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Study of the methods for visualizing intracellular signaling molecules

Research Project

Project/Area Number 18350045
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Analytical chemistry
Research InstitutionThe University of Tokyo (2007-2008)
Institute for Molecular Science (2006)

Principal Investigator

OZAWA Takeaki  The University of Tokyo, 大学院・理学系研究科, 教授 (40302806)

Co-Investigator(Kenkyū-buntansha) TAKEUCHI Masaki  東京大学, 大学院・理学系研究科, 助教 (00332271)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥16,880,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2006: ¥7,000,000 (Direct Cost: ¥7,000,000)
Keywords可視化 / バイオテクノロジー / 分析化学 / 生体分子
Research Abstract

In the present study, we studied the development of optical probes for visualizing bio molecules using luciferases, GFP and its spectral variants based on protein reconstitution methods. Moreover, we generated new concepts for molecular imaging such as luciferase cyclization by protein splicing and spatiotemporal analysis of protein-protein interactions based on split luciferase complementation. These results are expected to contribute to resolving biological function in live cells.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (75 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (25 results) (of which Peer Reviewed: 19 results) Presentation (28 results) Book (12 results) Remarks (2 results) Patent(Industrial Property Rights) (8 results) (of which Overseas: 1 results)

  • [Journal Article] Rapid and high-sensitivity cell-based assays of protein-protein interactions using split click beetle luciferase complementation : An approach to the study of G protein-coupled receptors2010

    • Author(s)
      N.Misawa
    • Journal Title

      Analytical Chemistry 82

      Pages: 2552-2560

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-Sensitivity Real-Time Imaging of Dual Protein-Protein Interactions in Living Subjects Using Multicolor Luciferases2009

    • Author(s)
      N. Hida, M. Awais, M. Takeuchi, N. Ueno, M. Tashiro, T. Singh, M. Hayashi, K. Ohmiya, T. Ozawa
    • Journal Title

      PLoS ONE 4

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-Sensitivity Real-Time Imaging of Dual Protein-Protein Interactions in Living Subjects Using Multicolor Luciferases2009

    • Author(s)
      N.Hida
    • Journal Title

      PLoS ONE 4

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging Biological Molecules Using Novel Optical Probes2009

    • Author(s)
      T.Ozawa
    • Journal Title

      Photomedicine and Photobiology 31

      Pages: 27-28

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bioluminescenct Imaging of MAPK function with intein-mediated reporter gene assay2009

    • Author(s)
      A.Kanno
    • Journal Title

      Methods in Molecular Biology 574

      Pages: 185-192

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Apoptosis Using Cyclic Luciferase in Living Mammals2009

    • Author(s)
      A.Kanno
    • Journal Title

      Methods in Molecular Biology 574

      Pages: 105-114

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein Reconstitution Methods for Visualizing Biomolecular Function in Living Cells2009

    • Author(s)
      T.Ozawa
    • Journal Title

      YAKUGAKU ZASSHI 129

      Pages: 289-295

    • NAID

      110007123175

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic Luciferase for Real-Time Sensing of Caspase-3 Activities in Living Mammals2007

    • Author(s)
      A. Kanno, Y. Yamanaka, H. Hirano, Y. Umezawa, T. Ozawa
    • Journal Title

      Angew.Chem.Int.Ed. 46

      Pages: 7595-7599

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nongenomic Activity of Ligands in the Association of Androgen Receptor with Src. S.B. Kim2007

    • Author(s)
      A. Kanno, T. Ozawa, H. Tao, Y. Umezawa
    • Journal Title

      ACS Chem.Biol. 2

      Pages: 484-492

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging Dynamics of Endogenous Mitochondrial RNA in Single Living Cells2007

    • Author(s)
      T. Ozawa, Y. Natori, M. Sato, Y. Umezawa
    • Journal Title

      Nature Methods 4

      Pages: 413-419

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Minimal Peptide Sequence That Targets Fluorescent and Functional Proteins into the Mitochondrial Intermembrane Space2007

    • Author(s)
      T. Ozawa, Y. Natori, Y. Sako, H. Kuroiwa, T. Kuroiwa, Y. Umezawa
    • Journal Title

      ACS.Chem.Biol. 2

      Pages: 176-186

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Proinflammatory Cytokine Sensor Cell for Assaying Inflammatory Activities of Nanoparticles2007

    • Author(s)
      S. B. Kim, T. Ozawa, H. Tao, Y. Umezawa
    • Journal Title

      Anal.Biochem. 362

      Pages: 148-150

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methods for Imaging and Analyses of Intracellular Organelles Using Fluorescent and Luminescent Proteins2007

    • Author(s)
      M. Takeuchi, T. Ozawa
    • Journal Title

      Anal.Sci. 23

      Pages: 25-29

    • NAID

      10018463984

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nongenomic Activity of Ligands in the Association of Androgen Receptor with Src2007

    • Author(s)
      S. B. Kim, A. Kanno, T. Ozawa, H. Tao, Y. Umezawa
    • Journal Title

      ACS Chem. Biol 2

      Pages: 484-492

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic Luciferase for Real-Time Sensing of Caspase-3 Activities in Living Mammals2007

    • Author(s)
      A. Kanno, Y. Yamanaka, H. Hirano, Y. Umezawa, T. Ozawa
    • Journal Title

      Angew. Chem. Int. Ed. 46

      Pages: 7595-7599

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Minimal Peptide Sequence That Targets Fluorescent and Functional Proteins into the Mitochondrial Intermembrane Space2007

    • Author(s)
      T.Ozawa, Y.Natori, Y.Sako, H.Kuroiwa, T.Kuroiwa, Y.Umezawa
    • Journal Title

      ACS Chemical Biology 2

      Pages: 176-186

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A Proinflammatory Cytokine Sensor Cell for Assaying Inflammatory Activities of Nanoparticles.2007

    • Author(s)
      S.B.Kim, T.Ozawa, H.Tao, Y.Umezawa
    • Journal Title

      Analytical Biochemistry 362

      Pages: 148-150

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Methods for Imaging and Analyses of Intracellular Organelles Using Fluorescent and Luminescent Proteins2007

    • Author(s)
      M.Takeuchi, T.Ozawa
    • Journal Title

      Analytical Science 23

      Pages: 25-29

    • NAID

      10018463984

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genetically Encoded Optical Probe for Detecting Release of Proteins from Mitochondria toward Cytosol in Living Cells and Animals2006

    • Author(s)
      A. Kanno, T. Ozawa, Y. Umezawa
    • Journal Title

      Anal.Chem. 78

      Pages: 8076-8081

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A. Method for Determining the Activities of Cytokines based on the Nuclear Transport of Nuclear Factor-Kappa B2006

    • Author(s)
      S. B. Kim, Y. Natori, T. Ozawa, H. Tao, Y. Umezawa
    • Journal Title

      Anal.Biochem. 359

      Pages: 147-149

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intein-Mediated Reporter Gene Assay for Detecting Protein-Protein Interactions in Living Mammalian Cells2006

    • Author(s)
      A. Kanno, T. Ozawa, Y. Umezawa
    • Journal Title

      Anal.Chem. 78

      Pages: 556-560

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Designing Split Reporter Proteins for Analytical Tools2006

    • Author(s)
      T. Ozawa
    • Journal Title

      Anal.Chim.Acta 556

      Pages: 58-68

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Genetically Encoded Optical Probe for Detecting Release of Proteins from Mitochondria toward Cytosol in Living Cells and Animals2006

    • Author(s)
      A.Kanno, T.Ozawa, Y.Umezawa
    • Journal Title

      Analytical Chemistry, 78

      Pages: 8076-8081

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A. Method for Determining the Activities of Cytokines based on the Nuclear Transport of Nuclear Factor-Kappa B2006

    • Author(s)
      S.B.Kim, Y.Natori, T.Ozawa, H.Tao, Y.Umezawa
    • Journal Title

      Analytical Biochemistry 359

      Pages: 147-149

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Frontiers in Bioimaging2006

    • Author(s)
      M.Takeuchi, T.Ozawa
    • Journal Title

      ACS Chemical Biology 1

      Pages: 333-334

    • Related Report
      2006 Annual Research Report
  • [Presentation] Engineered Fluorescent and Bioluminescent Proteins to Visualize Biological Function in Living Cells2010

    • Author(s)
      小澤岳昌
    • Organizer
      BIT Life Sciences' 3rd Annual PepCon-2010
    • Place of Presentation
      北京(中国)
    • Year and Date
      2010-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 蛍光・発光タンパク質を利用した生理機能と分子動態イメージング2010

    • Author(s)
      小澤岳昌
    • Organizer
      慶応シンポジウム
    • Place of Presentation
      横浜(神奈川)
    • Year and Date
      2010-03-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 光タンパク質を利用した生理機能と分子動態イメージング2010

    • Author(s)
      小澤岳昌
    • Organizer
      第5回ケミカルバイオロジー・第2回センシング バイオロジーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-02-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生理機能を可視化する分子イメージング2010

    • Author(s)
      小澤岳昌
    • Organizer
      第3回フロンティアサイエンス機構サイエンスセミナ
    • Place of Presentation
      金沢(石川)
    • Year and Date
      2010-01-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 不透明な生体内における分子イメージング2009

    • Author(s)
      小澤岳昌
    • Organizer
      富山発グリーンケミストリー導入型創薬イノベーションを基盤とする教育研究支援事業
    • Place of Presentation
      富山(富山)
    • Year and Date
      2009-12-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fluorescent and Bioluminescent Proteins to Visualize Biological Functions in Living Cells2009

    • Author(s)
      小澤岳昌
    • Organizer
      3^<rd> World Congress of Gene-2009
    • Place of Presentation
      Foshan(中国)
    • Year and Date
      2009-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規光プローブが拓く生体分子イメージング2009

    • Author(s)
      小澤岳昌
    • Organizer
      愛媛大学大学院医学系研究科セミナー
    • Place of Presentation
      松山(愛媛)
    • Year and Date
      2009-11-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生理機能の解析を日指したタンパク質再構成法の基礎と応用研究―再構成法の原理と使い方―2009

    • Author(s)
      小澤岳昌
    • Organizer
      第14回細胞生物学ワークショップ
    • Place of Presentation
      札幌(北海道)
    • Year and Date
      2009-11-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 発光タンパク質を利用した生体情報分子の可視化法2009

    • Author(s)
      小澤岳昌
    • Organizer
      酵素工学研究会第62回講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生細胞内の生理機能を可視化するレポータータンパク質再構成法2009

    • Author(s)
      小澤岳昌
    • Organizer
      第82回生化学会大会
    • Place of Presentation
      神戸(兵庫)
    • Year and Date
      2009-10-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fluorescent and Bioluminescent Proteins Engineered for Visualizing Biological Functions in Living Cells2009

    • Author(s)
      小澤岳昌
    • Organizer
      2^<nd> Switaerland-Japan Biomolecular Chemistry Symposium
    • Place of Presentation
      東京
    • Year and Date
      2009-09-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 分子プローブが拓く生細胞内シグナルの可視化法2009

    • Author(s)
      小澤岳昌
    • Organizer
      2009年電気化学秋季大会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規光プローブが拓く生体分子イメージング2009

    • Author(s)
      小澤岳昌
    • Organizer
      第31回日本光医学・光生物学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fluorescent and Bioluminescent Probes for Visualizing Biological Functions in Living Cells2009

    • Author(s)
      小澤岳昌
    • Organizer
      NF-kB Training Session & Symposium
    • Place of Presentation
      Liverpool(UK)
    • Year and Date
      2009-07-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fluorescent and Bioluminescent Proteins Engineered by Protein Splicing to Visualize Biological Function2009

    • Author(s)
      小澤岳昌
    • Organizer
      VIII European Symposium of the Protein Society
    • Place of Presentation
      Zurich(Swiss)
    • Year and Date
      2009-06-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Optical Imaging Using Split-Reporter Reconstitution Analysis ; From Single Cells to Living Animals2009

    • Author(s)
      小澤岳昌
    • Organizer
      1^<st> World Congress of International Academy of Nanomedicine
    • Place of Presentation
      Sanya(China)
    • Year and Date
      2009-06-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 最先端のバイオ分析:分析化学の現状と未来について2009

    • Author(s)
      小澤岳昌
    • Organizer
      第70回分析化学討論会高野山プレシンポジウム
    • Place of Presentation
      比叡山(和歌山)
    • Year and Date
      2009-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] タンパク質再構成法を用いた生理機能の可視化2009

    • Author(s)
      小澤岳昌
    • Organizer
      第4回分子イメージング学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Optical Imaging of Biomolecules in Living Cells and Animals Using Split-Reporter Reconstitution Analyses2009

    • Author(s)
      T. Ozawa
    • Organizer
      3rd International Workshop on Approaches to Single Cell Analysis
    • Place of Presentation
      Zurich
    • Related Report
      2008 Final Research Report
  • [Presentation] Fluorescence and bioluminescence biomolecular imaging : From single cells to living subjects2008

    • Author(s)
      T. Ozawa
    • Organizer
      11th International Symposium of Spectroscopical Society of Japan
    • Place of Presentation
      Sendai
    • Related Report
      2008 Final Research Report
  • [Presentation] Optical Imaging of Biomolecules in Living Cells and Animals Using Split-Reporter Reconstitution Analysis2008

    • Author(s)
      T. Ozawa
    • Organizer
      1st Workshop in the Advanced Light Microscopy (DKFZ)
    • Place of Presentation
      Heidelberg
    • Related Report
      2008 Final Research Report
  • [Presentation] Visualization of Biomolecules Using Split Reporter Reconstitution ; From a Single Cell to Living Animals2008

    • Author(s)
      T. Ozawa
    • Organizer
      International Symposium of Institute for Innovative Cancer Research
    • Place of Presentation
      Seoul
    • Related Report
      2008 Final Research Report
  • [Presentation] Visualization of Biomolecules in Living Cells Using Split-reporter Reconstitution Analysis2008

    • Author(s)
      T. Ozawa
    • Organizer
      NIPS-JST International Workshop [Advanced Nonlinear Imaging & Fluorescence-based Biosensors]
    • Place of Presentation
      Aichi
    • Related Report
      2008 Final Research Report
  • [Presentation] Protein Engineering for Biomolecular Imaging2007

    • Author(s)
      T. Ozawa
    • Organizer
      Tateshina Conference
    • Place of Presentation
      Nagano
    • Related Report
      2008 Final Research Report
  • [Presentation] Visualization of organelle-localized proteins in living cells using split-reporter reconstitution analysis2007

    • Author(s)
      T. Ozawa
    • Organizer
      VII European Symposium of the Protein Society, Stockholm
    • Place of Presentation
      Sweden
    • Related Report
      2008 Final Research Report
  • [Presentation] Imaging Biomolecules in Living Cells and Animals Using Split-Reporter Reconstitution Analysis2007

    • Author(s)
      T. Ozawa
    • Organizer
      1st International Symposium on Nanomedicine
    • Place of Presentation
      Aichi
    • Related Report
      2008 Final Research Report
  • [Presentation] Genetic approaches to identifying mitochondrial proteins and their localization2007

    • Author(s)
      T. Ozawa
    • Organizer
      Asian Society for Mitochondrial Research and Medicine, Seoul
    • Place of Presentation
      Korea
    • Related Report
      2008 Final Research Report
  • [Presentation] Design of split reporter proteins for biomolecular imaging2006

    • Author(s)
      T. Ozawa
    • Organizer
      Korean Society of Medical Biochemistry and Molecular Biology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2008 Final Research Report
  • [Book] 「蛍光・発光タンパク質を用いた再構成法による分子イメージング」実験医学2010

    • Author(s)
      小澤岳昌
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2008 Annual Research Report
  • [Book] 「生体分子と生理機能を可視化するタンパク質再構成法」シングルセル解析の最前線2010

    • Author(s)
      小澤岳昌
    • Total Pages
      9
    • Publisher
      シーエムシー出版
    • Related Report
      2008 Annual Research Report
  • [Book] 光る遺伝子2009

    • Author(s)
      小澤岳昌(監訳), 大森充香(訳)
    • Total Pages
      272
    • Publisher
      丸善
    • Related Report
      2008 Annual Research Report
  • [Book] 「蛍光タンパク質の設計と応用」超分子・サイエンス&テクノロジー2009

    • Author(s)
      小澤岳昌
    • Total Pages
      10
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2008 Annual Research Report
  • [Book] 「発光タンパク質で細胞内をみる」未来材料2009

    • Author(s)
      小澤岳昌
    • Total Pages
      8
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2008 Annual Research Report
  • [Book] 「RNAとタンパク質局在のイメージング(新しい地平をひらく分析手法の最前線)」化学フロンティア2009

    • Author(s)
      小澤岳昌
    • Total Pages
      8
    • Publisher
      化学同人
    • Related Report
      2008 Annual Research Report
  • [Book] 「新領域開拓の先導的立場を担う化学」化学2009

    • Author(s)
      小澤岳昌
    • Total Pages
      2
    • Publisher
      化学同人
    • Related Report
      2008 Annual Research Report
  • [Book] クラゲから生まれたGFP革命2008

    • Author(s)
      小澤岳昌, 宮脇敦史
    • Publisher
      現代化学
    • Related Report
      2008 Final Research Report
  • [Book] 可視化プローブによる時空間情報を損なわないミトコンドリアRNAの動態観察2008

    • Author(s)
      小澤岳昌
    • Publisher
      ナノイメージング
    • Related Report
      2008 Final Research Report
  • [Book] 生理機能を可視化する新たな分子プローブ, ナノメディシン, 宇理須恒雄編2008

    • Author(s)
      小澤岳昌
    • Publisher
      オーム社
    • Related Report
      2008 Final Research Report
  • [Book] 「細胞の構造と機能 : 細胞内」ナノテクのためのバイオ入門, 荻野俊郎, 宇理須恒雄編2007

    • Author(s)
      小澤岳昌
    • Publisher
      共立出版
    • Related Report
      2008 Final Research Report
  • [Book] バイオ・ケミルミネセンスハンドブック, 今井一洋, 近江谷克裕編2006

    • Author(s)
      小澤岳昌
    • Publisher
      丸善株式会社
    • Related Report
      2008 Final Research Report
  • [Remarks] 日経産業新聞2009年11月19日12面細胞常時観察タンパク質「発光の強さ2倍に」

    • URL

      http://www.chem.s.u-tokyo.ac.jp/users/analyt/index.html

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.chem.s.u-tokyo.ac.jp/users/analyt/index.html

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 活性化プロテアーゼインジケーター2010

    • Inventor(s)
      梅澤喜夫, 小澤岳昌, 管野憲
    • Industrial Property Rights Holder
      東京大学
    • Acquisition Date
      2010-04-16
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] タンパク質間相互作用の高感度検出法2010

    • Inventor(s)
      小澤岳昌, 三澤直美, 三浦研二, 岡本将, 西井重明
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2010-037921
    • Filing Date
      2010-02-23
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] cyclicGMP検出方法2009

    • Inventor(s)
      小澤岳昌, 竹内雅宜, 三浦研二
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2009-06-23
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] cyclicGMP検出方法2008

    • Inventor(s)
      小澤岳昌, 竹内雅宜, 三浦研二
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2008-164927
    • Filing Date
      2008-06-24
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] タンパク質問相互作用の検出法2008

    • Inventor(s)
      小澤岳昌, ムハンマド アワイス, 三浦研二
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2008-000107
    • Filing Date
      2008-01-07
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] タンパク質間相互作用の検出法2008

    • Inventor(s)
      小澤岳昌, ムハンマドアワイス, 三浦研二
    • Industrial Property Number
      2008-000789
    • Filing Date
      2008-01-07
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 活性化プロテアーゼインジケーター2007

    • Inventor(s)
      梅澤喜夫, 小澤岳昌, 管野憲
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2007-124924
    • Filing Date
      2007-05-09
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] プロテアーゼ活性化インジケーター2007

    • Inventor(s)
      梅澤喜夫, 小澤岳昌, 管野憲
    • Industrial Property Number
      2007-124924
    • Filing Date
      2007-05-09
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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