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Electron spin resonance imaging for brain/neuroscience studies

Research Project

Project/Area Number 18360194
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Measurement engineering
Research InstitutionHokkaido University (2008)
Yamagata University (2006-2007)

Principal Investigator

HIRATA Hiroshi  Hokkaido University, 大学院・情報科学研究科, 教授 (60250958)

Co-Investigator(Kenkyū-buntansha) 藤井 博匡  札幌医科大学, 保健医療学部, 教授 (70209013)
伊藤 康一  徳島文理大学, 薬学部, 教授 (30291149)
Co-Investigator(Renkei-kenkyūsha) FUJII Hirotada  札幌医科大学, 保健医療学部, 教授 (70209013)
ITOH Kouichi  徳島文理大学, 薬学部, 教授 (30291149)
Research Collaborator AKABA Hideo  北海道大学, 大学院・情報科学研究科, 博士研究員
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,590,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2007: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2006: ¥4,200,000 (Direct Cost: ¥4,200,000)
Keywords電子スピン共鳴 / イメージング / スライス選択 / 画像再構成 / マウス / 高速化 / 電子スピン共鳴イメージング / 共振器 / 脳 / スライス選択画像 / 一酸化窒素 / 電子スピン共鳴分光 / てんかん
Research Abstract

実験小動物として用いられるマウスを対象として、電子スピン共鳴(ESR)イメージング法の研究を行った。マウス頭部を計測する650MHzのマイクロ波共振器を作製し、ESR分光装置を改良した。また、スライス選択ESR画像を取得するイメージング法を開発した。さらに、データ取得を高速化することにより、マウス頭部において、半減時が短い六員環のナイトロキシルラジカルを可視化することに成功した。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (30 results)

All 2009 2008 2007 Other

All Journal Article (12 results) (of which Peer Reviewed: 5 results) Presentation (15 results) Remarks (3 results)

  • [Journal Article] Resolution recovery for EPR imaging of free radical molecules in mice2009

    • Author(s)
      Y. Ikebata, H. Sato-Akaba, T. Aoyama, H. Fujii, K. Itoh, H. Hirata
    • Journal Title

      Magnetic Resonance in Medicine (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of temporal resolution for three-dimensional continuous-wave electron paramagnetic resonance imaging2008

    • Author(s)
      H. Sato-Akaba, H. Fujii, and H. Hirata
    • Journal Title

      Review of Scientific Instruments Vol.79, No.12, article no.123701

      Pages: 7-7

    • Related Report
      2008 Final Research Report
  • [Journal Article] Development and testing of a CW-EPR apparatus for imaging of short-lifetime nitroxyl radicals in mouse head2008

    • Author(s)
      H. Sato-Akaba, H. Fujii, and H. Hirata
    • Journal Title

      Journal of Magnetic Resonance Vol.93, No.2

      Pages: 191-198

    • Related Report
      2008 Final Research Report
  • [Journal Article] Slice-selective images of free radicals in mice with modulated field gradient electron paramagnetic resonance (EPR) imaging2008

    • Author(s)
      H. Sato-Akaba, H. Abe, H. Fujii, and H. Hirata
    • Journal Title

      Magnetic Resonance in Medicine Vol.59, No.4

      Pages: 885-890

    • Related Report
      2008 Final Research Report
  • [Journal Article] A loop resonator for slice-selective in vivo EPR imaging in rats2008

    • Author(s)
      H. Hirata, G. He, Y. Deng, I. Salikhov, S. Petryakov, and J. L. Zweier
    • Journal Title

      Journal of Magnetic Resonance Vol.190, No.1

      Pages: 124-134

    • Related Report
      2008 Final Research Report
  • [Journal Article] Enhanced resolution for EPR imaging by two-step deblurring2008

    • Author(s)
      R. Ahmad, B. Clymer, D. S. Vikram, Y. Deng, H. Hirata, J. L. Zweier, and P. Kuppusamy
    • Journal Title

      Journal of Magnetic Resonance Vol.184, No.2

      Pages: 246-257

    • Related Report
      2008 Final Research Report
  • [Journal Article] Slice-selective images of free radicals in mice with modulated field gradient electron paramagnetic resonance (EPR) imaging2008

    • Author(s)
      H. Sato-Akaba, H. Abe, H. Fujii, H. Hirata
    • Journal Title

      Magnetic Resonance in Medicine 59

      Pages: 885-890

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and testing of a CW-EPR apparatus for imaging of short-lifetime nitroxyl radicals in mouse head2008

    • Author(s)
      H. Sato-Akaba, H. Fujii, H. Hirata
    • Journal Title

      Journal of Magnetic Resonance 193

      Pages: 191-198

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of temporal resolution for three-dimensional continuous-wave electron paramagnetic resonance imaging2008

    • Author(s)
      H. Sato-Akaba, H. Fujii, H. Hirata
    • Journal Title

      Review of Scientific Instruments 79

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A loop resonator for slice-selective in vivo EPR imaging in rats2008

    • Author(s)
      H. Hirata, G. He, Y. Deng, I. Salikhov, S. Petryakov, and J.L. Zweier
    • Journal Title

      Journal of Magnetic Resonance 190

      Pages: 124-134

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of multi-coil parallel-gap resonators for co-registration EPR/NMR imaging2007

    • Author(s)
      Y. Kawada, H. Hirata, and H. Fujii
    • Journal Title

      Journal of Magnetic Resonance 184・1

      Pages: 29-38

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Enhanced resolution for EPR imaging by two-step deblurring2007

    • Author(s)
      R. Ahmad, B. Clymer, D.S. Vikram, Y. Deng, H. Hirata, J.L. Zweier, and P. Kuppusamy
    • Journal Title

      Journal of Magnetic Resonance 184・2

      Pages: 246-257

    • Related Report
      2006 Annual Research Report
  • [Presentation] Superresolutiokn EPR Imaging : Phantom and Animal experiments2008

    • Author(s)
      Y. Ikebata, H. Sato-Akaba, T. Aoyama,H. Fujii, K. Itoh, and H. Hirata
    • Organizer
      6th Asia-Pacific EPR symposium, Cairns, Australia
    • Place of Presentation
      Invited
    • Year and Date
      2008-07-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 3D superresolution EPR imaging of nitroxyl radicals in mice2008

    • Author(s)
      Y. Ikebata, H. Sato-Akaba, H. Fujii, and H. Hirata
    • Organizer
      Proceedings of Iternational Society for Magnetic Resonance in Medicine (ISMRM) 16th Scientific Meeting and Exhibition
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-05-07
    • Related Report
      2008 Final Research Report
  • [Presentation] EPR imaging of short-lifetime nitroxyl radicals in mouse head2008

    • Author(s)
      H. Sato-Akaba, H. Fujii, and H. Hirata
    • Organizer
      Proceedings of Iternational Society for Magnetic Resonance in Medicine(ISMRM)16th Scientific Meeting and Exhibition
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-05-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Feasibility of spectral-spatial EPR imaging on diffusion of spin probes in biological tissues2007

    • Author(s)
      N. Watanabe, H. Sato-Akaba, K.Nakagawa, and H. Hirata
    • Organizer
      A Joint Conference of the International Symposium on Electron Spin Science and the 46th Annual Meeting of the Society of Electron Spin Science and Technology
    • Place of Presentation
      Shizuoka, Japan
    • Year and Date
      2007-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Fast 3D CW-EPR imaging with uniform distribution of projections2007

    • Author(s)
      H. Sato-Akaba, H. Fujii, and H. Hirata
    • Organizer
      Conference of the International Symposium on Electron Spin Science and the 46th Annual Meeting of the Society of Electron Spin Science and Technology
    • Place of Presentation
      Shizuoka, Japan,
    • Year and Date
      2007-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Feasibility of spectral-spatial EPR imaging on diffusion of spin probes in biological tissues2007

    • Author(s)
      N. Watanabe, H. Sato-Akaba, K. Nakagawa, and H. Hirata
    • Organizer
      A Joint Conference of the International Symposium on Electron Spin Science and the 46th Annual Meeting of the Society of Electron Spin Science and Technology
    • Place of Presentation
      静岡市グランシップ
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] New approaches to advanced CW-EPR imaging2007

    • Author(s)
      H. Hirata, H. Sato-Akaba, and H. Fujii
    • Organizer
      A Joint Conference of the International Symposium on Electron Spin Science and the 46th Annual Meeting of the Society of Electron Spin Science and Technology
    • Place of Presentation
      Shizuoka, Japan
    • Year and Date
      2007-11-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Development of tuning circuit for 650-MHz multi-coil parallel-gap resonator2007

    • Author(s)
      Y. Suzuki and H. Hirata
    • Organizer
      A Joint Conference of the International Symposium on Electron Spin Science and the 46th Annual Meeting of the Society of Electron Spin Science and Technology
    • Place of Presentation
      Shizuoka, Japan,
    • Year and Date
      2007-11-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Development of highly sensitive loop-gap resonator2007

    • Author(s)
      H. Abe, H. Sato-Akaba, and H. Hirata
    • Organizer
      A Joint Conference of the International Symposium on Electron Spin Science and the 46th Annual Meeting of the Society of Electron Spin Science and Technology
    • Place of Presentation
      Shizuoka, Japan
    • Year and Date
      2007-11-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Three-dimensional superresolution EPR imaging2007

    • Author(s)
      Y. Ikebata, H. Sato-Akaba, and H. Hirata
    • Organizer
      A Joint Conference of the International Symposium on Electron Spin Science and the 46thAnnual Meeting of the Society of ElectronSpin Science and Technology
    • Place of Presentation
      Shizuoka, Japan
    • Year and Date
      2007-11-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Slice-selective images of free radicals in mice with modulated field gradient EPR imaging2007

    • Author(s)
      H. Sato-Akaba, H. Abe, H. Fujii, and H. Hirata
    • Organizer
      A Joint Conference of the International Symposium on Electron Spin Science and the 46th Annual Meetingof the Society of Electron Spin Science and Technology
    • Place of Presentation
      Shizuoka, Japan
    • Year and Date
      2007-11-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Slice-selective images of free radicals in mice with modulated field gradient EPR imaging2007

    • Author(s)
      H. Sato-Akaba, H. Abe, H. Fujii, and H. Hirata
    • Organizer
      The 4th JSPS Core-to-Core Program Seminar : International In Vivo Redox Symposium
    • Place of Presentation
      Shizuoka, Japan
    • Year and Date
      2007-11-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Slice-selective images of free radicals in mice with modulated field gradient EPR imaging2007

    • Author(s)
      H. Sato-Akaba, H. Abe, H. Fujii, and H. Hirata
    • Organizer
      The 4th JSPS Core-to-Core Program Seminar: International In Vivo Redox Symposium
    • Place of Presentation
      清水市大平ホテル
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Tunable resonators and automatic control techniques in biomedical EPR spectroscopy2007

    • Author(s)
      H. Hirata
    • Organizer
      EPR2007 A Joint Conference of 12th In Vivo EPR pectroscopy and Imaging and 9th International EPR Spin Trapping, Chicago
    • Place of Presentation
      Invited
    • Year and Date
      2007-05-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Tunable resonators and automatic control techniques in biomedical EPR spectroscopy2007

    • Author(s)
      H. Hirata
    • Organizer
      EPR2007 A Joint Conference of 12th In Vivo EPR Spectroscopy and Imaging and 9th International EPR Spin Trapping
    • Place of Presentation
      米国シカゴヒルトンスーツシカゴ
    • Year and Date
      2007-05-01
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.bme.ist.hokudai.ac.jp/BPE/index-j.html

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.bme.ist.hokudai.ac.jp/BPE/index-j.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://esr.yz.yamagata-u.ac.jp/

    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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