Studies for mechanisms of gonadotropin gene regulation with novel pituitary transcription factors
Project/Area Number |
18380177
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Basic veterinary science/Basic zootechnical science
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Research Institution | Meiji University |
Principal Investigator |
KATO Yukio Meiji University, 農学部, 教授 (30114177)
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Co-Investigator(Renkei-kenkyūsha) |
KATO Takako 明治大学, 研究知財・戦略機構, 研究員 (90445859)
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Project Period (FY) |
2006 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥17,460,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2008: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2007: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2006: ¥9,400,000 (Direct Cost: ¥9,400,000)
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Keywords | 転写調節因子 / ホメオティック因子 / 性腺刺激ホルモン / 転写因子ネットワーク / 相互作用 / クローニング / 遺伝子 / 発現制御 / 内分泌学 / 生殖 / 細胞・組織 / 生殖腺刺激ホルモン / 遺伝子発現 |
Research Abstract |
交付期間で、新規転写因子PROP1の特異抗体を作製し、下垂体の発生過程における発現変動を解析し、PROP1が発生初期の下垂体の全細胞に存在し、その後ホルモン産生細胞の出現に伴いその数を減じることを初めて明らかにした。しかも、PROP1陽性細胞は常に細胞分化に重要な因子SOX2と共存する事も初めて明らかした。さらに、新規の転写因子PRX2の同様な解析を行い、PROP1-PRX2-下垂体の分化細胞と言う系譜の一端を明らかにした。
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Report
(4 results)
Research Products
(90 results)
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[Journal Article] Highly related LIM factors, LMO1, LMO3 and LMO4, play different roles in the regulation of pituitary glycoprotein hormone common α subunit gene2009
Author(s)
Susa T, Ishikawa A, Cai LY, Kato T, Matsumoto K, Kitahara K, Kurokawa R, Ono T, Kato Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Highly related LIM factors, LM01, LM03 and LM04, play different roles in the regulation of pituitary glycopro tein hormone common α subunit gene.2009
Author(s)
Susa T, Ishikawa A, Cai LY, Kato T, Matsumoto K, Kitahara K, Kurokawa R, Ono T, Kato Y
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Expression of porcine FSHβ subunit promoter-driven herpes simplex virus thymidine kinase gene in transgenic rats2007
Author(s)
Cai LY, Kato T, Ito K, Nakayama M, Susa T, Aikawa S, Maeda KI, Tsukamura H, Ohta A, Izumi SI, Kato Y
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Journal Title
J Reprod Dev 2007 53
Pages: 201-209
NAID
Related Report
Peer Reviewed
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[Journal Article] Expression of Porcine FSHb Subunit Promoter-driven Herpes Simplex Virus Thymidine Kinase Gene in Ttansgenic Rats.2007
Author(s)
Cai, L.Y., T.Kato, K.Ito, M.Nakayama, T.Susa, S.Aikawa, K.I.Maeda, H.Tsukamura, A.Ohta, S.I.Izumi, Y.Kato
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Journal Title
J.Reprod.Dev. 53(2)
Pages: 201-209
Related Report
Peer Reviewed
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[Journal Article] Expression of Porcine FSH β Subunit Promoter-driven Herpes Simplex Virus Thymidine Kinase Gene in Transgenic Rat2006
Author(s)
Cai L-Y, Kato T, Ito K, Nakayama M, Susa T, Aikawa T, Maeda, K-I, Tsukamura H, Ohta A, Izumi S-I, Kato Y.
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Journal Title
Journal on Molecular Endocrinology 53(in press)
NAID
Related Report
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