Studying Function of Alternative Splicing Products Based on Protein Structure Modeling
| Project/Area Number |
18370061
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Ochanomizu University |
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Principal Investigator |
GO Mitiko Ochanomizu University, バイオサイエンス学部, 特別客員教授 (70037290)
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| Co-Investigator(Kenkyū-buntansha) |
SHIONYU Masafumi 長浜バイオ大学, バイオサイエンス学部, 講師 (30345847)
由良 敬 お茶の水女子大学, 大学院・人間文化創成科学研究科, 教授 (50252226)
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| Co-Investigator(Renkei-kenkyūsha) |
YURA Kei お茶の水女子大学, 大学院・人間文化創成科学研究科研究院, 教授 (50252226)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,210,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2007: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2006: ¥5,600,000 (Direct Cost: ¥5,600,000)
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| Keywords | タンパク質立体構造 / 選択的スプライシング / ホモロジーモデリング / データベース / RNA編集 / 機能部位 / モジュール / 蛋白質間相互作用 / 理論生物学 / バイオインフォマティクス / RNA / リガンド結合部位 |
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| Research Abstract |
The number of genes in the genome was turned out to be unexpectedly small and alternative splicing (AS), a mechanism to produce more than one product out of a single gene, is expected to fill the gap in the numbers. It is difficult to experimentally elucidate the mechanisms of functional diversity of proteins produced by alternative splicing of the single genes. We built methods to identify AS products from the measured data, to predict structures of AS products (proteins), and to estimate difference of biochemical function of the products. The methods elucidated the differences in a number of cases.
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Report
(6 results)
Research Products
(59 results)
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[Journal Article] The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts.2008
Author(s)
Yamasaki, C., Murakami, K., Fujii, Y., Sato, Y., Harada, E.,..., Yura, K.(66th),..., Shionyu, M.(101th),..., Go, M.(107th),..., Gojobori, T.(138th)
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Journal Title
Nucleic Acids Research 36
NAID
Related Report
Peer Reviewed
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[Journal Article] The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts2008
Author(s)
Yamasaki, C., Murakami, K., Fujii, Y., Sato, Y., Harada, E., Yura, K. (66th), Shionyu, M. (101th), Go, M. (107th), Gojobori, T. (138th)
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Journal Title
Nucleic Acids Research 36
Pages: 793-799
NAID
Related Report
Peer Reviewed
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[Journal Article] Contribution of computational biology and structural genomics to understand genome and transcriptome.2007
Author(s)
Go, M., Yura, K., Shionyu, M.
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Journal Title
Proceedings of the International Symposium on Frontiers of Computational Science 2005 (ISFCS2005), (eds.Kaneda, Y., Kawamura, H., Sasai, M.)(Springer)
Pages: 75-80
Related Report
Peer Reviewed
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[Journal Article] Alternative splicing in human transcriptome : functional and structural influence on proteins.2006
Author(s)
Yura, K., Shionyu, M., Hagino, K., Hijikata, A., Hirashima, Y., Nakahara, T., Eguchi, T., Shinoda, K., Yamaguchi, A., Takahashi, K., Itoh, T., Imanishi, T., Gojobori, T., Go, M.
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Related Report
Peer Reviewed
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[Journal Article] Alternative splicing in human transcriptome : functional and structural influence on proteins2006
Author(s)
Yura, K., Shionyu, M., Hagino, K., Hijikata, A., Hirashima, Y., Nakahara, T., Eguchi, T., Shinoda, K., Yamaguchi, A., Takahashi, K., Itoh, T., Imanishi, T., Gojobori, T., Go, M.
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Peer Reviewed
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[Presentation] Systematic detection of protein regions affected by alternative splicing2006
Author(s)
Shionyu, M., Yura, K., Hijikata, A., Nakahara, T., Shinoda, K., Yamaguchi, A., Takahashi, K., Go, M.
Organizer
20th International Congress of Biochemistry and Molecular Biology
Place of Presentation
国立京都国際会館(京都市)
Year and Date
2006-06-22
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