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Mechanism of Biogenesis and Catalytic Function of Peptidyl Built-in Quinone Cofactors

Research Project

Project/Area Number 18370043
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Structural biochemistry
Research InstitutionOsaka University

Principal Investigator

TANIZAWA Katsuyuki  Osaka University, 産業科学研究所, 教授 (20133134)

Co-Investigator(Kenkyū-buntansha) OKAJIMA Toshihide  大阪大学, 産業科学研究所, 准教授 (10247968)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥17,390,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2006: ¥9,200,000 (Direct Cost: ¥9,200,000)
Keywords銅アミン酸化酵素 / トパキノン / ビルトイン型キノン補酵素 / キノヘムプロテイン / 分子内チオエーテル架橋 / 翻訳後修飾 / X線結晶解析 / 酵素触媒機構 / 分子内チオエ-テル架橋 / 酵素解媒機構 / ラジカル・SAMタンパク質
Research Abstract

Peptidyl built-in cofactors are produced by posttranslational modification of the cognate enzyme proteins, unlike ordinary cofactors which are mostly bio-synthesized from water soluble vitamins. In this study, we focused on two built-in quinone cofactor-containing enzymes, copper amine oxidase and quinohemoprotein amine dehydrogenase (QHNDH) that contain topa quinone (TPQ) and cysteine tryptophyl quinone (CTQ), respectively. For the reaction mechanism of copper amine oxidase, it has been demonstrated that the former reductive half-reaction is accompanied with the conformational change of TPQ. On the other hand, two proteins encoded close to the QHNDH genes, an [Fe-S]-cluster and S-adenosylmethionine-binding protein and a subtilisin-like protease, have been found to play essential roles for QHNDH biogenesis.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (60 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (20 results) (of which Peer Reviewed: 11 results) Presentation (27 results) Book (4 results) Remarks (9 results)

  • [Journal Article] 分子内架橋構造をもちトリプトファン残基に由来するキノン補酵素の生合成機構2009

    • Author(s)
      岡島俊英, 谷澤克行
    • Journal Title

      化学と生物 47

      Pages: 522-524

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Journal Article]2009

    • Author(s)
      Suzuki, S., Okajima, T., Tanizawa, K., Mure, M.(共蓍)
    • Journal Title

      Copper Amine Oxidases : Structures, Catalytic Mechanisms, and Role in Pathophysiology Cofactors of Amine Oxidases : Copper Ion and Its Substitution and the 2, 4, 5-Trihydoxylphenylalanine Quinone(Chapter3)(CRC Press, Taylor & francis Group)

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      Toshihide Okajima, Katsuyuki Tanizawa(共蓍)
    • Journal Title

      Copper amine Oxidases : Structures, Catalytic Mechanisms, and Role in Physiopathology Mechanism of TPQ Biogenesis in Prokaryotic Copper Amine Oxidase(Chapter8)(CRC Press, Taylor & francis Group)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Further Insight into the Mechanism of Stereoselective Proton Abstraction by Bacterial Copper Amine Oxidase.2008

    • Author(s)
      Taki, M., Murakawa, T., Nakamoto, T., Uchida, M., Hayashi, H., Tanizawa, K., Yamamoto, Y., Okajima, T.
    • Journal Title

      Biochemistry 47

      Pages: 7726-7733

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Further Insight into the Mechanism of Stereoselective Proton Abstraction by Bacterial Copper Amine Oxidase2008

    • Author(s)
      Taki, M., Murakawa, T., Nakamoto, T., Uchida, M., Hayashi, H., Tanizawa, K., Yamamoto, Y., Okajima, T.
    • Journal Title

      Biochemistry 47

      Pages: 7726-7733

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Further Insight into the Mechanism of Stereoselective Proton Abstraction by Bacterial Copper Amine Oxidase.2008

    • Author(s)
      Taki, M., Murakawa, T., Nakamoto, T., Uchida, M., Hayashi, H., Tanizawa, K., Yamamoto, Y., Okajima, T.
    • Journal Title

      Biochemistry 47(29)

      Pages: 7726-7733

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trapping of a Dopaquinone Intermediate in the TPQ Cofactor Biogenesis in a Copper-containing Amine Oxidase from Arthrobacter globiformis.2007

    • Author(s)
      Moore, R.H., Spies, M.A., Culpepper, M.B., Murakawa, T., Hirota, S., Okajima, T., Tanizawa K., Mure, M.
    • Journal Title

      J. Am. Chem. Soc. 129

      Pages: 11524-11534

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trapping of a Dopaquinone Intermediate in the TPQ Cofactor Biogenesis in a Copper-containing Amine Oxidase from Arthrobacter globiformis2007

    • Author(s)
      Moore, R. H., Spies, M. A., Culpepper, M. B., Murakawa, T., Hirota, S., Okajima, T., Tanizawa K., Mure, M.
    • Journal Title

      J. Am. Chem. Soc. 129

      Pages: 11524-11534

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Trapping of a Dopaquinone Intermediate in the TPQ Cofactor Biogenesis in a Copper-containing Amine Oxidase from Arthrobacter globiformis.2007

    • Author(s)
      Moore, R. H., Spies, M. A., Culpepper, M.B., Murakawa, T., Hirota, S., Okajima, T., Tanizawa K., and Mure M.
    • Journal Title

      J. Am, Chem. Soc. 129

      Pages: 11524-11534

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] nvolvement of a Putative [Fe-S]-Cluster-Binding Protein in the Biogenesis of Quinohemoprotein Amine Dehydrogenase.2006

    • Author(s)
      Ono, K., Okajima, T., Tani, M., Kuroda, S., Sun, D., Davidson, V.L., Tanizawa, K.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 13672-13684

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kinetic and Structural Studies on the Catalytic Role of the Aspartic Acid Residue Conserved in Copper Amine Oxidase.2006

    • Author(s)
      Chiu, Y.-C., Okajima, T., Murakawa, T., Uchida, M., Taki, M., Hirota, S., Kim, M., Hayashi, H., Yamamoto, Y., Tanizawa, K.
    • Journal Title

      Biochemistry 45

      Pages: 4105-4120

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantum Mechanical Hydrogen Tunneling in Bacterial Copper Amine Oxidase Reaction. Biochem.2006

    • Author(s)
      Murakawa, T., Okajima, T., Kuroda, S., Nakamoto, T., Taki, M., Yamamoto, Y., Hayashi, H., Tanizawa, K.
    • Journal Title

      Biophys. Res. Commun. 342

      Pages: 414-423

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新しいビルトイン型キノン補酵素CTQと分子内チオエーテル架橋構造-その特異な構造形成機構の解明に向けて-.2006

    • Author(s)
      谷澤克行
    • Journal Title

      酵素工学ニュース 56

      Pages: 5-9

    • Related Report
      2009 Final Research Report
  • [Journal Article] X線結晶解析と反応速度論的解析に基づく銅アミン酸化酵素の触媒機構.2006

    • Author(s)
      岡島俊英, 谷澤克行
    • Journal Title

      日本応用酵素協会誌 41

      Pages: 1-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] Involvement of a Putative [Fe-S]-Cluster-Binding Protein in the Biogenesis of Quinohemoprotein Amine Dehydrogenase2006

    • Author(s)
      Ono, K., Okajima, T., Tani, M., Kuroda, S., Sun, D., Davidson, V.L., Tanizawa, K.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 13672-13684

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Kinetic and Structural Studies on the Catalytic Role of the Aspartic Acid Residue Conserved in Copper Amine Oxidase2006

    • Author(s)
      Chiu, Y.-C., Okajima, T., Murakawa, T., Uchida, M., Taki, M., Hirota, S., Kim, M., Hayashi, H., Yamamoto, Y., Tanizawa, K.
    • Journal Title

      Biochemistry 45

      Pages: 4105-4120

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Involvement of a Putative [Fe-S]-Cluster-Binding Protein in the Biogenesis of Quinohemoprotein Amine Dehydrogenase.2006

    • Author(s)
      Kazutoshi Ono, Toshihide Okajima, Minobu Tani, Shun'ichi Kuroda, Dapeng Sun, Victor L. Davidson, Katsuyuki Tanizawa
    • Journal Title

      J. Biol. Chem. 281・19

      Pages: 13672-13684

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Kinetic and Structural Studies on the Catalytic Role of the Aspartic Acid Residue Conserved in Copper Amine Oxidase2006

    • Author(s)
      Yen-Chen Chiu, Toshihide Okajima, Takeshi Murakawa, Mayumi Uchida, Masayasu Taki, Shun Hirota, Misa Kim, Hiroshi Yamaguchi, Yoshiaki Kawano, Nobuo Kamiya, Shun'ichi Kuroda, Hideyuki Hayashi, Yukio Yamamoto, Katsuyuki Tanizawa
    • Journal Title

      Biochemistry 45・13

      Pages: 4105-4120

    • Related Report
      2006 Annual Research Report
  • [Journal Article] X線結晶解析と反応速度論的解析に基づく銅アミン酸化酵素の触媒機構2006

    • Author(s)
      岡島俊英, 谷澤克行
    • Journal Title

      日本応用酵素協会誌 41

      Pages: 1-7

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 新しいビルトイン型キノン補酵素CTQと分子内チオエーテル架橋構造-その特異な構造形成機構の解明に向けて-2006

    • Author(s)
      谷澤克行
    • Journal Title

      酵素工学ニュース 56

      Pages: 5-9

    • Related Report
      2006 Annual Research Report
  • [Presentation] ビルトイン型キノン補酵素の生合成システム2010

    • Author(s)
      谷澤克行
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学駒場キャンパス(東京都)
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Reductive Half-reactipn of Bacterial Copper Amine Oxidase is Controlled by the Conformational Change of the Topaquinone Cofactor2010

    • Author(s)
      Toshihide OKAJIMA, Katsuyuki TANIZAWA
    • Organizer
      International Symposium of Joint Research Network on Advanced Materials and Devices
    • Place of Presentation
      ホテルニドム(苫小牧市)
    • Year and Date
      2010-03-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Reductive Half-reaction of Bacterial Copper Amine Oxidase is Controlled by the Conformational Change of the Topaquinone Cofactor2010

    • Author(s)
      Toshihide Okajima, Akio Hamaguchi, Tadashi Nakai, Katsuyuki Tanizawa
    • Organizer
      物質・デバイス領域ネットワーク型共同研究拠点発足記念シンポジウム
    • Place of Presentation
      阪大コンベンションセンター(吹田市)
    • Year and Date
      2010-03-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] X-ray Crystallographic Evidence for Conformational Change of Topaquinone in the Reductive Half-reaction of Bacterial Copper Amine Oxidase2010

    • Author(s)
      Toshihide Okajima, Akio Hamaguchi, Tadashi Nakai, Katsuyuki Tanizawa
    • Organizer
      The 13th SANKEN International Symposium 2009/the 8th SANKEN Nanotechnology Symposium/the 3rd SANKENMSTEC Symposium/the 2nd SANKEN Alliance Symposium
    • Place of Presentation
      関西空港国際会議場(泉佐野市)
    • Year and Date
      2010-01-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] X-ray Crystallographic Evidence for Conformational Change of Topaquinone in the Reductive Half-reaction of Copper Amine Oxidase from Arthrobacter globiformis, Gordon Research Conference on Protein Cofactors2010

    • Author(s)
      Hamaguchi, A., Okajima, T., Nakai, T. Tanizawa, K., Murakawa, T., Hayashi, H.
    • Organizer
      Radicals and Quinones
    • Place of Presentation
      Ventura, CA, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Acid-Base Chemistry in the Reductive Half-Reaction of Copper Amine Oxidase from Arthrobacter globiformis2010

    • Author(s)
      Murakawa, T., Hayashi, H., Okajima, T., Tanizawa, K.
    • Organizer
      Gordon Research Conference on Protein Cofactors, Radicals and Quinones
    • Place of Presentation
      Ventura, CA, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Acid-Base Chemistry in the Reductive Half-Reaction of Copper Amine Oxidase from Arthrobacter globiformis2010

    • Author(s)
      Murakawa, T., Hayashi, H., Okajima, T., Tanizawa, K.
    • Organizer
      Gordon Research Conference on 'Protein Cofactors, Radicals and Quinones'
    • Place of Presentation
      Four Points Sheraton/Holiday Inn Express, Ventura, CA, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] X-ray Crystallographic Evidence for Conformational Change of Topaquinone in the Reductive Half-reaction of Copper Amine Oxidase from Arthrobacter globiformis2010

    • Author(s)
      Hamaguchi, A., Okajima, T., Nakai, T., Tanizawa, K., Murakawa, T., Hayashi, H.
    • Organizer
      Gordon Research Conference on 'Protein Cofactors, Radicals and Quinones'
    • Place of Presentation
      Four Points Sheraton/Holiday Inn Express, Ventura, CA, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 時間分割X線結晶構造解析による銅・トパキノン含有アミン酸化酵素反応機構の構造学的研究2009

    • Author(s)
      片岡未有, 冨永鮎子, 大津雅之, 岡島俊英, 谷澤克行, 山口宏
    • Organizer
      第47回日本生物物理学会年会
    • Place of Presentation
      アスティ徳島(徳島市)
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 速度論および構造解析に基づく酵素触媒反応におけるプロトントンネリング機構の解析2009

    • Author(s)
      村川武志, 岡島俊英, 谷澤克行, 林秀行
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 銅アミン酸化酵素反応トパセミキノンラジカル中間体を経由して進行する2009

    • Author(s)
      濱口章央, 岡島俊英, 村川武志, 林秀行, 谷澤克行
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 銅・トパキノン含有アミン酸化酵素における触媒反応機構の構造学的研究2009

    • Author(s)
      片岡未有, 冨永鮎子, 大津雅之, 岡島俊英, 谷澤克行, 山口宏
    • Organizer
      第9回日本蛋白質科学会年会
    • Place of Presentation
      熊本全日空ホテルニュースカイ(熊本市)
    • Year and Date
      2009-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Conformational Flexibility of the TPQ Cofactor in Bacterial Copper Amine Oxidase2009

    • Author(s)
      Toshihide Okajima, Shota Nakanishi, Katsuyuki Tanizawa
    • Organizer
      第12回産研/第7回ナノテクセンター/第2回MSTeC/第1回アライアンス国際シンポジウム
    • Place of Presentation
      大阪大学コンベンションセンター
    • Year and Date
      2009-01-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 銅含有アミン酸化酵素のトパキノン補酵素生成におけるコンセンサス配列中のアスパラギン残基の役割2008

    • Author(s)
      元山暁仁、中西将太、黒田俊一、岡島俊英、谷澤克行
    • Organizer
      第31回日本分子生物学会年会/第81回日本生化学会大会合同大会(BMB2008)
    • Place of Presentation
      神戸国際会議場・神戸国際展示場(兵庫県)
    • Related Report
      2009 Final Research Report
  • [Presentation] Involvement of an Iron Sulfur Protein and a Subtilisin-like Protease in the Biogenesis of Quinohemoprotein Amine Dehydrogenase2008

    • Author(s)
      Okajima, T., Ono, K., Tanizawa, K.
    • Organizer
      Japan-Holland Joint Seminar on New Aspects in Enzyme Science and Biotechnology
    • Place of Presentation
      九州大学西新プラザホール(福岡県)
    • Related Report
      2009 Final Research Report
  • [Presentation] Conformational Flexibility of the TPQ Cofactor in Bacterial Copper Amine Oxidase, Gordon Research Conference on Protein Cofactors2008

    • Author(s)
      Okajima, T., Nakanishi, S., Murakawa, T., Hayashi, H., Tanizawa, K.
    • Organizer
      Radicals and Quinones
    • Place of Presentation
      Ventura, CA, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Involvement of an Iron Sulfur Protein and a Subtilisin-like Protease in the Biogenesis of Quinohemoprotein Amine Dehydrogenase2008

    • Author(s)
      Okajima, T., Ono, K., Tanizawa, K.
    • Organizer
      Japan-Holland Joint Seminar on New Aspects in Enzyme Science and Biotechnology
    • Place of Presentation
      九州大学 西新プラザホール(福岡市)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 銅含有アミン酸化酵素のトパキノン補酵素生成におけるコンセンサス配列中のアスパラギン残基の役割2008

    • Author(s)
      元山暁仁, 中西将太, 黒田俊一, 岡島俊英, 谷澤克行
    • Organizer
      第31回日本分子生物学会年会/第81回日本生化学会大会合同大会(BMB2008)
    • Place of Presentation
      神戸国際会議場・神戸国際展示場
    • Related Report
      2008 Annual Research Report
  • [Presentation] 速度論および構造解析に基づく酵素触媒反応におけるプロトントンネリング機構の解析2008

    • Author(s)
      村川武志, 岡島俊英, 谷澤克行, 林秀行
    • Organizer
      第31回日本分子生物学会年会/第81回日本生化学会大会合同大会(BMB2008)
    • Place of Presentation
      神戸国際会議場・神戸国際展示場
    • Related Report
      2008 Annual Research Report
  • [Presentation] キノヘムプロテイン・アミン脱水素酵素の補酵素生合成におけるαサブユニットに結合したヘムの役割2008

    • Author(s)
      米倉弘倫, 岡島俊英, 小野和利, 黒田俊一, 谷澤克行
    • Organizer
      第31回日本分子生物学会年会/第81回日本生化学会大会合同大会(BMB2008)
    • Place of Presentation
      神戸国際会議場・神戸国際展示場
    • Related Report
      2008 Annual Research Report
  • [Presentation] Conformational Flexibility of the TPQ Cofactor in Bacterial Copper Amine Oxidase2008

    • Author(s)
      岡島俊英、中西将太、村川武志、林秀行、谷澤克行
    • Organizer
      Gordon Research Conference on Protein Derived Cofactors, Radicals and Quinones
    • Place of Presentation
      Ventura, California, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] A Subtilisin-like Protease Essential fbr the Biogenesis of Quinohemoprotein Amine Dehydrogenase2008

    • Author(s)
      岡島俊英、小野和利、長見篤、新山真由美、谷澤克行
    • Organizer
      Gordon Research Conference on Protein Derived Cofactors, Radicals and Quinones
    • Place of Presentation
      Ventura, California, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Involvement of a Putative Subtilisin-like Protease in the Biogenesis of Quinohemoprotein Amine Dehydrogenase2007

    • Author(s)
      小野和利、岡島俊英、黒田俊一、谷澤克行
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 銅含有アミン酸化酵素の触媒機構における保存性Asn残基の役割2007

    • Author(s)
      中西将太、岡島俊英、村川武志、林秀行、黒田俊一、谷澤克行
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] キノヘムプロテイン・アミン脱水素酵素のγ-サブユニットの構造形成機構2007

    • Author(s)
      新山真由美、小野和利、長見篤、黒田俊一、岡島俊英、谷澤克行
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] キノヘムプロテイン・アミン脱水素酵素の分子内チオエーテル架橋の形成機構と構造的役割2007

    • Author(s)
      長見篤、小野和利、新山真由美、黒田俊一、岡島俊英、谷澤克行
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Structural Basis for Stereospecific Proton Abstraction of Bacterial Copper Amine Oxidase2007

    • Author(s)
      岡島俊英、村川武志、邱彦成、多喜正泰、山本行男、林秀行、谷澤克行
    • Organizer
      2nd International Symposium on Diffraction Structural Biology 2007
    • Place of Presentation
      タワーホール船堀、東京都
    • Related Report
      2007 Annual Research Report
  • [Book] Cofactors of Amine Oxidases: Copper Ion and Its Substitution and the 2, 4, 5-Trihydoxylphenylalanine Quinone (Chapter 3). In'Copper Amine Oxidases: Structures, Catalytic Mechanisms, and Role in Pathophysiology'(Taylor & Francis Group)2009

    • Author(s)
      Suzuki, S., Okajima, T., Tanizawa, K., Mure, M.
    • Publisher
      CRC Press
    • Related Report
      2009 Final Research Report
  • [Book] Mechanism of TPQ Biogenesis in Prokaryotic Copper Amine Oxidase (Chapter 8). In'Copper Amine Oxidases: Structures, Catalytic Mechanisms, and Role in Pathophysiology'(Taylor & Francis Group)2009

    • Author(s)
      Okajima, T., Tanizawa, K.
    • Publisher
      CRC Press
    • Related Report
      2009 Final Research Report
  • [Book] LLC. Copper amine Oxidases : Structure, Catalytic Mechanism and Role in Physiopathology2009

    • Author(s)
      Okajima, T. & Tanizawa, K.
    • Publisher
      Taylor & Francis Group(印刷中)
    • Related Report
      2008 Self-evaluation Report
  • [Book] Copper amine Oxidases : Structure, Catalytic Mechanism and Role in Physiopathology2009

    • Author(s)
      Toshihide Okajima, Katsuyuki Tanizawa (共著)
    • Publisher
      Taylor & Francis Group, LLC
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/smb/project.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/smb/AGAO.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/smb/QHNDH.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/smb/tpq2.htm

    • Related Report
      2008 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/smb/new_page_9.htm

    • Related Report
      2008 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/smb/tpq2.htm

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/smb/new_page_9.htm

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/smb/tpq2.htm

    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/smb/new_page_9.htm

    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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