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Study on the mode of carbohydrate recognition by functional analysis of mannan-binding protein as a multi-functional protein.

Research Project

Project/Area Number 18370057
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional biochemistry
Research InstitutionRitsumeikan University

Principal Investigator

KAWASAKI Toshisuke  Ritsumeikan University, Organization for the Promotion of the COE Program, Professor (50025706)

Co-Investigator(Kenkyū-buntansha) NAGANO Seido  Ritsumeikan University, Institute of Science and Engineering College of Information Science and Engineering, Professor (40367991)
MA Bruce Yong  Ritsumeikan University, Institute of Science and Engineering College of Information Science and Engineering, Professor (00378788)
KAWASAKI Nobuko  Ritsumeikan University, Research Organization of Science and Engineering, Professor (70077676)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥17,520,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2007: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2006: ¥7,900,000 (Direct Cost: ¥7,900,000)
KeywordsAnimal Lectin / Host Defence / Complement Activation / Phosphomannan-Binding Protein / Subcellular Localization / Endoplasmic Reticulum / Golgi Apparatus / Monoclonal Antibodies / ブタ / ホスホマンナン / 糖鎖ライブラリー
Research Abstract

Mannan-binding protein (MBP) is a C-type serum lectin specific for mannose, fucose and N-acetylglucosamine, and is associated with the removal of pathogenic microorganisms from the host animals. While the pig has been proposed to be an attractive source of xeno transplantable tissues and organs, little is known about porcine MBP. In our previous studies, phosphomannan, but not mannan, was found to be an effective inhibitor of the C1q-independent bactericidal activity of newborn piglet serum against some rough strains of gram-negative bacteria. Here we show that a novel phosphomannan-binding lectin (PMBL) of 33 kDa under reducing conditions was isolated from both newborn and adult porcine serum and characterized. Porcine PMBL activated the complement system via the lectin pathway triggered by binding with both phosphomannan and mannan, which, unlike MBP, was effectively inhibited by mannose 6-phosphate-containing oligosaccharides. Our observations suggest that porcine PMBL plays a criti … More cal role in the innate immune defense from the newborn stage to adulthood. MBP is mainly synthesized in the liver and occurs naturally in two forms, serum MBP (S-MBP) and intracellular MBP (I-MBP). S-MBP activates complement in association with MBP-associated serine proteases via the lectin pathway. On the other hand, the subcellular localization of I-MBP and its functional implication have not been clarified yet. Here, we demonstrated that I-MBP shows distinct accumulation in cytoplasmic granules, and is predominantly localized in the ER and involved in COPII vesicle-mediated ER-to-Golgi transport. However, the subcellular localization of either a mutant (C236S/C244S) I-MBP, which lacks carbohydrate-binding activity, or the wild-type I-MBP in tunicamycin-treated cells shows an equally diffuse cytoplasmic distribution, suggesting that the unique accumulation of I-MBP in the ER and COPII vesicles is mediated by an N-glycan-lectin interaction. These results strongly indicate that I-MBP may function as a cargo transport lectin facilitating ER-to-Golgi traffic in glycoprotein quality control. In addition, we are preparing monoclonal antibodies recognizing MBP-ligand oligosaccharides expressed on the surfaces of a human colorectal carcinoma SW1116 cells. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (95 results)

All 2008 2007 2006 Other

All Journal Article (39 results) (of which Peer Reviewed: 17 results) Presentation (53 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Glycosylation-Dependent Interactions of C-Type Lectin DC-SIGN with Colorectal Tumor-Associated Lewis Glycans Impair the Function and Differentiation of Monocyte-Derived Dendritic Cells2008

    • Author(s)
      Nonaka M., et. al.
    • Journal Title

      Journal of Immunology 180(5)

      Pages: 3347-3356

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Development and Application of High Performance Liquid Chromatography Map of Glucuronyl N-glycans2008

    • Author(s)
      Yagi H., et. al.
    • Journal Title

      Open Glycoscience 1

      Pages: 8-18

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A new stochastic individual-based model for pattern formation and its application to predator-prey systems2008

    • Author(s)
      Yokoyama A., et. al.
    • Journal Title

      Journal of Biological Physics (Published online)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A new stochastic individual-based model for pattern formation and its application to predator-prey systems.2008

    • Author(s)
      Yokoyama A., et. al.
    • Journal Title

      Journal of Biological Physics (Published online)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Glycosylation-Dependent Interactions of C-Type Lectin DC-SIGN with Colorectal Tumor-Associated Lewis Glycans Impair the Function and Differentiation of Monocyte-Derived Dendritic Cells2008

    • Author(s)
      Nonaka M.
    • Journal Title

      Journal of Immunology 180(5)

      Pages: 3347-3356

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subcellular localization and physiological significance of intracellular mannan-binding protein2007

    • Author(s)
      Nonaka M., et. al.
    • Journal Title

      The Journal of Biological Chemistry 282(24)

      Pages: 17908-17920

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] LPS suppresses expression of asialogycoprotein-binding protein through TLR4 in thioglycolate-elicited peritoneal macrophages2007

    • Author(s)
      Ma, BY., et. al.
    • Journal Title

      Glycoconjugate Journal 24(4-5)

      Pages: 243-249

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Glycosylation-dependent interaction of CD45 with jacalin induces T lymphocyte activation and Th1/Th2 cytokine secretion2007

    • Author(s)
      Baba, M., et. al.
    • Journal Title

      Journal of Leukocyte Biology 81(4)

      Pages: 1002-1011

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Isolation,Cloning and characterization of a novel phosphomannan-binding lectin from porcine serum2007

    • Author(s)
      Ma, BY., et. al.
    • Journal Title

      Journal of Biological Chemistry 282(17)

      Pages: 12963-12975

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid,a sialic acid species involved in the negative modulation of B cell activation2007

    • Author(s)
      Naito Y., et. al.
    • Journal Title

      Molecular and Cellular Biology 27(8)

      Pages: 3008-3022

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Biological receptor scheme for the external synchronization of mutually coupled oscillator systems2007

    • Author(s)
      Yokoyama A., et. al.
    • Journal Title

      Journal of the Physical Society of Japan 77(2)

      Pages: 24002-24011

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 1章4.補体システムによる生体防御と糖鎖2007

    • Author(s)
      川嵜 伸子, 他
    • Journal Title

      古川鋼一編, 波及する糖鎖研究(羊土社)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The HNK-1 Carbohydrate in the Nervous System2007

    • Author(s)
      Kawasaki, T., et. al.
    • Journal Title

      Comprehensive Glycoscience 4

      Pages: 289-296

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Subcellular localization and physiological significance of intracellular mannan-binding protein.2007

    • Author(s)
      Nonaka M., et. al.
    • Journal Title

      The Journal of Biological Chemistry 282(24)

      Pages: 17908-17920

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] LPS suppresses expression of asialogycoprotein-binding protein throuth TLR4 in thioglycolate-elicited petitomeal macrophages.2007

    • Author(s)
      Ma, BY., et. al.
    • Journal Title

      Glycoconjugate Journal 24(4-5)

      Pages: 243-249

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Glycosylation-dependent interaction of CD45 with jacalin induces T lymphocyte activation and Thl/Th2 cytokine secretion.2007

    • Author(s)
      Baba, M:, et. al.
    • Journal Title

      Journal of Leukocyte Biology 81(4)

      Pages: 1002-1011

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Isolation, Cloning and characterization of a novel phosphomannan-binding lectin from porcine serum.2007

    • Author(s)
      Ma, BY., et. al.
    • Journal Title

      Journal of Biological Chemistry 828(17)

      Pages: 12963-12975

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Germinal center marker GL7 probes activation-dependent repression of N- glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B cell activation.2007

    • Author(s)
      Naito Y., et. al.
    • Journal Title

      Molecular and Cellular Biology 27(8)

      Pages: 3008-3022

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Biological receptor scheme for the external synchronization of mutually coupled oscillator systems.2007

    • Author(s)
      Yokoyama A., et. al.
    • Journal Title

      Journal of the Physical Society of Japan 77(2)

      Pages: 24002-24011

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The HNK-1 Carbohydrate in the Nervous System.2007

    • Author(s)
      Kawasaki, T., et. al.
    • Journal Title

      Comprehensive Glycoscience 4

      Pages: 289-296

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Subcellular localization and physiological significance of intracellular mannan-binding protein2007

    • Author(s)
      Nonaka M.
    • Journal Title

      The Journal of Biological Chemistry 282(24)

      Pages: 17908-17920

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LPS suppresses expression of asialogycoprotein-binding protein through TLR4 in thioglycolate-elicited peritoneal macrophages2007

    • Author(s)
      Ma B.Y.
    • Journal Title

      Glycoconjugate Journal (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Glycosylation-dependent interaction of CD45 with jacalin induces Tlymphocyte activation and Th1/Th2 cytokine secretion2007

    • Author(s)
      Baba M.
    • Journal Title

      Journal of Leukocyte Biology 81(4)

      Pages: 1002-1011

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Isolation, Cloning and characterization of a novel phosphomannan binding protein2007

    • Author(s)
      Ma B.Y.
    • Journal Title

      Journal of Biollgical Chemistry (on line)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B cell activation2007

    • Author(s)
      Naito Y.
    • Journal Title

      Molecular and Cellular Biology. 27(8)

      Pages: 3008-3022

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 1章4.補体システムによる生体防御と糖鎖2007

    • Author(s)
      川嵜 伸子
    • Journal Title

      波及・深刻化する糖鎖研究(羊土社)(吉川鋼一編) 25(7)

      Pages: 954-962

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The HNK-1 Carbohydrate in the Nervous System2007

    • Author(s)
      Kawasaki T.
    • Journal Title

      Comprehensive Glycoscience (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Crystal structure of GlcAT-S,a humanglucuronyltransferase,involved in the biosynthesis of the HNK-1 carbohydrate epitope2006

    • Author(s)
      Shiba T., et. al.
    • Journal Title

      Proteins 65(2)

      Pages: 499-508

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] GlycoEpitope:the Integrated Database of Carbohydrate Antigens and Antibodies2006

    • Author(s)
      Kawasaki T., et. al.
    • Journal Title

      Trends in Glycoscience and Glycotechnology 18(102)

      Pages: 267-272

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Physical and functional association of glucuronyltransferases and sulfo-transferase involved in HNK-1 biosynthesis2006

    • Author(s)
      Kizuka Y., et. al.
    • Journal Title

      Journal of Biological Chemistry 281(19)

      Pages: 13644-13651

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] KEGG as a glycome informatics resource2006

    • Author(s)
      Hashimoto, K., et. al.
    • Journal Title

      Glycobiology 16

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Crystal structure of GIcAT-S, a humanglucuronyltransferase, involved in the biosynthesis of the HNK-1 carbohydrate epitope.2006

    • Author(s)
      Shiba T., et. al.
    • Journal Title

      Proteins 65(2)

      Pages: 499-508

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] GlycoEpitope : the Integrated Database of Carbohydrate Antigens and Antibodies.2006

    • Author(s)
      Kawasaki T., et. al.
    • Journal Title

      Trends in Glycoscience and Glycotechnology 18(102)

      Pages: 267-272

    • NAID

      10019281987

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Physical and functional association of glucuronyltransferases and sulfo-transferase involved in HNK- 1 biosynthesis.2006

    • Author(s)
      Kizuka Y., et. al.
    • Journal Title

      Journal of Biological Chemistry 281(19)

      Pages: 13644-13651

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] KEGG as a glycome informatics resource.2006

    • Author(s)
      Hashimoto, K., et. al.
    • Journal Title

      Glycobiology 16

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Crystal structure of GlcAT-S, a humanglucuronyltransferase, involved in the biosynthesis of the HNK-1 carbohydrate epitope.2006

    • Author(s)
      Shiba T.
    • Journal Title

      Proteins 65(2)

      Pages: 499-508

    • Related Report
      2006 Annual Research Report
  • [Journal Article] GlycoEpitope : the Integrated Database of Carbohydrate Antigens and Antibodies2006

    • Author(s)
      Kawasaki T.
    • Journal Title

      Trends in Glycoscience and Glycotechnology 18(102)

      Pages: 267-272

    • NAID

      10019281987

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Physical and functional association of glucuronyltransferases and sulfotransferase involved in HNK-1 biosynthesis2006

    • Author(s)
      Kizuka Y.
    • Journal Title

      Journal of Biological Chemistry 281(19)

      Pages: 13644-13651

    • Related Report
      2006 Annual Research Report
  • [Journal Article] KEGG as a glycome informatics resource2006

    • Author(s)
      Hashimoto K.
    • Journal Title

      Glycobiology 16

    • Related Report
      2006 Annual Research Report
  • [Presentation] マンナン結合タンパク質によるmeprinのプロテアーゼ活性調節2008

    • Author(s)
      平野 真
    • Organizer
      日本薬学会第128年回
    • Place of Presentation
      神奈川
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Binding of MBP to Meprins Results in the Inhibition of the Proteolvtic Activity of Meprins and the Initiation of the Complement Activation2007

    • Author(s)
      平野 真
    • Organizer
      第30回分子生物学会年会第80回日本生化学会大会合同大会
    • Place of Presentation
      神奈川
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト結腸がん細胞より単離されたマンナン結合タンパク質リガンド糖タンパク質の性質2007

    • Author(s)
      川嵜 伸子
    • Organizer
      第30回分子生物学会年会第80回日本生化学会大会合同大会
    • Place of Presentation
      神奈川
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] C型レクチンンによる核酸認識とその免疫学的意義2007

    • Author(s)
      松本 尚悟
    • Organizer
      第30回分子生物学会年会第80回日本生化学会大会合同大会
    • Place of Presentation
      神奈川
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 樹状突起スパイン形成におけるHNK-1糖鎖機能に関する研究2007

    • Author(s)
      森田 一平
    • Organizer
      第30回分子生物学会年会第80回日本生化学会大会合同大会
    • Place of Presentation
      神奈川
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Glycosylation-Dependent Interaction of DC-SIGN with Colorectal Carci-noma-associated Glycans Induces Dysfunction of Monocvte-Derived Dendritic Cells2007

    • Author(s)
      瞬中 元裕
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Interaction of MBP with Meprins Activates Complement in the Ischemia/Reperfusion Injury of Kidney2007

    • Author(s)
      Hirano M., et. al.
    • Organizer
      HGPI Second Joint Japanese/German Meeting
    • Place of Presentation
      Lubeck,Germany
    • Year and Date
      2007-09-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The Interaction of MBP with Meprins Activates Complement in the Ischemia/Reperfusion Injury of Kidney.2007

    • Author(s)
      Hirano M., et. al.
    • Organizer
      HGPI Second Joint Japanese/German Meeting
    • Place of Presentation
      Lubeck, Germany
    • Year and Date
      2007-09-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The Interaction of MBP with Meprins Activates Complment in the Ische-mia/Reperfusion Iniury of kidney2007

    • Author(s)
      Hirano M.
    • Organizer
      HGPI Second Joint Japanese/German Meeting
    • Place of Presentation
      Lubeck,Germany
    • Year and Date
      2007-09-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Interaction of MBP with Meprins Causes the Inhibition of Proteolytic Activity of Meprins and the Activation of Complement2007

    • Author(s)
      Hirano M., et. al.
    • Organizer
      14th European Carbohydrate Symposium EUROCARB 14
    • Place of Presentation
      Lubeck,Germany
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Interaction of MBP with Meprins Causes the Inhibition of Proteolytic Activity of Meprins and the Activation of Complement.2007

    • Author(s)
      Hirano M., et. al.
    • Organizer
      14th European Carbohydrate Symposium EUROCARB 14
    • Place of Presentation
      Lubeck, Germany
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Interaction of MBP with Meprins Causes the Inhibition of Proteolytic Activity of Meprins and the Activation of Complement2007

    • Author(s)
      Hirano M.
    • Organizer
      Lubeck, Germany
    • Place of Presentation
      Lubeck,Germany
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Glycosylation dependent signaling event of T-lymphocytes through interaction with CD452007

    • Author(s)
      Kawasaki T.
    • Organizer
      14th European Carbohydrate Symposium EUROCARB 14
    • Place of Presentation
      Lubeck,Germany
    • Year and Date
      2007-09-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characterization of endogenous ligands for mannan-binding protein expressed on human colon cancer cells2007

    • Author(s)
      Kawasaki T.
    • Organizer
      14th European Carbohydrate Symposium EUROCARB 14
    • Place of Presentation
      Lubeck,Germany
    • Year and Date
      2007-09-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Glycosylation dependent signaling event of T-lymphocytes through interaction with CD45.2007

    • Author(s)
      Kawasaki T.
    • Organizer
      14th European Carbohydrate Symposium EUROCARB 14
    • Place of Presentation
      Lubeck, Germany
    • Year and Date
      2007-09-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Glycosvlation dependent signaling event of T-lymphocytes through interaction with CD452007

    • Author(s)
      kawasaki T.
    • Organizer
      14th European Carbohydrate SymPosium EUROCARB 14
    • Place of Presentation
      Lubeck,Germany
    • Year and Date
      2007-09-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Characterization of endogenous ligands for mannan-binding protein expressed on human colon cancer cells2007

    • Author(s)
      Kawasaki T.
    • Organizer
      14th European Carbohydrate SymPosium EUROCARB 14
    • Place of Presentation
      Lubeck,Germany
    • Year and Date
      2007-09-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Carbohydrate recognition by a host defence lectin:Mannan-binding protein2007

    • Author(s)
      Kawasaki T.
    • Organizer
      Glycobioinformatis and Modeling
    • Place of Presentation
      Heidelberg,Germany
    • Year and Date
      2007-08-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Carbohydrate recognition by a host defence lectin : Mannan-binding protein.2007

    • Author(s)
      Kawasaki T.
    • Organizer
      Glycobioinformatis and Modeling
    • Place of Presentation
      Heidelberg, Germany
    • Year and Date
      2007-08-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DC-SIGNによる結腸がん表面糖鎖の認識とその免疫生物学的意義2007

    • Author(s)
      野中 元裕
    • Organizer
      第27回日本糖質学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2007-08-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト結腸ガン細胞上に発現するマンナン結合タンパク質(MBP)の内在性糖鎖リガンド2007

    • Author(s)
      川嵜 伸子
    • Organizer
      第27回日本糖質学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2007-08-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] メダカ胚発生過程におけるHNK-1糖鎖の機能解析に関する研究2007

    • Author(s)
      安西 大輔
    • Organizer
      第27回日本糖質学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2007-08-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Glycosylation-Dependent Binding of DC-SIGN to Colorectal Tumor-Associated Glycans Impairs the Function and Maturation of Monocyte-Derived Dendritic Cells2007

    • Author(s)
      Nonaka M., et. al.
    • Organizer
      XIX International Symposium on Glycoconjugates
    • Place of Presentation
      Cairns,Australia
    • Year and Date
      2007-07-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Glycosylation-Dependent Binding of DC-SIGN to Colorectal Tumor-Associated Glycans Impairs the Function and Maturation of Monocyte-Derived Dendritic Cells.2007

    • Author(s)
      Nonaka M., et. al.
    • Organizer
      XIX International Symposium on Glycoconjugates
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2007-07-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Glvcosylation-Dependent Binding of DC-SIGH to Colorectal Tumor-Associated Glycans Impairs the Function and Maturation of Monocvte-Derived Dendritic Cells2007

    • Author(s)
      Nonaka M.
    • Organizer
      XIX International Symposium on Glycoconjugates
    • Place of Presentation
      Cairns,Australia
    • Year and Date
      2007-07-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Polylactosamine-type N-glycans Isolated from Human Colon Cancer Cells with Mannan-binding protein2007

    • Author(s)
      Kawasaki T.
    • Organizer
      第27回札幌がんセミナー国際シンポジウム
    • Place of Presentation
      北海道
    • Year and Date
      2007-07-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DC-SIGN Binding to Colorectal Carcinoma Induces Dysfunction of Monocyte-Derived Dendritic Cells2007

    • Author(s)
      Nonaka M., et. al.
    • Organizer
      第27回札幌がんセミナー国際シンポジウム
    • Place of Presentation
      北海道
    • Year and Date
      2007-07-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Polylactosamine-type N-glycans Isolated from Human Colon Cancer Cells with Mannan-binding protein.2007

    • Author(s)
      Kawasaki T.
    • Organizer
      The 27th International Symposium on Cancer in Sapporo
    • Place of Presentation
      Hokkaido
    • Year and Date
      2007-07-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DC-SIGN Binding to Colorectal Carcinoma Induces Dysfunction of Monocyte-Derived Dendritic Cells.2007

    • Author(s)
      Nonaka M., et. al.
    • Organizer
      The 27th International Symposium on Cancer in Sapporo
    • Place of Presentation
      Hokkaido
    • Year and Date
      2007-07-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Polylactosamine-type N-91ycalls IsoIated from Human Colon Cancer Cells with Mannan-binding protein2007

    • Author(s)
      Kawasaki T.
    • Organizer
      第27回札幌がんセミナー国際シンポジウム
    • Place of Presentation
      北海道
    • Year and Date
      2007-07-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] DC-SIGN Binding to Colorectal Carcinoma Induces Dysfunction of Mono-cute-Derived Dendritic Cells2007

    • Author(s)
      Nonaka M.
    • Organizer
      第27回札幌がんセミナー国際シンポジウム
    • Place of Presentation
      北海道
    • Year and Date
      2007-07-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] A highlyfucosylated polylactosame-type oligosaccharides on human colorectal carcinoma cells2006

    • Author(s)
      Kawasaki T.
    • Organizer
      Frontiers in Glycomics:Bioinformatics and Biomarkers in Disease
    • Place of Presentation
      Washington D.C.
    • Year and Date
      2006-09-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A highlyfucosylated polylactosame-type oligosaccharides on human colorectal carcinoma cells.2006

    • Author(s)
      Kawasaki T.
    • Organizer
      Frontiers in Glycomics : Bioinformatics and Biomarkers in Disease
    • Place of Presentation
      Washington D. C.
    • Year and Date
      2006-09-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural basis for acceptor substrate recognition of human glucuronyl transferases,GlcAT-S and GlcAT-P2006

    • Author(s)
      Shiba T., et. al.
    • Organizer
      Glyco T 2006
    • Place of Presentation
      つくば
    • Year and Date
      2006-06-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Application of the multi-dimensional HPLC mapping method to the branch specificties of sulfotransferases and glycosyltransferases2006

    • Author(s)
      Yagi H., et. al.
    • Organizer
      Glyco T 2006
    • Place of Presentation
      つくば
    • Year and Date
      2006-06-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural basis for acceptor substrate recognition of human glucuronyltransferases, G1cAT-S and G1cAT-P.2006

    • Author(s)
      Shiba T., et. al.
    • Organizer
      Glyco T 2006
    • Place of Presentation
      Tsukuba
    • Year and Date
      2006-06-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Application of the multi-dimensional HPLC mapping method to the branch specificties of sulfotransferases and glycosyltransferases.2006

    • Author(s)
      Yagi H., et. al.
    • Organizer
      Glyco T 2006
    • Place of Presentation
      Tsukuba
    • Year and Date
      2006-06-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Function and regulation of the HNK-1 carbohydrate in the nervous system2006

    • Author(s)
      Oka S., et. al.
    • Organizer
      第20回国際生化学・分子生物学会議
    • Place of Presentation
      つくば
    • Year and Date
      2006-06-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Function and regulation of the HNK-1 carbohydrate in the nervous system.2006

    • Author(s)
      Oka S., et. al.
    • Organizer
      Glyco T 2006
    • Place of Presentation
      Tsukuba
    • Year and Date
      2006-06-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The physiological significance of intracellular mannan-binding protein2006

    • Author(s)
      Nonaka M., et. al.
    • Organizer
      第20回国際生化学・分子生物学会議
    • Place of Presentation
      京都
    • Year and Date
      2006-06-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The physiological significance of intracellular mannan-binding protein.2006

    • Author(s)
      Nonaka M., et. al.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A multifunctional C-type lectin,mannan-binding protein:Interaction with various ligands2006

    • Author(s)
      Kawasaki T., et. al.
    • Organizer
      第20回国際生化学・分子生物学会議
    • Place of Presentation
      京都
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A unique type of HNK-1 carbohydrate expressed on phosphacan is biosynthesized by GlcAT-P2006

    • Author(s)
      Kizuka Y., et. al.
    • Organizer
      第20回国際生化学・分子生物学会議
    • Place of Presentation
      京都
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The lectin jacalin induces T lymphocyte activation through CD45 signaling2006

    • Author(s)
      Baba M., et. al.
    • Organizer
      第20回国際生化学・分子生物学会議
    • Place of Presentation
      京都
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mannan-binding protein binding to metalloproteases meprin α and β results in the proteolytic activity inhibition and the complement activation2006

    • Author(s)
      Hirano M., et. al.
    • Organizer
      第20回国際生化学・分子生物学会議
    • Place of Presentation
      京都
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characteristic endogenous ligands for mannan-binding protein expressed on SW116 human colon cancer cells2006

    • Author(s)
      Kawasaki N., et. al.
    • Organizer
      第20回国際生化学・分子生物学会議
    • Place of Presentation
      京都
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural and Biochemical Studies on Human Glucuronyltransferase,GlcAT-S,Involved in the Biosynthesis of the Carbohydrate HNK-12006

    • Author(s)
      Morita I., et. al.
    • Organizer
      第20回国際生化学・分子生物学会議
    • Place of Presentation
      京都
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A multifunctional C-type lectin, mannan-binding protein : Interaction with various ligands.2006

    • Author(s)
      Kawasaki T., et. al.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A unique type of HNK-1 carbohydrate expressed on phosphacan is biosynthesized by G1cAT-P.2006

    • Author(s)
      Kizuka Y., et. al.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The lectin jacalin induces T lymphocyte activation through CD45 signaling.2006

    • Author(s)
      Baba M., et. al.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mannan-binding protein binding to metalloproteases meprin α and β results in the proteolytic activity inhibition and the complement activation.2006

    • Author(s)
      Hirano M., et. al.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characteristic endogenous ligands for mannan-binding protein expressed on SW116 human colon cancer cells.2006

    • Author(s)
      Kawasaki N., et. al.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural and Biochemical Studies on Human Glucuronyltransferase, GlcAT-S, Involved in the Biosynthesis of the Carbohydrate HNK-1.2006

    • Author(s)
      Morita I., et. al.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] レーニンジャーの新生科学(上・下)第4版2007

    • Author(s)
      川嵜 敏祐編集
    • Total Pages
      1596
    • Publisher
      廣川書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] レーニンジャーの新生化学(上・下)第4版2007

    • Author(s)
      川嵜 敏祐編集
    • Total Pages
      1596
    • Publisher
      廣川書店
    • Related Report
      2007 Annual Research Report
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.glyco2.is.ritsumei.ac.jp/RCG/

    • Related Report
      2007 Final Research Report Summary

URL: 

Published: 2006-04-01   Modified: 2021-04-07  

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