| Budget Amount *help |
¥18,210,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2007: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2006: ¥5,600,000 (Direct Cost: ¥5,600,000)
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| Research Abstract |
The number of genes in the genome was turned out to be unexpectedly small and alternative splicing (AS), a mechanism to produce more than one product out of a single gene, is expected to fill the gap in the numbers. It is difficult to experimentally elucidate the mechanisms of functional diversity of proteins produced by alternative splicing of the single genes. We built methods to identify AS products from the measured data, to predict structures of AS products (proteins), and to estimate difference of biochemical function of the products. The methods elucidated the differences in a number of cases.
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