Studies on the mechanisms of left-right asymmetric development involving actin cytoskeleton and unconventional myosins inDrosophila

• Project/Area Number: 18370091
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Tokyo University of Science
• Principal Investigator: MATSUNO Kenji Tokyo University of Science, 基礎工学部, 教授 (60318227)
• Co-Investigator(Renkei-kenkyūsha): MAEDA Reo 東京理科大学, 基礎工学部, 助教 (40453831) ; 奥村 高志 東京理科大学, 基礎工学部, 特別研究員 (20449234)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥16,240,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥2,640,000); Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2007: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2006: ¥4,800,000 (Direct Cost: ¥4,800,000)
• Keywords: 左右非対称性 / 消化管 / 上皮細胞 / ミオシン / アクチン / E-カドヘリン / ショウジョウバエ / シミュレーション / ミオシンI / コンピュータ・シミュレーション / 質量分析 / 左右性 / 細胞骨格 / 左右非対称 / 非定型ミオシン

Research Abstract

動物のからだが左右非対称になる機構は、進化的に多様であり、脊椎動物の一部を除いて、ほとんど理解されていない
本研究では、遺伝学的解析手段が駆使できるショウジョウバエの消化管にみられるステレオタイプな左右非対称性に着目した。胚消化管の左右性に異常を示す突然変異体を網羅的に検索し、得られた遺伝子の機能を解析した。その結果、Myosin31DFが、DE-cadherinの機能を介して、消化管上皮細胞の形態を左右非対称にしていることがわかった。コンピュータ・シミュレーションによって、この左右非対称な形状が、左右非対称性形成に十分であることを示した

Research Products

• [Journal Article] The development and evolution of left-right asymmetry ininvertebrates : lessons fromDrosophila and snails (2008)
  • Author(s): Okumura, T., Utsuno, H., Kuroda, J., Gittenberger, E., Asami, T., andMatsuno, K.
  • Journal Title: Dev. Dyn. 237 Pages: 3497-3515
• [Journal Article] The head region of unconventional Myosin I familymembers is responsible for theorgan-specificity of their roles in left-right polarity in Drosophila (2008)
  • Author(s): Hozumi, S., Maeda, R., Taniguchi-Kanai, M., Okumura, T., Taniguchi, K., Kawakatsu, Y., Nakazawa, N., Hatori, R., and Matsuno, K.
  • Journal Title: Dev. Dyn. 237 Pages: 3528-3537
• [Journal Article] Drosophila HOPS and AP-3 complex genes are required for aDeltex-regulated activation of Notchin the endosomal trafficking pathway (2008)
  • Author(s): Wilkin, M. B., Tongngok, P., Gensch, N., Clemence, S., Motoki, M., Yamada, K., Hori, K., Taniguchi-Kanai, M., Franklin, E., Matsuno, K., and Baron, M.
  • Journal Title: Dev. Cell 15 Pages: 762-772
• [Journal Article] Distinct activation patterns of EGF receptor signaling inthe homoplastic evolution of eggshellmorphology in genus Drosophila (2008)
  • Author(s): Kagesawa, T., Nakamura, Y., Nishikawa, M., Akiyama, Y., Kajiwara, M., andMatsuno, K.
  • Journal Title: Mech. Dev. 125 Pages: 1020-1032
• [Journal Article] The development and evolution of left-right asymmetry in invertebrates : lessons from Drosophila and snails. (2008)
  • Author(s): Takashi Okumura
  • Journal Title: Dev. Dyn. 237 Pages: 3497-3515
  • Peer Reviewed
• [Journal Article] The head region of unconventional Myosin I family members is responsible for the organ-specificity of their roles in left-right polarity in Drosophila. (2008)
  • Author(s): Syunya Hozumi
  • Journal Title: Dev. Dyn. 237 Pages: 3528-3537
  • Peer Reviewed
• [Journal Article] Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of Notch in the endosomal trafficking pathway. (2008)
  • Author(s): Wilkin, M. B.
  • Journal Title: Dev. Cell 15 Pages: 762-772
  • Peer Reviewed
• [Journal Article] Distinct activation patterns of EGF receptor signaling in the homoplastic evolution of eggshell morphology in genus Drosophila. (2008)
  • Author(s): Tatsuo Kagesawa
  • Journal Title: Mech. Dev. 125 Pages: 1020-1032
  • Peer Reviewed
• [Journal Article] The O-fucosyltransferase O-fut1 is an extracellular component that isessential for the constitutiveendocytic trafficking of Notch inDrosophila (2007)
  • Author(s): Sasamura, T., Ishikawa, H. O., Sasaki, N., Higashi, S., Kanai, M., Nakao, S., Ayukawa, T., Aigaki, T.,Noda, K., Miyoshi, E., Taniguchi, N., and Matsuno, K.
  • Journal Title: Development 134 Pages: 1347-1356
• [Journal Article] Soma-dependent modulations contribute to divergence of rhomboid expressionduring evolution of Drosophilaeggshell morphology (2007)
  • Author(s): Nakamura, Y., Kagesawa, T., Nishikawa, M., Hayashi, Y., Kobayashi, S., Niimi, T., andMatsuno, K.
  • Journal Title: Development 134 Pages: 1529-1537
• [Journal Article] Roles of type I Myosins in Drosophila handedness (2007)
  • Author(s): Taniguchi, K., Hozumi, S., Maeda, R., Okumura, T., andMatsuno, K.
  • Journal Title: Fly 1 Pages: 287-290
• [Journal Article] D-JNK signaling in visceral muscle cells controls the laterality of theDrosophila gut (2007)
  • Author(s): Taniguchi, K., Hozumi, S., Maeda, R., Ooike, M., Sasamura, T., Aigaki, T., and Matsuno, K.
  • Journal Title: Dev. Biol. 311 Pages: 251-263
• [Journal Article] Mastermind-1 is required for Notch signal-dependent steps in lymphocytedevelopment in vivo (2007)
  • Author(s): Oyama, T., Harigaya, K., Muradil, A., Hozumi, K., Habu, S., Oguro, H., Iwama, A., Matsuno, K., Sakamoto, R., Sato M.,Yoshida, N., and Kitagawa, M.
  • Journal Title: Proc. Natl. Acad. Sci. USA 104 Pages: 9764-9769
• [Journal Article] The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport (2007)
  • Author(s): Araki, Y., Kawano, T., Taru, H., Saito, Y., Wada, S., Miyamoto, K., Kobayashi, H., Ishikawa, H. O., Ohsugi, Y., Yamamoto, T., Matsuno, K., Kinjo, M., and Suzuki, T.
  • Journal Title: EMBO J 26 Pages: 1475-1486
• [Journal Article] Roles of single-minded in the left-right asymmetric development andtissue specifications of theDrosophila embryonic gut (2007)
  • Author(s): Maeda, R., Hozumi, S., Taniguchi, K., Sasamura, T., Murakami, R., and Matsuno, K.
  • Journal Title: Mech. Dev. 124 Pages: 204-217
• [Journal Article] Polarized exocytosis and transcytosis of Notch during itsapical localization in Drosophilaepithelial cells (2007)
  • Author(s): Sasaki N., Sasamura, T., Ishikawa, H. O., Kanai, M., Ueda, R., Saigo, K., Aigaki, T., and Matsuno K.
  • Journal Title: Genes to Cells 12 Pages: 89-103
• [Journal Article] ショウジョウバエにおける左右非対称性形成の遺伝学的解析 (2007)
  • Author(s): 前田礼男, 穂積俊矢, 谷口喜一郎, 奥村高志, 松野健治
  • Journal Title: 生化学 6(12) Pages: 1131-1134
  • NAID: 10020284287
• [Journal Article] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. (2007)
  • Author(s): Toshinao Oyama
  • Journal Title: Proc. Natl. Acad. Sci. USA 104 Pages: 97649796-97649796
  • Peer Reviewed
• [Journal Article] D-JNK signaling in visceral muscle cells controls the laterality of the Drosophila gut. (2007)
  • Author(s): Kiichiro Taniguchi
  • Journal Title: Dev. Biol. 311 Pages: 251263-251263
  • Peer Reviewed
• [Journal Article] Roles of type I Myosins in Drosophila handedness. (2007)
  • Author(s): Kiichiro Taniguchi
  • Journal Title: Fly 1 Pages: 287290-287290
  • Peer Reviewed
• [Journal Article] Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells (2007)
  • Author(s): Nobuo Sasaki
  • Journal Title: Genes to Cells 12 Pages: 89-103
• [Journal Article] Roles of single-minded in the left-right asymmetric development and tissue specifications of the Drosophila embryonic gut (2007)
  • Author(s): Reo Maeda
  • Journal Title: Mech. Dev. 124 Pages: 204-217
• [Journal Article] The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport (2007)
  • Author(s): Yoichi Araki
  • Journal Title: EMBO J. 26 Pages: 1475-1486
• [Journal Article] The 0-fucosyltransferase 0-futl is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila (2007)
  • Author(s): Takeshi Sasamura
  • Journal Title: Development 134 Pages: 1347-1356
• [Journal Article] Soma-dependent modulations contribute to divergence of rhomboid expression during evolution of Drosophila eggshell morphology (2007)
  • Author(s): Yukio Nakamura
  • Journal Title: Development 134 Pages: 1529-1537
• [Journal Article] The first deltex null mutant indicates tissue-specific deltex-dependentNotch signaling in Drosophila (2006)
  • Author(s): Fuwa, T. J., Hori, K., Sasamura, T., Higgs, J., Baron, M. and Matsuno, K.
  • Journal Title: Mol. Genet. and Genom. 275 Pages: 251-263
• [Journal Article] A Drosophila unconventional myosin reverses the defaulthandedness in visceral organs (2006)
  • Author(s): Hozumi, S., Maeda, R., Taniguchi, K., Sasamura, T., Speder, P., Noselli, S., Aigaki, T., Murakami, R. and Matsuno, K.
  • Journal Title: Nature 440 Pages: 798-802
• [Journal Article] A Drosophila unconventional myosin reverses the default handedness in visceral organs (2006)
  • Author(s): Syunya Hozumi
  • Journal Title: Nature 440 Pages: 798-802
• [Presentation] doctor no and ken and barbie are involved in the left-right asymmetric development of the Drosophia embryonic gut. (2009)
  • Author(s): Reo Maeda
  • Organizer: 50th Annual Drosophila Research Conference
  • Place of Presentation: シカゴ、米国
• [Presentation] A novel role of Notch monosaccharide O-fucose modification is required for Delta-Notch but not Serrate-Notch signaing in Drosophila (2009)
  • Author(s): Tomonori Ayukawa
  • Organizer: 50th Annual Drosophila Research Conference
  • Place of Presentation: シカゴ、米国
• [Presentation] ショウジョウバエにおける左右非対称性の形成機構-遺伝学とコンピュタ・シミュレーションによるアプローチ (2008)
  • Author(s): 松野健治
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] ショウジョウバエにおける左右非対称性の形成機構-遺伝学とコンピュタ・シミュレーションによるアプローチ- (2008)
  • Author(s): 松野健治
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] Septate junctions are required for left-right asymmetric development ofthe embryonic gut in Drosophilamelanogaster. (2008)
  • Author(s): Yasuhiro Kawakatsu, Takasi Okumura, Reo Maeda, Kiichiro Taniguchi,Naotaka Nakazawa, Kenji Matsuno
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] Downstream signal of the Notch receptor diverges into two distinct pathways through its selective endocytic trafficking mediated by Deltex (2008)
  • Author(s): Kenta Yamada
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] Functions of a neurogenic gene, pecanex in Notch signaling (2008)
  • Author(s): Tomoko Yamakawa
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] A genome-wide RNAi screen to identify the genes regulating vesicular trafficking of Notch in Drosophila melanosaster (2008)
  • Author(s): Naoki Aoyama
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] A novel role of Notch monosaccharide 0-fucose modification is required for Delta-Notch but not Serrate-Notch signaling in Drosophila (2008)
  • Author(s): Tomonori Ayukawa
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] Septate junctions are required for left-right asymmetric devel opment of the embryonic gut in Drosophila melanogaster (2008)
  • Author(s): Yasuhiro Kawakatsu
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] DE-Cadherin-and MyosinID-dependent cell shape changes were involved inthe laterality of the Drosophilaembryonic gut. (2008)
  • Author(s): Kiichiro Taniguchi, Tadashi Ando, Takashi Okumura, MaikoTaniguchi-Kanai, Naotaka Nakazawa, Reo Maeda, Mitsutoshi Nakumura,Syunya Hozumi, Kenji Matsuno
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] A nonmuscle Myosin II heavy chain, Zipper, is required for theleft-right asymmetricmorphologenesis of the anteriormidgut in Drosophila embryo. (2008)
  • Author(s): Takashi Okumura, Hiroo Fujiwara, Kiichiro Taniguchi, Reo Maeda, HozukiSyunya, Naotaka Nakazawa, MitutoshiNakamura, Haruka Yamamoto, KenjiMstsuno
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] Wntシグナル構成因子であるLDL受容体をコードするショウジョウバエarrowの消化管の左右非対称性形成における機能. (2008)
  • Author(s): 黒田純平, 吉田匡, 山本遙, 奥村高志, 前田礼男, 谷口喜一郎, 川勝康弘, 中澤直高, 中村充利, 石尾彬, 尾崎あゆみ, 羽鳥僚, 松野健治
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] Doctor no and Ken and Barbie are involved in theleft-right asymmetrical developmentof the Drosophila embryonic gut. (2008)
  • Author(s): Reo Maeda, Shunya Hozumi, Kiichiro Taniguchi, Takeshi Sasamura, ToshiroAigaki, Kenji Matsuno
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] DE-cadherin-and MyosinID-dependent cell shape changes were involved in the laterality of the Drosophila embryonic gut (2008)
  • Author(s): Kiichiro Taniguchi
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] A nonmuscle Myosin II heavy chain, Zipper, is required for the left-right asymmetric morphogenesis of the anterior midgut in Drosophila embryo (2008)
  • Author(s): Takashi Okumura
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] Wntシグナル構成因子であるLDL受容体をコードするショウジョウバエarrowの消化管の左右非対称性形成における機能 (2008)
  • Author(s): 黒田純平
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] Doctor no and Ken and Barbie are involved in the left-right asymmetrical development of the Drosophila embryonic gut (2008)
  • Author(s): Reo Maeda
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] ショウジョウバエをモデル系としたペルオキシソーム病の病態研究 (2008)
  • Author(s): 中山実
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] ショウジョウバエをモデル系としたペルオキシソーム病の病態研究 (2008)
  • Author(s): 奥田貴之
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] ショウジョウバエ卵殻形態の進化をもたらしたEGFR情報伝達機構の多様化に関する研究 (2008)
  • Author(s): 影沢達夫
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] 二つのGDP-フコース輸送体の機能解析から明らかになったNotchのo-フコシル化の新規な機能 (2008)
  • Author(s): 松野健治
  • Organizer: 第28回日本糖質学会年会
  • Place of Presentation: つくば
  • Year and Date: 2008-08-19
• [Presentation] 小胞体とゴルジ体にそれぞれ局在する2つのGDP-フコース輸送体はNotchのO-フコシル化に重複した機能をもっている (2008)
  • Author(s): 鮎川友紀
  • Organizer: 第28回日本糖質学会年会
  • Place of Presentation: つくば
  • Year and Date: 2008-08-19
• [Presentation] Functions of a neurogenic gene, pecanex in Notch signaling (2008)
  • Author(s): Tomoko Yamakawa
  • Organizer: 第60回日本細胞生物学会代会
  • Place of Presentation: 横浜
  • Year and Date: 2008-07-01
• [Presentation] Downstream signaling of the Notch receptor diverges into two distinct pathways via its selective endocytic trafficking mediated by Deltex (2008)
  • Author(s): Kenta Yamada
  • Organizer: 第60回日本細胞生物学会代会
  • Place of Presentation: 横浜
  • Year and Date: 2008-07-01
• [Presentation] A genome-wide RNAi screen to identify the genes regulating vesicular trafficking of Notch in Drosophila melanogaster (2008)
  • Author(s): Naoki Aoyama
  • Organizer: 第60回日本細胞生物学会代会
  • Place of Presentation: 横浜
  • Year and Date: 2008-07-01
• [Presentation] Two GFP-fucose transporters, one localizes to endoplasmic reticuluman the other to Golgi, have redundant roles for the O-fucosylation of Notch (2008)
  • Author(s): Tomonori Ayukawa
  • Organizer: 第60回日本細胞生物学会代会
  • Place of Presentation: 横浜
  • Year and Date: 2008-07-01
• [Presentation] Septate junction and left-right asymmetry in Drosophila melanogaster (2008)
  • Author(s): Yasuhiro Kawakatus
  • Organizer: 第60回日本細胞生物学会代会
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-29
• [Presentation] ショウジョウバエ卵殻形態のホモプラシーは発生機構の異なった変化に起因する (2008)
  • Author(s): Tatuo Kagesawa
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
  • Year and Date: 2008-05-30
• [Presentation] Nonmuscle Myosin II heavy chain Zipper isrequired for the left-rightasymmetric morphology of the anteriormidgut in Drosophila embryo. (2008)
  • Author(s): Takashi Okumura, Hiroo Fujiwara, Kiichiro Taniguchi, Reo Maeda, Syunya Hozumi, Naotaka Nakazawa, Mitsutoshi Nakamura, HarukaYamamoto, Kenji Matsuno
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
  • Year and Date: 2008-05-28
• [Presentation] Nonmuscle Myosin II heavy chain Zipper is required for the left-right asymmetric morphology of the anterior midgut in Drosophila embryo (2008)
  • Author(s): Takashi Okumura
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
  • Year and Date: 2008-05-28
• [Presentation] Doctor no and Ken and Barbie are involved in the left-rightasymmetrical development of theDrosophila embryonic gut. (2008)
  • Author(s): Reo Maeda, Shunya Hozumi, Kiichiro Taniguchi, Takeshi Sasamura, ToshiroAigaki, Ryutaro Murakami, KenjiMatsuno
  • Organizer: 49th Annual Drosophila Resarch Conference
  • Place of Presentation: サンディエゴ
  • Year and Date: 2008-04-03
• [Presentation] Nonmuscle Myosin II heavy chain Zipper is required for the left-rightasymmetric morphology of theproventriculus and midgut in Drosophila embryo. (2008)
  • Author(s): Takashi Okumura, Hiroo Fujiwara, Kiichiro Taniguchi, Reo Maeda, Syunya Hozumi, Kenji Matsuno
  • Organizer: 49th Annual Drosophila Resarch Conference
  • Place of Presentation: サンディエゴ
  • Year and Date: 2008-04-03
• [Presentation] ショウジョウバエ胚の消化管における左右非対称な発生に関わる遺伝子のスクリーニング (2008)
  • Author(s): Naotaka Nakazawa, Kiichiro Taniguchi, Takashi Okumura, Reo Maeda, SyunyaHozumi, Mitutoshi Nakamura, HarukaYamamoto, Takeshi Kusama, Ryo Hatori, kenji Matsuno
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
• [Presentation] DE-Cadherin-and MyosinID-dependent cell shapechanges were involved in thelaterality of the Drosophilaembryonic gut. (2008)
  • Author(s): Kiichiro Taniguchi, Tadashi Ando, Takashi Okumura, Reo Maeda, NaotakaNakazawa, syunya Hozumi, KenjiMatsuno
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
• [Presentation] Doctor no and Ken and Barbie are involved in theLeft-right asymmetrical developmentof the Drosophila embryonic gut. (2008)
  • Author(s): Reo Maeda, Shunya Hozumi, Kiichiro Taniguchi, Takeshi Sasamura, ToshiroAiaki, Kenji Matsuno
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
• [Presentation] Fucose modification is essential for Delte-but not Serrate-dependent activation of Notch signaling in Drosophila. (2008)
  • Author(s): Tomonori Ayukawa
  • Organizer: 49th Annual Drosophila Resarch Conference
  • Place of Presentation: サンディエゴ、米国
• [Presentation] Roles of Drosophila Deltex in Suppressor of Hairless-independent Notch signaling. (2008)
  • Author(s): Kenta Yamada
  • Organizer: 49th Annual Drosophila Resarch Conference
  • Place of Presentation: サンディエゴ、米国
• [Presentation] Doctor no and Ken and Barbie are involved in the left-right asymmetrical development of the Drosophila embryonic gut. (2008)
  • Author(s): Reo maeda
  • Organizer: 49th Annual Drosophila Research Conference
  • Place of Presentation: サンディエゴ、米国
• [Presentation] Nonmuscle Myosin II heavy chain Zipper is required for the left-right asymmetric morphology of the proventriculus and midgut in Drosophila embryo. (2008)
  • Author(s): Takashi Okumura
  • Organizer: 49th Annual Drosophila Research Conference
  • Place of Presentation: サンディエゴ、米国
• [Presentation] Distinct modifications of EGF receptor signaling in homoplastic evolution of eggshell morphology in genus Drosophila. (2008)
  • Author(s): Tatsuo Kagesawa
  • Organizer: 49th Annual Drosophila Research Conference
  • Place of Presentation: サンディエゴ、米国
• [Presentation] ショウジョウバエを用いた□-セクレターゼ調節因子の網羅的検索 (2008)
  • Author(s): Naoki Aoyama
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
• [Presentation] DE-Cadherin-and MyosinID-dependent cell shape changes were involved in the laterality of the Drosophila embryonic gut (2008)
  • Author(s): Kiichiro Taniguchi
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
• [Presentation] Doctor no and Ken and Barbie are involved in the Left-right asymmetrical development of the Drosophila embryonic gut (2008)
  • Author(s): Reo Maeda
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
• [Presentation] Downstream signaling of the Notch receptor diverges into two distinct pathways via its selective endocytic trafficking mediated by Deltex (2008)
  • Author(s): Kenta Yamada
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
• [Presentation] Functions of a neurogenic gene, pecanex in Notch signaling (2008)
  • Author(s): Tomoko Yamakawa
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
• [Presentation] Two GFP-fucose transporters, one localizes to endoplasmic reticuluman the other to Golgi, have redundant roles for the O-fucosylation of Notch (2008)
  • Author(s): Tomonori Ayukawa
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
• [Presentation] Notch受容体EGF様配列のO-フコース修飾の機能 (2007)
  • Author(s): 松野 健治
  • Organizer: 第30回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-15
• [Presentation] ショウジョウバエ胚消化管の左右非対称性形成におけるsigle-minded遺伝子の役割. (2007)
  • Author(s): 前田礼男, 穂積俊矢, 谷口喜一郎, 笹村剛司, 村上柳太郎, 松野健治
  • Organizer: 第30回日本分子生物学会年会第80回日本生化学会大会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] A genetics screen to indentify genes involved inthe left-right asymmetricdevelopment of the embryonic gut inDrosophila. (2007)
  • Author(s): 吉田匡, 前田礼男, 谷口喜一郎, 奥村高志, 黒田純平, 中澤直高, 中村充利, 山本遙, 草間岳史, 松野健治
  • Organizer: 第30回日本分子生物学会年会第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] JNKシグナルにより制御される内臓筋細胞の編成はショウジョウバエ中腸前部の左右非対称的な屈曲に必要である. (2007)
  • Author(s): 谷口喜一郎, 穂積俊矢, 前田礼男, 大池雅, 笹村剛司, 相垣敏郎, 松野健治
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
  • Year and Date: 2007-05-28
• [Presentation] Roles of single-minded in the left-rightasymmetric development and tissuespecifications of the Drosophilaembryonic gut. (2007)
  • Author(s): Reo Maeda, Shunya Hozumi, Kiichiro Taniguchi, Takeshi Sasamura, RyutaroMurakami, Kenji Matsuno
  • Organizer: 48th Annual Drosophila Resarch Conference
  • Place of Presentation: フィラデルフィア
  • Year and Date: 2007-03-08
• [Presentation] The rearrangement of circular visceralmusculature cells controlled by JNKsignaling is involved in the left-right asymmetric looping of the anterior-midgut in Drosophila. (2007)
  • Author(s): Kiichiro Taniguchi, Shunya Hozumi, Reo Maeda, Shuichi Shirakabe, HirooFujiwara, Takeshi Sasamura, AigakiToshiro, Kenji Matsuno
  • Organizer: 48th Annual Drosophila Resarch Conference
  • Place of Presentation: フィラデルフィア
  • Year and Date: 2007-03-08
• [Presentation] ショウジョウバエ胚消化管の左右非対称性形成におけるsingle-minded遺伝子の役割. (2007)
  • Author(s): 前田礼男, 穂積俊矢, 谷口喜一郎, 笹村剛司, 村上柳太郎, 松野健治
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] A Drosophila unconventional myosins regulate handedness invisceral organs. (2006)
  • Author(s): Shynya Hozumi, Reo Maeda, Kiichiro Taniguchi, Maiko Kanai, SyuichiShirakabe, Takeshi Sasamura, ToshiroAigaki, Ryutaro Murakami, KenjiMatsuno
  • Organizer: 日本発生生物学会第39回大会
  • Place of Presentation: 広島
  • Year and Date: 2006-06-03
• [Presentation] The rearrangement of visceralmusculature cells controlled by JNK signaling is involved in the left-right asymmetric looping of theanterior-midgut in Drosophila. (2006)
  • Author(s): Kiichiro Taniguchi, Shunya Hozumi, Reo Maeda, Shuichi Shirakabe, HirroFujiwara Takeshi Sasamura, ToshiroAigaki, Kenji Matsuno
  • Organizer: 日本発生生物学会第39回大会
  • Place of Presentation: 広島
  • Year and Date: 2006-06-01
• [Presentation] A genetic screen to identify genes required for left-rightasymmetry in Drosophilamelanogaster (2006)
  • Author(s): Reo Maeda, Shunya Hozumi, Kiichiro Taniguchi, Syuichi Shirakabe, HirooFujikawa Takeshi Sasamutra, ToshiroAigaki, Ryutaro Nurakami, KenjiMatsuno
  • Organizer: 日本発生生物学会第39回大会
  • Place of Presentation: 広島
  • Year and Date: 2006-06-01
• [Presentation] ショウジョウバエ定型非筋ミオシンII重鎖Zipperは前胃の左右非対称な屈曲に必要である.
  • Author(s): 奥村高志, 藤原普夫, 谷口喜一郎, 前田礼男, 穂積俊矢, 吉田匡, 中澤尚高, 中村充利, 草間岳史, 山本遙, 松野健治
  • Organizer: 第30回日本分子生物学会年会第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
• [Book] 細胞工学 (2008)
  • Author(s): 奥村高志, 川勝康弘, 谷口喜一郎, 松野健治
  • Publisher: 秀潤社
• [Book] Glycoscience Lab Manual (2008)
  • Author(s): Ayukawa, T. and Matsuno K.
  • Publisher: Springer Verlag, Tokyo
• [Book] 細胞工学 (2008)
  • Author(s): 奥村高志
  • Total Pages: 553557
  • Publisher: 秀潤社
• [Book] Glycoscience Lab Manual (2008)
  • Author(s): Tomonori Ayukawa
  • Total Pages: 295298
  • Publisher: Springer Verlag, Tokyo
• [Book] 蛋白質核酸酵素 (2007)
  • Author(s): 穂積俊矢, 前田礼男, 谷口喜一郎, 松野健治
  • Publisher: 共立出版
• [Book] 蛋白質核酸酵素 (2007)
  • Author(s): 中越英樹, 松野健治
  • Publisher: 共立出版
• [Book] 蛋白質核酸酵素 (2007)
  • Author(s): 穂積俊矢
  • Total Pages: 227235
  • Publisher: 共立出版
• [Book] 細胞工学 (2006)
  • Author(s): 穂積俊矢, 前田礼男, 谷口喜一郎, 松野健治
  • Publisher: 秀潤社
• [Book] Bionics (2006)
  • Author(s): 前田礼男,穂積俊矢, 谷口喜一郎, 松野健治
  • Publisher: オーム社
• [Book] 細胞工学 (2006)
  • Author(s): 穂積 俊矢
  • Total Pages: 2
  • Publisher: 秀潤社
• [Remarks]
  • URL: http://matsuno-lab.homeip.net/frame.html
• [Remarks]
  • URL: http://matsuno-lab.homeip.net/frame.html
• [Remarks]
  • URL: http://matsuno-lab.homeip.net/frame.html