| Budget Amount *help |
¥18,170,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2007: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2006: ¥5,300,000 (Direct Cost: ¥5,300,000)
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| Research Abstract |
To understand the strategy of stress responses of microorganisms, I characterized two model microorganisms, E.coli and S.pombe. In E.coli, I found that a response regulator, ArcA is involved in fragella synthesis in addition to the well known aerobic-anaerobic responses. I also identified the whole genome binding sites of transcription factors, ArcA, H-NS and Fnr of E. coli by using ChIP-CHIP analysis.
By using fission yeast, S pombe, I started to identify and characterize factors involved in the chronological lifespan. In this project, I identified novel factors, Ecll family proteins that increase chronological lifespan of S. pombe when overexpressed. I also isolated some mutants and clones that affect chronological lifespan of S pombe. Based on these results, I was able to establish the basis for the development of the future research.
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