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Search for physiological substrates and functional analysis of F-box protein β-TrCP in vivo

Research Project

Project/Area Number 18370075
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cell biology
Research InstitutionTohoku University

Principal Investigator

NAKAYAMA Keiko  Tohoku University, Tohoku University, Graduate School of Medicine, Professor (60294972)

Co-Investigator(Kenkyū-buntansha) ISHIDA Noriko  Tohoku University, Graduate School of Medicine, Assistant Professor (10361073)
HARA Kentaro  Tohoku University, Graduate School of Medicine, COE Fellow (60400248)
中谷 雅明  東北大学, 大学院医学系研究科, 助手 (70422095)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥17,270,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2007: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2006: ¥9,600,000 (Direct Cost: ¥9,600,000)
KeywordsUbiquitin / F-box protein / knockout mouse / β-TrCP2 / circadian rhythm / 血管リモデリング / in situ hybridization
Research Abstract

Our purpose of this project is elucidation of the regulation of protein expression on development. We have analyzed the function of F-box proteins β-TrCP2, and demonstrated its role on development and differentiation during embryogenesis.
β-TrCP1 is the ubiquitin ligase which ubiquitinates β-catenin and l_<κ>βα The gene-targeted mouse of β-TrCP1, which we have generated, still exhibited degradation of β-catenin and l_<κ>βα, suggesting existence of other ubiquitin ligases for β-catenin and l_<κ>βα.
The gene-targeted mouse of β-TrCP2, the homologue of β-TrCP1 is embryonic lethal at embryonic day9.5. This difference of phenotype between β-TrCP1 knockout mouse and that of β-TrCP2, indicate that each proteins have different biological functions significantly, even though the difference of biochemical functions have not been reported.
We analyzed four proteins picked up based on the expression during early and middle embryogenesis and the consensus sequences, which are recognized by β-TrCP2. However, we did not detected bindings between these proteins and β-TrCP2, and ubiquitination and degradation by β-TrCP2.
We have generated β-TrCP2 conditional knockout mouse.
B-TrCP1 knockout primary embryonic fibroblasts have shown the abnormal regulation of Period 2 protein expression, suggesting that maintenance of circadian rhythm requires protein degradation by β-TrCP1.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (118 results)

All 2008 2007 2006

All Journal Article (92 results) (of which Peer Reviewed: 45 results) Presentation (26 results)

  • [Journal Article] Fbxw7 acts as a critical failsafe against premature loss of hematopoietic stem cells and development of T-ALL.2008

    • Author(s)
      Matsuoka, S., et. al.
    • Journal Title

      Genes Dev. 22

      Pages: 986-991

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Targeting the p27 E3 ligase SCFSkp2 results in p27-and Skp2-mediated cell cycle arrest, and activation of autophagy.2008

    • Author(s)
      Chen, Q., et. al.
    • Journal Title

      Blood 111

      Pages: 4690-4699

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Skp2 regulates the antiproliferative function of the tumor suppressorRASSF1A via ubiquitin-mediated degradation at the G(1)-S transition.2008

    • Author(s)
      Song, M. S., et. al.
    • Journal Title

      Oncogene (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] SCFβTrCP1 activates and ubiquitylates TAp63γ.2008

    • Author(s)
      Gallegos, J.R., et. al.
    • Journal Title

      J Biol Chem. 283

      Pages: 66-75

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] T. Fbxw7 acts as a critical failsafe against premature loss of hematopoietic stem cells and development of T-ALL2008

    • Author(s)
      Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K., Miyamoto, K., Yoshiwara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Hayashi, Y., Matsuzaki, Y., Nakayama, K., Ikeda, Y., Hata, A., Chiba, S., Nakayama, K.I., Suda, T.
    • Journal Title

      Genes Dev 22

      Pages: 986-991

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell cycle arrest, and activation of autophagy2008

    • Author(s)
      Chen, Q., Xie, W., Kuhn, D.J., Voorhees, P.M., Lopez-Girona, A., Mendy, D., Corral, L.G., Krenitsky, V.P., Xu, W., Moutouh-de Parseval, L., Webb, D.R., Mercurio, F., Nakayama, K.I., Nakayama, K., Orlowski, R.Z.
    • Journal Title

      Blood 111

      Pages: 4690-4699

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G(1)-S transition2008

    • Author(s)
      Song, M.S., Song, S.J., Kim, S.J., Nakayama, K., Nakayama, K.I. and Lim, D.S.
    • Journal Title

      Oncogene (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] SCFβTrCP1 activates and ubiquitylates TAp63γ2008

    • Author(s)
      Gallegos, J.R., Litersky, J., Lee, H., Sun, Y., Nakayama, K., Nakayama, K. and Lu, H.
    • Journal Title

      J Biol Chem. 283

      Pages: 66-75

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] SCF型ユビキチンリガーゼによる細胞周期制御と発癌2008

    • Author(s)
      中山敬一and中山啓子
    • Journal Title

      実験医学(増刊) 26

      Pages: 46-54

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells.2007

    • Author(s)
      Zhong, L., et. al.
    • Journal Title

      J. Clin. Invest. 117

      Pages: 2869-2876

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Negative feedback loop in the bim-caspase-3 axis regulating apoptosis and activity of osteoclasts.2007

    • Author(s)
      Wakeyama, H.
    • Journal Title

      J. Bone. Miner. Res. 22

      Pages: 1631-1639

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ablation of p27 enhance kainate-induced seizure and hippocampal degeneration.2007

    • Author(s)
      Ueyama, C., et. al.
    • Journal Title

      Neuroreport 18

      Pages: 1781-1785

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Noncanonical Wnt signaling through G protein-linked PKCδactivation promotes bone formation.2007

    • Author(s)
      Tu, X., et. al.
    • Journal Title

      Dev. Cell 12

      Pages: 113-127

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice.2007

    • Author(s)
      Suzuki, S., et. al.
    • Journal Title

      Am. J. Pafhol. 171

      Pages: 473-483

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cyclin D2 Translocates p27 out of the Nucleus and Promotes Its Degradation at the G0-G1 Transition.2007

    • Author(s)
      Susaki, E., et. al.
    • Journal Title

      Mol. Cell. Biol. 27

      Pages: 4626-4640

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Skp2 controls adipocyte proliferation during the development of obesity.2007

    • Author(s)
      Sakai, T., et. al.
    • Journal Title

      J. Biol. Chem 282

      Pages: 2038-2046

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice2007

    • Author(s)
      Shukla, A., et. al.
    • Journal Title

      Am. J. Pathol. 170

      Pages: 140-151

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis2007

    • Author(s)
      Onoyama, l., et. al.
    • Journal Title

      J. Exp. Med. 204

      Pages: 2875-2888

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Foxo3a is essential for maintenance of the hematopoietic stem cell pool.2007

    • Author(s)
      Miyamoto, K., et. al.
    • Journal Title

      Cell Stem Cell 1

      Pages: 101-112

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] nPKC{varepsilon}, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells2007

    • Author(s)
      Ehre, C., et. al.
    • Journal Title

      Am. J. Physiol.-Cell Physiol. 293

      Pages: 1445-1454

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The F Box Protein S Phase Kinase-associated Protein 2 Regulates Adipose Mass and Adipocyte Number in Vivo.2007

    • Author(s)
      Cooke, P. S., et. al.
    • Journal Title

      Obesity 15

      Pages: 1400-1408

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Protein kinase C-delta phosphorylates Ebpl and prevents its proteolytic degradation, enhancing cell survival.2007

    • Author(s)
      Liu Z., et. al.
    • Journal Title

      J. Neurochem. 100

      Pages: 1278-1288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex.2007

    • Author(s)
      Itoh, Y., et. al.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 390-396

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells2007

    • Author(s)
      Zhong, L., Georgia, S., Tschen, S.I., Nakayama, K., Nakayama, K.I., Bhushan, A.
    • Journal Title

      J. Clin. Invest 117

      Pages: 2869-2876

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Negative feedback loop in the bim-caspase-3 axis regulating apoptosis and activity of osteoclasts2007

    • Author(s)
      Wakeyama, H., Akiyama, T., Takahashi, K., Amano, H., Kadono, Y., Nakamura, M., Oshima, Y., Itabe, H., Nakayama, K.I., Nakayama, K., Nakamura, K. and Tanaka, S.
    • Journal Title

      J. Bone. Miner. Res. 22

      Pages: 1631-1639

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ablation of p27 enhance kainate-induced seizure and hippocampal degeneration2007

    • Author(s)
      Ueyama, C., Akashiba, H., Nakayama, K., Nakayama, K.I., Nishiyama, N., Matsuki, N.
    • Journal Title

      Neuroreport 18

      Pages: 1781-1785

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Noncanonical Wnt signaling through G protein-linked PKCδactivation promotes bone formation2007

    • Author(s)
      Tu, X., Joeng, K.S., Nakayama, K.I., Nakayama, K., Rajagopal, J., Carroll, T.J., McMahon, A.P., Long, F.
    • Journal Title

      Dev. Cell 12

      Pages: 113-127

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice2007

    • Author(s)
      Suzuki, S., Fukasawa, H., Kitagawa, K., Uchida, C, Hattori, T., Isobe, T., Oda, T., Misaki, T., Ohashi, N., Nakayama, K., Nakayama, K.I., Hishida, A., Yamamoto, T., Kitagawa, M.
    • Journal Title

      Am. J. Pathol. 171

      Pages: 473-483

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cyclin D2 Translocates p27 out of the Nucleus and Promotes Its Degradation at the G0-G1 Transition2007

    • Author(s)
      Susaki, E., Nakayama K., Nakayama, K. I.
    • Journal Title

      Mol. Cell. Biol. 27

      Pages: 4626-4640

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Skp2 controls adipocyte proliferation during the development of obesity2007

    • Author(s)
      Sakai, T., Sakaue, H., Nakamura, T., Okada, M., Matsuki, Y., Watanabe, E., Hiramatsu, R., Nakayama, K., Nakayama, K.I. and Kasuga, M.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 2038-2046

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice2007

    • Author(s)
      Shukla, A., Lounsbury, K. M., Barrett, T. F., Gell, J., Rincon, M., Butnor, K. J., Taatjes, D. J., Davis, G. S., Vacek, P., Nakayama, K. I., Nakayama K., Steele C., Mossman, B. T.
    • Journal Title

      Am. J. Pathol. 170

      Pages: 140-151

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis2007

    • Author(s)
      Onoyama, I., R. Tsunematsu, A. Matsumoto, T. Kimura, I. M. de Alboran, K. Nakayama, K. I. Nakayama
    • Journal Title

      J. Exp. Med 204

      Pages: 2875-2888

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Foxo3a is essential for maintenance of the hematopoietic stem cell pool2007

    • Author(s)
      Miyamoto, K., Araki, K.Y., Naka, K., Arai, F., Takubo, K., Yamazaki, S., Matsuoka, S., Miyamoto, T., Ito, K., Ohmura, M., Chen, C., Hosokawa, K., Nakauchi, H., Nakayama, K., Nakayama, K.I., Harada, M., Motoyama, N., Suda, T. and Hirao, A.
    • Journal Title

      Cell Stem Cell 1

      Pages: 101-112

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Davis. nPKC{varepsilon}, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells2007

    • Author(s)
      Ehre, C, Y. Zhu, L. H. Abdullah, J. Olsen, K. I. Nakayama, K. Nakayama, R. O. Messing, C. W.
    • Journal Title

      Am. J. Physiol. -Cell Physiol. 293

      Pages: 1445-1454

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The F Box Protein S Phase Kinase-associated Protein 2 Regulates Adipose Mass and Adipocyte Number in Vivo2007

    • Author(s)
      Cooke, P. S., Holsberger, D. R., Cimafranca, M. A., Meling, D. D., Beals, C. M., Nakayama, K., Nakayama, K. I., Kiyokawa, H.
    • Journal Title

      Obesity 15

      Pages: 1400-1408

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Protein kinase C-delta phosphorylates Ebp1 and prevents its proteolytic degradation, enhancing cell survival2007

    • Author(s)
      Liu, Z., Liu, X., Nakayama, K. I., Nakayama, K., Ye, K.
    • Journal Title

      J. Neurochem. 100

      Pages: 1278-1288

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex2007

    • Author(s)
      Itoh, Y., Masuyama, N., Nakayama, K., NakayamaK. I., Gotoh, Y.
    • Journal Title

      J. Biol. Chem 282

      Pages: 390-396

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] SCFbeta TRCP1 activates and ubiquitylates TAp63gamma2007

    • Author(s)
      J. R. Gallegos, et. al.
    • Journal Title

      J Biol Chem 283

      Pages: 66-75

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells,2007

    • Author(s)
      L. Zhong, et. al.
    • Journal Title

      J Clin lnvest 117

      Pages: 2869-2876

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of p27 enhance kainate-induced seizure and hippocampal Degeneration2007

    • Author(s)
      C. Ueyama, et. al.
    • Journal Title

      Neuroreport 18

      Pages: 1781-1785

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis2007

    • Author(s)
      l. Onoyama, et. al.
    • Journal Title

      J Exp Med 204

      Pages: 2875-2888

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] nPKC(varepsilon), a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells2007

    • Author(s)
      C. Ehre, et. al.
    • Journal Title

      Am J Physiol Cell Physiol 293

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein kinase C-delta phosphorylates Ebpl and prevents its proteolytic degradation, enhancing cell survival2007

    • Author(s)
      Z. Liu, et. al.
    • Journal Title

      J Neurochem 100

      Pages: 1278-1288

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative Feedback Loop in Bim-Caspase-3 Axis Regulating Apoptosis and Activity of Osteoclasts2007

    • Author(s)
      H. Wakeyama, et. al.
    • Journal Title

      J Bone Miner Res 22

      Pages: 1631-1639

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The F Box Protein S Phase Kinase-associated Protein 2 Regulates Adipose Mass and Adipocyte Number in Vivo,2007

    • Author(s)
      P. S. Cooke, et. al.
    • Journal Title

      Obesity(Silver Spring) 15

      Pages: 1400-1408

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin D2 Translocates p27 out of the Nucleus and Promotes Its Degradation at the G0-G1 Transition2007

    • Author(s)
      E. Susaki, et. al
    • Journal Title

      Mol Cell Biol 27

      Pages: 4626-4640

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skp2 controls adipocyte proliferation during the development ofobesity2007

    • Author(s)
      T. Sakai, et. al.
    • Journal Title

      J Biol Chem 282

      Pages: 2038-2046

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex2007

    • Author(s)
      Y. Itoh, et. al.
    • Journal Title

      J Biol Chem 282

      Pages: 390-396

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noncanonical Wnt signaling through G protein-linked PKC delta activation promotes bone formation2007

    • Author(s)
      X. Tu, et. al.
    • Journal Title

      Dev Cell 12

      Pages: 113-127

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asbestos-induced peribronchiolar cell proliferation and cytokine prodc-tion are attenuated in lungs of protein kinase C-delta knockout mice2007

    • Author(s)
      A. Shukla, et. al.
    • Journal Title

      Am J Pathol 170

      Pages: 140-151

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice2007

    • Author(s)
      S. Suzuki, et. al.
    • Journal Title

      Am J Pathol 171

      Pages: 473-483

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PKC-delta plays non-redundant role in insulin secretion in pancreatic beta cell.2007

    • Author(s)
      Uchida, T., et al.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 2707-2716

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-{delta} knockout mice.2007

    • Author(s)
      Shukla, A., et al.
    • Journal Title

      Am. J. Pathol. 170

      Pages: 140-151

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation.2007

    • Author(s)
      Tu, X., et al.
    • Journal Title

      Dev. Cell 12

      Pages: 113-127

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex.2007

    • Author(s)
      Itoh, Y., et al.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 390-396

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Skp2 controls adipocyte proliferation during the development of obesity.2007

    • Author(s)
      Sakai, T., et al.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 2038-2046

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Geminin is essential for the development of preimplantation mouse embryos.2006

    • Author(s)
      Hara, K., et. al.
    • Journal Title

      Genes Cells 11

      Pages: 1281-11293

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PKCδ regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation2006

    • Author(s)
      Pula, G., et. al.
    • Journal Title

      Blood 108

      Pages: 4035-4044

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence through activating ROS/PKC-δ signalling pathway.2006

    • Author(s)
      Takahashi, A., et. al.
    • Journal Title

      Nature Cell Biol. 8

      Pages: 1291-1297

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Double knockout mice show BASH and PKCδ have different epistatic relationships in B cell maturation and CD40-mediated activation.2006

    • Author(s)
      Nojima, T., et. al.
    • Journal Title

      Immunol. Lett. 105

      Pages: 48-54

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ubiquitin ligases controlling cell cycle and cancer.2006

    • Author(s)
      Nakayama, K.I., et. al.
    • Journal Title

      Nat. Rev. Cancer 6

      Pages: 369-381

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] HSP27 favors ubiquitination and proteasomal degradation of p27Kip1 and helps S-phase re-entry in stressed cells.2006

    • Author(s)
      Parcellier, A., et. al.
    • Journal Title

      FASEB J. 20

      Pages: 1179-1181

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Suppression of centrosome amplification after DNA damage depends on p27 accumulation.2006

    • Author(s)
      Sugihara, E., et. al.
    • Journal Title

      Cancer Res., 66, , 2006 66

      Pages: 4020-4029

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners.2006

    • Author(s)
      Iwanaga, R., et. al.
    • Journal Title

      Oncogene, 25, 2006 25

      Pages: 1786-1798

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] wo E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for aroteolysis.2006

    • Author(s)
      Nishitani, H., et. al.
    • Journal Title

      EMBO J., 25, , 2006 25

      Pages: 1126-1136

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PKCdelta is necessary for Smad3 expression and transforming growth factorbeta-induced fibronectin synthesis in vascular smooth muscle cells.2006

    • Author(s)
      Ryer, E. J., et. al.
    • Journal Title

      Arterioscler. Thromb. Vasc. Biol. 26

      Pages: 780-786

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCδ-dependent pathway in murine lung.2006

    • Author(s)
      Shukla, A., et. al.
    • Journal Title

      FASEB J. 20

      Pages: 997-999

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis.2006

    • Author(s)
      Gao, Y., et. al.
    • Journal Title

      Cancer Res. 66

      Pages: 11623-11631

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice.2006

    • Author(s)
      Fotovati, A., et. al.
    • Journal Title

      Cell Div. 1

      Pages: 4-4

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Geminin is essential for the development of preimplantation mouse embryos2006

    • Author(s)
      Hara, K., Nakayama, K.I., Nakayama, K.
    • Journal Title

      Genes Cells 11

      Pages: 1281-1293

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PKCδ regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation2006

    • Author(s)
      Pula, G., Schuh, K., Nakayama K., Nakayama, K. I., Walter, U., Poole, A. W.
    • Journal Title

      Blood 108

      Pages: 4035-4044

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence through activating ROS/PKC-5 signalling pathway2006

    • Author(s)
      Takahashi, A., Ohtani, N., Yamakoshi, K., lida, S., Tahara, H., Nakayama, K., Nakayama, K.I., Ide, T., Saya, H., Hara, E.
    • Journal Title

      Nature Cell Biol. 8

      Pages: 1291-1297

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Double knockout mice show BASH and PKCδhave different epistatic relationships in B cell maturation and CD40-mediated activation2006

    • Author(s)
      Nojima, T., Hayashi, K., Goitsuka, R., Nakayama, K., Nakayama, K.l., Kitamura, D.
    • Journal Title

      Immunol. Lett. 105

      Pages: 48-54

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ubiquitin ligases controlling cell cycle and cancer2006

    • Author(s)
      Nakayama, K.I., Nakayama, K.
    • Journal Title

      Nat. Rev. Cancer 6

      Pages: 369-381

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] HSP27 favors ubiquitination and proteasomal degradation of p27Kip1 and helps S-phase re-entry in stressed cells2006

    • Author(s)
      Parcellier, A., Brunet, M., Schmitt, E., Col, E., Didelot, C., Hammann, A., Nakayama, K., Nakayama, KI., Khochbin, S., Solary, E.., Garrido, C.
    • Journal Title

      FASEB J. 20

      Pages: 1179-1181

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Suppression of centrosome amplification after DNA damage depends on p27 accumulation2006

    • Author(s)
      Sugihara, E., Kanai, M., Saito, S., Nitta, T., Toyoshima, H., Nakayama, K., Nakayama, K.I., Fukasawa, K., Schwab, M., Saya, H., Miwa, M.
    • Journal Title

      Cancer Res. 66

      Pages: 4020-4029

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners2006

    • Author(s)
      Iwanaga, R., Komori, H., Ishida, S., Okamura, N., Nakayama, K., Nakayama, K. I., Ohtani, K.
    • Journal Title

      Oncogene 25

      Pages: 1786-1798

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis2006

    • Author(s)
      Nishitani, H., Sugimoto, N., Roukos, V., Nakanishi, Y., Saijo, M., Obuse, C., Tsurimoto, T., Nakayama, K. I., Nakayama, K., Fujita, M., Lygerou, Z., Nishimoto, T.
    • Journal Title

      EMBO J. 25

      Pages: 1126-1136

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PKCdelta is necessary for Smad3 expression and transforming growth factorbeta-induced fibronectin synthesis in vascular smooth muscle cells2006

    • Author(s)
      Ryer, E. J., Hom, R. P., Sakakibara, K., Nakayama, K. I., Nakayama, K., Faries, P. L, Liu, B., Kent, K. C.
    • Journal Title

      Arterioscler. Thromb. Vase. Biol. 26

      Pages: 780-786

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCδ-dependent pathway in murine lung2006

    • Author(s)
      Shukla, A., Barrett, T.F., Nakayama, K.I., Nakayama, K., Mossman, B.T. and Lounsbury, K.M.
    • Journal Title

      FASEB J. 20

      Pages: 997-999

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinomacell invasiveness and metastasis2006

    • Author(s)
      Gao, Y., Kitagawa, K., Hiramatsu, Y., Kikuchi, H., Isobe, T., Shimada, M., Uchida, C, Hattori, T., Oda, T., Nakayama, K., Nakayama, K.I., Tanaka, T., Konno, H., Kitagawa, M.
    • Journal Title

      Cancer Res. 66

      Pages: 11623-11631

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice2006

    • Author(s)
      Fotovati, A., Nakayama, K., Nakayama, K.I.
    • Journal Title

      Cell Div. 1

      Pages: 4-4

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Suppression of centrosome amplification after DNA damage depends on p27 accumulation.2006

    • Author(s)
      Sugihara, E., et al.
    • Journal Title

      Cancer Res. 66

      Pages: 4020-4029

    • Related Report
      2006 Annual Research Report
  • [Journal Article] PKCdelta is necessary for Smad3 expression and transforming growth factor beta-induced fibronectin synthesis in vascular smooth muscle cells.2006

    • Author(s)
      Ryer, E.J., et al.
    • Journal Title

      Arterioscler. Thromb. Vasc. Biol. 26

      Pages: 780-786

    • Related Report
      2006 Annual Research Report
  • [Journal Article] HSP27 favors ubiquitination and proteasomal degradation of p27Kip1 and helps S-phase re-entry in stressed cells.2006

    • Author(s)
      Parcellier, A., et al.
    • Journal Title

      FASEB J. 20

      Pages: 1179-1181

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice.2006

    • Author(s)
      Fotovati, A., et al.
    • Journal Title

      Cell Div. 1

      Pages: 4-4

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung.2006

    • Author(s)
      Shukla, A., et al.
    • Journal Title

      FASEB J. 20

      Pages: 997-999

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Geminin is essential for the development of preimplantation mouse embryos.2006

    • Author(s)
      Hara, K., et al.
    • Journal Title

      Genes Cells 11

      Pages: 1281-1293

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.2006

    • Author(s)
      Takahashi, A., et al.
    • Journal Title

      Nature Cell Biol. 8

      Pages: 1291-1297

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis.2006

    • Author(s)
      Gao, Y., et al.
    • Journal Title

      Cancer Res. 66

      Pages: 11623-11631

    • Related Report
      2006 Annual Research Report
  • [Journal Article] PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation.2006

    • Author(s)
      Pula, G., et al.
    • Journal Title

      Blood 108

      Pages: 4035-4044

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Double knockout mice show BASH and PKCd have different epistatic relationships in B cell maturation and CD40-mediated activation.2006

    • Author(s)
      Nojima, T., et al.
    • Journal Title

      Immunol. Lett. 105

      Pages: 48-54

    • Related Report
      2006 Annual Research Report
  • [Presentation] Gdx, an X-Linked Ubiquitin-Like Modifier, ls Conjugated to Cyclin F and Regulates Mitosis2008

    • Author(s)
      N. lshida, et. al.
    • Organizer
      4th lnternational Conference, Ubiquitin, Ubiquitin-Like Proteins, and Cancer
    • Place of Presentation
      Huston, TX, USA
    • Year and Date
      2008-07-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Gdx, an X-Linked Ubiquitin-Like Modifier, ls Conjugated to Cyclin Fand Regulates Mitosis.2008

    • Author(s)
      lshida, N., et. al.
    • Organizer
      4th lnternational Conference, Ubiquitin, Ubiquitin-Like Proteins, and Cancer
    • Place of Presentation
      Huston, TX, USA
    • Year and Date
      2008-02-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ubiquitin ligases required for the regulation of G0-G1 transision.2007

    • Author(s)
      Nakayama, K., et. al.
    • Organizer
      Office of Life Sciences/National University of Singapore and Tohoku University/Center of Excellence Joint Syposium
    • Place of Presentation
      Singapore
    • Year and Date
      2007-05-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 腎障害進行におけるSkp2発現亢進の解析:Skp2KOマウスを用いた検討2007

    • Author(s)
      鈴木小由理, et. al.
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規ユビキチン様修飾分子GdXによるcyclin Fと細胞周期M期の制御2007

    • Author(s)
      石田典子, et. al.
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] ユビキチンリガーゼFbw7は表皮角化細胞において増殖と分化を制御する2007

    • Author(s)
      石川善則, et. al.
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Fbxw7によるGO期維持機構とその破綻による発がん2007

    • Author(s)
      小野山一郎, et. al.
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Gemininは着床前初期発生に必須である,第30回日本分子生物学会年会2007

    • Author(s)
      原賢太郎, et. al.
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Control of Cell Cycle and Chromosomal Stability.2006

    • Author(s)
      Nakayama, K., et. al.
    • Organizer
      The 3rd International Symposium on "Novel perspecfives in cancer research and translationto the clinic
    • Place of Presentation
      Sendai,Japan
    • Year and Date
      2006-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Geminin is essential for the development of preimplantation mouse embryos.2006

    • Author(s)
      Hara, K., et. al.
    • Organizer
      The 3rd International Symposium on "Novel perspectives in cancer research and translation to the clinic,
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2006-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] FBW7 is a key regulator of Cell Cycle arrest and Tumorigenesis.2006

    • Author(s)
      Nakayama, K.
    • Organizer
      The 3rd International Symposium on "Novel perspectives in cancer research and translation to the clinic,
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2006-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] GdX, an X-linked ubiquitin-like modifier, is conjugated to cyclin F and regulates cell cycle.2006

    • Author(s)
      Ishida, N., et. al.
    • Organizer
      The 3rd International Symposium on "Novel perspectives in cancer research and translation to the clinic,
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2006-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Accumulation of Notch induces cell cycle arrest in the tumor suppressor Fbxw7-deficient MEFs.2006

    • Author(s)
      Ishikawa, Y., et. al.
    • Organizer
      The 3rd International Symposium on "Novel perspectives in cancer research and translation to the clinic
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2006-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of CDK inhibitors by ubiquitin ligase Fbxw7.2006

    • Author(s)
      Ishikawa Y., et. al.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2006-06-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] GdX, An X-Linked ubiquifin-like modifier, is conjugated to cyclin Fand regulates mitotic exit.2006

    • Author(s)
      Ishida, N., et. al.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2006-06-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Geminin is essential for development of preimplantation embryos2006

    • Author(s)
      Hara, K
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2006-06-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Suppression of centrosome amplification after DNA damage depends on p27 accumulation.2006

    • Author(s)
      Sugihara, E
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2006-06-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Fbw7 contributes to cell-cycle regulation and tumor suppression during development.2006

    • Author(s)
      Onoyama, I.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2006-06-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The role of FWD1a and FWD1b as circadian rhythm formation.2006

    • Author(s)
      Ohsaki, K.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2006-06-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] p27 can substitute for p57 in mouse development.2006

    • Author(s)
      Susaki, E
    • Organizer
      Cold Spring Harbor Symposium "The Cell Cycle"
    • Place of Presentation
      Cold Spring Harbor, NY
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] RASSF1A is required for Skp2-mediated G1-S transition and stabilization of p53.2006

    • Author(s)
      Song, M. S
    • Organizer
      Cold Spring Harbor Symposium "The Cell Cycle"
    • Place of Presentation
      Cold Spring Harbor, NY
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Fbw7 is a key regulator of cell-cycle arrest and tumorigenesis during development2006

    • Author(s)
      Onoyama, I.
    • Organizer
      Cold Spring Harbor Symposium ″The Cell Cycle″
    • Place of Presentation
      Cold Spring Harbor, NY
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Geminin is essential for development of preimplantation embryos2006

    • Author(s)
      Hara, K.
    • Organizer
      Cold Spring Harbor Symposium "The Cell Cycle"
    • Place of Presentation
      Cold Spring Harbor, NY
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] RASSF1A is required for Skp2-mediated G1-S transition and stabilization of p532006

    • Author(s)
      Song, M.S., Song, S.J., Kim, S.Y., Yang, T.-H., Pfeifer, G.P., Nakayama, K., Nakayama, K.I. and Lim, D.-S.
    • Organizer
      Cold Spring Harbor Symposium"The Cell Cycle"
    • Place of Presentation
      Cold Spring Harbor, NY
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Fbw7 is a key regulator of cell-cycle arrest and tumorigenesis during development2006

    • Author(s)
      Onoyama, I., Tsunematsu, R., Nakayama, K. and Nakayama, K.I.
    • Organizer
      Cold Spring Harbor Symposium"The Cell Cycle"
    • Place of Presentation
      Cold Spring Harbor, NY
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Geminin is essential for development of preimplantation embryos2006

    • Author(s)
      Hara, K., Nakayama, K. and Nakayama, K.
    • Organizer
      Cold Spring Harbor Symposium"The Cell Cycle"
    • Place of Presentation
      Cold Spring Harbor, NY
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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