Roles of reward system and punishment system in insect learning

• Project/Area Number: 18370027
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Animal physiology/Animal behavior
• Research Institution: Tohoku University
• Principal Investigator: MIZUNAMI Makoto Tohoku University, 大学院・生命科学研究科, 准教授 (30174030)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥15,770,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥2,370,000); Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2007: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2006: ¥5,500,000 (Direct Cost: ¥5,500,000)
• Keywords: 学習 / 行動 / 脳 / 報酬系 / 罰系 / 昆虫 / 薬理学 / 脳・神経 / 行動学 / 条件付け / 記憶 / 生体アミン

Research Abstract

本研究では、コオロギの嗅覚および視覚学習において、ドーパミン作動性ニューロンが罰情報を伝え、オクトパミン作動性ニューロンが報酬情報を伝えるのみならず、それらのニューロンの正常な活動が、記憶の読み出しにも必須であることを薬理学的な解析により明らかにした。この現象を説明するために、新規学習モデル「水波-宇ノ木モデル」を提案し、2次条件づけを用いた行動薬理学的解析により、モデルを検証した。さらにコオロギにおいて一般に罰記憶は報酬記憶より減衰しやすいことを明らかにし、これがヒトを含む動物の記憶に共通する性質であるとの仮説を提案した。

Research Products

• [Journal Article] Why the carrot is more effective than the stick : different dynamics of punishment memory and reward memory and its possible biological basis (2009)
  • Author(s): Nakatani Y, Matsumoto Y, Mori Y, Hirashima D, Nishino H, and Arikawa K, Mizunami M
  • Journal Title: Neurobiol. Learn. Mem (In press)
  • Peer Reviewed
• [Journal Article] Functional and topographic segregation of glomeruli revealed by local staining of antennalsensory neurons in the honeybee Apis mellifera (2009)
  • Author(s): Nishino H, Nishikawa M, Mizunami M, and Yokohari F
  • Journal Title: J. Comp. Neurol 515 Pages: 161-180
  • Peer Reviewed
• [Journal Article] Systemic RNA interference for the study of learning and memory in an insect (2009)
  • Author(s): Takahashi T., Hamada A., Miyawaki K., Matsumoto Y., Mito T., Noji S. and Mizunami M
  • Journal Title: J. Neurosci. Methods 179 Pages: 9-15
  • Peer Reviewed
• [Journal Article] Systemic RNA interference for the study of learning and memory in an insect (2009)
  • Author(s): Takahashi Y., et.al.
  • Journal Title: J. Neurosci. Methods 179 Pages: 9-15
  • Peer Reviewed
• [Journal Article] Functional and topographic segregation of glomeruli revealed by local staining of antennal sensory neurons in the honeybee Apis mellifera. (2009)
  • Author(s): Nishino H., et.al.
  • Journal Title: J Comp. Neurol. 515 Pages: 161-180
  • Peer Reviewed
• [Journal Article] Salivary conditioning with antennal gustatory unconditioned stimulus in an insect (2008)
  • Author(s): Watanabe H., Sato C., Kuramochi T., Nishino H. and Mizunami M
  • Journal Title: Neurobiol. Learn. Mem 90 Pages: 245-254
  • Peer Reviewed
• [Journal Article] Salivary conditioning with antennal gustatory unconditioned stimulus in an insect (2008)
  • Author(s): Watanabe H., et.al.
  • Journal Title: Neurobiol. Learn. Mem. 90 Pages: 245-254
  • Peer Reviewed
• [Journal Article] Neural pathways for the processing of alarm pheromone in the ant brain (2007)
  • Author(s): Yamagata N., Nishino H. and Mizunami M
  • Journal Title: J.Comp.Neurol 505 Pages: 424-442
  • Peer Reviewed
• [Journal Article] Pavlov' s cockroach : classical conditioning of salivation in an insect (2007)
  • Author(s): Watanabe H. and Mizunami M
  • Journal Title: PLoS ONE 6
  • Peer Reviewed
• [Journal Article] Both circumferential and longitudinal position of sensilla on an insect antennae influence afferent terminal location in glomeruli (2007)
  • Author(s): Nishino H. and Mizunami M
  • Journal Title: NeuroReport 18 Pages: 1765-1769
  • Peer Reviewed
• [Journal Article] Pavlov's cockroach: classical conditioning of salivation in an insect. (2007)
  • Author(s): Watanabe H, & Mizunami M.
  • Journal Title: PLoS ONE 6
  • Peer Reviewed
• [Journal Article] Neural pathways for the processing of alarm pheromone in the ant brain. (2007)
  • Author(s): Yamagata N, Nishino H & Mizunami M.
  • Journal Title: J. Comp. Neurol. 505 Pages: 424-442
  • Peer Reviewed
• [Journal Article] Both circumferential and longitudinal position of sensilla on an insect antennae influence afferent terminal location in glomeruli (2007)
  • Author(s): Nishino H. & Mizunami M.
  • Journal Title: NeuroReport 18 Pages: 1765-1769
  • Peer Reviewed
• [Journal Article] 生きもののデザイン (2007)
  • Author(s): 水波誠
  • Journal Title: Inter Communication 60 Pages: 110-111
• [Journal Article] Roles of octopaminergic and dopaminergic neurons in mediating reward and punishment signals in insect visual learning (2006)
  • Author(s): Unoki S., Matsumoto Y. and Mizunami M
  • Journal Title: Eur.J.Neurosci 24 Pages: 2031-2038
  • Peer Reviewed
• [Journal Article] Olfactory memory capacity of the cricket Gryllus Bimaculatus (2006)
  • Author(s): Matsumoto Y. and Mizunami M
  • Journal Title: Biol.Letters 2 Pages: 608-610
  • Peer Reviewed
• [Journal Article] Termination profiles of insect chemosensory afferents in the antennal lobe are dependent on their origin on the flagellum (2006)
  • Author(s): Nishino H. and Mizunami M
  • Journal Title: NeuroReport 17 Pages: 1303-1307
  • Peer Reviewed
• [Journal Article] Olfactory memory capacity of the cricket Gryllus Bimaculatus (2006)
  • Author(s): Matsumoto Y., Mizunami M.
  • Journal Title: Biology Letters 2 Pages: 608-610
• [Journal Article] Roles of octopaminergic and dopaminergic neurons in mediating reward and punishment signals in insect visual learning. (2006)
  • Author(s): Unoki S., Matsumoto Y., Mizunami, M.
  • Journal Title: European Journal of Neuroscience 24 Pages: 2031-2038
• [Journal Article] Termination profiles of insect chemosensory afferents in the antennal lobe are dependent on their origin on the flagellum (2006)
  • Author(s): Nishino H., Mizunami M.
  • Journal Title: Neuroreport 17 Pages: 1303-1307
• [Presentation] Cognitive process underlying insect classical conditioning (2009)
  • Author(s): Mizunami M.
  • Organizer: The 3rd Insect Genomes Research Meeting
  • Place of Presentation: 神戸
  • Year and Date: 2009-03-12
• [Presentation] セイヨウミツバチ前大脳における内側 (2008)
  • Author(s): 山方恒宏、水波誠、Menzel Randolf
  • Organizer: 外側嗅覚介在経路終末領域での匂い符号化様式日本動物学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-09-07
• [Presentation] コオロギの「習慣形成」どれだけ訓練すれば学習行動は習慣になるのか? (2008)
  • Author(s): 羽田野愛、松本幸久、水波誠
  • Organizer: 日本動物学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-09-05
• [Presentation] ワモンゴキブリの嗅覚報酬学習におけるオクトパミン受容体阻害剤の影響 (2008)
  • Author(s): 佐藤千尋、松本幸久、水波誠
  • Organizer: 日本動物学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-09-05
• [Presentation] フタホシコオロギの匂い学習・記憶とアセチルコリン受容体 (2008)
  • Author(s): 松本幸久、郭沛源、佐藤千尋、水波誠
  • Organizer: 日本動物学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-09-05
• [Presentation] ワモンゴキブリの学習に関わるニューロンの探索 (2008)
  • Author(s): 妹尾龍樹、渡邉英博、水波誠
  • Organizer: 日本動物学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-09-05
• [Presentation] フタホシコオロギにおける感覚的事前条件付けの成立 (2008)
  • Author(s): 平島大輔、松本幸久、水波誠
  • Organizer: 日本動物学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-09-05
• [Presentation] フタホシコオロギの加齢性記憶障害 (2008)
  • Author(s): 松本幸久、水波誠
  • Organizer: 日本比較生理生化学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-07-21
• [Presentation] 昆虫の古典的条件付けにおける認知過程とそのモデル化 (2008)
  • Author(s): 水波誠、宇ノ木佐会、森康博、平島大介、羽田野愛、松本幸久
  • Place of Presentation: 札幌
  • Year and Date: 2008-07-21
• [Presentation] 昆虫の古典的条件付けにおける認知過程とそのモデル化 (2008)
  • Author(s): 水波誠、他5名
  • Organizer: 日本比較生理生化学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-07-21
• [Presentation] ゴキブリ匂い学習におけるメカミラミン感受性ケニオン細胞の役割 (2008)
  • Author(s): 渡邉英博、水波誠
  • Organizer: 日本比較生理生化学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-07-19
• [Presentation] フタホシコオロギの視覚学習長期記憶における一酸化窒素の役割 (2008)
  • Author(s): 平島大介、宇ノ木佐会、松本幸久、水波誠
  • Organizer: 日本神経科学学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] フタホシコオロギの匂い学習の加齢性記憶障害 (2008)
  • Author(s): 松本幸久、高橋俊文、佐藤千尋、水波誠
  • Organizer: 日本神経科学学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] Simple and complex learning systems in insect brain (2008)
  • Author(s): Mizunami M.
  • Organizer: Functional Anatomy of the Arthropod Central Complex and Motor Systems
  • Place of Presentation: Varginia, USA
  • Year and Date: 2008-06-28
• [Presentation] Is"cognitive" system involved in classical conditioning in insects as in mammals? (2008)
  • Author(s): Mizunami M
  • Organizer: International Seminar : Evolutionary Studies in Behavioral Neuroscience
  • Place of Presentation: Hayama, Japan
  • Year and Date: 2008-06-25
• [Presentation] Roles of mushroom body intrinsic neurons in olfactory conditioning revealed by local brain injection of mecamylamine in cockroach (2008)
  • Author(s): Watanabe H, Mizunami M
  • Organizer: International Seminar : Evolutionary Studies in Behavioral Neuroscience
  • Place of Presentation: Hayama, Japan
  • Year and Date: 2008-06-25
• [Presentation] Is "cognitive" system involved in classical conditioning in insects as in mammals (2008)
  • Author(s): Mizunami M.
  • Organizer: International Seminar : Evolutionary Studies in Behavioral Neuroscience
  • Place of Presentation: 葉山、神奈川県
  • Year and Date: 2008-06-25
• [Presentation] Roles of mushroom body intrinsic neurons in olfactory conditioning revealed by local brain injection of mecamylamine in cockroach (2008)
  • Author(s): Watanabe H, Mizunami M.
  • Organizer: International Seminar : Evolutionary Studies in Behavioral Neuroscience
  • Place of Presentation: 葉山(神奈川県)
  • Year and Date: 2008-06-25
• [Presentation] Funcational anatomy of the Arthropod Central Complex and Motor systems (2008)
  • Author(s): Mizunami M
  • Organizer: Simple and Complex learning systems in insect brain(presentation on 12th)
  • Place of Presentation: Janeria Farm, Varginia, USA
• [Presentation] ワモンゴキブリを用いた唾液分泌の古典的条件づけにおける匂いCS経路の解析 (2007)
  • Author(s): 渡邉英博、水波誠
  • Organizer: 日本動物学会
  • Place of Presentation: 弘前
  • Year and Date: 2007-09-22
• [Presentation] フタホシコオロギの嗅覚学習における転写依存性の長期記憶 (2007)
  • Author(s): 丸山彩、松本幸久、根本悠子、水波誠
  • Organizer: 日本動物学会
  • Place of Presentation: 弘前
  • Year and Date: 2007-09-22
• [Presentation] CAMKIIはフタホシコオロギの嗅覚学習の長期記憶形成に関わる (2007)
  • Author(s): 根本悠子、松本幸久、丸山彩、水波誠
  • Organizer: 日本動物学会
  • Place of Presentation: 弘前
  • Year and Date: 2007-09-22
• [Presentation] フタホシコオロギの視覚学習長期記憶形成における一酸化窒素の役割 (2007)
  • Author(s): 平島大介、宇ノ木佐会、松本幸久、水波誠
  • Organizer: 日本動物学会
  • Place of Presentation: 弘前
  • Year and Date: 2007-09-22
• [Presentation] 昆虫の学習における水波-宇ノ木モデルの2次条件づけを用いた検証 (2007)
  • Author(s): 森康博、平島大介、羽田野愛、松本幸久、水波誠
  • Organizer: 日本動物学会
  • Place of Presentation: 弘前
  • Year and Date: 2007-09-22
• [Presentation] アリ脳における警報フェロモン情報処理 (2007)
  • Author(s): 水波誠、山方恒宏
  • Organizer: 日本動物学会
  • Place of Presentation: 弘前
  • Year and Date: 2007-09-22
• [Presentation] ゴキブリにおける状況依存的な嗅覚学習訓練 (2007)
  • Author(s): 佐藤千尋、松本幸久、佐倉緑、渡邉英博、水波誠
  • Organizer: 日本神経科学学会(Neuro2007)
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-11
• [Presentation] ワモンゴキブリの長期記憶形成におけるNOの役割 (2007)
  • Author(s): 倉持友和、渡邊英博、水波誠
  • Organizer: 日本神経科学学会(Neuro2007)
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] Nitric oxide synthase ds RNAが長期記憶の形成を抑制する (2007)
  • Author(s): 高橋俊文、國遠尚代、浜田明日香、松本幸久、三戸太郎、野地澄晴、水波誠
  • Organizer: 日本神経科学学会(Neuro2007)
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] ミツバチの匂い学習の長期記憶形成に関わるシグナル分子 (2007)
  • Author(s): 松本幸久、Sandox J-C, Devaud J-M、水波誠、Giurfa M
  • Organizer: 神経科学学会(Neuro2007)
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] OAergic reward system and DAergic punishment system underlying insect visual learning (2007)
  • Author(s): Mizunami M, Unoki S, Nakatani Y, Matsumoto Y
  • Organizer: The 8th congress of the international society for Neuroethology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2007-07-24
• [Presentation] Context-dependent learning in cockroaches (2007)
  • Author(s): Sato C, Matsumoto Y, Sakura M, Watanabe H, Mizunami M
  • Organizer: The 8th congress of the international society for Neuroethology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2007-07-24
• [Presentation] Parallel coding properties of odor identity and concentration in honeybee projection neuron boutons (2007)
  • Author(s): Yamagata N, Szyszka P, Mizunami M, Menzel R
  • Organizer: The 8th congress of the international society for Neuroethology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2007-07-24
• [Presentation] 唾腺ニューロンの活動による昆虫の状況依存学習の観測 (2007)
  • Author(s): 佐藤千尋、松本幸久、渡邉英博、水波誠
  • Organizer: 日本比較生理生化学会
  • Place of Presentation: 岡山
  • Year and Date: 2007-07-06
• [Presentation] ミツバチの匂い学習の長期記憶形成に関わるシグナル伝達物質 (2007)
  • Author(s): 松本幸久、Sandox J-C, Devaud J-M、水波誠、Giurfa M
  • Organizer: 日本比較生理生化学会
  • Place of Presentation: 岡山
  • Year and Date: 2007-07-06
• [Presentation] Salivary conditioning in cockroaches (2007)
  • Author(s): Watanabe H, Mizunami M
  • Organizer: The 8th congress of the international society for Neuroethology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2007-06-27
• [Presentation] Olfactory Coding in the Honeybee Brain II. Spatio-Temporal Patterns of Odor Responses in Projection Neuron Boutons in the Mushroom Bodies of the Honeybee (2007)
  • Author(s): Yamagata N, Szyszka P, Mizunami M. and Menzel R
  • Organizer: Goettingen Neurobiology Conference
  • Place of Presentation: Goettingen, Germany
  • Year and Date: 2007-03-30
• [Book] 下澤楯夫・針山孝彦(監修)「昆虫ミメティックス~昆虫の設計に学ぶ~」 昆虫の学習を司る報酬系と罰系(分担執筆) (2008)
  • Author(s): 水波誠(編集委員および分担執筆)
  • Publisher: NTS
• [Book] 下澤楯夫・針山孝彦(監修)「昆虫ミメティックス~昆虫の設計に学ぶ~」地平線検出器としての単眼とその応用(分担執筆) (2008)
  • Author(s): 水波誠(編集委員および分担執筆)
  • Publisher: NTS
• [Book] 下澤楯夫・針山孝彦(監修)「昆虫ミメティックス~昆虫の設計に学ぶ~」小さな脳、輝く知性(監訳) (2008)
  • Author(s): 水波誠(編集委員および分担執筆)
  • Publisher: NTS
• [Book] 下澤楯夫・針山孝彦(監修)「昆虫ミメティックス~昆虫の設計に学ぶ~」キノコ体の覚え書き : 地図からモデルへ(監訳) (2008)
  • Author(s): 水波誠(編集委員および分担執筆)
  • Publisher: NTS
• [Book] 昆虫の学習能力はどれくらい?(分担執筆)、山口恒夫編、「昆虫はスーパー脳」 (2008)
  • Author(s): 水波誠
  • Publisher: 技術評論社
• [Book] 探索昆蟲微小腦、(「昆虫-驚異の微小脳」の中国語版) (2008)
  • Author(s): 水波誠
  • Publisher: 陳玉華訳、世茂出版(台湾)
• [Book] 探索昆蟲微小腦 (2008)
  • Author(s): 水波誠
  • Total Pages: 291
  • Publisher: 世茂出版(台湾)
• [Book] 昆虫はスーパー脳 (2008)
  • Author(s): 水波誠(分担執筆)
  • Total Pages: 27
  • Publisher: 技術評論社
• [Book] 昆虫ミメテイックス (2008)
  • Author(s): 水波誠(分担執筆)
  • Total Pages: 24
  • Publisher: NTS
• [Book] 昆虫の微小脳 : 脳進化の1つの頂点(分担執筆)、小泉修・阿形清和編、「神経系の多様性 : その起源と進化」 (2007)
  • Author(s): 水波誠
  • Publisher: 培風館
• [Book] 神経系の多様性:その起源と進化 (2007)
  • Author(s): 山口恒夫編(水波誠他共著)
  • Publisher: 培風館
• [Book] 昆虫-驚異の微小脳 (2006)
  • Author(s): 水波誠
  • Total Pages: 291
  • Publisher: 中央公論新社(中公新書)
• [Book] 昆虫の学習と記憶の生物学(分担執筆)、曽我部正博編、「動物は何を考えているのか? : 学習と記憶の比較生物学」
  • Author(s): 水波誠
  • Publisher: 共立出版(印刷中)
• [Remarks]
  • URL: http://www.biology.tohoku.ac.jp/lab-www/microbrain/
• [Remarks]
  • URL: http://www.biology.tohoku.ac.jp/lab-www/microbrain/