Discovery and development of selectivity-defined inhibitors toward two acyl-CoA : cholesterol acyltransferase isozymes

• Project/Area Number: 18390008
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Kitasato University
• Principal Investigator: TOMODA Hiroshi Kitasato University, 薬学部, 教授 (70164043)
• Co-Investigator(Kenkyū-buntansha): INOKOSHI Junji 北里大学, 薬学部, 准教授 (30151640) ; NAGAMITSU Tohru 北里大学, 薬学部, 准教授 (90300756) ; SUNAZUKA Toshiaki 北里大学, 北里生命科学研究所, 教授 (30226592) ; 石橋 俊 自治医科大学, 医学部, 教授 (90212919)
• Co-Investigator(Renkei-kenkyūsha): ISHIBASHI Shun 自治医科大学, 医学部, 教授 (90212919)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,360,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥2,760,000); Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2007: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000); Fiscal Year 2006: ¥5,400,000 (Direct Cost: ¥5,400,000)
• Keywords: 動脈硬化症 / ACAT アイソザイム / 脂質代謝 / ケミカルバイオロジー / 医療・福祉 / ACATアイソザイム

Research Abstract

コレステロールアシル化酵素(ACAT)は動脈硬化症に関連し、機能の異なる2 種のアイソザイムACAT1 とACAT2 が存在する。真菌由来ボーベリオライドはACAT1 を選択的に阻害するがその誘導体からACAT1 選択的、ACAT2 選択的あるいは両アイソザイムを非選択的に阻害するものをつくり分けることができた。真菌由来ピリピロペンは高度にACAT2 選択的阻害を示すが、さらに優れたACAT2 選択性を有する誘導体の創製に成功した。これら選択性の異なる誘導体から、動脈硬化症の治療薬への発展が期待される。

Research Products

• [Journal Article] The selectivity of beauveriolide derivatives in inhibition toward the two isozymes of acyl-CoA (2009)
  • Author(s): Ohshiro T, Matsuda D, Nagai K, Doi T, Sunazuka T, Takahashi T, Rudel LL, Omura S, Tomoda H.
  • Journal Title: cholesterol acyltransferase . Chem. Pharm. Bull 57 Pages: 377-381
  • Peer Reviewed
• [Journal Article] Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-1 (2009)
  • Author(s): Yamazaki H, Omura S, Tomoda H
  • Journal Title: II. Structure elucidation. J. Antibiot 62 Pages: 207-211
  • Peer Reviewed
• [Journal Article] Pentacecilides new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1 : I. Taxonomy, fermentation, isolation and biological properties (2009)
  • Author(s): Yamazaki H, Kobayashi K, Matsuda D, Nonaka K, Masuma R, Omura S, Tomoda H.
  • Journal Title: J. Antibiot 62 Pages: 195-200
  • NAID: 10030635010
  • Peer Reviewed
• [Journal Article] Total synthesis of amidepsine B and revision of its absolute configuration (2009)
  • Author(s): Nagamitsu T, Marumoto K, Nagayasu A, Fukuda T, Arima S, Uchida R, Ohshiro T, Harigaya Y, Tomoda H, Omura S.
  • Journal Title: J. Antibiot 62 Pages: 69-74
  • NAID: 10030634591
  • Peer Reviewed
• [Journal Article] Expression of two human acyl-CoA : diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes (2009)
  • Author(s): Inokoshi J, Kawamoto K, Takagi Y, Matsuhama M, Omura S, Tomoda H.
  • Journal Title: J. Antibiot 62 Pages: 51-54
  • NAID: 10030634523
  • Peer Reviewed
• [Journal Article] Total synthesis of amidepsine B and revision of its absolute configuration (2009)
  • Author(s): T. Nagamitsu, et al.
  • Journal Title: J. Antibiot. 62 Pages: 69-74
  • NAID: 10030634591
  • Peer Reviewed
• [Journal Article] Expression of two human acyl-CoA : diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. (2009)
  • Author(s): J. Inokoshi, et al.
  • Journal Title: J. Antibiot. 62 Pages: 51-54
  • NAID: 10030634523
  • Peer Reviewed
• [Journal Article] Selective inhibition of acyl-CoA : cholesterol acyltransferase 2 isozyme by flavasperone and sterigmatocystin from Aspergillus species (2008)
  • Author(s): Sakai K, Ohte S, Ohshiro T, Matsuda D, Masuma R, Rudel LL, Tomoda H.
  • Journal Title: J. Antibiot 61 Pages: 568-572
  • NAID: 10022599820
  • Peer Reviewed
• [Journal Article] Inhibition of lipid droplet accumulation in mouse macrophages by stemphone derivatives. (2008)
  • Author(s): Koyama N, Kobayashi K, Yamazaki H, Tomoda H.
  • Journal Title: J. Antibiot 61 Pages: 509-514
  • NAID: 10021928336
  • Peer Reviewed
• [Journal Article] Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA : cholesterol acyltransferase 2 isozyme (2008)
  • Author(s): Ohshiro T, Ohte S, Matsuda D, Ohtawa M, Nagamitsu T, Sunazuka T, Harigaya Y, Rudel LL, Omura S, Tomoda H.
  • Journal Title: J. Antibiot 61 Pages: 503-508
  • NAID: 10021928313
  • Peer Reviewed
• [Journal Article] Synthesis and biological evaluation of a focused library of beauveriolides (2008)
  • Author(s): Nagai K, Doi T, Ohshiro T, Sunazuka T, Tomoda H, Takahashi T, Omura S.
  • Journal Title: Bioorg. Med. Chem. Lett. 18 Pages: 4397-4400
  • Peer Reviewed
• [Journal Article] Molecular target of piperine in the inhibition of lipid droplet accumulation in macrophages (2008)
  • Author(s): Matsuda D, Ohte S, Ohshiro T, Jiang W,Rudel L, Hong B, Si S, Tomoda H.
  • Journal Title: Biol. Pharm. Bull. 31 Pages: 1063-1066
  • NAID: 110006684316
  • Peer Reviewed
• [Journal Article] Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2 (2008)
  • Author(s): Parini P, Gustafsson U, Davis MA, Larsson L, Einarsson C, Wilson M, Rudling M, Tomoda H, Omura S, Sahlin S, Angelin B, Rudel LL, Eriksson M.
  • Journal Title: Arterioscler. Thromb. Vasc. Biol. 28 Pages: 1200-1206
  • Peer Reviewed
• [Journal Article] Identification of the interaction site within acyl-CoA : cholesterol acyltransferase 2 for the isoform-specific inhibitor pyripyropene A. (2008)
  • Author(s): Das A, Davis MA, Tomoda H, Omura S, Rudel LL.
  • Journal Title: J. Biol. Chem. 18 Pages: 10453-10460
  • Peer Reviewed
• [Journal Article] Discovery and combinatorial synthesis of fungal metabolites beauveriolides, novel antiatherosclerotic agents. (2008)
  • Author(s): Tomoda H, Doi T.
  • Journal Title: Acc. Chem. Res. 41 Pages: 32-39
  • Peer Reviewed
• [Journal Article] Selective inhibition of acyl-CoA : cholesterol acyltransferase 2 isozyme by fungal flavasperone and sterigmatocystin. (2008)
  • Author(s): K. Sakai, et al.
  • Journal Title: J. Antibiot. 61 Pages: 568-572
  • Peer Reviewed
• [Journal Article] Inhibition of lipid droplet accumulation in mouse macrophages by stemphone derivatives. (2008)
  • Author(s): N. Koyama, et al.
  • Journal Title: J. Antibiot. 61 Pages: 509-514
  • Peer Reviewed
• [Journal Article] Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA : cholesterol acyltransferase 2 isozyme. (2008)
  • Author(s): T. Ohshiro, et al.
  • Journal Title: J. Antibiot. 61 Pages: 503-508
  • Peer Reviewed
• [Journal Article] Relative and absolute stereochemistry of quinadoline B, an inhibitor of lipid droplet synthesis in macrophages. (2008)
  • Author(s): N. Koyama, et al.
  • Journal Title: Ore. Lett. 10 Pages: 5273-5276
  • Peer Reviewed
• [Journal Article] Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2. (2008)
  • Author(s): P. Parini, et al.
  • Journal Title: Arterioscler. Thromb. Vase. Biol. 28 Pages: 1200-1206
  • Peer Reviewed
• [Journal Article] Synthesis and biological evaluation of a focused library of beauveriolides (2008)
  • Author(s): K. Nagai, et al.
  • Journal Title: Bioorg. Med. Chem. Lett. 18 Pages: 4397-4400
  • Peer Reviewed
• [Journal Article] Identification of the interaction site within acyl-CoA : cholesterol acyltransferase 2 for the isoform-specific inhibitor pyripyropene A. (2008)
  • Author(s): A. Das, et al.
  • Journal Title: J. Biol. Chem. 283 Pages: 10453-10460
  • Peer Reviewed
• [Journal Article] Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor. (2008)
  • Author(s): D. Matsuda, et al.
  • Journal Title: J. Antibiot. 61 Pages: 318-321
  • Peer Reviewed
• [Journal Article] Molecular target of piperine in the inhibition of lipid droplet accumulation in macrophages. (2008)
  • Author(s): D. Matsuda, et al.
  • Journal Title: Biol. Pharm. Bull. 31 Pages: 1063-1068
  • Peer Reviewed
• [Journal Article] DGAT inhibitors for obesity (2007)
  • Author(s): Matsuda D, Tomoda H.
  • Journal Title: Curr. Opin. Investig. Drugs. 8 Pages: 836-841
  • Peer Reviewed
• [Journal Article] Potential therapeutics for obesity and atherosclerosis : inhibitors of neutral lipid metabolism from microorganisms (2007)
  • Author(s): Tomoda H, Omura S.
  • Journal Title: Pharmacol. Ther 115 Pages: 375-389
  • Peer Reviewed
• [Journal Article] Fungal isobisvertional, a new inhibitor of lipid droplet accumulation in mouse macrophages (2007)
  • Author(s): Koyama N, Ohshiro T, Tomoda H, Omura S.
  • Journal Title: Org. Lett. 9 Pages: 425-428
  • Peer Reviewed
• [Journal Article] Selectivity of microbial acyl-CoA : cholesterol acyltransferase inhibitors toward isozymes. (2007)
  • Author(s): Ohshiro T, Rudel LL, Omura S, Tomoda H.
  • Journal Title: J. Antibiot 60 Pages: 43-51
  • NAID: 10018493742
  • Peer Reviewed
• [Journal Article] Fungal isobisvertinol, a new inhibitor of lipid droplet accumulation in mouse macrophages (2007)
  • Author(s): Koyama, N., et. al.
  • Journal Title: Org. Lett. 9 Pages: 425-428
  • Peer Reviewed
• [Journal Article] Selectivity of microbial acyl-CoA:cholesterol acyltransferase in hibitors toward isozymes (2007)
  • Author(s): Ohshiro, T., et. al.
  • Journal Title: J. Antibiot. 60 Pages: 43-51
  • Peer Reviewed
• [Journal Article] Lariatin, novel anti-mycobacterial peptides with a lasso structure, produced by Rhodococcus jostii K01-B0171 (2007)
  • Author(s): Iwatsuki, M., et. al.
  • Journal Title: J. Antibiot. 60 Pages: 357-363
  • Peer Reviewed
• [Journal Article] Tensyuic acids,new antibiotics produced by Aspergillus niger FKI-2342 (2007)
  • Author(s): Hasegawa, Y., et. al.
  • Journal Title: Chem.Pharm.Bull 55 Pages: 1338-1341
  • Peer Reviewed
• [Journal Article] Fungal malformins inhibit bleomyccin-induced G2 checkpoint in Jurkat cells (2007)
  • Author(s): Hagimori, K., et. al.
  • Journal Title: Biol.Pharm.Bull. 30 Pages: 1379-1383
  • Peer Reviewed
• [Journal Article] Decursin and decursinol angelate selectively inhibit NADH-fumarate reductase of Ascaris suum (2007)
  • Author(s): Shiomi, K., et. al.
  • Journal Title: Planta Med. 73 Pages: 1478-1481
  • Peer Reviewed
• [Journal Article] DGAT inhibitors of obesity (2007)
  • Author(s): Matsuda, D.&Tomoda, H.
  • Journal Title: Curr. Opin Investig. Drugs 8 Pages: 836-841
  • Peer Reviewed
• [Journal Article] Discovery and combinatorial synthesis of fungal metabolite beauveriolides, novel antiatherosclerotic agents (2007)
  • Author(s): Tomoda, H.&Doi, T.
  • Journal Title: Acc.Chem.Res. 41 Pages: 32-39
  • Peer Reviewed
• [Journal Article] Potential therapeutics for obesity and atherosclerosis:inhibitors of neutral lipid metabolism from microorganisms (2007)
  • Author(s): Tomoda, H.&Omura, S.
  • Journal Title: Pharmacol.Ther. 115 Pages: 375-389
  • Peer Reviewed
• [Journal Article] Selectivity of microbial acyl-CoA : cholesterol acyltransferase inhibitors toward isozymes. (2007)
  • Author(s): T.Ohshiro et al.
  • Journal Title: J. Antibiot. 60(1) Pages: 43-51
• [Journal Article] Fungal isobisvertinol, a new inhibitor of lipid droplet accumulation in mouse macrophages. (2007)
  • Author(s): N.Koyama et al.
  • Journal Title: Org. Lett. 9(3) Pages: 425-428
• [Journal Article] Synthesis and biological evaluation of a beauveriolide analogue library. (2006)
  • Author(s): K.Nagai et al.
  • Journal Title: J. Comb. Chem. 71(20) Pages: 103-109
• [Journal Article] Molecular target of decursins in the inhibition of lipid droplet accumulation in macrophages. (2006)
  • Author(s): T.Ohshiro et al.
  • Journal Title: Biol. Pharm. Bull. 29(5) Pages: 981-984
• [Journal Article] Absolute stereochemistry of fungal beauveriolide III and ACAT inhibitory activity of four stereoisomers. (2006)
  • Author(s): T.Ohshiro et al.
  • Journal Title: J. Org. Chem. 71(20) Pages: 7643-7649
• [Journal Article] 脂質代謝を制御する機能分子の開拓 (2006)
  • Author(s): 供田 洋
  • Journal Title: 化学工業 57(10) Pages: 734-739
• [Journal Article] Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1 I. Taxonomy, fermentation, isolation and biological properties.
  • Author(s): H. Yamazaki, et al.
  • Journal Title: J. Antibiot. (印刷中)
  • Peer Reviewed
• [Journal Article] The Selectivity of beauveriolide derivatives in inhibition toward the two isozymes of acyl-CoA : cholesterol acyltransferase.
  • Author(s): T. Ohshiro, et al.
  • Journal Title: Chem. Pharm. Bull. (印刷中)
  • Peer Reviewed
• [Presentation] 真菌由来beauveroilide III のACAT1 選択的阻害活性に関する研究 (2009)
  • Author(s): 大場未央、松田大介、大城太一、土井隆行、高橋孝志、大村智、供田洋
  • Organizer: 日本薬学会第129年回年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-28
• [Presentation] 天然由来DGAT阻害剤のアイソザイム選択性に関する研究 (2009)
  • Author(s): 川本恭佑, 他
  • Organizer: 日本薬学会第129年回年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-28
• [Presentation] DNA傷害性シグナル伝達を阻害するpycnidioneの作用機構に関する研究 (2009)
  • Author(s): 金子真弓, 他
  • Organizer: 日本薬学会第129年回年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-28
• [Presentation] 真菌由来beauveroilide IIIのACAT1選択的阻害活性に関する研究 (2009)
  • Author(s): 大場未央, 他
  • Organizer: 日本薬学会第129年回年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-28
• [Presentation] ACAT2選択的阻害剤ピリピロペンAの抗動脈硬化作用 (2009)
  • Author(s): 坂井謙斗, 他
  • Organizer: 日本薬学会第129年回年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-28
• [Presentation] アイソザイム選択的阻害剤の開拓 (2009)
  • Author(s): 供田洋
  • Organizer: 日本薬学会第129年回年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-27
• [Presentation] ACAT2 選択的阻害剤pyripyropene Aの誘導体合成と構造活性相関 (2009)
  • Author(s): 大多和正樹、山崎寛之、松田大介、大城太一、針谷義弘、長光亨、大村智、供田洋
  • Organizer: 日本薬学会第129年回年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-27
• [Presentation] ACAT2 選択的阻害剤ピリピロペンA の抗動脈硬化作用 (2009)
  • Author(s): 坂井謙斗、大城太一、松田大介、野牛宏晃、Lawrence Rudel、大村智、石橋俊、供田洋
  • Organizer: 日本薬学会第129年回年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-27
• [Presentation] 真菌FKI-3765-1株が生産する新規マクロファージ内脂肪滴蓄積阻害物質の研究 (2009)
  • Author(s): 山崎寛之, 他
  • Organizer: 日本薬学会第129年回年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-27
• [Presentation] ACAT2選択的阻害剤pyripyropene Aの誘導体合成と構造活性相関 (2009)
  • Author(s): 大多和正樹, 他
  • Organizer: 日本薬学会第129年回年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-27
• [Presentation] マクロファージ内脂肪滴蓄積阻害剤beauveriolide の標的分子の解析 (2008)
  • Author(s): 松田大介、大城太一、土井隆行、大場未央、高橋孝志、大村智、供田洋
  • Organizer: 第31回日本分子生物学会年会第81 回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] マクロファージ内脂肪滴蓄積阻害剤beauveriolideの標的分子の解析 (2008)
  • Author(s): 松田大介, 他
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] G2期修復機構阻害物質pycnidione作用機序の解析 (2008)
  • Author(s): 金子真弓, 他
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] ACAT2 選択的阻害剤pyripyropene Aの誘導体合成と構造活性相関 (2008)
  • Author(s): 大多和正樹、山崎寛之、松田大介、大城太一、針谷義宏、長光亨、大村智、供田洋
  • Organizer: 第27回メディシナルケミストリーシンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-26
• [Presentation] ACAT阻害剤beauveriolide III の誘導体合成と構造活性相関 (2008)
  • Author(s): 伊牟田聡、広木康洋、土黒一郎、高橋孝志、土井隆行、大城太一、山崎寛之、松田大介、大村智、供田洋
  • Organizer: 第27回メディシナルケミストリーシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-26
• [Presentation] ステロイド代替骨格であるジフェニルペンタン誘導体の創製 : 核内受容体リガンドとHMG-CoA還元酵素阻害剤 (2008)
  • Author(s): 細田信之介, 他
  • Organizer: 第27回メディシナルケミストリーシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-26
• [Presentation] ACAT2選択的阻害剤pyripyropene Aの誘導体合成と構造活性相関 (2008)
  • Author(s): 大多和正樹, 他
  • Organizer: 第27回メディシナルケミストリーシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-26
• [Presentation] ACAT阻害剤beauveriolide IIIの誘導体合成と構造活性相関 (2008)
  • Author(s): 伊牟田聡, 他
  • Organizer: 第27回メディシナルケミストリーシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-26
• [Presentation] ACAT 阻害剤の復活をめざして (2008)
  • Author(s): 供田洋
  • Organizer: 北里大学薬学部特別公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-10-08
• [Presentation] 天然資源からの新しい抗動脈硬化薬の開拓研究 (2008)
  • Author(s): 供田洋
  • Organizer: 動脈硬化Update2008
  • Place of Presentation: 東京
  • Year and Date: 2008-09-06
• [Presentation] マクロファージ内脂肪滴蓄積阻害活性を示すツルリンドウ由来成分の作用機序の解析 (2008)
  • Author(s): 松田大介、小林翔、深澤征義、西島正弘、花田賢太郎、司書毅、供田洋
  • Organizer: 第21 回バイオサイエンスフォーラム
  • Place of Presentation: 相模原
  • Year and Date: 2008-08-01
• [Presentation] マクロファージ内脂肪滴蓄積阻害活性を示すツルリンドウ由来成分の作用機序の解析 (2008)
  • Author(s): 松田大介, 他
  • Organizer: 第21回バイオサイエンスフォーラム
  • Place of Presentation: 相模原
  • Year and Date: 2008-08-01
• [Presentation] 天然由来DGAT阻害剤のアイソザイム選択性 (2008)
  • Author(s): 川本恭佑, 他
  • Organizer: 第21回バイオサイエンスフォーラム
  • Place of Presentation: 相模原
  • Year and Date: 2008-07-31
• [Presentation] キサントン誘導体による脂肪滴蓄積阻害活性はacetyl-CoA carb oxylaseの阻害によるのだろうか? (2008)
  • Author(s): 松田大介, 他
  • Organizer: 第50回日本薬脂質生化学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-06-05
• [Presentation] 天然由来DGAT阻害剤のアイソザイム選択性 (2008)
  • Author(s): 猪腰淳嗣, 他
  • Organizer: 第50回目本薬脂質生化学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-06-05
• [Presentation] 海洋由来真菌 Aspergillus clavatonanicusFKI-1746 株の生産する新規マクロファーシ脂肪滴蓄積阻害物質 (2008)
  • Author(s): 小山信裕、井上勇佑、野中健一、山口裕一、増間碌郎、大村 智、供田 洋
  • Organizer: 第11 回マリンバイオテクノロジー学会大会
  • Place of Presentation: 京都
  • Year and Date: 2008-05-24
• [Presentation] Suppression of lipid droplet accumulation in mouse peritoneal macrophages by piperine (2008)
  • Author(s): D. Matsuda, S. Ohte, T. Ohshiro, W. Jiang, L. L. Rudel, B. Hong, S. Si, H. Tomoda
  • Organizer: The 4^<th> Korea-Japan Joint Symposium Chemical Biology for Bioactive Molecules
  • Place of Presentation: Kinugawa, Tochigi, Japan
  • Year and Date: 2008-05-21
• [Presentation] Suppression of lipid droplet accumulation in mouse peritoneal macrophages by piperine. (2008)
  • Author(s): D. Matsuda, et al.
  • Organizer: The 4^<th> Korea-Japan Joint Symposium Chemical Biology for Bioactive Molecules
  • Place of Presentation: Kinugavva, Tochigi, Japan
  • Year and Date: 2008-05-21
• [Presentation] Dinapinones, novel inhibitor of triacylglycerol synthesis in CHO-Kl cells produced by Penicillium pinophilum FKI-3864. (2008)
  • Author(s): S. Ohte, et al.
  • Organizer: The 4^<th> Korea-Japan Joint Symposium Chemical Biology for Bioactive Molecules
  • Place of Presentation: Kinugawa, Tochigi, Japan
  • Year and Date: 2008-05-21
• [Presentation] Microbial products inhibiting neutral lipid synthesis (2008)
  • Author(s): Tomoda H.
  • Organizer: The 12th Japan-Korea Joint Symposium Drug Design and Development
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2008-05-16
• [Presentation] 黒胡椒成分piperine によるマクロファージ内脂肪滴蓄積阻害作用 (2008)
  • Author(s): 松田大介、大城太一、司書毅、供田洋
  • Organizer: 第128 回日本薬学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-26
• [Presentation] 真菌FO-2942 株の生産する新しいamidepsine 成分に関する研究 (2008)
  • Author(s): 高木陽一, 猪腰淳嗣, 内田龍児, 増間碌郎, 大村智, 供田洋
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-26
• [Presentation] 黒胡椒成分piperineによるマクロファージ内脂肪滴蓄積阻害作用 (2008)
  • Author(s): 松田 大介, ら
  • Organizer: 日本薬学会
  • Place of Presentation: 横浜
• [Presentation] ACC1阻害剤による脂肪的蓄積阻害活性 (2008)
  • Author(s): 小林 翔, ら
  • Organizer: 日本薬学会
  • Place of Presentation: 横浜
• [Presentation] カイコを利用した感染簡易in vivo評価による抗真菌剤探索研究 (2008)
  • Author(s): 山口 史哲, ら
  • Organizer: 日本薬学会
  • Place of Presentation: 横浜
• [Presentation] Stemphone誘導体の生物活性研究(1)MRSAに対するイミペネム活性増強 (2008)
  • Author(s): 山崎 寛之, ら
  • Organizer: 日本薬学会
  • Place of Presentation: 横浜
• [Presentation] Stemphone誘導体の生物活性研究(2)マクロファージ脂肪滴蓄積阻害活性 (2008)
  • Author(s): 小山 信裕, ら
  • Organizer: 日本薬学会
  • Place of Presentation: 横浜
• [Presentation] Sphingofungin類によるamphotericin B の抗真菌活性増強作用に関する研究 (2008)
  • Author(s): 坂部 泰成, ら
  • Organizer: 日本薬学会
  • Place of Presentation: 横浜
• [Presentation] 真菌FHI-3864株の生産する新規トリアシルグリセロール生成阻害物に関する研究 (2008)
  • Author(s): 大手 聡, ら
  • Organizer: 日本薬学会
  • Place of Presentation: 横浜
• [Presentation] 真菌FHI-3864株の生産する undecaprenyl pyrophosphate synthase 阻害物質に関する研究 (2008)
  • Author(s): 中村 雄一郎, ら
  • Organizer: 日本薬学会
  • Place of Presentation: 横浜
• [Presentation] 真菌FKI-1746株が生産する新規マクロファージ脂肪滴蓄積阻害物質の研究 (2008)
  • Author(s): 井上 勇佑, ら
  • Organizer: 日本薬学会
  • Place of Presentation: 横浜
• [Presentation] F0-2942株の生産する新しいamidepsine成分に関する研究 (2008)
  • Author(s): 高木 陽一, ら
  • Organizer: 日本薬学会
  • Place of Presentation: 横浜
• [Presentation] β-ラクタム剤の抗MRSA活性増強作用を示す新規KB-3346-5物質の単離、および活性 (2008)
  • Author(s): 福本 敦, ら
  • Organizer: 日本薬学会
  • Place of Presentation: 横浜
• [Presentation] Bioactive products from marine-derived microorganism as probes in chemical biology (2007)
  • Author(s): H. Tomoda, D. Matsuda
  • Organizer: VI^<TM> US-Japan seminar : frontiers in marine natural productsresearch
  • Place of Presentation: Park city, Utah, USA
  • Year and Date: 2007-06-06
• [Presentation] 海洋由来脂質代謝阻害剤を用いたケミカルバイオロジー (2007)
  • Author(s): 松田大介、供田洋
  • Organizer: 第10回マリンバイオテクノロジー学会
  • Place of Presentation: 山形
  • Year and Date: 2007-05-27
• [Presentation] 海洋由来脂質代謝阻害剤を用いたケミカルバイオロジー (2007)
  • Author(s): 松田 大介、供田 洋
  • Organizer: 第10回マリンバイオテクノロジー学会
  • Place of Presentation: 仙台
• [Presentation] Selectivity of pyripyropene derivatives, ACAT inhibitors, toward the ACAT2 isozyme (2007)
  • Author(s): Ohshiro, T., et. al.
  • Organizer: SIM Annual Meeting&Exhibition
  • Place of Presentation: Denver,USA
• [Presentation] Bioactive products from marine-derived microorganism as probes in chemical biology (2007)
  • Author(s): Tomoda, H.&Matsuda, D.
  • Organizer: VI^<TM> US-Japan seminar:frontiers in marine natural products research
  • Place of Presentation: Park city,Utah,USA
• [Book] 動脈硬化Update2008 (2009)
  • Author(s): 供田洋 (分担執筆)
  • Publisher: ライフサイエンス出版