Function of neuregulin, a new paracrine factor, in spermatogenesis
| Project/Area Number |
18370025
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Morphology/Structure
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
ABE Shin-ichi Kumamoto University, 大学院・自然科学研究科, 教授 (90109637)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ETO Ko 熊本大学, 大学院・自然科学研究科, 助教 (40359964)
|
|---|
| Project Period (FY) |
2006 – 2008
|
| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥17,850,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2006: ¥5,500,000 (Direct Cost: ¥5,500,000)
|
|---|
| Keywords | イモリ / マウス / FSH / neuregulin / retinoic acid / プロラクチン / アポトーシス / RNA結合タンパク質 / prolactin / 精巣 / 減数分裂開始 / 精原細胞 / セルトリ細胞 / ニューレギュリン / 再凝集培養 / erbB受容体 / Spo11 |
|---|
| Research Abstract |
イモリ精巣と生後マウス精巣の培養系を用いてneuregulin(NRG)1やretinoic acid(RA)の減数分裂開始に対する作用を解析した。NRG1やRAはイモリやマウス精原細胞の増殖を直接促進する一方、セルトリ細胞を介して間接的に減数分裂を開始させること、NRG1はRAの下流で働くことが分かった。またプロラクチンによるイモリ精原細胞のアポトーシス誘起機構は、RNA結合タンパク質を介することによる。
|
Report
(4 results)
Research Products
(82 results)
-
-
[Journal Article] Promotion of spermatogonial proliferation by Neuregulin 1 in newt(Cynops pyrrhogaster)testis2008
Author(s)
Oral, O., Uchida, I., Eto, K., Nakayama, Y., Nishimura, O., Hirao, Y., Ueda, J., Tarui, H., Agata, K., Abe, S.-I
-
Journal Title
Mech. Dev. 2008 125
Pages: 906-917
Related Report
Peer Reviewed
-
[Journal Article] Purification and cDNA cloning of a novel protease inhibitor secreted into culture supernatant by MDCK cells2008
Author(s)
Nishiyama, K., Sugawara, K., Nouchi, T., Kawano, N., Soejima, K., Abe, S.-I., Mizokami, H
-
Journal Title
Biologicals 36
Pages: 122-133
Related Report
Peer Reviewed
-
-
[Journal Article] Mullerian inhibiting substance is required for germ cell proliferation during early gonadal differentiation in medaka(Oryzias latipes)2008
Author(s)
Shiraishi, E., Yoshinaga, N., Miura, T., Yokoi, H., Wakamatsu, Y., Abe, S.-I., Kitano, T
-
Journal Title
Endocrinology 149
Pages: 1813-1819
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Functional demonstration of the ability of a primary spermatogonium as a stem cell by tracing a single cell destiny in Xenopus laevis. Develop2006
Author(s)
Kawasaki T., Imura, F., Nakada, A., Kubota, H., Sakamaki, K., Abe, S.-I., Takamune, K
-
Journal Title
Growth, Differ 48
Pages: 525-535
Related Report
Peer Reviewed
-
-
-
[Journal Article] Assessment of estrogenic chemicals using an estrogen receptor α(ERα)- and ER β-mediated reporter gene assay in fish2006
Author(s)
Kitano, T., Koyanagi, T., Adachi, R., Sakimura, N., Takamune, K. and Abe, S.-I
-
Journal Title
Marine Biology 149
Pages: 49-55
Related Report
Peer Reviewed
-
[Journal Article] Assessment of estrogenic chemicals using an estrogen receptor α(ERα)- and ERβ-mediated reporter gene assay in fish.2006
Author(s)
Kitano T., Koyanagi, T., Adachi, R., Sakimura, N., Takemune, K., Abe, S.-I.
-
Journal Title
Marine Biology 149
Pages: 49-55
Related Report
-
-
-
[Journal Article] Functional demonstration of the ability of a primary spermatogonium as a stem cell by tracing a single cell destiny in Xenopus laevis.2006
Author(s)
Kawasaki T, Imura, F., Nakada, A., Kubota, H., Sakamaki, K., Abe, S.-I., Takamune, K.
-
Journal Title
Develop., Growth, Differ. 48
Pages: 525-535
NAID
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation]2007
Author(s)
深浦 一幸
Organizer
第32回日本比較内分泌学会
Place of Presentation
日光市
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
