Central regulation of feeding behavior and its evolutionary modeling
Project/Area Number |
18370024
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Morphology/Structure
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Research Institution | University of Toyama |
Principal Investigator |
MATSUDA Kouhei University of Toyama, 大学院・理工学研究部(理学), 教授 (60222303)
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Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Akiyoshi 北里大学, 海洋生命科学部, 教授 (10183849)
ANDO Hironori 九州大学, 大学院・農学研究院, 准教授 (60221743)
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Project Period (FY) |
2006 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥17,410,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2007: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2006: ¥7,400,000 (Direct Cost: ¥7,400,000)
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Keywords | キンギョ / 摂食行動 / 神経ペプチド / 脳室内投与 / 神経相関 / 神経回路 / 本能行 / 進化 / 神経回路網 / 本能行動 / 遺伝子発現 / トラフグ / アンタゴニスト / 魚類 |
Research Abstract |
哺乳類における最近の知見によれば、摂食行動は、脳の視床下部で発現する多数の脳ペプチドによって促進的あるいは抑制的に制御されていることが判明してきた。しかしながら、摂食行動の複雑な調節を司る神経機構の進化の過程における変遷については、殆ど判っていない。本研究は、キンギョにおける摂食行動の制御機構を明らかにすること、および得られた知見と他の動物における制御機構とを比較検討して、摂食行動の脳制御機構の進化の変遷を考察することを目的とした。キンギョの摂食行動が生殖や情動に関わる脳ペプチドの影響も強く受けながら制御されることを見出した。哺乳類や鳥類の機構と大きく異なる機構の存在も見出され、摂食調節の脳制御機構が進化的に変遷してきた可能性が示唆された。
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Report
(4 results)
Research Products
(276 results)
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[Journal Article] Pituitary adenylate cyclase-activating polypeptide induces somatolactin release from cultured goldfish pituitary cells.2009
Author(s)
Azuma, M., Tanaka, M., Nejigaki, Y., Uchiyama, M., Takahashi, A., Shioda, S., Matsuda, K.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus.2009
Author(s)
Matsuda, K., Kojima, K., Shimakura, S. I., Miura, T., Uohiyama, M., Shioda, S., Ando, H., Takahashi, A.
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Journal Title
Comparative Biochemistry and Physiology Part A : Mollecular and Integrative Physiology (in press)
Related Report
Peer Reviewed
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[Journal Article] Neuronal relationship between orexin-A- and neuropeptide Y-induced orexigenic actions in goldfish.2009
Author(s)
Kojima, K., Kamijo, M., Kageyama, H., Uchiyama, M., Shioda, S., Matsuda, K.
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Journal Title
Neuropeptides 43
Pages: 63-71
Related Report
Peer Reviewed
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[Journal Article] Purification and properties of ghrelin from the intestine of goldfish. Carassius auratus.2009
Author(s)
Miura, T., Maruyama, K., Kaiya, H., Miyazato, M., Kangawa, K., Uohiyama, M., Matsuda, K.
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Journal Title
Peptides 30
Pages: 758-765
NAID
Related Report
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[Journal Article] Activity of the pituitary-gonadal axis is increased prior to the onset of spawning migration of chum salmon.2009
Author(s)
Onuma TA, Sato S, Katsumata H, Makino K, Hu W, Jodo A, Davis ND, Dickey JT, Ban M, Ando H, Fukuwaka MA, Azumaya T, Swanson P, Urano A.
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Journal Title
Journal of Experimental Biology 212
Pages: 56-70
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[Journal Article] Corticotropin-releasing hormone mediates □-melanocyte-stimulating hormone-induced anorexigenic action in goldfish.2008
Author(s)
Matsuda, K., Kojima, K., Shimakura, S. I., Wada, K., Maruyama, K., Uohiyama, M., Kikuyama, S., Shioda, S.
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Journal Title
Peptides 29
Pages: 1930-1936
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[Journal Article] Neuronal interaction between melanin-concentrating hormone- and □-melanocyte-stimulating hormone-containing neurons in the goldfish hypothalamus.2008
Author(s)
Shimakura, S. I., Kojima, K., Nakamachi, T., Kageyama, H., Uchivama, M., Shioda, S., Takahashi, A., Matsuda, K.
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Journal Title
Peptides 29
Pages: 1432-1440
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[Journal Article] Effects of hypertonic stimuli and arginine vasotocin (AVT)on water absorption response in Japanese treefrog, Hyla japonica.2008
Author(s)
Maejima, S., Yamada, T., Hamada, T., Matsuda, K., Uchiyama, M.
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Journal Title
General and Comparative Endocrinology 157
Pages: 196-202
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[Journal Article] Effects of arginine vasotocin and vasopressin receptor antagonists on Na^+ and Cl^- transport in the isolated skin of two frog species, Hyla japonica and Rana nisromaculata.2008
Author(s)
Yamada, T., Nishio, T., Sano, Y., Kawago, K., Matsuda, K., Uchiyama, M.
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Journal Title
General and Comparative Endocrinology 157
Pages: 63-69
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Peer Reviewed
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[Journal Article] Inhibitory effect of chicken gonadotropin-releasing hormone II on food intake in the goldfish, Carassius auratus.2008
Author(s)
Matsuda, K., Nakamura, K., Shimakura, S. I., Miura, T., Kageyama, H., Uchiyama, M., Shioda, S., Ando, H.
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Journal Title
Hormones and Behavior 54
Pages: 83-89
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Peer Reviewed
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[Journal Article] □-Melanocyte-stimulating hormone mediates melanin-concentrating hormone-induced anorexigenic action in goldfish.2008
Author(s)
Shimakura, S. I., Miura, T., Maruyama, K., Nakamaohi, T., Uchiyama, M., Kageyama, H., Shioda, S., Takahashi, A., Matsuda, K.
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Journal Title
Hormones and Behavior 53
Pages: 323-328
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[Journal Article] Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on prolactin and somatolactin release from the goldfish pituitary in vitro.2008
Author(s)
Matsuda, K., Nejigaki, Y., Satoh, M., Shimaura, C., Tanaka, M., Kawamoto, K., Uchiyama, M., Kawauchi, H., Shioda, S., Takahashi, A.
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Journal Title
Regulatory Peptides 145
Pages: 72-79
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Peer Reviewed
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[Journal Article] Cellular localization of the Na^+/H^+ exchanger 3 (NHE3)during ontogeny in the pronephros and mesonephros of the Japanese black salamander, Hynobius nigrescens Stejneger.2008
Author(s)
Kumano, T., Konno, N., Wakasugi, T., Matsuda, K., Yoshizawa, H., Uohiyama, M.
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Journal Title
Cell and Tissue Research 331
Pages: 675-685
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[Journal Article] Isolation and characterisation of four cDNAs encoding neuromedin U(NMU)from the brain and gut of goldfish, and inhibitory effect of adeduced NMU on food intake and locomotor activity.2008
Author(s)
Maruyama, K., Konno, N., Ishiguro, K., Wakasugi, T., Uchiyama, M., Shioda, S., Matsuda, K.
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Journal Title
Journal of Neuroendocriaology 20
Pages: 71-78
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[Journal Article] Transcription elements and functional expression of proopiomelanocortin genes in the pituitary gland of the barfin flounder2008
Author(s)
Kobayashi, Y., Chiba, H., Amiya, N., Yamanome, T., Mizusawa, K., Amano, M., Takahashi, A.
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Journal Title
General and Comparative Endocrinology 158
Pages: 259-267
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Peer Reviewed
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[Journal Article] Interaction of orexin/hypocretin-like immunoreactive neurons with melanin-concentrating hormone and α-melanocyte-stimulating hormone neurons in the brain of a pleuronectiform fish. barfin flounder2008
Author(s)
Amiya, N., Amano, M., Iigo, M., Yamanome, T., Takahashi, A., Yamamori, K.
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Journal Title
Fisheries Science 74
Pages: 1040-1046
NAID
Related Report
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[Journal Article] Food deprivation increases the expression of melanocortin-4 receptor in the liver of barfin flounder. Verasper moseri.2008
Author(s)
Kobavashi, Y., Tsuchiya, K., Yamanome, T., Sohioth, H, B., Kawauchi, H., Takahashi, A.
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Journal Title
General and Comparative Endocrinology 155
Pages: 280-287
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[Journal Article] Scale osteoblasts and osteoclasts sensitivel respond to low-gravity loading centrifuge2008
Author(s)
Suzuki N, Omori K, Nakamura M, Tabata MJ, Ikegami M, Ijiri K, Kitamura KI, Shimizu N, Kondo T, Kondo T, Matsuda K. Ando H. Kasahara H, Nagase M, Nara M. Hattori A.
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Journal Title
Biological Sciences of Space
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[Journal Article] Effect of the diazepam-binding inhibitor-derived peptide, octadecaneuropeptide, on food intake in goldfish2007
Author(s)
Matsuda K, Wada K, Miura T, Maruyama K, Shimakura SI, Uchiyama M, Leprince J, Tonon MC, Vaudry H.
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Journal Title
Neuroscience 150
Pages: 425-432
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[Journal Article] Space biology utilizing fish scale2007
Author(s)
Suzuki N, Omori K, Ijiri K, Kitamura KI, Shimizu N, Tabata MJ, Ikegame M, Nakamura M, Kondo T, Matsuda K, Ando H, Kasahara H, Nagase M, Hattori, A.
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Journal Title
Space Utilization Res 23
Pages: 318-321
NAID
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[Journal Article] Space biology utilizing fish scale2007
Author(s)
Suzuki N, Omori K, ljin k, Kitamura KI, Shimizu N, Tabata MJ, IKEGAME M, Nakamura M, Kondo T, Matsuda K, Ando H. Kasahara H, Nanase M, Htttori A.
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Journal Title
Space Utilization and Research 23
Pages: 318-321
NAID
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[Journal Article] Regulations of food intake in the goldfish by interaction between ghrelin and ore2007
Author(s)
Miura T., Maruyama, K., shimakura, S.T., Kaiya, H., Uchiyama, M., Kangawa, K., Shioda, S., Matsua, K.
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Journal Title
Related Report
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[Journal Article] Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on prolactin and somatolactin release from the goldfish pituitary in vitro.2007
Author(s)
Matsuda, K., Nejigaki, Y., Satoh, M., Shimaura, C., Tanaka, M., Kawamoto, K., Uchiyama, M., Kawauchi, H., Shioda, S., Takahashi, A.
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Journal Title
Regulatory Peptides (in press)
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[Journal Article] Immunolocalization and mRNA expression of the epithelial Na* channel -subunit in the kidney and urinary bladder of the marine toad, Bufo marinus, under hyperosmotic conditions.2007
Author(s)
Konno, N., Hyodo, S., Yamada, T., Matsuda, K., Uchiyama, M.
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Journal Title
Cell Tissue Res (in press)
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[Journal Article] Feeding-induced changes of melanin-concentrating hormone (MCH)-like immunoreactivity in goldfish brain.2007
Author(s)
Matsuda, K., Shimakura, S.I., Miura, T., Maruyama, K., Uchiyama, M., Kawauchi, H., Shioda, S., Takahashi, A.
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Journal Title
Cell Tissue Res (in press)
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[Journal Article] The melanin-concentrating hormone receptor 2(MCH-R2) mediates the effect of MCH to control body color for background adaptation in the barfin flounder.2007
Author(s)
Takahashi, A., Kosugi, T., Kobayashi, Y., Yamanome, Y., Schioth, B.H., Kawauchi, H.
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Journal Title
Gen Comp Endocrinol (in press)
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[Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases neuronal cell death after focal ischemia associated with interleukin-6 (IL-6) signaling2006
Author(s)
Ohtaki H, Nakamachi T, Dohi K, Aizawa Y, Takaki A, Hodoyama K, Yofu S, hashimoto H, Shintani N, Baba A, Kopf M, Iwakura Y, Matsuda K, Arimura A, Shioda S.
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Journal Title
Proc. Natl. Acad. Sci. USA 103
Pages: 7488-7493
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[Journal Article] Neuropeptide Y mediates ghrelin-induced feeding in the goldfish, Carassius auratus.2006
Author(s)
Miura, T., Maruyama, K., Shimakura, S.I., Kaiya, H., Uchiyama, M., Kangawa, K., Shioda, S., Matsuda, K.
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Journal Title
Neurosci iLett 407
Pages: 279-283
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[Journal Article] Regulation of food intake by acyl and des-acyl ghrelins in the goldfish.2006
Author(s)
Matsuda, K., Miura, T., Kaiya, H., Maruyama, K., Shimakura, S.I., Uchiyama, M., Kangawa, K., Shioda, S.
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Journal Title
Peptides 27
Pages: 2321-2325
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[Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases neuronal cell death after focal ischemia associated with interleukin-6 (IL-6) signaling.2006
Author(s)
Ohtaki, H., Nakamachi, T., Dohi, K., Aizawa, Y., Takaki, A., Hodoyama, K., Yofu, S., hashimoto, H., Shintani, N., Baba, A., Kopf, M., Iwakura, Y., Matsuda, K., Arimura, A., Shioda, S.
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Journal Title
Proc. Natl. Acad. Sci. USA 103
Pages: 7488-7493
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[Journal Article] Molecular cloning and functional characterization of a prolactin-releasing peptide homolog from Xenopus laevis.2006
Author(s)
Sakamoto, T., Oda, A., Yamamoto, K., Kaneko, M., Kikuyama, S., Nishikawa, A., Takahashi, A., Kawauchi, H., Tsutsui, K., Fujimoto, M.
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Journal Title
Peptides 27
Pages: 3347-3351
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[Journal Article] Identification of sea lamprey GTHβ-like cDNA and its evolutionary implications.2006
Author(s)
Sower, S.A., Moriyama, S., Kasahara, M., takahashi, A., Nozaki, M., Uchida, K., dahlstrom, J.M., Kwauchi, H.
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Journal Title
Gen Comp Endocrinol 148
Pages: 22-32
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[Journal Article] A systematic immunohistochemical survey on the distribution patterns of GH, prolactin, somatolactin, β-TSH, β-FSH, β-LH, ACTH, and α-MSH in the adenohypophysis of Oreochromis niloticus, the Nile tilapia.2006
Author(s)
Kasper, R.S., Shved, N., Takahashi, A., Reinecke, M., Eppler, E.
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Journal Title
Cell Tissue Res 325
Pages: 303-313
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[Journal Article] Occurrence of two functionally distinct proopiomelanocortin genes in all modern lampreys.2006
Author(s)
Takahashi, A., Nakata, O., Moriyama, S., Nozaki, M., Joss, J.M.P., Sower, S.A., Kawauchi, H.
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Journal Title
Gen Comp Endocrinol 148
Pages: 72-78
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[Journal Article] Expression of three proopiomelanocortin subtype genes and mass spectrometric identification of POMC-derived peptides in pars distalis and pars intemedia of barfin flounder pituitary.2006
Author(s)
Takahashi, A., Amano, M., Amiya, N., Yamanome, T., Yamamori, K., Kawauchi, H.
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Journal Title
Gen Comp Endocrinol 145
Pages: 280-286
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[Presentation] Purification and characterization of ghrelin from the intestine of goldfish, Carassius auratus2008
Author(s)
Miura T, Maruyama K, Shimakura SI, Uchiyama M, Kaiya H, Miyazato M, Kangawa K, Shioda S, Matsuda K
Organizer
The 24^<th> Conference of European Comparative Endocrinologists
Place of Presentation
Genova, Italy
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[Presentation] Distribution of NPY-like immunoreactivity in the brain of putfertish, and stimulatory effect of NPY on food intake.2008
Author(s)
Matsuda K, Kamijo M, Wada K, Miura T, Kojima K, Motohashi E, Ikegami T, Maruyama K, Uchiyama M, Ando H.
Organizer
The 9th Neuropeptide Y International Meeting
Place of Presentation
Okinawa
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[Presentation] Gene expression analysis in the brain of medaka (Oryzias Iatipes) exposed to tributyltin.2007
Author(s)
Sei N, Nakayama K, Oshima Y, Satone H, Ooba Y, Enomoto A, Kang I, Shimasaki Y, Ando H, Tashiro K, Honio T.
Organizer
15th International Conference on Environmental Bioindicators
Place of Presentation
Hong Kong
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