Algorithm analysis of chemosensory transduction that controls the behavioral state of living organisms and its application to engineering system design

• Project/Area Number: 18360396
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biofunction/Bioprocess
• Research Institution: Osaka University
• Principal Investigator: OHTAKE Hisao Osaka University, 大学院・工学・研究科, 教授 (10127483)
• Co-Investigator(Kenkyū-buntansha): OMASA Kenji 大阪大学, 大学院・工学・研究科, 准教授 (00252586) ; HONDA Khosuke 大阪大学, 大学院・工学・研究科, 助教 (90403162)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,480,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥1,980,000); Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2007: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2006: ¥8,900,000 (Direct Cost: ¥8,900,000)
• Keywords: 化学感覚 / アルゴリズム / 定型的行動 / 脳

Research Abstract

終脳が嗅覚中枢として発達した魚類(金魚)と統合中枢である大脳をもつ哺乳動物(マウスとラット)を実験生物に用いて、電気生理学、光学計測技術および計算機シミュレーション技術等を駆使して、高等生物における化学感覚の受容と統合から定型的な行動が実行されるアルゴリズムを解析した。化学感覚の受容と定型的行動の指令と制御に関わるアルゴリズムを、自動制御可能な人工物の定型的行動と比較することにより、新しい人工物の設計原理を考察した

Research Products

• [Journal Article] Performance of mice in discrimation for liquor odrors (2008)
  • Author(s): Takiguchi, N., Okuhara, K., Kuroda, A., Kato, J. and Ohtake, H
  • Journal Title: Behavioral evidence for olfactory attention. Chem. Senses 33 Pages: 283-290
• [Journal Article] A Neural Network Model of the Olfactory System of Mice (2008)
  • Author(s): Soh, Z., Tsuji, T., Suzuki, M., Takiguchi, N. and Ohtake, H.
  • Journal Title: Computer Simulation of the Attention Behavior of mice for some components in an odor Robotics 12 Pages: 75-80
• [Journal Article] Improved production of recombinant human antithrombin III in Chinese hamster ovary cells by ATF4 overexpression (2008)
  • Author(s): Ohya, T., Hayashi, T., Kiyama, E., Nishii, H., Miki, H., Kobayashi, K., Honda, K., Omasa, T. and Ohtake, H.
  • Journal Title: Biotechnol. Bioeng 100 Pages: 317-324
• [Journal Article] Performance of mice in discrimation for liquor odrors : Behavioral evidence for olfactory attention. (2008)
  • Author(s): Takiguchi, N., Okuhara, K., Kuroda, A., Kato, J., Ohtake, H.
  • Journal Title: Chemical Senses 33 Pages: 283-290
  • Peer Reviewed
• [Journal Article] A Neural Network Model of the Olfactory System of Mice : Computer Simulation of the Attention Behavior of mice for some components in an odor. (2008)
  • Author(s): Soh, Z., Tsuji, T., Suzuki, M., Takiguchi, N. And Ohtake, H.
  • Journal Title: Artificial Life and Robotics 12 Pages: 75-80
  • Peer Reviewed
• [Journal Article] Biomimeticcontrol of mobile robots based on the chemotactic response model of Paramecium (2007)
  • Author(s): Hirano, A., Tsuji, T., Takiguchi, N., and Ohtake, H.
  • Journal Title: Trans. JSME 73 Pages: 2757-2764
• [Journal Article] Utilization of hydrophobic bacterium Rhodococcus opacus Strain B-4 as whole-cell biocatalyst in anhydrous organic solvents (2007)
  • Author(s): Yamashita, S. Satoi, M., Honda, K., Samejima, Y., Omasa, T., Kato, J., and Ohtake, H.
  • Journal Title: Appl. Microbiol. Biotechnol 74 Pages: 761-767
• [Journal Article] Inhibition of quorum sensing in Pseudomonas aeruginosa by N-acyl cyclopentylamides (2007)
  • Author(s): Ishida, T., Ikeda, T., Takiguchi, N.,Kuroda, A., Ohtake, H., Kato, J.
  • Journal Title: Appl. Environ. Microbiol 73 Pages: 3183-3188
• [Journal Article] Biomimeticcontrol of mobile robots based on the chemotactic response model of Paramecium. (2007)
  • Author(s): Hirano, A., Tsuji, T., Takiguchi, N., and Ohtake, H.
  • Journal Title: 日本機械学会論文集 73 Pages: 2757-2764
  • Peer Reviewed
• [Journal Article] Identification and characterization of the chemotactic transducer in Pseudomona aeruginosa PAO1 for positive chemotaxis to trichloroethylene (2006)
  • Author(s): H.-E. Kim, M. Shitashiro, A. Kurda, N. Takiguchi, H. Ohtake, J. Kato
  • Journal Title: J. Bacteriol 188 Pages: 6700-6702
• [Journal Article] Simulation for chemotactic response of Paramecium using virtual Paramecium (2006)
  • Author(s): Hirano, A., Tsuji, T., Takiguchi, N., and Ohtake, H
  • Journal Title: Trans. SICE 42 Pages: 1252-1259
  • NAID: 10018407977
• [Journal Article] Recognition of Culture State Using Two-dimensional Gel Electrophoresis with an Artificial Neural Network (2006)
  • Author(s): N. Izawa, M. Kishimoto, K. Konishi, T. Omasa, S. Shioya, H. Ohtake
  • Journal Title: Proteomics 6 Pages: 3730-3738
• [Journal Article] Module-Based Analysis of Robustness Tradeoffs in the Heat Shock Response System (2006)
  • Author(s): H. Kurata, H. El-Samad, R. Iwasaki, H. Ohtake, J. C. Doyle, I. Grigorova,C. A.Gross, M. Khammash
  • Journal Title: PLoS Comput. Biol 2 Pages: 663-675
• [Journal Article] Module-Based Analysis of Robustness Tradeoffs in the Heat Shock Response System (2006)
  • Author(s): H.Kurata et al.
  • Journal Title: PLoS Comput. Biol. 2 Pages: 663-675
• [Journal Article] Performance of mice in discrimation for liquor odrors: Behavioral evidence for olfactory attention
  • Author(s): Takiguchi, N., Okuhara, K., Kuroda, A., Kato, J. and Ohtake, H.
  • Journal Title: Chemical Senses (印刷中)
  • Peer Reviewed