Studies on Supramolecular Photochirogenesis Mediated by Biopolymers

• Project/Area Number: 18350064
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Polymer chemistry
• Research Institution: Tohoku University (2007-2008); Osaka University (2006)
• Principal Investigator: WADA Takehiko Tohoku University, 多元物質科学研究所, 教授 (20220957)
• Co-Investigator(Kenkyū-buntansha): MORI Tadashi 大阪大学, 大学院・工学研究科, 准教授 (70311769)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,230,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥2,730,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2007: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000); Fiscal Year 2006: ¥6,400,000 (Direct Cost: ¥6,400,000)
• Keywords: 生体高分子 / ヒト血清アルブミン / 光反応 / 超分子不斉光化学反応 / 不斉反応場 / 不斉合成 / アントラセン / ナノ組織体

Research Abstract

本研究、自然共生型プロセスである光による不斉合成に、血清アルブミンを不斉反応場として活用する生体系高分子を用いる超分子不斉光反応という新たな方法論を提案し、この方法論の有用性を実証した。本研究で構築した生体高分子を反応場とする基底状態相互作用解析法、そして基底状態ならびに励起状態双方における相互作用制御に基づく高効率超分子不斉光化学反応の実現は、一般性を有し、今後適用反応例の拡大、基質特異性の向上により不斉光化学反応の有効な方法論としての展開が期待される。

Research Products

• [Journal Article] Entrainer Effect on Photochirogenesis in Near-and Supercritical Carbon Dioxide : Dramatic Enhancement of Enantioselectivity (2008)
  • Author(s): Nishiyama, Yasuhiro ; Wada, Takehiko ; Asaoka, Sadayuki ; Mori, Tadashi ; McCarty, Taylor A.; Kraut, Nadine D.; Bright, Frank V.; Inoue, Yoshihisa
  • Journal Title: J.Am.Chem.Soc. 130 Pages: 7526-7527
  • Peer Reviewed
• [Journal Article] Enantiodifferentiating Photoisomerization of Cyclooctene Included and Sensitized by Aroyl-□-cyclodextrins : A Critical Enantioselectivity Control by Substituents (2008)
  • Author(s): Lu, Runhua ; Yang, Cheng ; Cao, Yujuan ; Tong, Linhui ; Jiao, Wei ; Wada, Takehiko ; Wang, Zhizhong ; Mori, Tadashi ; Inoue, Yoshihisa
  • Journal Title: J.Org.Chem. 73 Pages: 7695-7701
  • Peer Reviewed
• [Journal Article] Structural and Photophysical Properties of Self-Assembled Porphyrin Nanoassemblies Organized by Ethylene Glycol Derivatives (2008)
  • Author(s): Sandanayaka, Atula S. D.; Araki, Yasuyuki ; Wada, Takehiko ; Hasobe, Taku
  • Journal Title: J.Phys.Chem.C 112 Pages: 19209-19216
  • Peer Reviewed
• [Journal Article] Supramolecular enantiodifferentiating photoisomerization of(Z)-cyclooctene in lyotropic and thermotropic liquid crystals (2008)
  • Author(s): Xiao, Debao ; Wada, Takehiko ; Inoue, Yoshihisa
  • Journal Title: Chirality 21 Pages: 110-113
  • Peer Reviewed
• [Journal Article] Supramolecular complexation and photochirogenesis with inherently chiral molecular clip : enantiodifferentiating photoisomerization of(Z,Z)-1,3-cyclooctadiene and polar photoaddition to 1,1-diphenylpropene (2008)
  • Author(s): Fukuhara, Gaku ; Klaerner, Frank-Gerrit ; Mori, Tadashi ; Wada, Takehiko ; Inoue, Yoshihisa
  • Journal Title: Photochem. Photobio. Sci. 7 Pages: 1493-1500
  • Peer Reviewed
• [Journal Article] Fullerene-encapsulated porphyrin hexagonal nanorods. An anisotropic donor-acceptor composite for efficient photoinduced electron transfer and light energy conversion (2008)
  • Author(s): Hasobe, Taku ; Sandanayaka, Atula S. D.; Wada, Takehiko ; Araki, Yasuyuki
  • Journal Title: Chem.Comm. Pages: 3372-3374
  • NAID: 120001856658
  • Peer Reviewed
• [Journal Article] Fluorescence resonance energy transfer between cationic porphyrins accelerated with DNA as a template (2008)
  • Author(s): D'Souza, Francis ; Rogers, Lisa M.; Islam, D.-M. Shafiqul; Araki, Yasuyuki ; Ito, Osamu ; Wada, Takehiko
  • Journal Title: Chem. Lett. 37 Pages: 460-461
  • NAID: 10021079828
  • Peer Reviewed
• [Journal Article] Ethylene receptor antagonists : strained alkenes are necessary but not sufficient (2008)
  • Author(s): Pirrung, Michael C.; Bleecker, Anthony B.; Inoue, Yoshihisa ; Rodriguez, Fernando I.; Sugawara, Norimitsu ; Wada, Takehiko ; Zou, Yunfan ; Binder, Brad M
  • Journal Title: Chem. Biology 15 Pages: 313-321
  • Peer Reviewed
• [Journal Article] Chiroptical properties and racemization behavior of highly distorted donor-acceptor tetracyanoanthraquinodimethane with interconvertible planar chirality (2008)
  • Author(s): Saito, Hideaki ; Mori, Tadashi ; Origane Yumi ; Wada Takehiko ; Inoue, Yoshihisa
  • Journal Title: Chirality 20 Pages: 278-281
  • Peer Reviewed
• [Journal Article] Supramolecular enantiodifferentiating photoisomerization of cyclooctene with modified β-cyclodextrins : critical control by a host structure (2008)
  • Author(s): Lu, Runhua ; Yang, Cheng ; Cao, Yujuan ; Wang, Zhizhong ; Wada, Takehiko ; Jiao, Wei ; Mori, Tadashi ; Inoue, Yoshihisa
  • Journal Title: Chem. Comm. Pages: 374-376
  • Peer Reviewed
• [Journal Article] Entrainer Effect on Photochirogenesis in Near-and Supercritical Carbon Dioxide : Dramatic Enhancement of Enantioselectivity (2008)
  • Author(s): Y. Nishivama
  • Journal Title: J. Am. Chem. Soc. 130 Pages: 7526-7527
  • Peer Reviewed
• [Journal Article] Enantiodifferentiating Photoisomerization of Cyclooctene Included and Sensitized by Aroy1-13-cyclodextrins : A Critical Enantioselectivity Control by Substituents (2008)
  • Author(s): R. Lu
  • Journal Title: J. Org. Chem. 73 Pages: 7695-7701
  • Peer Reviewed
• [Journal Article] Structural and Photophysical Properties of Self-Assembled Porphyrin Nanoassemblies Organized by Ethylene Glycol Derivatives (2008)
  • Author(s): A. Sandanayaka
  • Journal Title: J. Phys. Chem. C 112 Pages: 19209-19216
  • Peer Reviewed
• [Journal Article] Supramolecular enantiodifferentiating photoisomerization of (Z)-cyclooctene in lyotropic and thermotropic liquid crystals (2008)
  • Author(s): D. Xiao
  • Journal Title: Chirality 21 Pages: 110-113
  • Peer Reviewed
• [Journal Article] Supramolecular complexation and photochirogenesis with inherently chiral molecular clip : enantiodifferentiating photoisomerization of (Z, Z)-1, 3-cyclooctadiene and polar photoaddition to 1, 1-diphenylpropene (2008)
  • Author(s): G. Fukuhara
  • Journal Title: Photochem. Photobio. Sci. 7 Pages: 1493-1500
  • Peer Reviewed
• [Journal Article] Fullerene-encapsulated porphyrin hexagonal nanorods. An anisotropic donor-acceptor composite for efficient photoinduced electron transfer and light energy conversion (2008)
  • Author(s): T. Hasobe
  • Journal Title: Chem. Comm. Pages: 3372-3374
  • Peer Reviewed
• [Journal Article] Fluorescence resonance energy transfer between cationic porphyrins accelerated with DNA as a template (2008)
  • Author(s): F. D'Souza
  • Journal Title: Chem. Lett. 37 Pages: 460-461
  • Peer Reviewed
• [Journal Article] Ethylene receptor antagonists : strained alkenes are necessary but not sufficient (2008)
  • Author(s): M. Pirrung
  • Journal Title: Chem. Biology 15 Pages: 313-321
  • Peer Reviewed
• [Journal Article] Chiroptical properties and racemization behavior of highly distorted donor-acceptor tetracyanoanthraquinodimethane with interconvertible planar chirality (2008)
  • Author(s): H. Saito
  • Journal Title: Chirality 20 Pages: 278-281
  • Peer Reviewed
• [Journal Article] Supramolecular enantiodiffbrentiating photoisomerization of cyclooctenewith modified β-cyclodextrins : critical control by a host structure (2008)
  • Author(s): R. Lu
  • Journal Title: Chem. Comm. Pages: 374-376
  • Peer Reviewed
• [Journal Article] Highly Enantiomeric Supramolecular[4+4]Photocyclodimerization of 2-Anthracenecarboxylate Mediated by Human Serum Albumin (2007)
  • Author(s): Nishijima, Masaki ; Wada, Takehiko ; Mori, Tadashi ; Pace, Tamara C. S.; Bohne, Cornelia ; Inoue, Yoshihisa
  • Journal Title: J Am. Chem. Soc. 129 Pages: 3478-3479
  • Peer Reviewed
• [Journal Article] Supramolecular Photochirogenesis with Biomolecules. Mechanistic Studies on the Enantiodifferentiation for the Photocyclodimerization of 2-Anthracenecarboxylate Mediated by Bovine Serum Albumin (2007)
  • Author(s): Nishijima, Masaki ; Pace, Tamara C. S.; Nakamura, Asao ; Mori, Tadashi ; Wada, Takehiko ; Bohne, Cornelia ; Inoue, Yoshihisa
  • Journal Title: J. Org. Chem,(Cover picture, The April Calendar of JOC in 2008) 72 Pages: 2707-2715
  • Peer Reviewed
• [Journal Article] Mechanistic Study on the Enantiodifferentiating Anti-Markovnikov Photoaddition of Alcohols to 1,1-Diphenyl-1-alkenes in Near-Critical and Supercritical Carbon Dioxide (2007)
  • Author(s): Nishiyama, Yasuhiro ; Kaneda, Masayuki ; Asaoka, Sadayuki ; Saito, Ryota ; Mori, Tadashi ; Wada, Takehiko ; Inoue, Yoshihisa
  • Journal Title: J.Phys.Chem.A 111 Pages: 13432-13440
  • Peer Reviewed
• [Journal Article] Dynamic Switching between Single-and Double-Axial Rotaxanes Manipulated by Charge and Bulkiness of Axle Termini (2007)
  • Author(s): Yang, Cheng ; Ko, Young Ho ; Selvapalam, Narayanan ; Origane, Yumi ; Mori, Tadashi ; Wada, Takehiko ; Kim, Kimoon ; Inoue, Yoshihisa
  • Journal Title: Org.Lett. 9 Pages: 4789-4792
  • Peer Reviewed
• [Journal Article] Inherently chiral molecular clips : synthesis, chiroptical properties, and application to chiral discrimination (2007)
  • Author(s): Fukuhara, Gaku ; Madenci, Suereyya ; Polkowska, Jolanta ; Bastkowski, Frank ; Klaerner, Frank-Gerrit ; Origane, Yumi ; Kaneda, Masayuki ; Mori, Tadashi ; Wada, Takehiko ; Inoue, Yoshihisa
  • Journal Title: Chem.-A Eur. J,(Cover picture) 13 Pages: 2473-2479
  • Peer Reviewed
• [Journal Article] Supramolecular enantiodifferentiating photoisomerization of(Z,Z)-1,3-cyclooctadiene included and sensitized by naphthalene-modified cyclodextrins (2007)
  • Author(s): Yang, Cheng ; Mori, Tadashi ; Wada, Takehiko ; Inoue, Yoshihisa
  • Journal Title: New J.Chem. 31 Pages: 697-702
  • Peer Reviewed
• [Journal Article] Regioselective[2+2]-photocycloaddition reactions of chiral tetronates-influence of temperature, pressure, and reaction medium (2007)
  • Author(s): Fleck, Martin ; Yang, Cheng ; Wada, Takehiko ; Inoue, Yoshihisa ; Bach, Thorsten
  • Journal Title: Chem.Comm. Pages: 822-824
  • Peer Reviewed
• [Journal Article] A remarkable stereoselectivity switching upon solid-state versus solution-phase enantiodifferentiating photocyclodimerization of 2-anthracenecarboxylic acid mediated by native and 3,6-anhydro-g-cyclodextrins (2007)
  • Author(s): Yang, Cheng ; Nishijima, Masaki ; Nakamura, Asao ; Mori, Tadashi ; Wada, Takehiko ; Inoue, Yoshihisa
  • Journal Title: Tetrahedron Lett. 48 Pages: 4357-4360
  • Peer Reviewed
• [Journal Article] Enhanced ternary 1:2 host-guest complexation of amino-g-cyclodextrins with 2-anthracenecarboxylic acid (2007)
  • Author(s): Yang, Cheng ; Fukuhara, Gaku ; Nakamura, Asao ; Origane, Yumi ; Mori, Tadashi ; Wada, Takehiko ; Inoue, Yoshihisa
  • Journal Title: J. Incl. Phenom. Macrocycl. Chem. 57 Pages: 433-437
  • Peer Reviewed
• [Journal Article] Critical control by temperature and pressure of enantiodifferentiating anti-markovnikov photoaddition of methanol to diphenylpropene in near critical and supercritical carbon dioxide (2007)
  • Author(s): Nishiyama, Yasuhiro, Wada, Takehiko, Mori, Tadashi, Inoue, Yoshihisa
  • Journal Title: Chem.Lett. 36 Pages: 1488-1489
  • NAID: 10020012265
  • Peer Reviewed
• [Journal Article] Asymmetric photosensitized addition of methanol to(R)-(+)-(Z)-limonene in a microreactor (2007)
  • Author(s): Matsushita, Yoshihisa, Ichimura, Teijiro, Suzuki, Tadashi, Wada, Takehiko, Inoue, Yoshihisa
  • Journal Title: J.Photochem.Photobio., A : Chem. 192 Pages: 166-171
  • Peer Reviewed
• [Journal Article] Highly Enantiomeric Supramolecular[4+4]Photocyclodimerization of 2-Anthracenecarboxylate Mediated by Human Serum Albumin (2007)
  • Author(s): M. Nishijima
  • Journal Title: J. Am. Chem. Soc. 129 Pages: 3478-3479
  • Peer Reviewed
• [Journal Article] Supramolecular Photochirogenesis with Biomolecules. Mechanistic Studies on the Enantiodifferentiation for the Photocyclodimerization of 2-Anthracenecarboxylate Mediated by Bovine Serum Albumin (2007)
  • Author(s): M. Nishijima
  • Journal Title: J. Org. Chem. 72 Pages: 2707-2715
  • Peer Reviewed
• [Journal Article] Entropy-Controlled Supramolecular Photochirogenesis: Enantiodifferentiating Z-E Photoisomerization of Cyclooctene Included and Sensitized by Permethylated 6-O-Modified β-Cyclodextrins (2007)
  • Author(s): Y. Nishiyama
  • Journal Title: J. Phys. Chem. A 111 Pages: 13432-13440
  • Peer Reviewed
• [Journal Article] Dynamic Switching between Single- and Double-Axial Rotaxanes Manipulated by Charge and Bulkiness of Axle Termini (2007)
  • Author(s): C. Yang
  • Journal Title: Org. Lett. 9 Pages: 4789-4792
  • Peer Reviewed
• [Journal Article] Inherently chiral molecular clips: synthesis, chiroptical properties, and application to chiral discrimination (2007)
  • Author(s): G. Fukuhara
  • Journal Title: Chem.-A Eur. J. 13 Pages: 2473-2479
  • Peer Reviewed
• [Journal Article] Supramolecular enantiodifferentiating photoisomerization of(Z, Z)-1,3-cyclooctadiene included and sensitized by naphthalene-modified cyclodextrins (2007)
  • Author(s): C. Yang
  • Journal Title: New J. Chem. 31 Pages: 697-702
  • Peer Reviewed
• [Journal Article] Enhanced Ternary 1:2 Host-Guest Complexation of Amino-γ-cyclodextrins with 2-Anthracene- carboxylic Acid, (2007)
  • Author(s): C. Yang
  • Journal Title: J. Inclusion Phenom. Macrocyclic Chem. Pages: 433-437
  • Peer Reviewed
• [Journal Article] Inherently chiral molecular clips: synthesis, chiroptical properties, and application to chiral discrimination (2007)
  • Author(s): G. Fukuhara
  • Journal Title: Chem. 13 Pages: 2473-2479
  • Peer Reviewed
• [Journal Article] Critical control by temperature and pressure of enantiodifferentiating anti-markovnikov photoaddition of methanol to diphenylpropene in near critical and supercritical carbon dioxide (2007)
  • Author(s): Y. Nishiyama
  • Journal Title: Chem. Lett. 36 Pages: 1488-1489
  • Peer Reviewed
• [Journal Article] Asymmetric photosensitized addition of methanol to(R)-(+)-(Z)-limonene in a microreactor (2007)
  • Author(s): K. Sakeda
  • Journal Title: J. Photochem. Photobio., A: Chem. 192 Pages: 166-171
  • Peer Reviewed
• [Journal Article] Regioselective[2+2]-photocycloaddition reactions of chiral tetronates-influence of temperature, pressure, and reaction medium (2007)
  • Author(s): M. Fleck
  • Journal Title: Chem. Comm. Pages: 822-824
  • Peer Reviewed
• [Journal Article] Supramolecular enantiodifferentiating photoisomerization of(Z, Z)-1,3-cycloocatadiene included and sensitized by naphthalene-modified cyclodextrins. (2007)
  • Author(s): C. Yang.
  • Journal Title: Tetrahedron Lett. 48 Pages: 4357-4360
  • Peer Reviewed
• [Journal Article] Highly Enantiomeric Supramolecular [4+4] Photocyclodimerization of 2-Anthracenecarboxylate Mediated by Human Serum Albumin (2007)
  • Author(s): M.Nishijima, T.Wada, T.Mori, T.C.S.Pace, C.Bohne, Y.Inoue
  • Journal Title: J. Am. Chem. Soc. 129(印刷中)
• [Journal Article] Supramolecular Photochirogenesis with Biomolecules. Mechanistic Studies on the Enantiodifferentiation for the Photocyclodimerization of 2-Anthracenecarboxylate Mediated by Bovine Serum Albumin (2007)
  • Author(s): M.Nishijima, T.Wada, T.C.S.Pace, A.Nakamura, T.Mori, C.Bohne, Y.Inoue
  • Journal Title: J. Org. Chem. 72(印刷中)
• [Journal Article] Inherently Chiral Molecular Clips : Synthesis, Chiroptical Properties, and Application to Chiral Discrimination (2007)
  • Author(s): G.Fukuhara, F.Klarner, Y.Origane, T.Wada, Y.Inoue
  • Journal Title: Chem.-Eur. J. (印刷中)
• [Journal Article] Enhanced Ternary 1 : 2 Host-Guest Complexation of Amino-γ-cyclodextrins with 2-Anthracene- carboxylic Acid (2007)
  • Author(s): C.Yang, G.Fukuhara, A.Nakamura, T.Mori, T.Wada, Y.Inoue
  • Journal Title: J. Inclusion Phenom. Macrocyclic Chem. (印刷中)
• [Journal Article] Pharmacological Activity and Structural Analysis of a Benzamide (TKS159) and Its Optical Isomers in an In Vitro Study and in an In Vivo Study in Mice (2007)
  • Author(s): J.Mizoguchi, T.Yanagi, K.Anzai, K.Kodama, O.Kamoda, C.Kamei, T.Wada, Y.Inoue
  • Journal Title: Methods Find. Exper. Clin. Pharm. (Methods and Findings in Experimental and Clinical Pharmacology) (印刷中)
• [Journal Article] Entropy-Controlled Supramolecular Photochirogenesis : Enantiodifferentiating Z-E Photoisomerization of Cyclooctene Included and Sensitized by Permethylated 6-O-Modified β-Cyclodextrins (2006)
  • Author(s): G. Fukuhara, T. Mori, T. Wada, and Y. Inoue
  • Journal Title: J.Org.Chem. 71 Pages: 8233-8233
  • Peer Reviewed
• [Journal Article] Enantio-Differentiating Photo-Cyclodimerization of 2-Anthracene-Carboxylic Acid Mediated by γ-Cyclodextrins with a Flexible or Rigid Cap (2006)
  • Author(s): C. Yang, A. Nakamura, T. Wada, and Y. Inoue
  • Journal Title: Org.Lett. 8 Pages: 3005-3005
  • Peer Reviewed
• [Journal Article] Enantiodifferentiating Photocyclodimerization of 2-Anthracenecarboxylic Acid Using a Chiral N-(2-Hydroxymethyl-4-pyrrolidinyl)benzamide Template (2006)
  • Author(s): J. Mizoguchi, Y. Kawanami, T. Wada, K. Kodama, K. Anzai, T. Yanagi, and Y. Inoue
  • Journal Title: Org.Lett. 8 Pages: 6051-6051
  • Peer Reviewed
• [Journal Article] Solvent switching of stereoselectivity in[4+4]photocyclodimerization of 2-anthracenecarboxylic acid (2006)
  • Author(s): J. Mizoguchi, T. Wada, and Y. Inoue
  • Journal Title: Chem.Lett. 35 Pages: 738-738
  • NAID: 10017604335
  • Peer Reviewed
• [Journal Article] The first supramolecular photosensitization of enantiodifferentiating bimolecular reaction: anti-Markovnikov photoaddition of methanol to 1,1-diphenylpropene sensitized by modified β-cyclodextrin (2006)
  • Author(s): G. Fukuhara, T. Mori, T. Wada, and Y. Inoue
  • Journal Title: Chem. Comm. Pages: 1712-1712
  • Peer Reviewed
• [Journal Article] Switching of Product's Chirality in Diastereodifferentiating [2+2] Photocycloaddition of (E)- versus (Z)-Stilbene to Chiral Fumarate upon Direct and Charge-Transfer-Band Excitation (2006)
  • Author(s): H. Saito, T. Mori, T. Wada, and Y. Inoue
  • Journal Title: Org. Lett. 8 Pages: 1909-1909
  • Peer Reviewed
• [Journal Article] Pressure and Temperature-Controlled Enantio-Differentiating [4+4]-Photo-Cyclodimerization of 2-Anthracene-carboxylate Mediated by Secondary Face- and Skeleton-Modified γ-Cyclodextrins (2006)
  • Author(s): C. Yang, A. Nakamura, G. Fukuhara, Y. Origane, T. Mori, T. Wada, and Y. Inoue
  • Journal Title: J. Org. Chem. 71 Pages: 3126-3126
  • Peer Reviewed
• [Journal Article] Absolute configuration determination of donor-acceptor [2.2]paracyclophanes by comparison of theoretical and experimental vibrational circular dichroism spectra (2006)
  • Author(s): T. Furo, T. Mori, Y. Origane, T. Wada, H. Izumi, and Y. Inoue
  • Journal Title: Chirality 18 Pages: 205-205
  • Peer Reviewed
• [Journal Article] New Insights into the Geometry of Resorc[4]arenes: Solvent-Mediated Supramolecular Conformational and Chiroptical Control (2006)
  • Author(s): C. Schiel, G. A. Hembury, V. V. Borovkov, M. Klaes, C. Agena, T. Wada, S. Grimme, Y. Inoue, and J. Mattay
  • Journal Title: J.Org.Chem. 71 Pages: 976-976
  • Peer Reviewed
• [Journal Article] Entropy-Controlled Supramolecular Photochirogenesis : Enantiodifferentiating Z-E Photoisomerization of Cyclooctene Included and Sensitized by Permethylated 6-O-Modified β-Cyclodextrins (2006)
  • Author(s): G.Fukuhara, T.Mori, T.Wada, Y.Inoue
  • Journal Title: J. Org. Chem. 71 Pages: 8233-8243
• [Journal Article] Enantio-Differentiating Photo-Cyclodimerization of 2-Anthracene-Carboxylic Acid Mediated by γ-Cyclodextrins with a Flexible or Rigid Cap (2006)
  • Author(s): C.Yang, A.Nakamura, T.Wada, Y.Inoue
  • Journal Title: Org. Lett. 8 Pages: 3005-3008
• [Journal Article] Enantiodifferentiating Photocyclodimerization of 2-Anthracenecarboxylic Acid Using a Chiral N-(2-Hydroxymethyl-4-pyrrolidinyl)benzamide Template (2006)
  • Author(s): J.Mizoguchi, Y.Kawanami, T.Wada, K.Kodama, K Anzai, T.Yanagi, Y.Inoue
  • Journal Title: Org. Lett. 8 Pages: 6051-6054
• [Journal Article] Solvent switching of stereoselectivity in [4+4] photocyclodimerization of 2-anthracenecarboxylic acid (2006)
  • Author(s): J.Mizoguchi, T.Wada, Y.Inoue
  • Journal Title: Chem. Lett. 35 Pages: 738-739
  • NAID: 10017604335
• [Journal Article] The first supramolecular photosensitization of enantiodifferentiating bimolecular reaction : anti-Markovnikov photoaddition of methanol to 1,1-diphenylpropene sensitized by modified β-cyclodextrin (2006)
  • Author(s): G.Fukuhara, T.Mori, T.Wada, Y.Inoue
  • Journal Title: Chem. Comm. Pages: 1712-1713
• [Journal Article] Switching of Product's Chirality in Diastereodifferentiating [2+2] Photocycloaddition of (E)- versus (Z)-Stilbene to Chiral Fumarate upon Direct and Charge-Transfer-Band Excitation (2006)
  • Author(s): H.Saito, T.Mori, T.Wada, Y.Inoue
  • Journal Title: Org. Lett. 8 Pages: 1909-1912
• [Journal Article] Absolute configuration determination of donor-acceptor [2.2]paracyclophanes by comparison of theoretical and experimental vibrational circular dichroism spectra (2006)
  • Author(s): T.Furo, T.Mori, Y.Origane, T.Wada, H.Izumi, Y.Inoue
  • Journal Title: Chirality 18 Pages: 205-208
• [Presentation] 細胞内環境応答型人工核酸の創製-がん細胞特異的遺伝治療薬開発を目指して- (2008)
  • Author(s): 和田健彦
  • Organizer: 有機化学コロキウムー有機化学のフロンティアー
  • Place of Presentation: 八戸
  • Year and Date: 2008-10-11
• [Presentation] 刺激応答性人工核酸の創製-がん細胞特異的遺伝子治療薬開発を目指して- (2008)
  • Author(s): 和田健彦
  • Organizer: 第7回化学系薬学若手研究者セミナー
  • Place of Presentation: 仙台
  • Year and Date: 2008-10-04
• [Presentation] SUPRAMOLECULAR PHOTOCHIROGENESIS WITH BIOPOLYMERS (2008)
  • Author(s): 和田健彦
  • Organizer: XXII^<nd> IUPAC SYMPOSIUM ON PHOTOCHE MISTRY
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 2008-08-28
• [Presentation] Synthesis of Peptide Ribonucleic Acid (PRNA)-DNA Chimera and Interaction with DNA and RNA (2008)
  • Author(s): Takehiko Wada
  • Organizer: 8^th International Biorelated Polymers Symposium
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2008-08-19
• [Presentation] 外部刺激応答性人工核酸の創製-がん細胞特異的遺伝子治療薬の開発を目指して- (2008)
  • Author(s): 和田健彦
  • Organizer: 第20回生体機能関連化学若手の会サマースクール
  • Place of Presentation: 白石
  • Year and Date: 2008-08-07
• [Presentation] SUPRAMOLECULAR PHOTOCHIROGENESIS WITH BIOPOLYMERS, XXII^<nd> IUPAC SYMPOSIUM ON PHOTOCHEMISTRY (2008)
  • Author(s): Takehiko Wada, and Yoshihisa Inoue
  • Organizer: Gothenburg
  • Place of Presentation: Sweden
  • Year and Date: 2008-07-30
• [Presentation] RNA Recognition and Complexation Behavior Control of α-Peptide Ribonucleic Acids Containing Arginine Residue by External Factors-Toward a Cancer Cell Specific Gene Therapic Compound- (2008)
  • Author(s): Takehiko Wada
  • Organizer: 35^th Controlled Release Society Annual Meeting
  • Place of Presentation: New York, USA
  • Year and Date: 2008-07-15
• [Presentation] アルギニン含有α-ペプチドリボ核酸とRNAとの錯体形成挙動に対するセリン導入効果 (2008)
  • Author(s): 和田健彦
  • Organizer: 第57回高分子年次大会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-29
• [Presentation] Supramolecular photochirogenesis with bio-and biorelated molecules (2008)
  • Author(s): Takehiko Wada and Yoshihisa Inoue
  • Organizer: Prof. Nicolas J. Turro's 70 Anniversary Symposium
  • Place of Presentation: New York, USA
  • Year and Date: 2008-05-23
• [Presentation] Supramolecular photochirogenesis with bio- and biorelated molecules (2008)
  • Author(s): 和田健彦
  • Organizer: Prof. Nicolas J. Turro's 70 Anniversary Symposium
  • Place of Presentation: New York, USA
  • Year and Date: 2008-05-23
• [Presentation] 生体高分子をキラル反応場とする超分子不斉光化学 (2008)
  • Author(s): 和田健彦
  • Organizer: シンポジウム モレキュラー・キラリティー
  • Place of Presentation: 岡山
  • Year and Date: 2008-05-22
• [Presentation] 生体高分子をキラル反応場とする超分子不斉光化学 (2008)
  • Author(s): 和田健彦
  • Organizer: シンポジウムモレキュラー・キラリティー2008
  • Place of Presentation: 岡山大学
  • Year and Date: 2008-05-21
• [Presentation] Supramolecular Asymmetric Photochirogenesis: Enantiodifferentiating Photocyclodimerization of Anthracene Derivatives in the Presence of Bovine and Human Serum Albumins (2007)
  • Author(s): Takehiko Wada, Masaki Nishijima, Tamara C. S. Pace, Tadashi Mori, Cornelia Bohne, Yoshihisa Inoue
  • Organizer: 2007 Korea-Japan Symposium on Frontier Photoscience
  • Place of Presentation: Gyeongju, Korea
  • Year and Date: 2007-11-25
• [Presentation] RNA Recognition and Recognition Control of a-Peptide Ribonucleic Acids Containing Arginine Residue by External Factors (2007)
  • Author(s): Takehiko Wada, Akihiro Nishio, Nobuya Sawa, Mayuko Kikkawa, Hirofumi Sato, Shiro Futaki, Yoshihisa Inoue
  • Organizer: 4^th International Peptide Symposium
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2007-11-22
• [Presentation] A novel strategy for reversible control of conformation and DNA/RNA recognition of peptide ribonucleic acid (PRNA) by external factors (2007)
  • Author(s): Takehiko Wada
  • Organizer: 2007 the first Japanese-Swiss Symposium on Chemical Biology(JSCB07)
  • Place of Presentation: EPFL Lausanne, Swiss
  • Year and Date: 2007-06-26
• [Presentation] 人工核酸を活用した新しい遺伝子治療法提案 (2007)
  • Author(s): 和田健彦
  • Organizer: 大阪大学大学院薬学研究科特別講演会
  • Place of Presentation: 大阪
  • Year and Date: 2007-06-12
• [Presentation] 外部刺激応答型人工核酸の創製 (2007)
  • Author(s): 和田健彦
  • Organizer: 多元研講演会「核酸医薬への応用を目指した人工核酸の新しいサイエンス」
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-18
• [Presentation] 外部刺激応答性人工核酸の構築 (2007)
  • Author(s): 和田健彦
  • Organizer: FIBER Lectures in NANOBIO NOW Series Part 19
  • Place of Presentation: 神戸
  • Year and Date: 2007-04-07
• [Presentation] Enantiodifferentiating Photoisomerization of Cyclic Olefins Sensitized by Chiral [10]Paracyclophanes (2007)
  • Author(s): Takehiko Wada, Ryo Maeda, Tadashi Mori, Nobuhiro Kanomata, and Yoshihisa Inoue
  • Organizer: ICORP Symposium 2007
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2007-01-23
• [Presentation] 外部刺激応答型人工核酸の創製 (2007)
  • Author(s): 和田健彦
  • Organizer: 第19回名古屋カンファレンス
  • Place of Presentation: 名古屋
  • Year and Date: 2007-01-18
• [Presentation] 外部刺激応答型人工核酸の創製 (2007)
  • Author(s): 和田健彦
  • Organizer: 第18回名古屋カンファレンス招待講演者
  • Place of Presentation: 名古屋大学・野依記念交流会館
  • Year and Date: 2007-01-18
• [Presentation] International Conference of 43rd Japanese Peptide Symposium (2007)
  • Author(s): Takehiko Wada
  • Organizer: 4th Peptide Engineering Meeting
  • Place of Presentation: Yokohama, Japan
• [Presentation] 刺激応答型人工核酸の創製 (2006)
  • Author(s): 和田健彦
  • Organizer: 第52回高分子夏期大学講演者
  • Place of Presentation: 愛媛・ホテル奥道後
  • Year and Date: 2006-07-27
• [Presentation] International Congress on Nanobiotechnology & Nanomedicine (2006)
  • Author(s): Takehiko Wada
  • Organizer: NanoBio2006
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2006-06-20
• [Remarks]
  • URL: http://db.tagen.tohoku.ac.jp/php/db/
• [Remarks]
  • URL: http://www.tagen.tohoku.ac.jp/labo/wada/index-j.html