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Development of drugs protecting plants from environmental stress in semi-arid land

Research Project

Project/Area Number 18380192
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Boundary agriculture
Research InstitutionKyoto University

Principal Investigator

HIRAI Nobuhiro  Kyoto University, 大学院・農学研究科, 教授 (00165151)

Co-Investigator(Kenkyū-buntansha) MIZUTANI Masaharu  京都大学, 化学研究所, 助教 (60303898)
TODOROKI Yasushi  静岡大学, 農学部, 准教授 (30324338)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,060,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2006: ¥6,400,000 (Direct Cost: ¥6,400,000)
Keywords生物環境 / 環境保全 / 植物 / 生理活性 / 有機化学 / 環境 / バイオテクノロジー
Research Abstract

半乾燥地帯における植物の環境ストレス保護剤の開発を目的として、環境ストレスへの適応反応を誘導する植物ホルモン・アブシシン酸の代謝不活性化酵素に関する研究を行った。その結果、アブシシン酸水酸化酵素の選択的阻害剤の開発に成功するとともに、アブシシン酸の最終不活性化酵素であるファゼイン酸還元酵素活性の諸性質を明らかにした。これにより、アブシシン酸の不活性化制御による植物保護の道を拓いた。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (32 results)

All 2009 2008 2007 2006

All Journal Article (13 results) (of which Peer Reviewed: 10 results) Presentation (19 results)

  • [Journal Article] Structure-activity relationship of uniconazole, a potent inhibitor of ABA 8'-hydroxylase, with a focus on hydrophilic functional groups and conformation2008

    • Author(s)
      Todoroki, Y., Kobayashi, K., Yoneyama, H., Hiramatsu, S., Jin, M.-H., Watanabe, B., Mizutani, M.and Hirai. N
    • Journal Title

      Bioorganic and Medicinal Chemistry 16

      Pages: 3141-3152

    • NAID

      120000796527

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity relationship of uniconazole, a potentinh ibitor of ABA 8' -hydroxylase, with a focus on hydrophilic functional groups and conformation.2008

    • Author(s)
      Y. Todoroki, K. Kobayashi, H. Yoneyama, S. Hiramatsu, M. -H. Jin, B. Watanabe, M. Mizutani, N. Hirai
    • Journal Title

      Bioorganic and Medicnal Chemistry 16

      Pages: 3141-3152

    • NAID

      120000796527

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity relationship of uniconazole, a potent inhibitor of ABA 8'-hydroxylase, with a focus on hydrophilic functional groups and conformation.2008

    • Author(s)
      Y. Todoroki, K. Kobayashi, H. Yoneyama, S. Hiramatsu, M.-H. Jin, B. Watanabe, M. Mizutani, and N. Hirai
    • Journal Title

      Bioorganic and Medicinal Chemistry 16

      Pages: 3141-3152

    • NAID

      120000796527

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of the minor ABA metabolite 7'-hydroxy-ABA on Arabidopsis ABA 8'-hydroxylase CYP707A32007

    • Author(s)
      Shimomura,H. Etoh, H., Mizutani, M., Hirai, N., and Todoroki. Y
    • Journal Title

      Bioorganic and Medicinal Chemistry Letters 17

      Pages: 4977-4981

    • NAID

      120001438370

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] アブシジン酸および植物ステロイドの代謝系に関わるシトクロムP450の酵素化学的研究2007

    • Author(s)
      水谷正治
    • Journal Title

      植物の生長調節 42

      Pages: 260-268

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] シトクロムP450の分子進化と植物の化学的多様性の獲得2007

    • Author(s)
      水谷正治
    • Journal Title

      蛋白質・核酸・酵素 52

      Pages: 1454-1464

    • NAID

      40015648125

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of the minor ABA metabolite 7'-hydroxy-ABA on Arabidopsis ABA 8'-hydroxylase CYP707A3.2007

    • Author(s)
      H. Shimomura, H. Etoh, M. Mizutani, N. Hirai, Y. Todoroki
    • Journal Title

      Bioorganic and Medicinal Chemistry Letters 17

      Pages: 4977-4981

    • NAID

      120001438370

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A potent growth retardant, Uniconazole is a potent inhibitor of ABA catabolism in Arabidopsis. Bioscience2006

    • Author(s)
      Saito, S., Okamoto, M., Shinoda, S., Kushiro, T., Koshiba, T., Kamiya, Y., Hirai, N., Todoroki, Y., Sakata, K., Nambara E. and Mizutani, M
    • Journal Title

      Biotechnology and Biochemistry 70

      Pages: 1731-1739

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new non-azole inhibitor of ABA 8'-hydroxylase: effect of the hydroxyl group substituted for geminal methyl groups in the six-membered ring2006

    • Author(s)
      Araki, Y., Miyawaki,A., Miyashita, T., Mizutani, M., Hirai, N. and Todoroki.Y
    • Journal Title

      Bioorganic and Medicinal Chemistry Letters 16

      Pages: 3302-3305

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] CYP707A1 and CYP707A2, which encode ABA 8'-hydroxylase, are indispensable for a proper control of seed dormancy and germination in Arabidopsis2006

    • Author(s)
      Okamoto, M., Kuwahara, A., Seo, M., Kushiro, T., Asami, T., Hirai, N., Kamiya, Y., Koshiba, T., and Nambara, E
    • Journal Title

      Plant Physiology 141

      Pages: 97-107

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A potent growth retardant, Uniconazole is a potent inhibitor of ABA catabolism in Arabidopsis.2006

    • Author(s)
      Saito, S.
    • Journal Title

      Biosci. Biotech. Biochem. 70 (7)

      Pages: 1731-1739

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A new non-azole inhibitor of ABA 8ユ-hydroxylase : effect of the hydroxyl group substituted for geminal methyl2006

    • Author(s)
      Araki, Y.
    • Journal Title

      Bioorg. Med. Chem. Lett. 16

      Pages: 3302-3305

    • Related Report
      2006 Annual Research Report
  • [Journal Article] CYP707A1 and CYP707A2, which encode ABA 8ユ-hydroxylase, are indispensable for a proper control of seed dormancy2006

    • Author(s)
      Okamoto, M.
    • Journal Title

      Plant Physiol 141 (1)

      Pages: 97-107

    • Related Report
      2006 Annual Research Report
  • [Presentation] ABA代謝物質ファゼイン酸の還元酵素の性質2009

    • Author(s)
      藤井佑典, 近藤悟, 水谷正治, 轟泰司,平井伸博
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      マリンメッセ福岡(福岡市)
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] アブシジン酸代謝不活性化酵素CYP707Aの特異的阻害剤アブシナゾールE2009

    • Author(s)
      轟泰司, 平松佐織, 白倉美奈穂, 水谷正治, 平井伸博
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      マリンメッセ福岡(福岡市)
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] アブシジン酸代謝不活性化酵素CYP707Aの特異的阻害剤アブシナゾールF2009

    • Author(s)
      青山光, 小林亨太郎, 白倉美奈穂, 平松佐織, 水谷正治, 平井伸博, 轟泰司
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      マリンメッセ福岡(福岡市)
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] アブシシン酸8'水酸化酵素制御とリンゴの乾燥耐性2009

    • Author(s)
      須川瞬, 大川克哉, 小原均, 上野琴巳, 水谷正治, 轟 泰司, 平井伸博, 近藤悟
    • Organizer
      日本園芸学会2009年度春季大会
    • Place of Presentation
      明治大学(東京都)
    • Year and Date
      2009-03-20
    • Related Report
      2008 Final Research Report
  • [Presentation] アブシジン酸8'水酸化酵素制御とリンゴの乾燥耐性2009

    • Author(s)
      須川瞬, 大川克哉, 小原均, 上野琴巳, 水谷正治, 轟泰司, 平井伸博, 近藤悟
    • Organizer
      日本園芸学会2009年度春季大会
    • Place of Presentation
      明治大学(東京都)
    • Year and Date
      2009-03-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] ABA代謝物質ファゼイン酸の還元酵素の性質2008

    • Author(s)
      藤井佑典, 近藤悟, 水谷正治, 轟 泰司, 平井伸博
    • Organizer
      植物化学調節学会第43回大会
    • Place of Presentation
      つくばカピオ(つくば市)
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation]2008

    • Author(s)
      白倉美奈穂, 小林亨太郎, 青山光, 平松佐織, 水谷正治, 平井伸博, 轟泰司
    • Organizer
      植物化学調節学会第43回大会
    • Place of Presentation
      つくばカピオ(つくば市)
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] クリック反応を利用した高選択性アゾール系P450阻害剤の創製と探索.2008

    • Author(s)
      平松佐織, 白倉美奈穂, 水谷正治, 平井伸博, 轟泰司
    • Organizer
      植物化学調節学会第43回大会
    • Place of Presentation
      つくばカピオ(つくば市)
    • Year and Date
      2008-10-30
    • Related Report
      2008 Final Research Report
  • [Presentation] クリック反応を利用した高選択性アゾール系P450阻害剤の創製と探索2008

    • Author(s)
      平松佐織, 白倉美奈穂, 水谷正治, 平井伸博, 轟泰司
    • Organizer
      植物化学調節学会第43回大会
    • Place of Presentation
      つくばカピオ(つくば市)
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Structure-activity studies of uniconazole derivatives as strong inhibitors against ABA 8'-hydroxylase2008

    • Author(s)
      Todoroki, Y., Yoneyama, H., Kobayashi, K,. Jin, M-H, Hirai, N. and Mizutani, M
    • Organizer
      19th International Conference of Plant Growth Substances
    • Place of Presentation
      Puerto Vallarta, Mexico
    • Year and Date
      2008-07-23
    • Related Report
      2008 Final Research Report
  • [Presentation] Asymmetric ligand binding ofABA 8'-hydroxylase2008

    • Author(s)
      Ueno, K., Mizutani, M., Hirai, N., Todoroki, Y
    • Organizer
      19th International Conference of Plant Growth Substances
    • Place of Presentation
      Puerto Vallarta, Mexico
    • Year and Date
      2008-07-23
    • Related Report
      2008 Final Research Report
  • [Presentation] Structure-activity studies of uniconazole derivatives as strong inhibitors against ABA 8'-hydroxylase.2008

    • Author(s)
      Y. Todoroki, H. Yoneyama, K. Kobayashi, M-H, Jin, N. Hirai, M. Mizutani,
    • Organizer
      19th International Conference of Plant Growth Substances
    • Place of Presentation
      Puerto Vallarta, Mexico
    • Year and Date
      2008-07-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Asymmetric ligand binding of ABA 8'-hydroxylase.2008

    • Author(s)
      K. Ueno, M. Mizutani, N. Hirai, Y. Todoroki,
    • Organizer
      19th International Conference of Plant Growth Substances
    • Place of Presentation
      Puerto Vallarta, Mexico
    • Year and Date
      2008-07-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] 果樹におけるアブシシン酸8'水酸化酵素阻害による乾燥耐性付与2008

    • Author(s)
      須川 瞬, 大川克哉, 小原 均, 上野琴巳, 水谷正治, 轟 泰司, 平井伸博、近藤悟
    • Organizer
      日本園芸学会2008年度大会
    • Place of Presentation
      東京農業大学(東京都)
    • Year and Date
      2008-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 部位特異的変異を用いたアブシジン酸代謝酵素基質認識メカニズムの解明2008

    • Author(s)
      平松佐織, 上野琴巳, 水谷正治, 平井伸博, 轟泰司
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名城大学(名古屋市)
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] アブシジン酸8'-水酸化酵素リガンドの基本構造2007

    • Author(s)
      上野琴巳, 水谷正治, 平井伸博, 轟泰司
    • Organizer
      植物化学調節学会第42回大会
    • Place of Presentation
      静岡県男女共同参画センターあざれあ(静岡市)
    • Year and Date
      2007-10-29
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Uniconazoleの立体配座とABA 8'-hydroxylase阻害活性の関係2007

    • Author(s)
      小林享太郎, 米山英高, 平松佐織, 金美紅, 渡辺文太, 水谷正治, 平井伸博, 轟 泰司
    • Organizer
      植物化学調節学会第42回大会
    • Place of Presentation
      静岡県男女共同参画センターあざれあ(静岡市)
    • Year and Date
      2007-10-29
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] アブシジン酸8'-水酸化酵素による不斉リガンドの結合2007

    • Author(s)
      上野琴巳, 水谷正治, 平井伸博, 轟泰司
    • Organizer
      日本ケミカルバイオロジー研究会
    • Place of Presentation
      京都大学(京都市)
    • Year and Date
      2007-05-09
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] アブシジン酸8'-水酸化酵素の不斉認識2007

    • Author(s)
      上野琴巳, 水谷正治, 平井伸博, 轟泰司
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京農業大学(東京都)
    • Year and Date
      2007-03-26
    • Related Report
      2008 Final Research Report 2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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