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Molecular level study for acetic acid resistance mechanism of acetic acid bacteria

Research Project

Project/Area Number 18380059
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied microbiology
Research InstitutionYamaguchi University

Principal Investigator

SUSHITA Kazunobu  Yamaguchi University, 農学部, 教授 (50107736)

Co-Investigator(Kenkyū-buntansha) 外山 博英  山口大学, 農学部, 助教授 (60240884)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2006: ¥7,800,000 (Direct Cost: ¥7,800,000)
Keywords酢酸菌 / 酢酸耐性能 / 好気呼吸鎖 / エネルギー生成能 / 菌膜多糖 / 酢酸耐性 / 呼吸鎖 / エネルギー生成 / 膜小胞 / 高温酢酸発酵 / 酸化ストレス / 反転膜小胞
Research Abstract

酢酸菌の「酢酸発酵」には, 酢酸を生成するエタノール酸化能に加えて, 生成された高濃度酢酸に対する耐性能が必要である.本研究では, この酢酸耐性機構を, 酸化呼吸鎖や酢酸排出系と関連させて, 解析した.結果, 酢酸菌の属間および種間で様々に異なる能力を示す酢酸耐性能は, 共通して, そのエタノール酸化反応, 特にその中心となるアルコール脱水素酵素, によるエネルギー生成能と密接に関係していること, 細胞膜に存在する酢酸排出系に加えて, 細胞膜リン脂質および細胞表面に存在するヘテロ多糖が重要な役割を果たすことが明らかにした.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (68 results)

All 2009 2008 2007 2006 Other

All Journal Article (28 results) (of which Peer Reviewed: 23 results) Presentation (23 results) Book (6 results) Remarks (3 results) Patent(Industrial Property Rights) (8 results)

  • [Journal Article] A tightly bound quinone functions in ubiquinone reaction sites of quinoprotein alcohol dehydrogenase of acetic acid bacteria, Gluconobacter suboxydans2008

    • Author(s)
      K. Matsushita, Y. Kobayashi, M. Mizuguchi, H. Toyama, O. Adachi, K. Sakamoto, H. Miyoshi
    • Journal Title

      Biosci Biotechnol Biochem 72(10)

      Pages: 2723-2731

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 耐熱性発酵微生物の発見とその展開2008

    • Author(s)
      松下一信, 赤田倫治, 山田守
    • Journal Title

      化学と生物 46(7)

      Pages: 472-477

    • NAID

      10024333992

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular taxonomy of Acetobacter syzygii SKU19 and Characterization of its acetic acid adapted strains2008

    • Author(s)
      W. Sintuprapa, G. Theeragool, W. Yongmanitchai, P. Srifah-Huehne, K. Matsushita
    • Journal Title

      Kasetsart J.(Nat. Sci.) 42

      Pages: 701-714

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] タイで分離された耐熱性酢酸菌の機能解析とその利用2008

    • Author(s)
      松下一信
    • Journal Title

      バイオサイエンスとインダストリー 66(3)

      Pages: 130-134

    • NAID

      10024745281

    • Related Report
      2008 Final Research Report
  • [Journal Article] Energy metabolism of unique acetic acid bacterium, Asaia bogorensis, which lacks ethanol oxidation activity2008

    • Author(s)
      Y. Ano, H. Toyama, O. Adachi, K. Matsushita
    • Journal Title

      Biosci. Biotechnol. Biochem 72(4)

      Pages: 989-997

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Energy metabolism of unique acetic acid bacterium, Asaia bogorensis, which lacks ethanol oxidation activity2008

    • Author(s)
      Y. Ano
    • Journal Title

      Biosci. Biotechnol. Biochem. 72(4)

      Pages: 989-997

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purification and properties of two different dihydroxyacetone rcductases in Gluconobacter suboxydans grown on glycerol2008

    • Author(s)
      Adachi O
    • Journal Title

      Biosci Biotechnol Biochem. 72(8)

      Pages: 2124-2132

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular taxonomy of Acetobacter syzygii SKU19 and Characterization of itsacetic acid adapted strains2008

    • Author(s)
      W. Sintuprapa
    • Journal Title

      Kasetsart J. (Nat. Sci. ) 42

      Pages: 701-714

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A tightly bound quinone functions in ubiquinone reaction sites of quinoprotein alcohol dehydrogenase of acetic acid bacteria, Gluconobacter suboxydans2008

    • Author(s)
      K. Matsushita
    • Journal Title

      Biosci Biotechnol Biochem. 72(10)

      Pages: 2723-2731

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The occurrence of a novel NADH dehydrogenase,distinct from the old yellow enzyme,in Gluconobacter strains.2008

    • Author(s)
      Shinagawa E, et. al.
    • Journal Title

      Biosci Biotechnol Biochem. 72(1)

      Pages: 260-264

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the respiratory chain in ethanologenic Zymomonas mobilis with a cyanide-resistant bd-type ubiquinol oxidase as the only terminal oxidase and its possible physiological roles.2008

    • Author(s)
      Sootsuwan K, et. al.
    • Journal Title

      J Mol Microbiol Biotechnol. 14(4)

      Pages: 163-175

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of quinoprotein ethanol dehydrogenase gene and adjacent genes in Pseudomonas putida HK52008

    • Author(s)
      Promden W, et. al.
    • Journal Title

      FEMS Microbiol Lett. 280(2)

      Pages: 203-209

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct physiological roles of two membrane-bound dehydrogenases responsible for D-sorbitol oxidation in Gluconobacter frateurii.2008

    • Author(s)
      W. Soemphol, et. al.
    • Journal Title

      Biosci.Biotechnol.Biochem. 72(3)

      Pages: 842-850

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formaldehyde elimination with formaldehyde and formate oxidase in membrane of acetic acid bacteria.2008

    • Author(s)
      Shinagawa E, et. al.
    • Journal Title

      J Biosci Bioeng. 105(3)

      Pages: 292-295

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新規な微生物資源としての耐熱性酢酸菌の分離・分類・保存および機能解析2007

    • Author(s)
      松下一信
    • Journal Title

      Institute For Fermentation, Osaka, Research Communications 21

      Pages: 19-29

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The highly tolerant acetic acid bacterium Gluconacetobacter europaeus adapts to the presence of acetic acid by changes in lipid composition, morphological properties and PQQ-dependent ADH expression2007

    • Author(s)
      Trcek J, Jernejc K, Matsushita K.
    • Journal Title

      Extremophiles 11(4)

      Pages: 627-635

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] L-Sorbose reductase and its transcriptional regulator involved inL-sorbose utilization of Gluconobacter frateurii.2007

    • Author(s)
      W. Soemphol, et. al.
    • Journal Title

      J. Bacteriol. 189(13)

      Pages: 4800-4808

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The highly tolerant acetic acid bacterium Gluconacetobacter europaeusadapts to the presence of acetic acid by changes in lipid composition,morphological properties and PQQ-dependent ADH expression.2007

    • Author(s)
      Trcek J, et. al.
    • Journal Title

      Extremophiles 11(4)

      Pages: 627-635

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Enzymes Required for Enzymatic Quantification of 5-Keto-D-gluconate and 2-Keto-D-gluconate.2007

    • Author(s)
      Saichana, Y, et. al.
    • Journal Title

      Biosci.Biotechnol.Biochem. 71(10)

      Pages: 2478-2486

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrochemistry of D-Gluconate 2-Dehydrogenase from Gluconobacter frateurii on Indium Tin Oxide Electrode Surface.2007

    • Author(s)
      S. Tsujimura, et. al.
    • Journal Title

      Chemical Letters 36(9)

      Pages: 1164-1165

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-bound,2-keto D-gluconate-yielding D-gluconate dehydro-genase from Gluconobacter dioxyacetonicus IFO 3271:Molecularproperties and gene disruption.2007

    • Author(s)
      H. Toyama, et. al.
    • Journal Title

      Appl.Environ.Microbiol. 73(20)

      Pages: 6551-6556

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conversion of capsular polysaccharide, involved in pellicleformation, to extracellular polysaccharide bygalE deletion in Acetobacter tropicalis2006

    • Author(s)
      A. Deeraksa, S. Moonmangmee, H. Toyama, O. Adachi and K. Matsushita
    • Journal Title

      Biosci. Biotechnol. Biochem 70

      Pages: 2536-2539

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between acetic acid resistance and characteristics of PQQ-dependent ADH in acetic acid bacteria2006

    • Author(s)
      J. Trcek, H. Toyama, J. Czuba, A. Misiewicz, and K. Matsushita
    • Journal Title

      Appl. Microbiol. Biotechnol 70(3)

      Pages: 366-373

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between acetic acid resistance and characteristics of PQQ-dependent ADH in acetic acid bacteria.2006

    • Author(s)
      J.Trcek, et al.
    • Journal Title

      Appl.Microbiol.Biotechnol. 70,No.3

      Pages: 366-373

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel type of formaldehyde-oxidizing enzyme from the membrane of Acetobacter sp.SKU 14.2006

    • Author(s)
      E.Shinagawa, et al.
    • Journal Title

      Biosci.Biotechnol.Biochem. 70,No.4

      Pages: 850-857

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Conversion of capsular polysaccharide, involved in pellicle formation, to extracellular polysaccharide by galE deletion in Acetobacter tropicalis.2006

    • Author(s)
      A.Deeraksa, et al.
    • Journal Title

      Biosci.Biotechnol.Biochem., 70,No.10

      Pages: 2536-2539

    • Related Report
      2006 Annual Research Report
  • [Journal Article] High shikimate production from quinate with two enzymatic systems of acetic acid bacteria.2006

    • Author(s)
      O.Adachi, et al.
    • Journal Title

      Biosci.Biotechnol.Biochem., 70,No.10

      Pages: 2579-2582

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Biochemical and spectroscopic properties of cyanide-insensitive quinol oxidase from Gluconobacter oxydans

    • Author(s)
      T. Mogi, Y. Ano, T. Nakatsuka, H. Toyama, A. Mouri, H. Miyoshi, C. T. Migita, H. Ui, K. Shiomi, S. Omura, K. Kita, K. Matsushita
    • Journal Title

      J. Biochem (in press)

    • NAID

      10026302925

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Characterization in some thermosensitive mutants obtained from thermotolerant Acetobacter tropicalis SKU11002009

    • Author(s)
      W. Soemphol, A. Deeraksa, H. Toyama, O. Adachi, K. Matsushita
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡(講演要旨集)
    • Year and Date
      2009-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 高温適応酢酸発酵株の育種とその機能解析2009

    • Author(s)
      秦野智行、今田智子、外山博英, 薬師寿治, 足立収生、松下一信
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡(講演要旨集)
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 高温適応酢酸発酵株の育種とその機能解析2009

    • Author(s)
      秦野智行
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Thermotolerant Acetic Acid Bacteria : its Physiological Features and Application for High Temperature Oxidative Fermentation2009

    • Author(s)
      K. Matsushita
    • Organizer
      ACP(JSPS-NRCT Asian Core Program)Satellite Seminar
    • Place of Presentation
      Ho Chi Minh City, Vietnam
    • Year and Date
      2009-03-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 酢酸菌と酢酸発酵 : その発酵生理学から見えてくるもの2009

    • Author(s)
      松下一信
    • Organizer
      おかやまバイオアクティブ研究会第33回シンポジウム : 発酵温故知新〜基礎研究から応用まで〜
    • Place of Presentation
      岡山大学
    • Year and Date
      2009-01-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of structure and function of membrane-bound alcohol dehydrogenase from acetic acid bacteria2008

    • Author(s)
      M. Goto
    • Organizer
      2^<nd> International Conference on Acetic Acid Bacteria (2^<nd> ICAAB)
    • Place of Presentation
      Nogoya, Japan
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Acetic Acid Bacteria Research : Recent progress and the future direction2008

    • Author(s)
      K. Matsushita
    • Organizer
      2^<nd> International Conference on Acetic Acid Bacteria (2^<nd> ICAAB)
    • Place of Presentation
      Nogoya, Japan
    • Year and Date
      2008-11-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Expression of Quinoprotein Alcohol Dehydrogenase (PQQ-ADH) and Adaptive Responses to High Concentration of Ethanol and Acetic Acid in Thermotolerant Acetic Acid Bacteria2008

    • Author(s)
      G. Theeragool
    • Organizer
      2^<nd> International Conference on Acetic Acid Bacteria (2^<nd> ICAAB)
    • Place of Presentation
      Nogoya, Japan
    • Year and Date
      2008-11-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Purification and characterization of alcohol dehydrogenases from thermotolerant Acetobacter pasteurianus strains2008

    • Author(s)
      W. Kanchanarach
    • Organizer
      2^<nd> International Conference on Acetic Acid Bacteria (2^<nd> ICAAB)
    • Place of Presentation
      Nogoya, Japan
    • Year and Date
      2008-11-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Respiratory chain related to acetic acid fermentation in Acetobacter pasteurianus IFO 32832008

    • Author(s)
      Y. Matsumura
    • Organizer
      2^<nd> International Conference on Acetic Acid Bacteria (2^<nd> ICAAB)
    • Place of Presentation
      Nogoya, Japan
    • Year and Date
      2008-11-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 環境微生物としての酢酸菌 : その生存戦略と産業利用2008

    • Author(s)
      松下一信
    • Organizer
      薮田セミナー : 環境微生物利用の新展開
    • Place of Presentation
      倉敷
    • Year and Date
      2008-04-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Isolation and characterization of genes involved in thermotolerance in thermotolerant Acetobacter2008

    • Author(s)
      W. Soemphol, A. Deeraksa, H. Toyama, O. Adachi, K. Matsushita
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      福岡(講演要旨集)
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Purification and characterization of alcohol dehydrogenases from thermotolerant Acetobacter pasteurianus strains2008

    • Author(s)
      W. Kanchanarach, O. Adachi, H. Toyama, K. Matsushita
    • Organizer
      2^<nd> International Conference on Acetic Acid Bacteria (2^<nd> ICAAB)
    • Place of Presentation
      held in Nogoya, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Respiratory chain related to acetic acid fermentation in Acetobacter pasteurianus IFO 32832008

    • Author(s)
      Y. Matsumura, T. Yakushi, O. Adachi, K. Matsushita
    • Organizer
      2^<nd> International Conference on Acetic Acid Bacteria (2^<nd> ICAAB)
    • Place of Presentation
      held in Nogoya, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] High Temperature-Acetic Acid Fermentation in Thermotolerant Acetobacter pasteurianus SKU 11082008

    • Author(s)
      T. Hatano, T. Imada, O. Adachi, H. Toyama, K. Matsushita
    • Organizer
      2^<nd> International Conference on Acetic Acid Bacteria (2^<nd> ICAAB)
    • Place of Presentation
      held in Nogoya, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Analysis of structure and function of membrane-bound alcohol dehydrogenase from acetic acid bacteria2008

    • Author(s)
      M. Goto, I. Miyahara, K. Hirotsu, Y. Kobayashi, T. Nakatsuka, H. Toyama, O. Adachi, K. Matsushita
    • Organizer
      2^<nd> International Conference on Acetic Acid Bacteria (2^<nd> ICAAB)
    • Place of Presentation
      held in Nogoya, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression of Quinoprotein Alcohol Dehydrogenase (PQQADH) and Adaptive Responses to High Concentration of Ethanol and Acetic Acid in Thermotolerant Acetic Acid Bacteria2008

    • Author(s)
      G. Theeragool, U. Masud, W. Sintuprapa, H. Toyama, O. Adachi, K. Matsushita
    • Organizer
      2^<nd> International Conference on Acetic Acid Bacteria (2^<nd> ICAAB)
    • Place of Presentation
      held in Nogoya, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] 酢酸菌アルコール脱水素酵素の立体構造2007

    • Author(s)
      後藤勝, 宮原郁子, 広津建, 小林由宜, 中柄朋子, 外山博英, 足立收生, 松下一信
    • Organizer
      日本生体エネルギー研究会第33回討論会
    • Place of Presentation
      山口大学(講演要旨集)
    • Year and Date
      2007-11-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Molecular characterization of quinoprotein alcohol dehydrogenase (PQQADH) and NAD-dependent alcohol dehydrogenases (NAD-ADHs) in thermotolerant acetic acid bacteria2007

    • Author(s)
      G. Theeragool, P. Chinnawirotpisan, W. Sintuprapa, U. Masud, N. Lotong, W. Kanchanarach, H. Toyama, O. Adachi, K. Matsushita
    • Organizer
      The 6^<th> JSPS-NRCT Joint Seminar on Development of Thermotolerant Microbial Resources and Their Applications
    • Place of Presentation
      Walailak, Thailand
    • Related Report
      2008 Final Research Report
  • [Presentation] Production mechanism of pellicle poly- saccharide in thermotolerant acetic acid bacteria2007

    • Author(s)
      S. Moonmangmee, A. Deeraksa, S. Tantratian, H. Toyama, O. Adachi, G. Theeragool, N. Lotong, K. Matsushita
    • Organizer
      The 6^<th> JSPS-NRCT Joint Seminar on Development of Thermotolerant Microbial Resources and Their Applications
    • Place of Presentation
      Walailak, Thailand
    • Related Report
      2008 Final Research Report
  • [Presentation] The Quinoprotein Glycerol Dehydrogenase Functions with Cytochromebo_3 in Gluconobacter Respiratory Chain to Produce L-Sorbose and 5-Ketoeluconate2007

    • Author(s)
      K. Matsushita, et. al.
    • Organizer
      Japanese-German Workshop on Enzyme Technology
    • Place of Presentation
      Kanazawa, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Acetobacter属酢酸菌のctaAのクローニングとその機能解析2006

    • Author(s)
      加山知穂、小池雅文、滝川雄介、福島浩太、阿野嘉孝、外山博英、松下一信
    • Organizer
      日本生体エネルギー研究会第32回討論会
    • Place of Presentation
      東工大(講演要旨集)
    • Year and Date
      2006-12-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 酢酸菌アルコール脱水素酵素の結合型キノンの機能2006

    • Author(s)
      中柄朋子、小林由宜、外山博英、足立収生、松下一信
    • Organizer
      日本生体エネルギー研究会第32回討論会
    • Place of Presentation
      東工大(講演要旨集)
    • Year and Date
      2006-12-14
    • Related Report
      2008 Final Research Report
  • [Book] 酵素ハンドブック第3版(編集 : 八木達彦, 福井俊郎, 一島英治, 鏡山博行, 虎谷哲夫)2008

    • Author(s)
      松下一信他203名共同執筆
    • Publisher
      朝倉書店
    • Related Report
      2008 Final Research Report
  • [Book] 第1章特性 : 第3節細胞外多糖 : 酢酸菌が生成する菌膜へテロ多糖2008

    • Author(s)
      松下一信
    • Publisher
      バイオフィルムの基礎と制御(株)エヌ・ティー・エス第1編基礎編
    • Related Report
      2008 Final Research Report
  • [Book] バイオフィルムの基礎と制御2008

    • Author(s)
      松下 一信
    • Total Pages
      432
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2007 Annual Research Report
  • [Book] Mordern Biooxidation, Enzymes, Reactions and Applications2007

    • Author(s)
      O. Adachi, et. al.
    • Total Pages
      299
    • Publisher
      Wiley-VCH Verlag GmbH&Co.KGaA,Weinheim
    • Related Report
      2007 Annual Research Report
  • [Book] In : Modern Multidisciplinary Applied Microbiology, A. Mendez-Vilas (ed), Wiley- VCH Verlag GmbH & Co. KgaA, Weinheim2006

    • Author(s)
      J. Trcek, H. Toyama, J. Czuba, A. Misiewicz, and K. Matsushita
    • Publisher
      Towards understanding the acetic acid resistance in Gluconacetobacter europaeus
    • Related Report
      2008 Final Research Report
  • [Book] Towards understanding the acetic acid resistance in Gluconacetobacter europaeus. In : Modern Multidisciplinary Applied Microbiology2006

    • Author(s)
      J.Trcek, et al.
    • Total Pages
      800
    • Publisher
      Wiley-VCH Verlag GmbH & Co.KgaA, Weinheim
    • Related Report
      2006 Annual Research Report
  • [Remarks] 研究室

    • URL

      http://web.cc.yamaguchi-u.ac.jp/~oubi

    • Related Report
      2008 Final Research Report
  • [Remarks] 研究室ホームページ:

    • URL

      http://web.cc.yamaguchi-u.ac.jp/~oubi/

    • Related Report
      2008 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://web.cc.yamaguchi-u.ac.JP/~oubi/

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 高温酢酸発酵酢酸菌2008

    • Inventor(s)
      松下一信、秦野智行、薬師寿治、足立收生
    • Industrial Property Rights Holder
      山口大学
    • Industrial Property Number
      2008-287703
    • Filing Date
      2008-11-10
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 高温酢酸発酵酢醍菌2008

    • Inventor(s)
      松下一信, 秦野智行, 薬師寿治, 足立收生
    • Industrial Property Rights Holder
      山口大学
    • Industrial Property Number
      2008-287703
    • Filing Date
      2008-11-10
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 5-ケトグルコン酸産生能を有する高温耐性菌、および高温耐性菌を用いた5-ケトグルコン酸の製造方法2008

    • Inventor(s)
      松下一信, イチポン サイチャナ, 外山博英, 足立収生, ジュアンティップ ムーマンミー
    • Industrial Property Rights Holder
      山口大学
    • Industrial Property Number
      2008-320867
    • Filing Date
      2008-12-17
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] キナ酸および/またはカフェ酸の製造方法2008

    • Inventor(s)
      松下 一信, 足立 牧生
    • Industrial Property Rights Holder
      山口大学
    • Industrial Property Number
      2008-049837
    • Filing Date
      2008-02-29
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 酢酸菌Acetobacter pasteurianus IFO3191が産生するヘテロ多糖からなるメラニン生産抑制剤2007

    • Inventor(s)
      大岡朗、松下一信、外山博英、アーパポーン・デラクサ、ソンポーン・ムーマンミー、足立収生
    • Industrial Property Rights Holder
      宇部興産/山口大学
    • Industrial Property Number
      2007-096621
    • Filing Date
      2007-04-21
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 酢酸菌Acetobacter pasteurianus IFO3191が産生するヘテロ多糖からなるメラニン生産抑制剤2007

    • Inventor(s)
      大岡 朗, 他
    • Industrial Property Rights Holder
      宇部興産・山口大学
    • Industrial Property Number
      2007-096621
    • Filing Date
      2007-04-21
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 酵素機能電極、バイオセンサ、及び燃料電池2007

    • Inventor(s)
      福田裕章, 小松さと子, 松下一信, 戸山博英
    • Industrial Property Rights Holder
      デンソー/山口大学
    • Industrial Property Number
      2007-081714
    • Filing Date
      2007-03-27
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] 酢酸菌の菌体外水溶性多糖を含む免疫調節組成物2006

    • Inventor(s)
      松下一信, 外山博英, アーパーポーン・デラクサ, ソンポーン・ムーマンミー, 足立収生, 川中 聡, 八尾理文, 木村 隆
    • Industrial Property Rights Holder
      ユニチカ/山口大学
    • Industrial Property Number
      2006-117944
    • Filing Date
      2006-04-21
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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