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Structure-function correlation of disease-related functional RNA

Research Project

Project/Area Number 18370046
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Structural biochemistry
Research InstitutionYokohama City University

Principal Investigator

KATAHIRA Masato  Yokohama City University, International Graduate School of Arts and Sciences, Professor (70211844)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥15,320,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2006: ¥9,600,000 (Direct Cost: ¥9,600,000)
Keywordsmulti-drug resistance / anti-cancer dru / aptamer / Rev / 4'-thioDNA / Vault / C型肝炎 / 構造 / IRES / 薬剤耐性 / NMR / RNA
Research Abstract

Vault particle is related to multi-drug resistance. We found that RNA component of the vault (vault RNA)binds to anti-cancer drug, mitoxantrone. On the basis of chemical shift perturbation with NMR, we found that vault RNA binds to several other anti-cancer drugs. The binding site for drugs was also identified. By blocking the binding site with its complementary oligonucleotide, the trap of drugs by vault. RNA may be suppressed, which could lead to the overcome of the multi-drug resistance.
The aptamer composed of RNA containing the Rev-responsive element and the Rev peptide was developed by our collaborator, Professor Morii of Kyoto University. We analyzed the structure of this aptamer in complex with its ligand. The formation of new hydrogen bonds was observed for RNA upon the binding of the Rev peptide and the ligand, respectively. The secondary structure of RNA was deduced. The structure determination of the aptamer is in progress.
It was reported that DNA composed of the 4'-thiodeoxyriboses, 4'-thioDNA, exhibits remarkable features. Particularly, 4'-thioDNA is resistant to cleavage by DNase I. We determined the structure of 4'-thioDNA by NMR. DNA usually takes on B-form. 4'-thioDNA, however, takes on A-form which is the form for RNA. DNase I binds to DNA through the interaction at the narrow and relatively deep minor groove of the B-form. The minor groove of 4'-thioDNA is wide and shallow, which is characteristic to A-form, and is not suitable for the binding of DNase I. The other remarkable features of 4'-thioDNA were also interpreted on the basis of the determined structure.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (75 results)

All 2008 2007 2006

All Journal Article (35 results) (of which Peer Reviewed: 16 results) Presentation (33 results) Book (7 results)

  • [Journal Article] Unexpected A-form formation of 4'-thioDNA insolution,revealed by NMR,and the implications as to the mechanism of nuclease-resistance2008

    • Author(s)
      Matsugami, A., Ohyama, T., Inada, M., moue, N., Minakawa, N., Matsuda, A., Katahira, M.
    • Journal Title

      Nucleic Acids Res 36

      Pages: 1805-1812

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Unexpected A-form formation of 4'-thioDNA in solution, revealed by NMR, and the implications as to the mechanism of nuclease-resistance2008

    • Author(s)
      Matsugami, A., Ohyama, T., Inada, M., Inoue, N., Minakawa, N., Matsuda, A., Katahira, M
    • Journal Title

      Nucleic Acids Res 36

      Pages: 1805-1812

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Unexpected A-form formation of 4'-thioDNA in solution, revealed by NMR, and the implications as to the mechanism of nuclease-resistance2008

    • Author(s)
      Matsugami, A., Ohyama, T., Inada, M., Inoue, N., Minakawa, N., Matsuda, A., Katahira, M.
    • Journal Title

      Nucleic Acids Res. 36

      Pages: 1805-1812

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of human telomeric DNA under physiological ionic conditions stabilized by proper incorporation of 8-bromoguanosines,as deternuned by NMR2007

    • Author(s)
      Matsugami, M., Xu, Y., Noguchi, Y., Sugiyama, H. and Katahira, M.
    • Journal Title

      FEBS J. 274

      Pages: 3545-3556

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Structural analysis of the fundamental polymer of the sheath constructed by Sphaerotilus natans2007

    • Author(s)
      Takeda., M., Miyanoiri, Y., Nogami, T., Oda, K., Saito, T., Kato, K., Koizumi, J.I., Katahira, M.
    • Journal Title

      Biosci.Biotechnol.Biochem 71

      Pages: 2992-2998

    • NAID

      10027522051

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Interactions with RNA/DNA of proteins involved in the regulation of transcription,translation and telomere elongation2007

    • Author(s)
      Ohyama, T., Furukawa, A., Miyoshi, T., Takada, Y., OhgaraS., Hiratsuka, K., Ixnai, T., Okano, H., Nakagama, H., Nagata, T. and Katahira, M.
    • Journal Title

      Nucleic Acids Symp.Ser No.51

      Pages: 77-78

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Structure of 4'-thioDNA which exhibits endonuclease resistance2007

    • Author(s)
      Matsugami A., Ohyama, T., Inada, M., moue, N., Minakawa, N., Matsuda, A. and Katahira, M.
    • Journal Title

      Nucleic Acids Symp.Ser No.51

      Pages: 141-142

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Structure of human telomeric DNA under physiological ionic conditions stabilized by proper incorporation of 8-bromoguanosines, as determined by NMR2007

    • Author(s)
      Matsugami, M., Xu, Y., Noguchi, Y., Sugiyama, H., Katahira, M
    • Journal Title

      FEBS J 274

      Pages: 3545-3556

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Structural analysis of the fundamental polymer of the sheath constructed by Sphaerotilus natans2007

    • Author(s)
      Takeda, M., Miyanoiri, Y., Nogami, T., Oda, K., Saito, T., Kato, K., Koizumi, J. I., Katahira, M
    • Journal Title

      Biosci. Biotechnol. Biochem 71

      Pages: 2992-2998

    • NAID

      10027522051

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interactions with RNA/DNA of proteins involved in the regulation of transcription, translation and telomere elongation2007

    • Author(s)
      Ohyama, T., Furukawa, A., Miyoshi, T., Takada, Y., Ohgara, S., Hiratsuka, K., Imai, T., Okano, H., Nakagama, H., Nagata, T., Katahira, M
    • Journal Title

      Nucleic Acids Symp. Ser 51

      Pages: 77-78

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Structure of 4'-thioDNA which exhibits endonuclease resistance2007

    • Author(s)
      Matsugami, A., Ohyama, T., Inada, M., Inoue, N., Minakawa, N., Matsuda, A., Katahira, M
    • Journal Title

      Nucleic Acids Symp. Ser 51

      Pages: 141-142

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Structure of human telomeric DNA under physiological ionic conditions stabilized by proper incorporation of 8-bromoguanosines, as determined by NMR2007

    • Author(s)
      Matsugami, M., Xu, Y., Noguchi, Y., Sugiyama, H. and Katahira, M.
    • Journal Title

      FEBS J. 274

      Pages: 3545-3556

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural analysis of the fundamental polymer of the sheath constructed by Sphaerotilus natans2007

    • Author(s)
      Takeda, M., Miyanoiri, Y., Nogami, T., Oda, K., Saito, T., Kato, K., Koizumi, J. I., Katahira, M.
    • Journal Title

      Biosci. Biotechnol. Biochem. 71

      Pages: 2992-2998

    • NAID

      10027522051

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interactions with RNA/DNA of proteins involved in the regulation of transcription, translation and telomere elongation2007

    • Author(s)
      Ohyama, T., Furukawa, A., Miyoshi, T., Takada, Y., Ohgara, S., Hiratsuka, K., Imai, T., Okano, H., Nakagama, H., Nagata, T. and Katahira, M.
    • Journal Title

      Nucleic Acids Symp. Ser. 51

      Pages: 77-78

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of 4'-thioDNA which exhibits endonuclease resistance2007

    • Author(s)
      Matsugami A., Ohyama, T., Inada, M., Inoue, N., Minakawa, N., Matsuda, A. and Katahira, M.
    • Journal Title

      Nucleic Acids Symp. Ser. 51

      Pages: 141-142

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of human telomeric DNA under physiological ionic conditions stabilized by proper incorporation of 8-bromoguanosines,as determined by NMR2007

    • Author(s)
      Matsugami, M他
    • Journal Title

      FEBS J 印刷中

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular mechanism for maintenance of G-rich short tandem repeats capable of adopting G4 DNA structures2006

    • Author(s)
      Nakagama, H., Higuchi, K., Tanaka, E., Tsuchiya, N., Nakashima, K., Katahira, M. and Fukuda, H.
    • Journal Title

      Mutat.Res 598

      Pages: 120-131

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Structural property of DNA that migrates faster in gelelectrophoresis,as deduced by CD spectroscopy2006

    • Author(s)
      Matsugami, A., Tani, K., Ouhashi, K., Uesugi, S., Morita, M., Ohyama, T. and Katahira M.
    • Journal Title

      Nucleosides, Nucleotides and Nucleic Acids 25

      Pages: 417-425

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of 2-(cysteinyl)amido-2-deoxy-D-galacturonic acidresidue from the sheath of Leptothrix cholodnii2006

    • Author(s)
      Makita, H., Nakahara, Y., Fukui, H., Miyanoiri, Y., Katahira, M., Seki, H., Takeda, M.and Koizumi, J.
    • Journal Title

      Biosci.Biotech.& Biochem 70

      Pages: 1265-1268

    • NAID

      10018531700

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Unichrom,a novel nuclear matrix protein,binds to the Ars insulator and canonical MARs2006

    • Author(s)
      Tagashira, H., Shimotori, T., Sakamoto, N., Katahira, M., Miyanoiri, Y., Yamamoto, T., Mitsunaga-Nakatsubo K., Kusunoki, S.and Akasaka, K.
    • Journal Title

      Zoological Science 23

      Pages: 9-21

    • NAID

      110004775619

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Structural analysis of DNA containing(6-4)photoproduct in complex with distamycin A by NMR2006

    • Author(s)
      Tsuchibayashi, H., Ohyama, T., Matsugami, A., Nanjo, T., Iwai, S. and Katahira, M.
    • Journal Title

      Nucleic Acids Symp.Ser No.50

      Pages: 237-238

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The new models of the human telomere DNA in K^+ solution revealed by NMR analysis assisted by the incorporation of 8-bromoguanines2006

    • Author(s)
      Matsugami, A., Tsuchibayashi, H., Xu, Y., Noguchi, Y., Sugiyama, H. and Katahira, M.
    • Journal Title

      Nucleic Acids Symp.Ser No.50

      Pages: 42-43

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Molecular mechanism for maintenance of G-rich short tandem repeats capable of adopting G4 DNA structures2006

    • Author(s)
      Nakagama, H., Higuchi, K., Tanaka, E., Tsuchiya, N., Nakashima, K., Katahira, M., Fukuda, H
    • Journal Title

      Mutat. Res 598

      Pages: 120-131

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Structural property of DNA that migrates faster in gel electrophoresis, as deduced by CD spectroscopy2006

    • Author(s)
      Matsugami, A., Tani, K., Ouhashi, K., Uesugi, S., Morita, M., Ohyama, T., Katahira, M
    • Journal Title

      Nucleosides, Nucleotides and Nucleic Acids 25

      Pages: 417-425

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of 2-(cysteinyl)amido-2-deoxy-D-galacturonic acid residue from the sheath of Leptothrix cholodnii2006

    • Author(s)
      Makita, H., Nakahara, Y., Fukui, H., Miyanoiri, Y., Katahira, M., Seki, H., Takeda, M., Koizumi, J
    • Journal Title

      Biosci. Biotech. & Biochem 70

      Pages: 1265-1268

    • NAID

      10018531700

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Unichrom, a novel nuclear matrix protein, binds to the Ars insulator and canonical MARs2006

    • Author(s)
      Tagashira, H., Shimotori, T., Sakamoto, N., Katahira, M., Miyanoiri, Y., Yamamoto, T., Mitsunaga-Nakatsubo K., Kusunoki, S., Akasaka, K
    • Journal Title

      Zoological Science 23

      Pages: 9-21

    • NAID

      110004775619

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Structural analysis of DNA containing (6-4) photoproduct in complex with distamycin A by NMR2006

    • Author(s)
      Tsuchibayashi, H., Ohyama, T., Matsugami, A., Nanjo, T., Iwai, S., Katahira, M
    • Journal Title

      Nucleic Acids Symp. Ser 50

      Pages: 237-238

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The new models of the human telomere DNA in K+ solution revealed by NMR analysis assisted by the incorporation of 8-bromoguanines2006

    • Author(s)
      Matsugami, A., Tsuchibayashi, H., Xu, Y., Noguchi, Y., Sugiyama, H., Katahira, M
    • Journal Title

      Nucleic Acids Symp. Ser 50

      Pages: 42-43

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Unichrom, a novel nuclear matrix protein, binds to the Ars insulator and canonical MARs2006

    • Author(s)
      Tagashira, H他
    • Journal Title

      Zoological Science 23

      Pages: 9-21

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structural property of DNA that migrates faster in gel electrophoresis,as deduced by CD spectroscopy2006

    • Author(s)
      Matsugami, A他
    • Journal Title

      Nucleosides,Nucleotides and Nucleic Acids 25

      Pages: 417-425

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of 2-(cysteinyl)amido-2-deoxy-D-galacturonic acid residue from the sheath of Leptothrix cholodnii2006

    • Author(s)
      Makita, H他
    • Journal Title

      Biosci.Biotech. & Biochem 70

      Pages: 1265-1268

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular mechanism for maintenance of G-rich short tandem repeats capable of adopting G4 DNA structures2006

    • Author(s)
      Nakagama, H他
    • Journal Title

      Mutat.Res 598

      Pages: 120-131

    • Related Report
      2006 Annual Research Report
  • [Journal Article] NMRによるタンパク質構造解析の展望2006

    • Author(s)
      宮ノ入洋平他
    • Journal Title

      酵素工学ニュース 55

      Pages: 29-34

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structural analysis of DNA containing (6-4) photoproduct in complex with distamycin A by NMR2006

    • Author(s)
      Tsuchibayashi, H他
    • Journal Title

      Nucleic Acids Symp. Ser. 50

      Pages: 237-238

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The new models of the human telomere DNA in K^+ solution revealed by NMR analysis assisted by the incorporation of 8-bromoguanines2006

    • Author(s)
      Matsugami, A他
    • Journal Title

      Nucleic Acids Symp. Ser 50

      Pages: 42-43

    • Related Report
      2006 Annual Research Report
  • [Presentation] Structures and interactions of 4'-thioDNA and RNA/DNA-binding proteins2008

    • Author(s)
      Ohyama, T., Furukawa, A., Takada, Y., Ono, A., Matsugami, A., Mashima, T., Nagata, T.and Katahira, M.
    • Organizer
      XXIII International Conference on Magnetic Resonance in Biological Systems
    • Place of Presentation
      アメリカ
    • Year and Date
      2008-08-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structure determination of amulti-domain protein by the use of PRE and RDC,and the unexpected A-form structure of 4'-thioDNA exhibiting nuclease-resistance2008

    • Author(s)
      Ohyama, T., Furukawa, A., Matsugami, A., Mashima, T., Nagata, T. and Katahira, M.
    • Organizer
      Korea-Japan Symposiumon Biological NMR
    • Place of Presentation
      韓国
    • Year and Date
      2008-04-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Attempt to construct the ion channel composed of nucleic acids2008

    • Author(s)
      Miyoshi, T., Matsugami, A., Nomura, S., Akiyoshi, K.and Katahira M.
    • Organizer
      International Conference on Membrane Interface
    • Place of Presentation
      博多
    • Year and Date
      2008-01-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structure determination of a multi-domain protein by the use of PRE and RDC, and the unexpected A-form structure of 4'-thioDNA exhibiting nuclease-resistance2008

    • Author(s)
      Ohyama, T., Furukawa, A., Matsugami, A., Mashima, T., Nagata, T., Katahira, M
    • Organizer
      Korea-Japan Symposium on Biological NMR
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structures and interactions of 4'-thioDNA and RNA/DNA-binding proteins2008

    • Author(s)
      Ohyama, T., Furukawa, A., Takada, Y., Ono, A., Matsugami, A., Mashima, T., Nagata, T., Katahira, M
    • Organizer
      XXIII International Conference on Magnetic Resonance in Biological Systems
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Attempt to construct the ion channel composed of nucleic acids2008

    • Author(s)
      Miyoshi, T., Matsugami, A., Nomura, S., Akiyoshi, K., Katahira M
    • Organizer
      International Conference on Membrane Interface
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 多剤耐性に関与するVault粒子のRNA成分と薬剤の相互作用の解析2007

    • Author(s)
      高田 祐輔, 松上 明正, 工藤 倫子, ゴピナス スバシュCB, クマール ペンメチャK.R, 片平 正人
    • Organizer
      第30回日本分子生物学会年会第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 多剤耐性に関与するVault粒子のRNA成分と薬剤の相互作用の解析2007

    • Author(s)
      真嶋司
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 機能性核酸とタンパク質の構造生物学2007

    • Author(s)
      片平 正人
    • Organizer
      関西07講演会
    • Place of Presentation
      姫路
    • Year and Date
      2007-09-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The structure of human telomeric DNA and the interactions of hnRNP A1/hnRNPD proteins with telomeric DNA2007

    • Author(s)
      Matsugami, A., Ohyama, T., Ono, A., Ono, M., Nagata, T.and Katahira, M.
    • Organizer
      International Workshop on Perspectives on Stable Isotope Aided NMR Methods for Protein Structural Analvsis
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] (Structural studies on transcriptional and post-transcriptional generegulation by NMR2007

    • Author(s)
      Nagata, T., Ohyama, T., Noto, K., Niyada, E., Miyanoiri, Y., Imai, T., Okano, H., Hiratsuka, K., Katahira, M.
    • Organizer
      International Workshop on Perspectives on Stable Isotope Aided NMR Methods for Protein Structural Analysis
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The structure of human telomeric DNA and the interactions of hnRNP A1 /hnRNP D proteins with telomeric DNA2007

    • Author(s)
      Matsugami, A., Ohyama, T., Ono, A., Ono, M., Nagata, T., Katahira, M
    • Organizer
      International Workshop on Perspectives on Stable Isotope Aided NMR Methods for Protein Structural Analysis
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural studies on transcriptional and post-transcriptional gene regulation by NMR2007

    • Author(s)
      Nagata, T., Ohyama, T., Noto, K., Niyada, E., Miyanoiri, Y., Imai, T., Okano, H., Hiratsuka, K., Katahira, M
    • Organizer
      International Workshop on Perspectives on Stable Isotope Aided NMR Methods for Protein Structural Analysis
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] テロメア及びテロメア結合タンパク質の構造・機能とテロメア長の制御2006

    • Author(s)
      片平 正人
    • Organizer
      NMR 2006
    • Place of Presentation
      東京
    • Year and Date
      2006-12-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] エンドヌクレアーゼ耐性を示す4'-thioDNAの構造解析2006

    • Author(s)
      稲田 雅士, 片平 正人
    • Organizer
      分子生物学フォーラム
    • Place of Presentation
      名古屋
    • Year and Date
      2006-12-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] HCV IRESを捕捉するRNAアプタマーの構造解析2006

    • Author(s)
      小泉 大輔, 片平 正人
    • Organizer
      分子生物学フォーラム
    • Place of Presentation
      名古屋
    • Year and Date
      2006-12-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural studies on the neural RNA-binding protein Musashil in complex with its cognate RNA by NMRi2006

    • Author(s)
      Ohyama, T., Nagata, T., Miyanoiri, Y., Imai, T., Okano, H. and Katahira, M.
    • Organizer
      RNA 2006 Izu-Functional RNAs and Regulatory Machinery
    • Place of Presentation
      伊豆
    • Year and Date
      2006-12-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural Biology of Functional RNA and DNA2006

    • Author(s)
      片平 正人
    • Organizer
      第45回NMR討論会
    • Place of Presentation
      京都
    • Year and Date
      2006-11-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural analysis of Musashi protein complexed with target RNA2006

    • Author(s)
      大山 貴子, 片平 正人
    • Organizer
      NMR討論会
    • Place of Presentation
      京都
    • Year and Date
      2006-11-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 8-プロモグアニンの導入にアシストされたNMR解析によって示されたヒトテロメアDNAのカリウム溶液中における新規モデル2006

    • Author(s)
      松上 明正, 片平 正人
    • Organizer
      第33回核酸化学シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2006-11-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] (6-4)光損傷部位を含む DNA とジスタマイシンAの複合体のNMRによる構造解析2006

    • Author(s)
      土林 寛昭, 片平 正人
    • Organizer
      第33回核酸化学シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2006-11-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] タンパク質・DNA・RNA・リガンド問の相対配置・相互作用のNMR法による解析2006

    • Author(s)
      片平 正人
    • Organizer
      遺伝学研究セミナー
    • Place of Presentation
      三島
    • Year and Date
      2006-10-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Investigations of functional RNA/DNA and RNA/DNA-binding proteins2006

    • Author(s)
      Tsuchibayashi, H., Ohyama, T., Matsugami, A., Miyanoiri, Y., Niyada, E., Nagata, T.and Katahira.M.
    • Organizer
      4th Japan-Taiwan NMR Symposium
    • Place of Presentation
      台湾
    • Year and Date
      2006-10-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 病気の発症ないしは抑制に関連したタンパク質及び機能性核酸の構造生物学2006

    • Author(s)
      片平 正人
    • Organizer
      よこはまNMR構造生物学研究会
    • Place of Presentation
      横浜
    • Year and Date
      2006-09-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structures of Musashi in Complex with RNA,Wild and Mutant (Phosphorylation-Mimicking)DNA-Binding Proteins,GT-1,and Telomere DNA in K+ Solution2006

    • Author(s)
      Ohyama, T., Tsuchibayashi, H., Matsugami, A., Miyanoiri, Y., Niyada, E., Nagata, T.and Katahira, M.
    • Organizer
      The Switzerland-Japan Symposium on Structural Biology 2006
    • Place of Presentation
      スイス
    • Year and Date
      2006-09-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structures of telomere DNA in K+ solution,Musashi in complex with RNA,and wild and mutant(phosphorylation-mimicking)DNA-binding proteins,GT-12006

    • Author(s)
      Ohyama, T., Tsuchibayashi, H., Matsugami, A., Miyanoiri, Y., Niyada, E., Nagata, T. and Katahira, M.
    • Organizer
      XXII International Conference on Magnetic Resonance in Biological Systems
    • Place of Presentation
      ドイツ
    • Year and Date
      2006-08-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 翻訳を抑制するタンパク質及びRNAに関する構造解析2006

    • Author(s)
      片平 正人
    • Organizer
      第8回RNAミーティング
    • Place of Presentation
      淡路
    • Year and Date
      2006-07-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Wild and mutant(phosphorylation-mimicking)GT-1structures,hnRNP D-telomere DNA complex structure,and Musashi structure complexed with RNA2006

    • Author(s)
      Ohyama, T., Tsuchibayashi, H., Matsugami, A., Miyanoiri, Y., Niyada, E., Enokizono, Y., Nagata, T.and Katahira, M.
    • Organizer
      Korea-Japan Bilateral Symposium on Biological NMR
    • Place of Presentation
      韓国
    • Year and Date
      2006-07-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Investigations of functional RNA/DNA and RNA/DNA-binding proteins2006

    • Author(s)
      Tsuchibayashi, H., Ohyama, T., Matsugami, A., Miyanoiri, Y., Niyada, E., Nagata, T., Katahira, M
    • Organizer
      4th Japan-Taiwan NMR Symposium
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structures of Musashi in Complex with RNA, Wild and Mutant (Phosphorylation-Mimicking) DNA-Binding Proteins, GT-1, and Telomere DNA in K+ Solution2006

    • Author(s)
      Ohyama, T., Tsuchibayashi, H., Matsugami, A., Miyanoiri, Y., Niyada, E., Nagata, T., Katahira, M
    • Organizer
      The Switzerland-Japan Symposium on Structural Biology 2006
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Wild and mutant (phosphorylation-mimicking) GT-1 structures, hnRNP D-telomere DNA complex structure, and Musashi structure complexed with RNA2006

    • Author(s)
      Ohyama, T., Tsuchibayashi, H., Matsugami, A., Miyanoiri, Y., Niyada, E., Enokizono, Y., Nagata, T., Katahira, M
    • Organizer
      Korea-Japan Bilateral Symposium on Biological NMR
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structures of telomere DNA in K+ solution, Musashi in complex with RNA, and wild and mutant (phosphorylation-mimicking) DNA-binding proteins, GT-12006

    • Author(s)
      Ohyama, T., Tsuchibayashi, H., Matsugami, A., Miyanoiri, Y., Niyada, E., Nagata, T., Katahira, M
    • Organizer
      XXII International Conference on Magnetic Resonance in Biological Systems
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural studies on the neural RNA-binding protein Musashil in complex with its cognate RNA by NMRi2006

    • Author(s)
      Ohyama, T., Nagata, T., Miyanoiri, Y., Imai, T., Okano, H., Katahira, M
    • Organizer
      RNA 2006 Izu -Functional RNAs and Regulatory Machinery-
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] RNA2007

    • Author(s)
      片平 正人
    • Total Pages
      662
    • Publisher
      朝倉書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 紫外吸収スペクトル2007

    • Author(s)
      大山 貴子、松上 明正、片平 正人
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 生物物理学ハンドブック(分担)2007

    • Author(s)
      片平正人
    • Publisher
      朝倉書店
    • Related Report
      2007 Annual Research Report 2006 Annual Research Report
  • [Book] 生命科学のための機器分析実験ハンドブック(分担)2007

    • Author(s)
      大山貴子、松上明正、片平正人
    • Publisher
      羊土社
    • Related Report
      2007 Annual Research Report
  • [Book] NMRの応用・生体高分子2006

    • Author(s)
      片平 正人
    • Publisher
      丸善
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] NMRによるタンパク質構造解析の展望-Musashiタンパク質によるRNAの認識機構の解析を例に2006

    • Author(s)
      宮ノ入 洋平、片平 正人
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 第5版 実験化学講座8NMR・ESR(分担)2006

    • Author(s)
      片平正人
    • Publisher
      丸善
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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