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Evolutionary origin of the complement system central to animal innate immunity

Research Project

Project/Area Number 18370096
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Evolutionary biology
Research InstitutionThe University of Tokyo

Principal Investigator

NONAKA Masaru  The University of Tokyo, Graduate School of Science, Professor (40115259)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥17,510,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2007: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2006: ¥8,800,000 (Direct Cost: ¥8,800,000)
KeywordsComplement / Evolution / Cnidaria / Gene duplication / Lamprey / 免疫学 / 遣伝子 / 遺伝子 / ネマトステラ
Research Abstract

The complement system of mammals is a highly sophisticated and powerful body defense system composed of more than 30 serum and cell surface proteins. Its main function is to opsonize pathogens through covalent binding of the central component C3 using its unique intramolecular thioester bond. Most complement components show unique domain structures indicating that domain shuffling played an important role in establishing these components. In addition, there are many pairs of gene duplication products in the mammalian complement genes. To elucidate the evolutionary origin of the complement system, complement genes were searched from the recently analyzed cnidarian Nematostella vectensis genome. Two C3 (third complement component), two Bf (complement factor B) and one MASP (mannan-binding protein-associated serine protease) genes were identified. The entire protein-coding sequences of these cDNAs determined by RT-PCR and 5' and 3'RACE predicted a high degree of conservation of the primar … More y structure at the functionally important sites, suggesting that these complement components have been established and played a similar role as those of mammals, before the emergence of Bilateria. However, no complement genes have been identified in the D. melanogaster or C. elegans genomes, and the only complement gene reported thus far from protostome are the C3 and Bf genes of horseshoe crab. Moreover, our attempt to identify the C3 gene from Platyhelminthes, Sipuncula, Annelida and Mollusca failed, suggesting that the once established complement genes have been lost in most Protostome lineages. In contrast, complement genes have been identified from all deuterostomes analyzed thus far. However, liver EST analysis of lamprey showed that there were jawed vertebrate lineage- specific gene duplications of key component genes of the complement system. These gene duplications are believed to have played an important role in establishing the modern complement system of mammals, especially the classical pathway of activation. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (71 results)

All 2008 2007 2006

All Journal Article (24 results) (of which Peer Reviewed: 10 results) Presentation (46 results) Book (1 results)

  • [Journal Article] A Three-step Proteolytic Cascade Mediates the Activation of the Peptidoglycan-induced Toll Pathway in an Insect2008

    • Author(s)
      Kim, C. H., et. al.
    • Journal Title

      J. Biol. Chem. 283

      Pages: 7599-7607

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The amphioxus genome illuminates vertebrate origins and cephalochordate biology2008

    • Author(s)
      Holland, L. Z., et. al.
    • Journal Title

      Genome Res. (印刷中)(掲載確定)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A Three-step Proteolytic Cascade Mediates the Activation of the Peptidoglycan-induced Toll Pathway in an Insect2008

    • Author(s)
      Kim, C. H., Kim, S. J., Kan, H., Kwon, H. M., Roh, K. B., Jiang, R., Yang, Y., Park, J. W., Lee, H. H., Ha, N. C., Kang, H. J., Nonaka, M., Soderhall, K., Lee B. L.
    • Journal Title

      J. Biol. Chem. 283

      Pages: 7599-7607

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The amphioxus genome illuminates vertebrate origins and cephalochordate biology2008

    • Author(s)
      Holland, L. Z., Ricard Albalat, R., Azumi, K., Benito-Gutierrez, E., Blow, M. J., Bronner-Fraser, M., Brunet, F., Butts, T., Candiani, S., Dishaw, L. J., Ferrier, D. E. K., Jordi Garcia-Fernandez, J., Gibson-Brown, J., Gissi, C., Godzik, A., Hallbook, F., Hirose, D., Hosomichi, K., Ikuta, T., Inoko, H., Kasahara, M., Kasamatsu, J., Kawashima, T., Kimura, A., Kobayashi, M., Kozmik, Z., Kubokawa, K., Laudet, V., Litman, G. W., McHardy, A., Meulemans, D., Nonaka, M., Olinski, R. P., Pancer, Z., Pennacchio, L. A., Pestarino, M., Rast, J. P., Rigoutsos, I., Robinson-Rechavi, M., Roch, G., Saiga, H., Sasakura, Y., Satake, M., Satou, Y., Schubert, M., Sherwood, N., Shiina, T., Takatori, N., Tello, J., Vopalensky, P., Wada, S., Xu, A., Ye, Y., Yoshida, K., Yoshizaki, F., Yu, J. K., Zhang, Q., Zmasek, C. M., Putnam, N. H., Rokhsar, D. S., Satoh, N., Holland, P. W. H.
    • Journal Title

      Genome Res. (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A Three-step Proteolytic Cascade Mediates the Activation of the Peptidoglycan-induced Toll Pathway inan Insect2008

    • Author(s)
      Kim, C.H., et. al.
    • Journal Title

      J.Biol.Chem 283

      Pages: 7599-7607

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The amphioxus genome illuminates vertebrate origins and cephalochordate biology2008

    • Author(s)
      Holland, L.Z., et. al.
    • Journal Title

      Genome Res (掲載確定済)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profile during the life cycle of the urochordate Ciona intestinalis2007

    • Author(s)
      Azumi, K., et. al.
    • Journal Title

      Dev. Biol. 308

      Pages: 572-582

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Gene expression profile during the life cycle of the urochordate Ciona intestinalis2007

    • Author(s)
      Azumi, K., Sabau, S. V., Fujie, M., Usami, T., Koyanagi, R., Kawashima, T., Fujiwara, S., Ogasawara, M., Satake, M., Nonaka. M., Wang, H. G., Satou, Y., Satoh, N.
    • Journal Title

      Dev. Biol. 308

      Pages: 572-582

    • NAID

      120002220974

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gene expression profile during the life cycle of the urochordate ciona intestinalis2007

    • Author(s)
      Azumi, K., et. al.
    • Journal Title

      Dev.Biol 308

      Pages: 572-582

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ancestral organization of the major histocompatibility complex revealed in the amphibian Xenopus2006

    • Author(s)
      Ohta, Y., Goetz, W., Hossain, M. Z., Nonaka, M.& Flajnik, M. F.
    • Journal Title

      J. Immunol. 176

      Pages: 3674-3685

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression patterns of Hox genes in larvae of the sea lily Metacrinus rotundus2006

    • Author(s)
      Hara, Y., Yamaguchi, M., Akasaka, K., Nakano, H., Nonaka, M. & Amemiya, S.
    • Journal Title

      Dev. Genes Evol. 216

      Pages: 797-809

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The DNA sequence of medaka chromosome LG222006

    • Author(s)
      Sasaki, T., Shimizu, A., Ishikawa, S. K., Imai, S., Asakawa, S., Murayama, Y., Khorasani, M. Z., Mitani, H., Furutani-Seiki, M., Kondoh, H., Nanda, I., Schmid, M., Schartl, M., Nonaka, M., Takeda, H., Hori, H., Himmelbauer, H., Shima, A. & Shimizu, N.
    • Journal Title

      Genomics 89

      Pages: 124-133

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genomic view of the evolution of the complement system2006

    • Author(s)
      Nonaka, M. & Kimura, A.
    • Journal Title

      Immunogenetics 58

      Pages: 701-713

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] MHCを中心とした獲得免疫の進化2006

    • Author(s)
      野中 勝、塚本 健太郎
    • Journal Title

      生体の科学 57

      Pages: 516-517

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ancestral organization of the major histocompatibility complex revealed in the amphibian Xenopus2006

    • Author(s)
      Ohta, Y., Goetz, W., Hossain, M. Z., Nonaka, M., Flajnik, M. F.
    • Journal Title

      J. Immunol. 176

      Pages: 3674-3685

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression patterns of Hox genes in larvae of the sea lily Metacrinus rotundus2006

    • Author(s)
      Hara, Y., Yamaguchi, M., Akasaka, K., Nakano, H., Nonaka, M., Amemiya, S.
    • Journal Title

      Dev. Genes Evol. 216

      Pages: 797-809

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The DNA sequence of medaka chromosome LG222006

    • Author(s)
      Sasaki, T., Shimizu, A., Ishikawa, S. K., Imai, S., Asakawa, S., Murayama, Y., Khorasani, M. Z., Mitani, H., Furutani-Seiki, M., Kondoh, H., Nanda, I., Schmid, M., Schartl, M., Nonaka, M., Takeda, H., Hori, H., Himmelbauer, H., Shima, A., Shimizu, N.
    • Journal Title

      Genomics 89

      Pages: 124-133

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Genomic view of the evolution of the complement system2006

    • Author(s)
      Nonaka, M., Kimura, A.
    • Journal Title

      Immunogenetics 58

      Pages: 701-713

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Journal Article] Evolution of acquired immunity focusing on MHC (in Japanese)2006

    • Author(s)
      Nonaka, M., Tsukamoto, K.
    • Journal Title

      Seitai no Kagaku 57

      Pages: 516-517

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Complement system2006

    • Author(s)
      Nonaka, M.
    • Journal Title

      Evolution in "Encyclopedia of life sciences", John Wiley & Sons, Ltd.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ancestral organization of the major histocompatibilitycomplex revealed in the amphibian Xenopus2006

    • Author(s)
      Ohta, Y., Goetz, W., Hossain, M.Z., Nonaka, M., Flajnik, M.F.
    • Journal Title

      J. Immunol. 176

      Pages: 3674-3685

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression patterns of Hox genes in larvae of the sea lily Metacrinus rotundus2006

    • Author(s)
      Hara, Y., Yamaguchi, M., Akasaka, K., Nakano, H., Nonaka, M., Amemiya,S.
    • Journal Title

      Dev. Genes Evol. 216

      Pages: 797-809

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The DNA sequence of medaka chromosome LG222006

    • Author(s)
      sasaki, T., Shimizu, A., ishikawa, S.K., Imai, S., Asakawa, S., Murayama, Y., Khorasani, M.Z., Mitani, H., Furutani-Seiki, M., Kondoh, H., Nanda, T., Schmid, M., Scharti, M, Nonaka, M., Takeda, H, Hori, H., Himmelbauer, H., Shima, A., Shimizu,N.
    • Journal Title

      Genomics 89

      Pages: 124-133

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MHCを中心とした獲得免疫の進化2006

    • Author(s)
      野中 勝, 塚本 健太郎
    • Journal Title

      生体の科学 57

      Pages: 516-517

    • Related Report
      2006 Annual Research Report
  • [Presentation] 刺胞動物イソギンチャク(Nematostella vectensis)の補体系遺伝子解析:LC3, Bf, MASP cDNAの構造解析2007

    • Author(s)
      坂口 絵理
    • Organizer
      第44回補体シンポジゥム
    • Place of Presentation
      東海大学、平塚市
    • Year and Date
      2007-08-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Ancient origin and evolution of the complement system2007

    • Author(s)
      Masaru Nonaka
    • Organizer
      International workshop on origin of vertebrates; Approaches from genome biology and informatics
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] "Ancient origin and evolution of the complement System, International workshop on origin of vertebrates2007

    • Author(s)
      Masaru Nonaka
    • Organizer
      Approaches from genome biology and informatics
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 硬骨魚メダカ属におけるMHCクラスI領域の種間変異2007

    • Author(s)
      メタ ラトネイシュ バイ
    • Organizer
      日本比較免疫学会第19回学術集会
    • Place of Presentation
      舞阪文化センター、浜松市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 硬骨魚類メダカ近縁種におけるMHC class I領域内PSMB8遺伝子多型の解析2007

    • Author(s)
      三浦 ふみ
    • Organizer
      日本比較免疫学会第19回学術集会
    • Place of Presentation
      舞阪文化センター、浜松市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Lysine-type peptidoglycan recognition signal mediated by PGRP-SA/GNBP1 is triggered by auto activating modular serine protease2007

    • Author(s)
      Su-Jin Kim
    • Organizer
      第44回補体シンポジウム
    • Place of Presentation
      東海大学、平塚市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 刺胞動物イソギンチャク(Nematostella vectensis)の補体系遺伝子解析:I. C3, Bf, MASP cDNAの構造解析2007

    • Author(s)
      坂口絵理
    • Organizer
      第44回補体シンポジウム
    • Place of Presentation
      東海大学、平塚市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 刺胞動物イソギンチャク(Nematostella vectensis)の補体系遺伝子解析:II. C3, Bf, MASP遺伝子の発現解析2007

    • Author(s)
      木村鮎子
    • Organizer
      第44回補体シンポジウム
    • Place of Presentation
      東海大学、平塚市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] サメ補体C5遺伝子の構造解析2007

    • Author(s)
      南雲浩之
    • Organizer
      第44回補体シンポジウム
    • Place of Presentation
      東海大学、平塚市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] メダカ近縁種におけるMHC class I領域内PSMB8遺伝子の二型性の解析2007

    • Author(s)
      三浦ふみ
    • Organizer
      日本進化学会第9回京都大会
    • Place of Presentation
      京都大学、京都市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] メダカ免疫プロテアソームサブユニット遺伝子及びMHCクラスI遺伝子の種内多型解析2007

    • Author(s)
      塚本健太郎
    • Organizer
      日本進化学会第9回京都大会
    • Place of Presentation
      京都大学、京都市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Comparative genomic analysis of the MHC class I region of the Uryzias species2007

    • Author(s)
      Ratnesh Bhai Mehta
    • Organizer
      The International Symposium of Oryzias Fish
    • Place of Presentation
      Bangkok, Thailand
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PSMB8 gene polymorphism: Interspecific diversity among the Genus Oryzias2007

    • Author(s)
      Fumi Miura
    • Organizer
      The International Symposium of Oryzias Fish
    • Place of Presentation
      Bangkok, Thailand
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Interspecific diversity of the MHC class I region among Oryzias genus2007

    • Author(s)
      Ratnesh Bhai Mehta, Masaru Nonaka
    • Organizer
      19th Japanese Association for Developmental and Comparative Immu-nology
    • Place of Presentation
      Hamamatsu
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PSMB8 gene polymorphism : Interspecific diversity among the Genus Oryzias2007

    • Author(s)
      Fumi Miura, Kentaro Tsukamoto, Masaru Nonaka
    • Organizer
      19th Japanese Association for Developmental and Comparative Immu-nology
    • Place of Presentation
      Hamamatsu
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Lysine-type peptidoglycan recognition signal mediated by PGRP-SA/GNBP1 is triggered by auto activating modular serine protease2007

    • Author(s)
      Su-Jin Kim, Chan Hee Kim, Ji-Won Park, Kyung-Bak Rob, Hyun Mi Kwon, Nam-Chul Ha, Masaru Nonaka, Bok Luel Lee
    • Organizer
      44th Complement symposium
    • Place of Presentation
      Hiratsuka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The complement genes of a cnidaria, sea anemome, Nematostella vectensis I. Structural analysis of the C3, Bf, and MASP genes2007

    • Author(s)
      Eri Sakaguchi, Ayuko Kimura, Mayumi Nonaka, Masaru Nonaka
    • Organizer
      44th Complement symposium
    • Place of Presentation
      Hiratsuka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The complement genes of a cnidaria, sea anemome, Nematostella vectensis II. Expression analysis of the C3, Bf, and MASP2007

    • Author(s)
      Ayuko Kimura, Masaru Nonaka
    • Organizer
      44th Complement symposium
    • Place of Presentation
      Hiratsuka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural analysis of the sharks C5 genes2007

    • Author(s)
      Hiroyuki Nagumo, Shinpei Hayashi, Masaru Nonaka
    • Organizer
      44th Complement symposium
    • Place of Presentation
      Hiratsuka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PSMB8 gene dimorphism : Interspecific diversity among the Genus Oryzias2007

    • Author(s)
      Fumi Miura, Kentaro Tsukamoto, Masaru Nonaka
    • Organizer
      9th Annual Meeting of Society of Evolu-tionary study
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Intraspecific polymorphism of the immunoproteasome subunit genes and MHC class IA genes of medaka Oryzias latipes2007

    • Author(s)
      Kentaro Tsukamto, Masaru Nonaka
    • Organizer
      9th Annual Meeting of Society of Evolu-tionary study
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Comparative genomic analysis of the MHC class I region of the Oryzias species2007

    • Author(s)
      Ratnesh Bhai Mehta, Mayumi Nonaka, Masaru Nonaka
    • Organizer
      The International Symposium of Oryzias, Fish
    • Place of Presentation
      Bangkok, Thailand
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PSMB8 gene polymorphism : Interspecific diversity among the Genus Oryzias2007

    • Author(s)
      Fumi Miura, Kentaro Tsukamoto, Masaru Nonaka
    • Organizer
      The International Symposium of Oryzias, Fish
    • Place of Presentation
      Bangkok, Thailand
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 硬骨魚メダカ属におけるMHCクラス1領域の種間変異2007

    • Author(s)
      メタ ラトネイシュ バイ
    • Organizer
      日本比較免疫学会第19回学術集会
    • Place of Presentation
      舞阪文化センター、浜松市
    • Related Report
      2007 Annual Research Report
  • [Presentation] 硬骨魚類メダカ近縁種におけるMHCclassI領域内PSMB8遺伝子多型の解析2007

    • Author(s)
      三浦 ふみ
    • Organizer
      日本比較免疫学会第19回学術集会
    • Place of Presentation
      舞阪文化センター、浜松市
    • Related Report
      2007 Annual Research Report
  • [Presentation] 刺胞動物イソギンチャク(Nematostella vectensis)の補体系遺伝子解析:1.C3, Bf, MASP cDNAの構造解析2007

    • Author(s)
      坂口 絵理
    • Organizer
      第44回補体シンポジゥム
    • Place of Presentation
      東海大学、平塚市
    • Related Report
      2007 Annual Research Report
  • [Presentation] 刺胞動物イソギンチャク(Nematostella vectensis)の補体系遺伝子解析:II.C3, Bf, MASP遺伝子の発現解析2007

    • Author(s)
      木村 鮎子
    • Organizer
      第44回補体シンポジウム
    • Place of Presentation
      東海大学、平塚市
    • Related Report
      2007 Annual Research Report
  • [Presentation] メダカ近縁種におけるMHCclassI領域内PSMB8遺伝子の二型性の解析2007

    • Author(s)
      三浦 ふみ
    • Organizer
      日本進化学会第9回京都大会
    • Place of Presentation
      京都大学、京都市
    • Related Report
      2007 Annual Research Report
  • [Presentation] 二胚葉動物ネマトステラ(Nematostella vectensis)の原始補体系2006

    • Author(s)
      木村鮎子
    • Organizer
      第43回補体シンポジウム
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝臓EST解析による無脊椎動物ヤツメウナギ補体系遺伝子の網羅的単離2006

    • Author(s)
      木村鮎子
    • Organizer
      日本比較免疫学会第18画学術集会
    • Place of Presentation
      広島
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PSMB8を指標としたメダカMHCクラスI領域の種内多型解析2006

    • Author(s)
      塚本健太郎
    • Organizer
      日本比較免疫学会第18回学術集会
    • Place of Presentation
      広島
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] メダカ属に見られるdmrtl遺伝子重複:日本メダカの性決定遺伝子を生じた以外にも?2006

    • Author(s)
      近藤真理子
    • Organizer
      日本進化学会2006年大会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヤツメウナギ補体系遺伝子の網羅的単離を目指した肝臓EST解析2006

    • Author(s)
      木村鮎子
    • Organizer
      日本動物学会第77回大会
    • Place of Presentation
      島根
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] メダカ主要組織適合性抗原複合体(MHC)クラスI領域の種内多型2006

    • Author(s)
      塚本健太郎
    • Organizer
      日本動物学会第77回大会
    • Place of Presentation
      島根
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] メダカの鱗移植における急性拒絶反応の主要決定因子の解析2006

    • Author(s)
      坂内 英美
    • Organizer
      日本動物学会第77回大会
    • Place of Presentation
      島根
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The complement system of ascidians2006

    • Author(s)
      Masaru Nonaka
    • Organizer
      10th International Congress International Society of Developmental and Comparative Immunology
    • Place of Presentation
      Charleston, South Carolina, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Intraspecific diversity of the MHC class I region of a teleost medaka, Oryzias latipes2006

    • Author(s)
      Kentaro Tsukamoto
    • Organizer
      10th International Congress International Society of Developmental and Comparative Immunology
    • Place of Presentation
      Charleston, South Carolina, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The complement system of lamprey, a jawless vertebrate, revealed by liver EST analysis2006

    • Author(s)
      Ayuko Kimura
    • Organizer
      21th International Complement Workshop
    • Place of Presentation
      Beijing, China
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Primitive Complement system of a bilateralian cnidaria, Nematostella vectensis2006

    • Author(s)
      Ayuko Kimura, Eri Sakaguchi, Masaru Nonaka
    • Organizer
      43th Complement symposium
    • Place of Presentation
      Fukuoka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The complement system of Lamprey, a jawless vertebrate, revealed by liver EST analysis2006

    • Author(s)
      Ayuko Kimura, Masaru Nonaka
    • Organizer
      18th Japanese Association for Developmental and Comparative Immu-nology
    • Place of Presentation
      Hiroshima
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Intraspecific polymorphism of PSMB8 genes in the medaka, Oryzias latipes2006

    • Author(s)
      Kentaro Tsukamoto, Masaru Nonaka
    • Organizer
      18th Japanese Association for Developmental and Comparative Immu-nology
    • Place of Presentation
      Hiroshima
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Gene duplication of medaka Dmrtl2006

    • Author(s)
      Mario Kondo, Kiyoshi Naruse, I. Nanda, M. Schartl, Masaru Nonaka
    • Organizer
      8th Annual Meeting of Society of Evolu-tionary study
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Lamprey liver EST analysis for identification of the complement genes2006

    • Author(s)
      Ayuko Kimura, Kazuho Ikeo, Masaru Nonaka
    • Organizer
      77th Annual Meeting of Zoological Soci-ety
    • Place of Presentation
      Shimane
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Intraspecific diversity of the MHC class I region of a teleost medaka, Oryzias latipes2006

    • Author(s)
      Kentaro Tsukamoto, Mitsuru Sakaizumi, Masayoshi Hata, Masaru Nonaka
    • Organizer
      77th Annual Meeting of Zoological Soci-ety
    • Place of Presentation
      Shimane
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of major determinant of acute rejection of transplanted scales in medaka2006

    • Author(s)
      Hidemi Bannai, Masaru Nonaka
    • Organizer
      77th Annual Meeting of Zoological Soci-ety
    • Place of Presentation
      Shimane
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The complement system of lamprey, a jawless vertebrate, revealed by liver EST analysis2006

    • Author(s)
      Ayuko Kimura, Masaru Nonaka
    • Organizer
      21st International Complement Workshop
    • Place of Presentation
      Beijing, China
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Encyclopedia of life sciences2006

    • Author(s)
      Nonaka, M ほか
    • Publisher
      John Wiley & Sons, Ltd
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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