Davelopment of methodology for the preparation of membrane proteins

• Project/Area Number: 18390006
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: The University of Tokushima
• Principal Investigator: OTAKA Akira The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (20201973)
• Co-Investigator(Kenkyū-buntansha): SHIGENAGA Akira 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (10423394)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥13,990,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥1,890,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2006: ¥5,800,000 (Direct Cost: ¥5,800,000)
• Keywords: 不溶性膜タンパク質 / インテイン / エクステイン / ペプチドチオエステル / アシル転位 / スプライシング / アシル転移

Research Abstract

極めて溶解性の低い膜タンパク質の化学合成に向けた化学的基盤として、自然界に見出されるタンパク質の自己編集システムであるインテインーエクステイン系に着目した。この系は、基本的に2つのペプチド結合の切断反応と3っのアシル基転移反応から成り立っている。このインテインーエクステイン系の模倣力杯溶性タンパク質合成に有用と考え、系に含まれる基本的反応の模倣を通じて、不溶性タンパク質合成に役立つ幾つかの反応システムを見出し、その応用展開について検討を加えた。

Research Products

• [Journal Article] Synthesis of Amide-type Fluoroalkene Dipeptide Isosteres by Intramolecular Redox Reaction (2009)
  • Author(s): Y. Yamaki, A. Shigenaga, J. Li, Y. Shimohigashi, A. Otaka
  • Journal Title: J. Org. Chem 74 Pages: 3278-3285
  • Peer Reviewed
• [Journal Article] Synthesis of Fluoroalkene Dipeptide Isosteres by Intramolecular Redox Reaction Utilizing N-Heteorocyclic Carbenes(NHCs) (2009)
  • Author(s): Y. Yamaki, A. Shigenaga, K. Tomita, T. Narumi, N. Fujii, A. Otaka
  • Journal Title: J. Org. Chew 74 Pages: 3272-3277
  • Peer Reviewed
• [Journal Article] FRET-based assay of the processing reaction kinetics of stimulus-responsive peptides : influence of amino acid sequence on reaction kinetics (2009)
  • Author(s): A. Shigenaga, J. Yamamoto, H. Hirakawa, K. Yamaguchi, A. Otaka
  • Journal Title: Tetrahedron 65 Pages: 2212-2216
  • NAID: 120006493353
  • Peer Reviewed
• [Journal Article] N-S acyl-transfer-mediated synthesis of peptide thioesters using anilide derivatives (2009)
  • Author(s): S. Tsuda, A. Shigenaga, K. Bandoh, A. Otaka
  • Journal Title: Org. Lett 11 Pages: 823-826
  • Peer Reviewed
• [Journal Article] Electrostatically constrained a-helical peptide inhibits replication of HIV-1 resistant to Enfuvirtide (2009)
  • Author(s): H. Nishikawa, S. Nakamura, E. Kodama, S. Ito, K. Kajiwara, K. Izumi, Y. Sakagami, S. Oishi, T. Ohkubo, Y. Kobayashi, A. Otaka, N. Fujii, and M. Matsuoka
  • Journal Title: Int. J. Cell. Biol 41 Pages: 891-899
  • Peer Reviewed
• [Journal Article] Synthesis of fluoroalkene dipeptide isosteres by intramolecular redox reaction utilizing N-heterocyclic carbenes (2009)
  • Author(s): Yamaki, Y.
  • Journal Title: The Journal of Organic Chemistry 74(in press)
  • Peer Reviewed
• [Journal Article] Synthesis of amide-type fluoroalkene dipeptide isosteres by intramolecular redox reaction (2009)
  • Author(s): Yamaki, Y.
  • Journal Title: The Journal of Organic Chemistry 74(in press)
  • Peer Reviewed
• [Journal Article] FRET-based assay of the processing reaction kinetics of stimulus-responsive peptides : Influence of amino acid sequence on reaction kinetics (2009)
  • Author(s): Shigenaga, A.
  • Journal Title: Tetrahedron 65 Pages: 2212-2216
  • NAID: 120006493353
  • Peer Reviewed
• [Journal Article] N→S acyl-transfer-mediated synthesis of peptide thioesters using anilide derivatives (2009)
  • Author(s): Tsuda, S.
  • Journal Title: Organic Letters 11 Pages: 823-826
  • Peer Reviewed
• [Journal Article] Influence of an amino acid sequence on kinetics of peptide bond cleavage reaction induced by a stimulus-responsive amino acid (2009)
  • Author(s): Shigenaga, A.
  • Journal Title: Peptide Science 2008 Pages: 395-396
  • NAID: 10027166583
  • Peer Reviewed
• [Journal Article] The application of peptide thioacids to NCL-type sequential condensation of peptide fragments (2009)
  • Author(s): Sumikawa, Y.
  • Journal Title: Peptide Science 2008 Pages: 175-176
  • Peer Reviewed
• [Journal Article] Synthesis of fluoroalkene dipeptide isostere utilizing intramolecular redox reaction (2009)
  • Author(s): Yamaki, Y.
  • Journal Title: Peptide Science 2008 Pages: 49-50
  • Peer Reviewed
• [Journal Article] Synthesis of peptide thioester using N-substituted aniline derivatives (2009)
  • Author(s): Tsuda, S.
  • Journal Title: Peptide Science 2008 Pages: 17-18
  • Peer Reviewed
• [Journal Article] Identification of minimal sequence for HIV-1 fusion inhibitors (2008)
  • Author(s): H. Nishikawa, S. Oishi, M. Fujita, K. Watanabe, R. Tokiwa, H. Ohno, E. Kodama, K. Izumi, K. Kajiwara, T. Naitoh, M. Matsuoka, A. Otaka, and N. Fujii
  • Journal Title: Bioorg. Med. Chem 20 Pages: 9184-9187
  • Peer Reviewed
• [Journal Article] Synthesis of a nucleocytoplasmic shuttle peptide possessing a stimulus-responsive amino acid (2008)
  • Author(s): A. Shigenaga, D. Tsuji, N. Nishioka, S. Tsuda, K. Itoh and A. Otaka
  • Journal Title: Chemical Biology 1 Pages: 7-10
  • Peer Reviewed
• [Journal Article] Heptad Repeat-Derived Peptides Block Protease-Mediated Direct Entry from the Cell Surface of Severe Acute Respiratory Syndrome Coronavirus but Not Entry via the Endosomal Pathway (2008)
  • Author(s): M. Ujike, H. Nishikawa, A. Otaka, N. Yamamoto, N. Yamamoto, M. Matsuoka, E. Kodama, N. Fujii, and F. Taguchi
  • Journal Title: J. Virology 82 Pages: 588-592
  • Peer Reviewed
• [Journal Article] 刺激応答型アミノ酸を利用した核-細胞質シャトルペプチドの開発 (2008)
  • Author(s): 重永 章
  • Journal Title: ケミカルバイオロジー 1 Pages: 7-10
• [Journal Article] Heptad Repeat-Derived Peptides Block Protease-Mediated Direct Entry from the Cell Surface of Severe Acute Respiratory Syndrome Coronavirus but Not Entry via the Endosomal Pathway (2008)
  • Author(s): Ujiike, M.
  • Journal Title: J. Virology 82 Pages: 588-592
  • Peer Reviewed
• [Journal Article] Development of stimulus-responsive amino acid with peptide bond-cleavage ability and its application to a nucleocytoplasmic shuttle peptide (2008)
  • Author(s): Shigenaga, A.
  • Journal Title: Peptide Science 2007 Pages: 97-98
  • NAID: 10021906680
  • Peer Reviewed
• [Journal Article] Synthesis of a stimulus-responsive processing device and its application to a nucleocytoplasmic shuttle peptide (2007)
  • Author(s): A. Shigenaga, D. Tsuji, N. Nishioka, S. Tsuda, K. Itoh and A. Otaka
  • Journal Title: Chem Bio Chem 8 Pages: 1929-1931
  • NAID: 120006493351
  • Peer Reviewed
• [Journal Article] Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using amarium(II) diiodide (SmI_2)-mediated reductive alkylation reaction (2007)
  • Author(s): Y. Sasaki, A. Shigenaga, N. Fujii and A. Otaka
  • Journal Title: Tetrahedron 63 Pages: 2000-2008
  • Peer Reviewed
• [Journal Article] Development of copper-mediated allylation of γ-activated-α,113-unsaturated lactam toward peptide mimetic synthesis (2007)
  • Author(s): Y. Sasaki, K. Yamaguchi, T. Tsuji, A. Shigenaga, N. Fujii and A. Otaka
  • Journal Title: Tetrahedron Lett 48 Pages: 3221-3224
  • Peer Reviewed
• [Journal Article] Development of copper-mediated allylation of γ-activated-α,β-unsaturated lactam toward peptide mimetic synthesis (2007)
  • Author(s): Sasaki Y.
  • Journal Title: Tetrahedron Lett. 48 Pages: 3221-3224
  • Peer Reviewed
• [Journal Article] Synthesis of(Z)-alkene-containing cis-proline dipeptide mimetics using samarium(II)diiodide(SmI2)-mediated reductive alkylation reaction (2007)
  • Author(s): Sasaki, Y.
  • Journal Title: Tetrahedron 63 Pages: 2000-2008
  • Peer Reviewed
• [Journal Article] Synthesis of a stimulus-responsive processing device and its application to anucleocytoplasmic shuttle peptide (2007)
  • Author(s): Shigenaga, A.
  • Journal Title: ChemBioChem 8 Pages: 1929-1931
  • Peer Reviewed
• [Journal Article] Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using samarium(II) diiodide (SmI2)-mediated reductive alkylation reaction. (2007)
  • Author(s): Sasaki, Y.
  • Journal Title: Tetrahedron 63 Pages: 2000-2008
• [Journal Article] Development of copper-mediated allylation of γ-activated-α,β-unsaturated lactam toward peptide mimetic synthesis. (2007)
  • Author(s): Sasaki, Y.
  • Journal Title: Tetrahedron 48 Pages: 3221-3224
• [Journal Article] A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres (2006)
  • Author(s): T. Narumi, A. Niida, K. Tomita, S. Oishi, A. Otaka, H. Ohno and N. Fujii
  • Journal Title: Chem. Commun 45 Pages: 4720-4722
  • Peer Reviewed
• [Journal Article] Stereoselective Synthesis of(Z)-Alkene-Containing Proline Dipeptide Mimetics (2006)
  • Author(s): Y. Sasaki, A. Niida, T. Tsuji, A. Shigenaga, N. Fujii, and A. Otaka
  • Journal Title: J. Org. Chem 71 Pages: 4969-4979
  • Peer Reviewed
• [Journal Article] Specific recognition of the collagen triple helix by chaperone HSP47. II. The HSP47-binding structural motif in collagens and related proteins (2006)
  • Author(s): T. Koide, Y. Nishikawa, S. Asada, C. M. Yamazaki, Y. Takahara, D. L. Homma, A. Otaka, K. Ohtani, N. Wakamiya, K. Nagata, and K. Kitagawa
  • Journal Title: J. Biol. Chem 281 Pages: 11177-11185
  • Peer Reviewed
• [Journal Article] Synthesis of(Z)-Alkene and(E)-Fluoroalkene-Containing Diketopiperazine Mimetics Utilizing Oraganocopper-Mediated Reduction-Alkylation and Diastereoseleetivity Examination Using DFT Calculations (2006)
  • Author(s): A. Niida, M. Mizumoto, T. Narumi, E. Inokuehi, S. Oishi, H. Ohno, A. Otaka, K. Kitaura, and N. Fujii
  • Journal Title: J. Org. Chem 71 Pages: 4118-4129
  • Peer Reviewed
• [Journal Article] Stereoselective Synthesis of 3,6-Disubstituted-3,6-dihydropyridin-2-ones as Potential Diketopiperazine Mimetics Using Organocopper-Mediated anti-SN2'Reactions and Their Use in the Preparation of Low-Molecule CXCR4 Antagonists (2006)
  • Author(s): Niida, H. Tanigaki, E. Inokuchi, Y. Sasaki, S. Oishi, H. Ohno, H. Tamamura, Z. Wang, S. C. Peiper, K. Kitaura, A. Otaka, and N. Fujii
  • Journal Title: A. J. Org. Chem 71 Pages: 3942-3951
  • Peer Reviewed
• [Journal Article] α2 Isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle (2006)
  • Author(s): M. Nakano, T. Hamada, T. Hayashi, S. Yonemitsu, L. Miyamoto, T. Toyoda, S. Tanaka, H. Masuzaki, K. Ebihara, Y. Ogawa, K. Hosoda, G. Inoue, Y. Yoshimasa, A. Otaka, T. Fushiki, and K. Nakao
  • Journal Title: Metab. Clinic. Experiment 55 Pages: 300-308
  • Peer Reviewed
• [Journal Article] Unequivocal Synthesis of (Z)-Alkene and (E)-Fluoroalkene Dipeptide Isosters to Probe Structural Requirements of Peptide Transporter PEPTI (2006)
  • Author(s): A. Niida, K, Tomita, M. Mizuinoto, H. Tanigaki, T. Terada, S. Oishi, A. Otaka, K. Inui, and N. Fujii
  • Journal Title: Org. Lett 8 Pages: 613-616
  • Peer Reviewed
• [Journal Article] Cysteine-derived S-Protected Oxazolidinones : Potential Chemical. Devices for the Preparation of Peptide Thioesters (2006)
  • Author(s): Y. Ohta, S. Itch, A. Shigenaga, S. Shintaku, N. Fujii, and A. Otaka
  • Journal Title: Org. Lett 8 Pages: 467-470
  • Peer Reviewed
• [Journal Article] Design and Synthesis of Downsized Metastin(45-54) Analogs with Maintenance of High GPR54 Agonistic Activity. (2006)
  • Author(s): Niida, A.
  • Journal Title: Bioorg.Med.Chem.Lett. 16 Pages: 134-137
• [Journal Article] Cysteine-derived S-Protected Oxazolidinones : Potential Chemical Devices for the Preparation of Peptide Thioesters. (2006)
  • Author(s): Ohta, Y.
  • Journal Title: Org.Lett. 8 Pages: 467-470
• [Journal Article] Application of Tri- and Trtrasubstituted Alkene Dipeptide Mimetics to Conformational Studies of Cyclic RGD Peptides. (2006)
  • Author(s): Oishi, S.
  • Journal Title: Tetrahedron 46 Pages: 1416-1424
• [Journal Article] Unequivocal Synthesis of (Z)-Alkene and (E)-Fluoroalkene Dipeptide Isosters to Probe Structural Requirements of Peptide Transporter PEPT1. (2006)
  • Author(s): Niida, A.
  • Journal Title: Org.Lett. 8 Pages: 613-616
• [Journal Article] Stereoselective Synthesis of 3,6-Disubstitude-3,6-dihydropyridin - 2-ones as Potential Diketopiperazine Mimetics Using Organocopper-Mediated anti-SN2' Reactions and Their Use in the Preparation of Low-Molecule CXCR4 Antagonists. (2006)
  • Author(s): Niida, A.
  • Journal Title: J. Org. Chem. 71 Pages: 3942-3951
• [Journal Article] Synthesis of (Z)-Alkene and (E)-Fluoroalkene-Containing Diketopiperazine Mimetics Utilizing Oraganocopper-Mediated Reduction-Alkylation and Diastereoselectivity Examination Using DFT Calculations. (2006)
  • Author(s): Niida, A.
  • Journal Title: J.Org.Chem. 71 Pages: 4118-4129
• [Journal Article] Stereoselective Synthesis of (Z)-Alkene-Containing Proline Dipeptide Mimetics. (2006)
  • Author(s): Sasaki, Y.
  • Journal Title: J.Org.Chem. 71 Pages: 4969-4979
• [Journal Article] A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres. (2006)
  • Author(s): Narumi, T.
  • Journal Title: Chem.Commun. Pages: 4720-4722
• [Presentation] 任意の刺激応答型ペプチド結合切断デバイスの反応速度に与えるアミノ酸配列の影響 (2009)
  • Author(s): 重永章、山本純、平川寛子、山口圭子、大高章
  • Organizer: 日本薬学会第129回年会
  • Place of Presentation: 京都
• [Presentation] 分子内NCLを利用した環状ペプチド合成法の開発(1) (2009)
  • Author(s): 前田奈美、津田修吾、石澤祥衣、重永章、大高章
  • Organizer: 日本薬学会第129回年会
  • Place of Presentation: 京都
• [Presentation] 分子内NCLを利用した環状ペプチド合成法の開発(2) (2009)
  • Author(s): 西山由希子、中本亜樹、重永章、大高章
  • Organizer: 日本薬学会第129回年会
  • Place of Presentation: 京都
• [Presentation] 蛋白質化学合成を指向した無保護ペプチドフラグメント順次縮合法の開発 (2009)
  • Author(s): 庄川栄健、津田修吾、重永章、大高章
  • Organizer: 日本薬学会第129回年会
  • Place of Presentation: 京都
• [Presentation] 光刺激応答型アミド結合切断反応のケージドセラミド創製への応用 (2009)
  • Author(s): 平川寛子、西岡直美、山口圭子、重永童、大高章
  • Organizer: 日本薬学会第129回年会
  • Place of Presentation: 京都
• [Presentation] Influence of an amino acid sequence on kinetics of peptide bond cleavage reaction induced by a stimulus-responsive amino acid (2008)
  • Author(s): 重永 章
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-29
• [Presentation] The application of peptide thioacids to NCL-type sequential condensation of peptide fragments (2008)
  • Author(s): 住川栄健
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-29
• [Presentation] Synthesis of fluoroalkene dipeptide isosteres utilizing intramolecular redox reaction catalyzed by N-heterocyclic carbene (2008)
  • Author(s): 八巻陽子
  • Organizer: The 12th Japan-Korea Joint Symposium on Drug Design and Development
  • Place of Presentation: 仙台
  • Year and Date: 2008-05-14
• [Presentation] ペプチド結合切断能を有する光応答型アミノ酸の開発と核-細胞質シャトルペプチドへの応用 (2008)
  • Author(s): 重永 章
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-26
• [Presentation] 人工プロテインスプライシングシステムにおけるペプチド結合切断のための側鎖修飾型アスパラギンの検討 (2008)
  • Author(s): 津田 修吾
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-26
• [Presentation] 光刺激応答型アミド結合切断デバイスを利用したケージドセラミドの創製 (2008)
  • Author(s): 平川寛子、西岡直美、山口圭子、重永章、大高章
  • Organizer: 創薬懇話会2008
  • Place of Presentation: 徳島
• [Presentation] 分子内redox反応を利用したフルオロアルケンジペプチドイソスターの合成 (2008)
  • Author(s): 八巻陽子、重永章、大高章
  • Organizer: 第34回反応と合成の進歩シンポジウム
  • Place of Presentation: 京都
• [Presentation] 光刺激応答型アミド結合切断反応を利用したケージドセラミドの創製 (2008)
  • Author(s): 平川寛子、西岡直美、山口圭子、重永章、大高章
  • Organizer: 第47回日本薬学会病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 岡山
• [Presentation] N-Sアシルシフトを利用した環状ペプチドライブラリー構築の試み (2008)
  • Author(s): 前田奈美、津田修吾、重永章、大高章
  • Organizer: 第47回日本薬学会病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 岡山
• [Presentation] ペプチド結合切断能を有する側鎖修飾型アスパラギンの開発 (2008)
  • Author(s): 森下巧、津田修吾、前田奈美、重永章、大高章
  • Organizer: 第47回日本薬学会病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 岡山
• [Presentation] 近赤外二光子励起応答型ペプチド結合切断デバイスの開発 (2008)
  • Author(s): 山本純、住川栄健、西岡直美、重永章、古田寿昭、大高章
  • Organizer: 第47回日本薬学会病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 岡山
• [Presentation] Synthesis of peptide thioester using N-substituted aniline derivatives (2008)
  • Author(s): 津田修吾、前田奈美、坂東清美、重永章、大高章
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
• [Presentation] Synthesis of fluoroalkene dipeptide isostere utilizing intramolecular redox reaction (2008)
  • Author(s): 八巻陽子、重永章、大高章
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
• [Presentation] Influence of anamino acid sequence on kinetics of peptide bond cleavage reaction induced byastimulus-responsiveamino acid (2008)
  • Author(s): 重永章、西岡直美、山本純、平川寛子、住川栄健、山口圭子、大高章
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
• [Presentation] The application of peptide thioacids to NGL-type sequential condensation of peptide fragments (2008)
  • Author(s): 住川栄健、津田修吾、重永章、大高章
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
• [Presentation] Development of UV irradiation-responsive amino acid with peptide bond cleavage ability and its application to a nucleocytoplasmic shuttle peptide (2008)
  • Author(s): 津田修吾、重永章、辻大輔、西岡直美、住川栄健、伊藤孝司、大高章
  • Organizer: 第22回内藤コンファレンス
  • Place of Presentation: 札幌
• [Presentation] チオカルボン酸を利用した化学的蛋白質合成法の開発に関する研究 (2008)
  • Author(s): 住川栄健、津田修吾、重永章、大高章
  • Organizer: 第24回若手化学者のための化学道場
  • Place of Presentation: 徳島
• [Presentation] Cleavage of peptide bonds for the preparation of functional peptides (2008)
  • Author(s): 大高章、重永章、西岡直美、辻大輔、伊藤孝司
  • Organizer: The 12th Japan-Korea Joint Symposium on Drug Design and Development
  • Place of Presentation: 仙台
• [Presentation] Synthesis of fluoroalkene dipeptide isosteres utilizing intramolecular redox reaction catalyzed by N-heterocyclic carbene (2008)
  • Author(s): 八巻陽子、重永章、大高章
  • Organizer: The l2th Japan-Korea Joint Symposium on Drug Design and Development
  • Place of Presentation: 仙台
• [Presentation] 任意の刺激応答型ペプチド結合切断デバイスの開発 (2008)
  • Author(s): 重永章、西岡直美、山本純、大高章
  • Organizer: 日本ケミカルバイオロジー研究会第3回年会
  • Place of Presentation: 東京
• [Presentation] ペプチド結合切断能を有する光応答型アミノ酸の開発と核一細胞質シャトルペプチドへの応用 (2008)
  • Author(s): 重永章、辻大輔、西岡直美、山本純、津田修吾、伊藤孝司、大高章
  • Organizer: 日本薬学会第128回年会
  • Place of Presentation: 横浜
• [Presentation] 人工プロテインスプライシングシステムにおけるペプチド結合切断のための側鎖修飾型アスパラギンの検討 (2008)
  • Author(s): 津田修吾、前田奈美、重永章、大高章
  • Organizer: 日本薬学会第128回年会
  • Place of Presentation: 横浜
• [Presentation] 有機銅試薬を用いたSN2型アリル化反応の開発とプロリン型ジペプチドイソスターの合成 (2007)
  • Author(s): 山口 圭子
  • Organizer: 第46回日本薬学会病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 高知
  • Year and Date: 2007-11-11
• [Presentation] Development of stimulus-responsive amino acid with peptide bond-cleavage ability and its application to a nucleocytoplasmic shuttle peptide (2007)
  • Author(s): 重永 章
  • Organizer: 第44回ペプチド討論会
  • Place of Presentation: 富山
  • Year and Date: 2007-11-08
• [Presentation] ペプチド結合切断能を有する刺激応答型アミノ酸の開発と核-細胞質シャトルペプチドへの展開 (2007)
  • Author(s): 西岡 直美
  • Organizer: 第33回反応と合成の進歩シンポジウム
  • Place of Presentation: 長崎
  • Year and Date: 2007-11-05
• [Presentation] Amide bond cleavage for the preparation of functional peptides (2007)
  • Author(s): 大高 章
  • Organizer: Roche Colorado Corporation Peptide Symposium
  • Place of Presentation: Colorado,USA
  • Year and Date: 2007-09-27
• [Presentation] 刺激応答型アミノ酸を利用した核-細胞質シャトルペプチドの開発 (2007)
  • Author(s): 重永 章
  • Organizer: 日本ケミカルバイオロジー研究会第2回年会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-09
• [Presentation] ペプチド結合切断能を有する刺激応答型アミノ酸の開発と核一細胞質シャトルペプチドへの展開 (2007)
  • Author(s): 重永章、辻大輔、西岡直美、津田修吾、伊藤孝司、大高章
  • Organizer: 第33回反応と合成の進歩シンポジウム
  • Place of Presentation: 長崎
• [Presentation] Development of stimulus-responsive amino acid with peptide bond-cleavage ability and it sapplication to a nucleocytoplasmic shuttle peptide (2007)
  • Author(s): 重永章、辻大輔、西岡直美、津田修吾、伊藤孝司、大高章
  • Organizer: 第44回ペプチド討論会
  • Place of Presentation: 富山
• [Presentation] 機能性ペプチドの創製を目指したアミド結合切断法の開発 (2007)
  • Author(s): 津田修吾、前田奈美、西岡直美、重永章、大高章
  • Organizer: 第46回日本薬学会病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 高知
• [Presentation] N-ヘテロサイクリックカルベンを利用したフルオロアルケンイソスターの合成 (2007)
  • Author(s): 八巻陽子、住川栄健、重永章、大高章
  • Organizer: 第46回日本薬学会病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 高知
• [Presentation] 有機銅試薬を用いたS_N2'型アリル化反応の開発とプロリン型ジペプチドイソスターの合成 (2007)
  • Author(s): 山口圭子、辻貴志、佐々木義一、重永童、大高章
  • Organizer: 第46回日本薬学会病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 高知
• [Presentation] Development of amino acid derivative with amide cleavage ability and its use for the design of shuttle peptides (2007)
  • Author(s): 大高章、重永章、辻大輔、西岡直美、津田修吾、伊藤孝司
  • Organizer: 4^<th>International Peptide Symposium in conjunction with 7^<th> Australian Aeptide Conference and 2^<nd> Asia-Facific International Peptide Symposium
  • Place of Presentation: Queensland, Australia
• [Presentation] 刺激応答型アミノ酸を利用した核上細胞質シャトルペプチドの開発 (2007)
  • Author(s): 重永章、辻大輔、津田修吾、伊藤孝司、大高章
  • Organizer: 日本ケミカルバイオロジー研究会第2回年会
  • Place of Presentation: 京都
• [Presentation] 外部刺激応答型ペプチドプロセシングデバイスの開発 (2007)
  • Author(s): 重永章、津田修吾、大高章
  • Organizer: 日本薬学会第127回年会
  • Place of Presentation: 富山
• [Presentation] N-ヘテロサイクリックカルベンによる分子内レドックス反応を利用したフルオロアルケンイソスターの合成 (2007)
  • Author(s): 八巻陽子、重永章、富田健嗣、鳴海哲夫、藤井信孝、大高章
  • Organizer: 日本薬学会第127回年会
  • Place of Presentation: 富山
• [Presentation] 外部刺激応答型ペプチドの合成と外部刺激応答能の検討 (2006)
  • Author(s): 重永章、新宅沙織、大高章
  • Organizer: 第32回反応と合成の進歩シンポジウム
  • Place of Presentation: 広島
• [Presentation] Developlnent of Photo-responsive Self-processing Peptides (2006)
  • Author(s): 重永章、新宅沙織、大高章
  • Organizer: 43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting
  • Place of Presentation: 横浜
• [Presentation] Synthesis of (Z)-alkene cis-Xaa-Pro type dipeptide isosteres using organocopper-mediated anti-SN2'reactions (2006)
  • Author(s): 辻貴志、佐々木義一、山口圭子、重永章、藤井信孝、大高章
  • Organizer: 43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting
  • Place of Presentation: 横浜
• [Presentation] 有機銅試薬を用いたプロリン型(Z)-アルケンジペプチドイソスターの立体選択的合成・研究 (2006)
  • Author(s): 辻貴志佐々木義一、山口圭子、重永章、藤井信孝、大高章
  • Organizer: 第45回日本薬学会病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 広島
• [Presentation] 光刺激応答型ペプチドの開発と速度論的検討 (2006)
  • Author(s): 重永章、新宅沙織、大高章
  • Organizer: 第7回長井長義記念シンポジウム
  • Place of Presentation: 徳島
• [Presentation] Design, Synthesis and Photo-processing Reaction of Peptides Possessing the External Stimulus-responsive Amino Acid (2006)
  • Author(s): 重永章、新宅沙織、大高章
  • Organizer: 29th European Peptide Symposium
  • Place of Presentation: Gdansk, Poland
• [Presentation] Ragio-and Stereoselective Synthesis of(Z)-Alkene cis-Xaa-Pro Dipeptide Mimetics with Organocopper-mediated Anti-SN2'Reactions (2006)
  • Author(s): 佐々木義一、辻貴志、新居田歩、重永章、藤井信孝、大高章
  • Organizer: 29th European Peptide Symposium
  • Place of Presentation: Gdansk,Poland
• [Presentation] Development of Chemical Devices for Chemical Legations (2006)
  • Author(s): 大高章、太田悠介、重永章、藤井信孝
  • Organizer: The 11^<th> Akabori Conference
  • Place of Presentation: Kloster Danz, Germany
• [Presentation] Development of Photo-triggered Seif-processing Peptides (2006)
  • Author(s): 重永章、新宅沙織、大高章
  • Organizer: ICOB-5&ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products
  • Place of Presentation: 京都
• [Presentation] Preparation of peptide thioaster utilizing S-protected oxazalidinone derived from systeine (2006)
  • Author(s): 大高章、太田悠介、重永章、藤井信孝
  • Organizer: The 11th Korea-Japan Joint Symposium On Drug Design and Development
  • Place of Presentation: Jeju Island, Korea
• [Presentation] Synthesis of (Z)-alkane-containing Pro dipeptide isosteres corresponding to cis-prolyl peptides (2006)
  • Author(s): 佐々木義一、新居田歩、辻貴志、重永章、藤井信孝、大高章
  • Organizer: The 11th Korea-Japan Joint Symposium On Drug Design and Development
  • Place of Presentation: Jeju Island, Korea
• [Book] 新しい薬をどう創るか(ブルーバックス) (2008)
  • Author(s): 大高 章, 他京都大学大学院薬学研究科編
  • Publisher: 講談社
• [Remarks]
  • URL: http://www.ph.tokushima-u.ac.jp/?&rf=444
• [Remarks]
  • URL: http://www.ph.tokushima-u.ac.jp/?&rf=444