| Budget Amount *help |
¥16,060,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2006: ¥10,600,000 (Direct Cost: ¥10,600,000)
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| Research Abstract |
Multi-component coupling reactions, especially three-component reactions based on the sequential additions of nucleophiles and electrophiles to carbon-carbon multiple bonds are quite important to provide a variety of organic compounds ; however, there are few examples of the reactions initiated by the additions of carbocations to carbon-carbon multiple bonds. In this project, we focus on the development of this type of cationic multi-component couplings on the basis of the cattion pool method. We have developed a new method to construct a substituted tetrahydrofuran ring in a highly stereoselective manner by using intramolecular cationic carbo-hydroxylation, and a method to provide chiral diamino alcohols which is based on the sequential C-C bond formations initiated by the addition of a cation pool to an enamide.
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