon-carbon multiple bonds are quite important to provide a variety of organic compounds ; however, there are few examples of the reactions initiated by the additions of carbocations to carbon-carbon multiple bonds. In this project, we focus on the development of this type of cationic multi-component couplings on the basis of the cattion pool method. We have developed a new method to construct a substituted tetrahydrofuran ring in a highly stereoselective manner by using intramolecular cationic carbo-hydroxylation, and a method to provide chiral diamino alcohols which is based on the sequential C-C bond formations initiated by the addition of a cation pool to an enamide.
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Report
(4 results)
Research Products
(59 results)
