• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Multiphasic Mixture Modeling and Simulation of Coronary Circulation

Research Project

Project/Area Number 18360054
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Materials/Mechanics of materials
Research InstitutionKyushu University

Principal Investigator

CHEN Xian  Kyushu University, Digital Medicine Initiative, Professor (70313012)

Co-Investigator(Kenkyū-buntansha) SUGIURA Seiryo  The University of Tokyo, School of Frontier Sciences, Professor (10272551)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥9,710,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥810,000)
Fiscal Year 2007: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2006: ¥6,200,000 (Direct Cost: ¥6,200,000)
KeywordsCoronary Circulation / Mixture Theory / Finite Element Method / Biomechanics / Bio-material Modeling / 生体材料モデル
Research Abstract

In this research, based on the multiphasic mixture theory, a hierarchical coronary theoretical model is proposed for the coronary system, in which the vessels have tree structure gradually bifurcating from artery and vein to capillary bed, by treating the myocardial matrix as solid phase and blood in each hierarchy of the vessel tree as specific fluid phase. Furthermore, the incompressible condition of the solid and fluid phases was imposed by applying Lagrange multiplier method. The residual weighted method was introduced for finite element formulation and followed by the descritization. The tangential stiffness matrix was derived for iterative computation of the nonlinear problems. Since the fluid variables have large degrees of freedom at a node due to the hierarchy structure, for the computational efficiency, the finite element equations were reformulated by adopting pressure as nodal variable instead of the relative velocity of fluid phase. The formulation was implemented into a home-made program and built in a multi-scale and multi-physics heart simulator. The numerical examples show that the characteristic predominate wave form of arteries (or veins) blood flow in diastolic (or systolic) can be represented by applying the proposed model and thus suggest the usability in the clinical application. It is expected that the effect of the myocardial contraction on the intramyocardial pressure and furthermore on the blood perfusion in coronary system can be elucidated by applying the proposed approach and to make contribution to etiology elucidation of the ischemic heart disease and diagnostic treatment.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (6 results)

All 2006

All Journal Article (2 results) Presentation (4 results)

  • [Journal Article] 多孔質超弾性理論に基づく冠循環血流動態の有限要素解析2006

    • Author(s)
      陳 媛, 陳 献 他4名
    • Journal Title

      理論応用力学講演会講演論文集 55

      Pages: 319-320

    • NAID

      130005020492

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 多孔質超弾性理論に基づく冠循環系と左右両心室の流体構造連成解析2006

    • Author(s)
      渡邉浩志, 陳媛, 陳献 他3名
    • Journal Title

      第19回計算力学講演会講演論文集

      Pages: 323-324

    • Related Report
      2006 Annual Research Report
  • [Presentation] 多孔質超弾性理論に基づく冠循環血流動態の有限要素解析2006

    • Author(s)
      陳 媛, 陳 献, 他4名
    • Organizer
      第55回理論応用力学講演会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 多孔質超弾性理論に基づく冠循環系と左右両心室の流体構造連成解析2006

    • Author(s)
      渡邉 浩志, 陳 媛, 陳 献, 他3名
    • Organizer
      第19回計算力学講演会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Finite Element Analysis on the Hemodynamics of Coronary Circulation Based on Porohyperelastic Theory2006

    • Author(s)
      Chen, Y., Chen, X., Watanabe, H., Washio, T., Sugiura, S., Hisada, T
    • Organizer
      The 55th National Congress of Theoretical and Applied Mechanics, Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Fluid-Structure Interaction Analysis of Left and Right Ventricles with Coronary Circulation Based on Porohyperelastic Theory2006

    • Author(s)
      Watanabe, H., Chen, Y., Chen, X., Washio, T., Sugiura, S., Hisada, T
    • Organizer
      JSME 18th Computational Mechanics Conference, Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi