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Study on the network in ovary-uterus-immune systems in regulating ovulation cycle

Research Project

Project/Area Number 18380166
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied animal science
Research InstitutionOkayama University

Principal Investigator

OKUDA Kiyoshi  Okayama University, 大学院・自然科学研究科, 教授 (40177168)

Co-Investigator(Kenkyū-buntansha) ACOSTA Tj  岡山大学, 大学院・自然科学研究科, 准教授 (80379718)
Research Collaborator SKARZYNSKI Dariusz J  ポーランド科学アカデミー, 教授
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,630,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2006: ¥8,400,000 (Direct Cost: ¥8,400,000)
Keywords繁殖 / 代謝・内分泌制御 / 機能性物質 / ウシ / 卵巣 / 子宮 / 免疫系 / クロストーク / プロスタグランジン / アポトーシス / 細胞内シグナル / プロスタグランディン
Research Abstract

本研究により、黄体で合成されるPGF2a、PGE2、コルチゾール、アセチルコリンが細胞死抑制因子として黄体機能の維持に作用すること、また、低酸素環境は黄体機能の衰退と消失(細胞死)に重要な環境要因であることが明らかにされた。また、コルチゾール、interleukin-1aは、子宮内膜のPGF2a合成制御因子として作用し、排卵周期の発現のみならず妊娠成立にも重要な役割を果たすことが示された

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (102 results)

All 2009 2008 2007 2006 Other

All Journal Article (58 results) (of which Peer Reviewed: 48 results) Presentation (41 results) Remarks (3 results)

  • [Journal Article] Survival role of locally produced acetylcholine in the bovine corpus luteum2009

    • Author(s)
      Al-zi'abi MO, Bowolaksono A, Okuda K.
    • Journal Title

      Biology of Reproduction 80 (4)

      Pages: 823-832

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin F2a stimulates 11b-hydroxysteroid dehydrogenase 1 enzyme bioactivity and protein expression in bovine endometrial stromal cells2009

    • Author(s)
      Lee HY, Acosta TJ, Skarzynski DJ, Okuda K.
    • Journal Title

      Biology of Reproduction 80 (4)

      Pages: 657-664

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatic acid modulates prostaglandin secretion in the bovine uterus2008

    • Author(s)
      Woclawek-Potocka I, Brzezicka E, Komiyama J, Siemieniuch M, Okuda K, Skarzynski DJ.
    • Journal Title

      Reproduction 137(1)

      Pages: 95-105

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-apoptptic roles of prostaglandin E2 and F2a in bovine luteal steridogenic cells2008

    • Author(s)
      Bowolaksono A, Nishimura R, Hojo T, Sakumoto R, Acosta TJ, Okuda K.
    • Journal Title

      Biology of Reproduction 79(2)

      Pages: 310-317

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Urinary concentrations of estrone-3-glucuronide and estrous behavior in a captive female giant panda (Ailuropoda melanoleuca)2008

    • Author(s)
      Hama N, Kanemitsu H, Sakamoto K, Oyama Y, Acosta TJ, Ishikawa O, Pengyan W, Okuda K.
    • Journal Title

      Journal of Reproduction and Development 54(4)

      Pages: 281-285

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The influence of tumor necrosis factor a (TNF) on the secretory function of bovine corpus luteum : TNF and its receptor expression during the estrous cycle2008

    • Author(s)
      Korzekwa A, Murakami S, Woclawek-Potocka I, Bah MM, Okuda K, Skarzynski DJ.
    • Journal Title

      Reproductive Biology 8(3)

      Pages: 245-262

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of prostaglandin biosysynthesis by interleukin-1 in cultured bovine endometrial cells2008

    • Author(s)
      Tanikawa M, Lee HY, Watanabe K, Majewska M, Skarzynski DJ, Piotrowska KK, Park SB, Lee DS, Park CK, Acosta TJ, Okuda K.
    • Journal Title

      Journal of Endocrinology 199

      Pages: 425-434

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cortisol is a suppressor of apoptosis in bovine corpus luteum2008

    • Author(s)
      Komiyama J, Nishimura R, Lee HY, Sakumoto R, Tetsuka M, Acosta TJ, Skarzynski DJ, Okuda K.
    • Journal Title

      Biology of Reproduction 78(5)

      Pages: 888-895

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia promotes luteal cell death in bovine corpus luteum2008

    • Author(s)
      Nishimura R, Komiyama J, Tasaki Y, Acosta TJ, Okuda K.
    • Journal Title

      Biology of Reproduction 78(3)

      Pages: 529-536

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatic acid modulates prostaglandin secretion in the bovine uterus.2008

    • Author(s)
      Woclawek-Potocka l
    • Journal Title

      Reproduction 137

      Pages: 95-105

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-apoptptio roles of prostaglandin E2 and F2α in bovine luteal steridogenic cells.2008

    • Author(s)
      Bowolaksono A
    • Journal Title

      Biology of Reproduction 79

      Pages: 310-317

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary concentrations of estrone-3-glucuronide and estrous behavior in a captive female giantpanda (Ailuropoda melanoleuca).2008

    • Author(s)
      Hama N
    • Journal Title

      Journal of Reproduction and Development 54

      Pages: 281-285

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The influence of tumor necrosis factor a(TNF)on the secretory function of bovine corpusluteum : TNF and its receptor expression during the estrous cycle.2008

    • Author(s)
      Korzekwa A
    • Journal Title

      Reproductive Biology 8

      Pages: 245-262

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of prostaglandin biosysynthesis by interleukin-l in cultured bovine endometrial cells.2008

    • Author(s)
      Tanikawa M
    • Journal Title

      Journal of Endocrinology 199

      Pages: 425-434

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cortisol is a suppressor of apoptosis in bovine corpus luteum.2008

    • Author(s)
      Komiyama J
    • Journal Title

      Biology of Reproduction 78

      Pages: 888-895

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia promotes luteal cell death in bovine corpus luteum.2008

    • Author(s)
      Nishimura R
    • Journal Title

      Biology of Reproduction 78

      Pages: 529-536

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation ofluteal function and corpus luteum regression in cows : hormonal control. immune mechnisms and inter-cellular commnication.2008

    • Author(s)
      Skarzynski DJ
    • Journal Title

      Reproduction in Domestic Animals 43

      Pages: 57-65

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cortisol is a suppressor of apoptosis in bovine corpus luteum.2008

    • Author(s)
      Junichi KOMIYAMA
    • Journal Title

      Biology of Reproduction 78(In print)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia promotes luteal cell death in bovine corpus luteum.2008

    • Author(s)
      Ryo NISHIMURA
    • Journal Title

      Biology of Reproduction 78(3)

      Pages: 529-536

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in expression of 11β-hydroxysteroid dehydrogenase type-1, type-2 and glucocorticoid receptor mRNAs in porcine corpus luteum during the estrous cycle.2008

    • Author(s)
      Ryosuke SAKUMOTO
    • Journal Title

      Molecular Reproduction and Development 75(5)

      Pages: 925-930

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in expression of 11・-hydroxysteroid dehydrogenase type-1, type-2 and glucocorticoid receptor mRNAs in porcine corpus luteum during the estrous cycle2007

    • Author(s)
      Sakumoto R, Ito I, Okuda K.
    • Journal Title

      Molecular Reproduction and Development 75(5)

      Pages: 925-930

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene silencing of cyclooxygenase-2 mRNA by RNA interference in bovine cumulus-granulosa cells2007

    • Author(s)
      Kobayashi S-I, Sakatani M, Kobayashi S, Okuda K, Takahashi M.
    • Journal Title

      Journal of Reproduction and Development 53(6)

      Pages: 1305-1311

    • NAID

      10020173139

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expressions of estrogen receptors in bovine corpus luteum : cyclic changes and effects of prostaglandin F2・ and cytokines2007

    • Author(s)
      Shibaya M, Matsuda A, Hojo T, Acosta TJ, Okuda K.
    • Journal Title

      Journal of Reproduction and Development 53(5)

      Pages: 1059-1068

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fas-mediated apoptosis is suppressed by calf serum in cultured bovine luteal cells2007

    • Author(s)
      Skarzynski DJ, Shibaya M, Tasaki Y, Korzekwa A, Murakami S, Woclawek-Potocka I, Majewska M, Okuda K.
    • Journal Title

      Reproductive Biology 7(1)

      Pages: 3-15

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Infusion of exogenous tumor necrosis factor dose dependently alters the length of the luteal phase in cattle : differential response to treatment with indomethacin and L-NAME, a nitric oxide synthase inhibitor2007

    • Author(s)
      Skarzynski DJ, Woclawek-Potocka I, Korzekwa A, Bah MM, Piotrowska K, Barszczewska B, Okuda K.
    • Journal Title

      Biology of Reproduction 76(4)

      Pages: 619-627

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of glucocorticoid in the regulation of prostaglandin biosynthesis in non-pregnant bovine endometrium2007

    • Author(s)
      Lee HY, Acosta TJ, Tanikawa M, Sakumoto R, Komiyama J, Tasaki Y, Piskula M, Skarzynski DJ, Tetsuka M, Okuda K.
    • Journal Title

      Journal of Endocrinology 193(1)

      Pages: 127-135

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of storage and passage of luteal endothelial cells on endothelin-1 and prostaglandin F2・ production2007

    • Author(s)
      Acosta TJ, Yoshioka S, Komiyama J, Lee SH, Grazul-Bilska AT, Skarzynski DJ, Okuda K.
    • Journal Title

      Journal of Reproduction and Development 53(3)

      Pages: 473-480

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene silencing of cyclooxygenase-2 mRNA by RNA interference in bovine cumulus-granulosa cells.2007

    • Author(s)
      Shinichi KOBAYASHI
    • Journal Title

      Journal of Reproduction and Development 53(6)

      Pages: 1305-1311

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expressions of estrogen receptors in bovine corpus luteum: cyclic changes and effects of prostaglandin F2α and cytokines.2007

    • Author(s)
      Masami SHIBAYA
    • Journal Title

      Journal of Reproduction and Development 53(5)

      Pages: 1059-1068

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fas-mediated apoptosis is suppressed by calf serum in cultured bovine luteal cells.2007

    • Author(s)
      Dariusz J. SKARZYNSKI
    • Journal Title

      Reproductive Biology 7(1)

      Pages: 3-15

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of glucocorticoid in the regulation of prostaglandin biosynthesis in non-pregnant bovine endometrium.2007

    • Author(s)
      Hwa-Yong LEE
    • Journal Title

      Journal of Endocrinology 193(1)

      Pages: 127-135

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide in bovine corpus luteum: possible mechanisms of action in luteolysis.2007

    • Author(s)
      Anna KORZEKWA
    • Journal Title

      Animal Science Journal 78(3)

      Pages: 233-242

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Species-differences in the mechanism for apoptosis during structural luteolysis.2007

    • Author(s)
      Norihiro SUGINO
    • Journal Title

      Journal of Reproduction and Development 53(5)

      Pages: 977-986

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 牛子宮のプロスタグランジンF2α分泌調節機構に関する最近の知見と考察2007

    • Author(s)
      Kiyoshi OKUDA
    • Journal Title

      家畜診療 54(12)

      Pages: 713-723

    • NAID

      40015739921

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 直腸検査の問題点とその背景2007

    • Author(s)
      Kiyoshi OKUDA
    • Journal Title

      家畜人工授精 239(3)

      Pages: 20-30

    • NAID

      40015417707

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Effects of storage and passage of luteal endothelial cells on endothelin-1and prostaglandin F2αproduction.2007

    • Author(s)
      TomasJ.ACOSTA
    • Journal Title

      Journal of Reproduction and Development 53(in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Infusion of exogenous tumor necrosis factor dose dependently alters the length of the luteal phase in cattle : differential responses to treatment with indomethacin and L-NAME、 a nitric oxide synthase inhibitor.2007

    • Author(s)
      DariuszJ.SKARZYNSKI
    • Journal Title

      Biology of Reproduction 27(in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Phyto- and endogenous estrogens differently activate intracellular calcium ion mobilization in the bovine endometrial cells2006

    • Author(s)
      Woclawek-Potocka I, Borkowski K, Korzekwa A, Okuda K, Skarzynski DJ.
    • Journal Title

      Journal of Reproduction and Development 52(6)

      Pages: 731-740

    • NAID

      130000053968

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide induces apoptosis in bovine luteal cells2006

    • Author(s)
      Korzekwa A, Okuda K, Woclawek-Potocka I, Murakami S, Skarzynski DJ.
    • Journal Title

      Journal of Reproduction and Development 52(3)

      Pages: 353-361

    • NAID

      130000054621

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxygen concentration is an important factor for modulating progesterone synthesis in bovine corpus luteum2006

    • Author(s)
      Nishimura R, Sakumoto R, Tatsukawa Y, Acosta TJ, Okuda K.
    • Journal Title

      Endocrinology 147(9)

      Pages: 4273-80

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible roles of intracellular cyclic AMP, protein kinase C and calcium ion in the apoptotic signaling pathway in bovine luteal cells2006

    • Author(s)
      Tatsukawa Y, Bowolaksono A, Nishimura R, Komiyama J, Acosta TJ, Okuda K.
    • Journal Title

      Journal of Reproduction and Development 52(4)

      Pages: 517-22

    • NAID

      10020351661

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Equol and para-ethyl-phenol stimulate prostaglandins F2・ in bovine corpus luteum2006

    • Author(s)
      Woclawek-Potocka I, Bober A, 23. Korzekwa A, Okuda K, Skarzynski DJ.
    • Journal Title

      Prostaglandins & other Lipid Mediators 79

      Pages: 287-297

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of mRNAs for interleukin-4, interleukin-6 and their receptors in porcine corpus luteum during the estrous cycle2006

    • Author(s)
      Sakumoto R, Komatsu T, Kasuya E, Saito T, Okuda K.
    • Journal Title

      Domestic Animal Endocrinology 31(3)

      Pages: 46-257

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of intraluteal prostaglandin F2・, progesterone and oxytocin in basal and pulsatile progesterone release from developing bovine corpus luteum2006

    • Author(s)
      Bah MM, Acosta TJ, Pilawski W, Deptula KM, Okuda K, Skarzynski DJ.
    • Journal Title

      Prostaglandins & other Lipid Mediators 79

      Pages: 218-229

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bovine corpus luteum is an extrapituitary site of prolactin production2006

    • Author(s)
      Shibaya M, Murakami S, Tatsukawa Y, Skarzynski DJ, Acosta TJ, Okuda K.
    • Journal Title

      Molecular Reproduction and Development 73

      Pages: 512-519

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phyto-and endogenous estrogens differently activate intracellular calcium ion mobilization in bovine endometrial cells.2006

    • Author(s)
      Izabela WOCLAWEK-POTOCKA
    • Journal Title

      Journal of Reproduction and Development 52・6

      Pages: 731-740

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Oxygen concentration is an important factor fbr modulating progesterone synthesis in bovine corpus luteum.2006

    • Author(s)
      Ryo NISHIMURA
    • Journal Title

      Endocrinology 147・9

      Pages: 4273-4280

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Possible roles of intracellular cyclic AMP, protein kinase C and calcium ion in the apoptotic signaling pathway in bovine luteal cells.2006

    • Author(s)
      Yuko TATSUKAWA
    • Journal Title

      Journal of Reproduction and Development 52・4

      Pages: 517-522

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nitric oxide induces apoptosis in bovine luteal cells.2006

    • Author(s)
      Anna KORZEKWA
    • Journal Title

      Journal of Reproduction and Development 52・3

      Pages: 353-361

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role ofintraluteal prostaglandin F2αprogesterone and oxytocin in basal and pulsatile progesterone release from developing bovine corpus luteum.2006

    • Author(s)
      Mamadou M.BAH
    • Journal Title

      Prostaglandins&other Lipid Mediators 79・3-4

      Pages: 218-229

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Equol and para-ethyl-phenol stimulate prostaglandin Fαsecretion in bovine corpus luteum : intracellular mechanisms of action.2006

    • Author(s)
      Izabela WOCLAWEK-POTOCKA
    • Journal Title

      Prostaglandins&other Lipid Mediators 79・3-4

      Pages: 287-297

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bovine corpus luteum is an extrapituitary site of prolactin production.2006

    • Author(s)
      Masami SHIBAYA
    • Journal Title

      Molecular Reproduction and Development 73・4

      Pages: 512-519

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Acute changes in circulating concentrations of progesterone, nitric oxide and partial pressure of oxygen during prostaglandin F2α induced luteolysis in cattle

    • Author(s)
      Acosta TJ, Bah MM, Korzekwa A, Woclawek-Potocka I, Markiewicz W, Jaroszewski JJ, Okuda K, Skarzynski DJ.
    • Journal Title

      Journal of Reproduction and Development (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of exogenous tumonecrosis factor-a on the secretory function of the bovine reproductive tract depend on tumor necrosis factor-1 concentrations

    • Author(s)
      Skarzynski DJ, Piotrowska KK, Bah MM, Korzekwa A, Woclawek-Potocka I, Sawai K, Okuda K.
    • Journal Title

      Reproduction in Domestic Animals (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Survival role of locally produced acetylcholine in the bovine corpus luteum.

    • Author(s)
      Al-zi'abi MO
    • Journal Title

      Biology of Reproduction (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin F2α stimulates 11β-hydroxysteroid dehydrogenase 1 enzyme bioactivity and protein expression in bovine endometrial stromal cells.

    • Author(s)
      Lee HY
    • Journal Title

      Biology of Reproduction (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute changes in circulating concentrations of progesterone, nitric oxide and partial pressure of oxygen during prostaglandin F2α induced luteolysis in cattle.

    • Author(s)
      Acosta TJ
    • Journal Title

      Journal of Reproduction and Development (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of exogenous tumor necrosis factor-a on the secretory function of the bovine reproductive tract depend on tumor necrosis factor-1 concentrations.

    • Author(s)
      Skarzynski DJ
    • Journal Title

      Reproduction in Domestic Animals (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ウシの発情周期発現機構における子宮の役割2009

    • Author(s)
      奥田潔
    • Organizer
      第110回日本畜産学会シンポジウム「ルミナントバイオロジーの進展開」招待講演
    • Place of Presentation
      神奈川
    • Related Report
      2008 Final Research Report
  • [Presentation] Possible roles of hypoxia in luteal formation and regression in cattle2008

    • Author(s)
      Okuda K
    • Organizer
      V Jubilee Congress of the Society for Biology of Reproduction
    • Place of Presentation
      Worclaw, Poland
    • Related Report
      2008 Final Research Report
  • [Presentation] Hypoxia plays important roles not only in leteolysis but in luteal formation in cattle2008

    • Author(s)
      Okuda K, Nishimura R Acosta TJ
    • Organizer
      First World Congress on Reproductive Biology
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] ウシ黄体細胞におけるアポトーシス抑制因子としての黄体形成ホルモン (LH) の役割2008

    • Author(s)
      owolaksono A, 西村亮, Acosta TJ, 奥田潔
    • Organizer
      第101回日本繁殖生物学会大会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] ウシ黄体における発情周期を通じた血管分布変化および中期黄体内血管分布に及ぼす PGF2α の影響2008

    • Author(s)
      法上拓生, Al-zi'abi MO, Acosta TJ, 奥田潔
    • Organizer
      第101回日本繁殖生物学会大会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] Prostaglandin F2α stimulates 11β-hydroxysteroid dehydrogenase type1 activity and protein expression in bovine endometrial stromal cells2008

    • Author(s)
      Lee HY, Acosta TJ, Okuda K
    • Organizer
      41th Annual Meeting Society for the Study of Reproduction
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] ウシ子宮内膜の glucocorticoid receptor α および 11β-hydroxysteroid dehydrogenases protein 発現に及ぼす cortisol の影響2008

    • Author(s)
      李和容, Acosta TJ, 奥田潔
    • Organizer
      第145回日本獣医学会学術集会
    • Place of Presentation
      神奈川
    • Related Report
      2008 Final Research Report
  • [Presentation] ウシ黄体の形成および退行における低酸素環境の意義2008

    • Author(s)
      西村亮, 小見山純一, Acosta TJ, 奥田潔
    • Organizer
      第145回日本獣医学会学術集会
    • Place of Presentation
      神奈川
    • Related Report
      2008 Final Research Report
  • [Presentation] ウシ黄体の形成および退行における低酸素環境の意義2008

    • Author(s)
      西村 亮
    • Organizer
      第145回 日本獣医学会
    • Place of Presentation
      神奈川
    • Related Report
      2007 Annual Research Report
  • [Presentation] Possible anti-apoptotic roles of prostaglandins in bovine luteal cells2007

    • Author(s)
      Okuda K, Bowolaksono A, Nishimura R, Sakumoto R, Komiyama J, Acosta TJ
    • Organizer
      40th Annual Meeting Society for the Study of Reproduction
    • Place of Presentation
      San Antonio, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] 低酸素環境はウシ黄体細胞のプロジェステロン合成を抑制することによりアポトーシスを誘導する2007

    • Author(s)
      西村亮, Acosta TJ, 奥田潔
    • Organizer
      第100回日本繁殖生物学会大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Prostaglandin (PG) F2・ は 11・-hydroxysteroid dehydrogenase (11HSD) 1 活性 および protein 発現を刺激する2007

    • Author(s)
      李和容, Acosta TJ, 小見山純一, 田崎ゆかり, 奥田潔
    • Organizer
      第100回日本繁殖生物学会大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Immunohistochemical study on cFLIP in the bovine corpus luteum2007

    • Author(s)
      Al-zi'abi O, Hojo T, Matsuda-Minehata F, Acosta TJ, Manabe N, Okuda K
    • Organizer
      第108回日本畜産学会
    • Place of Presentation
      岡山
    • Related Report
      2008 Final Research Report
  • [Presentation] ウシ子宮内膜のglucocorticoid receptor αおよび11β-hydroxysteroid dehydrogenases protein発現に及ぼすcortisolの影響2007

    • Author(s)
      李 和容
    • Organizer
      第145回 日本獣医学会
    • Place of Presentation
      神奈川
    • Related Report
      2007 Annual Research Report
  • [Presentation] ウシ黄体細胞におけるアポトーシス抑制因子としてのprostaglandin F2αの役割2007

    • Author(s)
      Anom BOWOLAKSONO
    • Organizer
      第100回 日本繁殖生物学会大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] ウシ子宮内膜のプロスタグランディン F2α分泌における子宮内膜上皮-間質細胞間相互作用の解明2007

    • Author(s)
      柴谷 雅美
    • Organizer
      第100回 日本繁殖生物学会大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] ウシ黄体における glucocorticoidの生理的役割2007

    • Author(s)
      小見山 純一
    • Organizer
      第100回 日本繁殖生物学会大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] ウシ黄体由来血管内皮細胞における一酸化窒素(NO)合成酵素タンパク発現 調節機構に関する研究2007

    • Author(s)
      吉岡 伸
    • Organizer
      第100回 日本繁殖生物学会大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] ウシ子宮内膜における vascular endothelial growth factor の生理的役割2007

    • Author(s)
      田崎 ゆかり
    • Organizer
      第100回 日本繁殖生物学会大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 低酸素環境はウシ黄体細胞のプロジェステロン合成を抑制することによりアポトーシスを誘導する2007

    • Author(s)
      西村 亮
    • Organizer
      第100回 日本繁殖生物学会大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] Prostaglandin (PG) F2α は 11β-hydroxysteroid dehydrogenase (11HSD)1活性および protein 発現を刺激する2007

    • Author(s)
      李 和容
    • Organizer
      第100回 日本繁殖生物学会大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] Immunohistochemical study on cFLIP in the bovine corpus luteum2007

    • Author(s)
      Omar AL-ZI'ABI
    • Organizer
      第108回 日本畜産学会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] ウシ子宮内膜間質細胞の prostaglandin 合成能における glucocorticoid の作用機序2007

    • Author(s)
      大河原 弘美
    • Organizer
      第108回 日本畜産学会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] ウシ黄体における cellular FLICE-like inhibitory protein (cFLIP)の発現解析2007

    • Author(s)
      法上 拓生
    • Organizer
      第108回 日本畜産学会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] ウシ黄体由来血管内皮細胞(LEC)のprostaglandin F2α(PGF)分泌調節機構の解明2007

    • Author(s)
      李 〓昇
    • Organizer
      第108回 日本畜産学会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] Possible anti-apoptotic roles of prostaglandins in bovine luteal cells.2007

    • Author(s)
      Kiyoshi OKUDA
    • Organizer
      第40回 Society for the Study of Reproduction
    • Place of Presentation
      アメリカ・テキサス州サンアントニオ
    • Related Report
      2007 Annual Research Report
  • [Presentation] Acute changes in circulating concentrations of oxygen, nitric oxide and progesterone during prostaglandin F2α-induced luteolysis in cows.2007

    • Author(s)
      Tomas J. ACOSTA
    • Organizer
      第40回 Society for the Study of Reproduction
    • Place of Presentation
      アメリカ・テキサス州サンアントニオ
    • Related Report
      2007 Annual Research Report
  • [Presentation] Glucocorticoid is a suppressor of apoptosis in bovine corpus luteum.2007

    • Author(s)
      Junichi KOMIYAMA
    • Organizer
      第40回 Society for the Study of Reproduction
    • Place of Presentation
      アメリカ・テキサス州サンアントニオ
    • Related Report
      2007 Annual Research Report
  • [Presentation] Expressions of estrogen receptors α and β are regulated by prostaglandin F2α, tumor necrosis factor α and interferon γ in bovine luteal cells.2007

    • Author(s)
      Masami SHIBAYA
    • Organizer
      第40回 Society for the Study of Reproduction
    • Place of Presentation
      アメリカ・テキサス州サンアントニオ
    • Related Report
      2007 Annual Research Report
  • [Presentation] Expression of hypoxia-inducible factor-1α, vascular endothelial growth factor and its receptors in bovine endometrium throughout the estrous cycle.2007

    • Author(s)
      Yukari TASAKI
    • Organizer
      第40回 Society for the Study of Reproduction
    • Place of Presentation
      アメリカ・テキサス州サンアントニオ
    • Related Report
      2007 Annual Research Report
  • [Presentation] ウシ黄体におけるapoptosisに及ぼすglucocorticoidの影響2007

    • Author(s)
      小見山 純一
    • Organizer
      第107回 日本畜産学会
    • Place of Presentation
      神奈川
    • Related Report
      2007 Annual Research Report
  • [Presentation] ウシ黄体細胞のapoptosis抑制因子としてのprostaglandinsの役割2007

    • Author(s)
      Anom BOWOLAKSONO
    • Organizer
      第107回 日本畜産学会
    • Place of Presentation
      神奈川
    • Related Report
      2007 Annual Research Report
  • [Presentation] Blood consentreations of O_2 and NO during PGF2α-induced luteolysis in cows.2007

    • Author(s)
      Tomas J. ACOSTA
    • Organizer
      第107回 日本畜産学会
    • Place of Presentation
      神奈川
    • Related Report
      2007 Annual Research Report
  • [Presentation] 低酸素環境による黄体退行誘導メカニズムの解析2006

    • Author(s)
      西村亮, 作本亮介, Acosta TJ, 奥田潔
    • Organizer
      第99回日本繁殖生物学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] ウシ黄体由来血管内皮細胞における一酸化窒素 (NO) 合成酵素 mRNA 発現2006

    • Author(s)
      Acosta TJ, 吉岡伸, 小見山純一, 西村亮, Skarzynski DJ, 奥田潔
    • Organizer
      第99回日本繁殖生物学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] ウシ黄体における aromatase 及び estrogen receptor 発現に及ぼす prostaglandin F2・ の影響2006

    • Author(s)
      柴谷雅美, Acosta TJ, 奥田潔
    • Organizer
      第99回日本繁殖生物学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] ウシ子宮内膜における発情周期を通じた 11・-hydroxysteroid dehydrogenase (11HSD) 1 活性とその活性におよぼす PGF2・ の影響2006

    • Author(s)
      李和容, Acosta TJ, 西村亮, 小見山純一, 田崎ゆかり, 作本亮介, 手塚雅文, 奥田潔ウシ子宮内膜における発情周期を通じた 11・-hydroxysteroid dehydrogenase (11HSD) 1 活性とその活性におよぼす PGF2・ の影響
    • Organizer
      第99回日本繁殖生物学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] ウシ黄体における11・-hydroxysteroid dehydrogenase type1 (11HSD1) 活性および glucocorticoid2006

    • Author(s)
      小見山純一, 西村亮, 李和容, 作本亮介, 手塚雅文, Acosta TJ, 奥田潔
    • Organizer
      (GC) の作用機序. 第99回日本繁殖生物学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] Survival factors against apoptosis in bovine corpus luteum2006

    • Author(s)
      Okuda K, Bowolaksono A, Nishimura R, Sakumoto R, Acosta TJ
    • Organizer
      39th Annual Meeting of the Society for the Study of Reproduction
    • Place of Presentation
      Omaha, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Oxygen concentration is an important factor for luteolysis in cattle2006

    • Author(s)
      Nishimura R, Sakumoto R, Acosta TJ, Okuda K
    • Organizer
      39th Annual Meeting of the Society for the Study of Reproduction
    • Place of Presentation
      Omaha, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of glucocorticoid on prostaglandin production in bovine endometrium2006

    • Author(s)
      Lee HY, Acosta TJ, Sakumoto R, Tetsuka M, Okuda K
    • Organizer
      39th Annual Meeting of the Society for the Study of Reproduction
    • Place of Presentation
      Omaha, USA
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.cc.okayama-u.ac.jp/~kokuda

    • Related Report
      2008 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.cc.okavama-u.ac.jp/~kokuda/

    • Related Report
      2007 Annual Research Report
  • [Remarks] 研究業績

    • URL

      http://www.cc.okayama-u.ac.jp/~kokuda/top.htm

    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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