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Molecular genetic study on the pathophysiology of psychiatric disorders based on the role of PACAP

Research Project

Project/Area Number 18390025
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionOsaka University

Principal Investigator

SHINTANI Norihito (2008)  Osaka University, 大学院・薬学研究科, 助教 (10335367)

橋本 均 (2006-2007)  Osaka University, 薬学研究科, 准教授 (30240849)

Co-Investigator(Kenkyū-buntansha) BABA Akemichi  大阪大学, 大学院・薬学研究科, 教授 (70107100)
AGO Yukio  大阪大学, 大学院・薬学研究科, 助教 (50403027)
HASHIMOTO Ryota  大阪大学, 子どものこころの分子制御機構研究センター, 特任准教授 (10370983)
新谷 紀人  大阪大学, 薬学研究科, 助教 (10335367)
Co-Investigator(Renkei-kenkyūsha) KUNUGI Hiroshi  国立精神神経センター (40234471)
TOHYAMA Masaya  大阪大学, 大学院・医学系研究科, 教授 (40028593)
TAKEDA Masatoshi  大阪大学, 大学院・医学系研究科, 教授 (00179649)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,740,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2006: ¥6,300,000 (Direct Cost: ¥6,300,000)
Keywords薬理学 / 臨床遺伝学 / 精神疾患 / 神経ペプチドPACAP / 精神疾患・障害 / うつ病 / 遺伝子改変マウス / 疾患モデル / ADHD / セロトニン神経 / early growth response / 分子遺伝学 / 一塩基多型(SNP) / 統合失調症 / SNPs(一塩基多型)
Research Abstract

精神疾患とPACAPとの関連について、(1)ヒトPACAPの一塩基多型と種々精神疾患/病態との関連、(2)同分子病態としての脳神経核応答性低下およびセロトニン神経機能変化の同定、3)神経発達障害仮説(同病因のひとつ)を支持する知見、4)注意欠陥多動症(ADHD)治療薬とセロトニン1A受容体作動薬の併用による鎮静化作用に関する知見、を基礎および臨床の側面的から明らかにし、統合失調症、双極性障害、ADHDの分子病態研究におけるPACAPという新しい視点の導入を達成した。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (117 results)

All 2009 2008 2007 2006 Other

All Journal Article (57 results) (of which Peer Reviewed: 34 results) Presentation (54 results) Book (2 results) Remarks (4 results)

  • [Journal Article] Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons2009

    • Author(s)
      Tsuchida R, Shintani N, Hashimoto H, Baba A, 計9名
    • Journal Title

      Biol Pharm Bull. 32

      Pages: 728-731

    • NAID

      110007160668

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non-stimulant atomoxetine in mice.2009

    • Author(s)
      Tsuchida R, Shintani N, Hashimoto H, Baba A, 計9名
    • Journal Title

      J Pharmacol Sci. 109

      Pages: 396-402

    • NAID

      10025735194

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Depression-like behavior in the forced swimming test in PACAP-deficient mice : amelioration by the atypical antipsychotic risperidone2009

    • Author(s)
      Hashimoto H, Hashimoto R, Shintani N, Takeda M, Baba A, 計9名
    • Journal Title

      J Neurochem. 110

      Pages: 595-602

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of osemozotan, an serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos-expression in prefrontal cortical neurons2009

    • Author(s)
      Tsuchida R, et al.
    • Journal Title

      Biol. Pharm. Bull. (in press. )

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non-stimulant atomoxetine in mice2009

    • Author(s)
      Tsuchida R, et al.
    • Journal Title

      J. Pharmacol. Sci. (in press. )

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of prefrontal dopaminergic neurotransmission in glucocorticoid receptor-mediated modulation of methamphetamine-induced hyperactivity2009

    • Author(s)
      Ago Y, et al.
    • Journal Title

      Synapse 63

      Pages: 7-14

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Galantamine improves apomorphine-induced deficits of prepulse inhibition via muscarinic ACh receptors in mice2009

    • Author(s)
      Yano K, et al.
    • Journal Title

      Br. J. Pharmacol. 156

      Pages: 173-180

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls2009

    • Author(s)
      Hashimoto R, et al.
    • Journal Title

      The World Journal of Biological Psychiatry (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuropsychotoxicity of abused drugs : effects of serotonin receptor ligands on methamphetamine- and cocaine-induced behavioral sensitization in mice2008

    • Author(s)
      Ago Y, Nakamura S, Baba A, Matsuda T.
    • Journal Title

      J Pharmacol Sci. 106

      Pages: 15-21

    • NAID

      10024317275

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-releasing hormone inhibits pituitary adenylyl cyclase-activating polypeptide coupling to 3', 5'-cyclic adenosine-5'-monophosphate pathway in LbetaT2 gonadotrope cells through novel protein kinase C isoforms and phosphorylation of pituitary adenylyl cyclase-activating polypeptide type I receptor.2008

    • Author(s)
      Lariviere s, et al.
    • Journal Title

      Endocrinology 149

      Pages: 6389-6398

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-deficient mice2008

    • Author(s)
      Hatanaka M, et al.
    • Journal Title

      Neurosci. Lett. 444

      Pages: 153-156

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvements of PHI-nitric oxide and PACAP-BK channel in the sustained relaxation of mouse gastric fundus2008

    • Author(s)
      Hagi K, et al.
    • Journal Title

      Eur. J. Pharmacol. 590

      Pages: 80-86

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PACAP provides colonic protection against dextran sodium sulfate induced colitis2008

    • Author(s)
      Azuma Y, et al.
    • Journal Title

      J. Cell. Physiol. 216

      Pages: 111-119

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症関連因子とPACAP2008

    • Author(s)
      尾形勝弥, 他
    • Journal Title

      医学のあゆみ 227

      Pages: 971-973

    • Related Report
      2008 Annual Research Report
  • [Journal Article] PACAP受容体2008

    • Author(s)
      橋本均, 他
    • Journal Title

      日薬理誌 132

      Pages: 189-191

    • NAID

      10024383899

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Antidepressant-like effects of the glucocorticoid receptor antagonist RU-43044 are associated with changes in prefrontal dopamine in mouse models of depression2008

    • Author(s)
      Ago Y, et al.
    • Journal Title

      Neuropharmacology 55

      Pages: 1355-1363

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 精神機能と環境因子2008

    • Author(s)
      吾郷由希夫, 他.
    • Journal Title

      脳21 11

      Pages: 81-87

    • Related Report
      2008 Annual Research Report
  • [Journal Article] メタンフェタミン誘発行動感作への前頭葉セロトニン神経系の関与2008

    • Author(s)
      吾郷由希夫, 他.
    • Journal Title

      日本神経精神薬理学雑誌 28

      Pages: 85-91

    • NAID

      10023965457

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbpl, a susceptibility gene for schizophrenia2008

    • Author(s)
      Hattori S, et al.
    • Journal Title

      Biochem Biophys Res Commun 373

      Pages: 298-302

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A possible association between missense polymorphism of the Breakpoint Cluster Region gene and lithium prophylaxis in bipolar disorder2008

    • Author(s)
      Masui T, et al.
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry 32

      Pages: 204-208

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 精神疾患のトランスレーショナルリサーチ、Translational research in mental disorder2008

    • Author(s)
      橋本亮太, 他
    • Journal Title

      神経化学 47

      Pages: 348-352

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 統合失調症の病態研究の最先端2008

    • Author(s)
      石井良平, 他
    • Journal Title

      臨床精神医学 37

      Pages: 1305-1314

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Abnormal microstructres of the basal ganglia in schizophrenia revealed by diffusion tensor imaging2008

    • Author(s)
      Hashimoto R
    • Journal Title

      The World Journal of Biological Psychiatry (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuropsychotoxicity of abused drugs: effects of serotonin receptor ligands on methamphetamine-and cocaine-induced behaviral sensitization in mice2008

    • Author(s)
      Ago Y
    • Journal Title

      J Pharmacol Sci 106

      Pages: 15-21

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A possible association between missense polymorphism of the Breakpoint Cluster Region gene and lithium prohylaxs in biolar disorder2008

    • Author(s)
      Masui T
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biologigal Psychiatry 32

      Pages: 204-208

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症の分子病態とPACAP2008

    • Author(s)
      新谷紀人
    • Journal Title

      脳と精神の医学 (in press)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia2007

    • Author(s)
      Hashimoto R, Hashimoto H, Shintani N, Kunugi H, Baba A, 計9名
    • Journal Title

      Mol.Psychiatry 12

      Pages: 1026-1032

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel DISC1-interacting partner DISC1-Binding Zinc-finger protein : implication in the modulation of DISC1-dependent neurite outgrowth2007

    • Author(s)
      Hattori T, Hashimoto H, Shintani N, Baba A, Tohyama M, Katayama T, 計9名
    • Journal Title

      Mol.Psychiatry 12

      Pages: 398-407

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia2007

    • Author(s)
      Hashimoto R
    • Journal Title

      Mol Psychiatry 12

      Pages: 1026-1032

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel DISC1-interacting partner DBZ (DISC1-Binding Zinc finger protein): implication in the modulation of DISC1-dependent neurite outgrowth2007

    • Author(s)
      Hattori T
    • Journal Title

      Mol Psychiatry 12

      Pages: 398-407

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice2007

    • Author(s)
      Fujii H
    • Journal Title

      Peptides 28(9)

      Pages: 1674-1679

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test2007

    • Author(s)
      Ago Y
    • Journal Title

      J Pharmacol Sci 104(2)

      Pages: 153-158

    • NAID

      10024314374

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rhanserin Reverses Repeated Methamphetamine-Induced Behavioral and Neurochemical Sensitization in Mice2007

    • Author(s)
      Ago Y
    • Journal Title

      Synapse 61

      Pages: 757-763

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of postsynaptic serotonin receptors in risperidone-induced increase in acetylcholine release in rat prefrontal contrex2007

    • Author(s)
      Sato M
    • Journal Title

      Eur. J. Pharmacol 559

      Pages: 155-160

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A possible association between the Va1158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects2007

    • Author(s)
      Hashimoto R
    • Journal Title

      Neurosci lett 428(1)

      Pages: 17-20

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi2007

    • Author(s)
      Hattori S
    • Journal Title

      Behavioural Brain Research 180(1)

      Pages: 69-76

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postsynaptic density: A key convergent site for schizophrenia susceptibility factors and possible target for drug development2007

    • Author(s)
      Hashimoto R
    • Journal Title

      Drugs Today (Barc) 43(9)

      Pages: 645-654

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular pharmacologic approaches to functional a nalysis of new biological molecules for drug discovery2007

    • Author(s)
      Baba A
    • Journal Title

      Yakugaku Zasshi 127(10)

      Pages: 1643-1654

    • Related Report
      2007 Annual Research Report
  • [Journal Article] ミニレビュー:ニューロペプチドPACAPと精神神経機能:変異マウスからの予想外の知見2007

    • Author(s)
      橋本均
    • Journal Title

      生化学 79(4)

      Pages: 375-379

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 新しいGPCRリガンド研究の現状と展望-神経ペプチドPACAPの生理機能2007

    • Author(s)
      新谷紀人
    • Journal Title

      ホルモンと臨床 55

      Pages: 131-139

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 統合失調症とセロトニン1A受容体2007

    • Author(s)
      吾郷由希夫
    • Journal Title

      脳21 10(3)

      Pages: 44-48

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 動物個体を用いた概日リズム解析法2007

    • Author(s)
      川口ちひろ
    • Journal Title

      日本薬理学雑誌 130

      Pages: 193-199

    • Related Report
      2007 Annual Research Report
  • [Journal Article]2007

    • Author(s)
      馬場明道
    • Journal Title

      神経ペプチドPACAP-新しい創薬標的分子探索へ 遺伝子医学MOOK(8)

      Pages: 168-172

    • Related Report
      2007 Annual Research Report
  • [Journal Article]2007

    • Author(s)
      新谷紀人
    • Journal Title

      PACAP欠損マウス, Keyword精神第4版 遺伝子医学MOOK(8)

      Pages: 214-215

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyapl-1-)2006

    • Author(s)
      Shintani N, Hashimoto H, Baba A, 計9名
    • Journal Title

      Ann N Y Acad Sci 1070

      Pages: 545-549

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lack of trimethyltin (TMT)-induced elevation of plasma corticosterone in PACAP-deficient mice2006

    • Author(s)
      Morita Y, Shintani N, Hashimoto H, Baba A, 計9名
    • Journal Title

      Ann N Y Acad Sci 1070

      Pages: 450-456

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] New insights into the central PACAPergic system from the phenotypes in PACAP- and PACAP receptor-knockout mice2006

    • Author(s)
      Hashimoto H, Shintani N, Baba A
    • Journal Title

      Ann N Y Acad Sci 1070

      Pages: 75-89

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyapl-deficient mice2006

    • Author(s)
      Tanaka K, Shintani N, Hashimoto H, Hashimoto R, Kunugi H, Baba A
    • Journal Title

      J.Neurosci. 26

      Pages: 5091-5097

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modification of cocaine-induced behavioral and neurochemical effects by serotonin_<1A> receptor agonist/antagonist in mice2006

    • Author(s)
      Nakamura, S., et al.
    • Journal Title

      Synapse 60・7

      Pages: 479-484

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap 1^<-/->)2006

    • Author(s)
      Shintani, N., et al.
    • Journal Title

      Ann N Y Acad Sci 1070

      Pages: 545-549

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Lack of trimethyltin (TMT)-induced elevation of plasma corticosterone in PACAP-deficient mice2006

    • Author(s)
      Morita, Y., et al.
    • Journal Title

      Ann N Y Acad Sci 1070

      Pages: 450-456

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inhibition of self-renewal and induction of neural differentiation by PACAP in neural progenitor cells2006

    • Author(s)
      Hirose, M., et al.
    • Journal Title

      Ann N Y Acad Sci 1070

      Pages: 342-347

    • Related Report
      2006 Annual Research Report
  • [Journal Article] New insights into the central PACAPergic system from the phenotypes in PACAP-and PACAP receptor-knockout mice2006

    • Author(s)
      Hashimoto, H., et al.
    • Journal Title

      Ann N Y Acad Sci 1070

      Pages: 75-89

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice2006

    • Author(s)
      Tanaka, K., et al.
    • Journal Title

      J Neurosci 26・19

      Pages: 5091-5097

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-62006

    • Author(s)
      Ohtaki, H., et al.
    • Journal Title

      Proc Natl Acad Sci USA 103・19

      Pages: 7488-7493

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia

    • Author(s)
      Hashimoto, R., et al.
    • Journal Title

      Mol Psychiatry (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel DISC1-interacting partner DBZ (DISC1-Binding Zinc finger protein) : implication in the modulation of DISC1-dependent neurite outgrowth

    • Author(s)
      Hattori, T., et al.
    • Journal Title

      Mol Psychiatry (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] PACAP induces early growth response gene in cortical neuron2009

    • Author(s)
      尾形勝弥, 他
    • Organizer
      第82回日本薬理2006学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] PACAP induces early growth response gene in cortical neuron2009

    • Author(s)
      尾形勝弥, 他
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Phenotypic changes associated with noggin-induced neuronal differentiation of embryonic stem (ES) cells2009

    • Author(s)
      篠原季久子, 他
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Impaired nocifensive behaviours and mechanical hyperalgesia, but enhanced thermal hyperalgesia in pituitary adenylate-cyclase activating polypeptide deficient mice2009

    • Author(s)
      Sandor K, et al.
    • Organizer
      30th Annual Winter Neuropeptide Conference
    • Place of Presentation
      Colorado, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] L-PGDS-PGD2-CRTH2 signaling cascade specifically involved in light-induced phase advance of circadian rhythm2009

    • Author(s)
      Hatanaka M, et al.
    • Organizer
      第4回日本統合失調症学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] PACAP knockout mice, an animal model ofpsychomotor dysfunction-gene xenvironment2009

    • Author(s)
      Shintani N, et al.
    • Organizer
      第一回アジア統合失調症ワークショップ「統合失調症ワークショップシンポジウム」
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] Functional Analysis of One of the Susceptibility Genes for Schizophrenia ; Pituitary Adenylate Cyclase-activating Polypeptide2009

    • Author(s)
      Yamada K, et al.
    • Organizer
      第一回アジア統合失調症ワーグショップ「統合失調症ワークショップシンポジウム」
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] PACAP遺伝子欠損マウスの異常行動発現に対する豊かな環境飼育の影響2009

    • Author(s)
      嶋田祥子, 他
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 精神疾患と環境因子:長期隔離飼育マウスの行動薬理2009

    • Author(s)
      吾郷由希夫, 他
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] IMPAIRED PREPULSE INHIBITION OF ACOUSTIC STARTLE RESPONSE IN JAPANESE PATIENTS WITH SCHIZOPHRENIA2009

    • Author(s)
      Takahashi H, et al.
    • Organizer
      The 1^<st> Asian Workshop on Schizophrenia Research
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] PACAP欠損マウスの精神・神経機能変化に対するADHD治療薬アトモキセチンの改善作用2008

    • Author(s)
      芝崎 康宏, 他
    • Organizer
      ファーマ・バイオフォーラム2008
    • Place of Presentation
      東京
    • Year and Date
      2008-11-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 多能性幹細胞からのセロトニン神経細胞の分化誘導2008

    • Author(s)
      高井良宏, 他
    • Organizer
      第114回日本薬理学会近畿部会
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] PACAP遺伝子欠損マウスにおけるストレス受容の障害2008

    • Author(s)
      齋田洋子, 他
    • Organizer
      第113回日本薬理学会近畿部会
    • Place of Presentation
      岡山
    • Year and Date
      2008-06-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] PACAP欠損マウスのPPI障害および新奇物体記憶障害に対するADHD治療薬の作用解析2008

    • Author(s)
      芝崎 康宏, 他
    • Organizer
      第113回日本薬理学会近畿部会
    • Place of Presentation
      岡山
    • Year and Date
      2008-06-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 微小組織特異的網羅的遺伝子発現解析による神経ペプチドPACAPの標的分子同定2008

    • Author(s)
      新谷紀人
    • Organizer
      日本薬学会128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] PACAP遺伝子欠損マウスにおける非視覚光受容反応の障害2008

    • Author(s)
      畑中道賢
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] 概日リズムの光誘発性位相前進に特異的な新規シグナル系の同定2008

    • Author(s)
      中村玲子
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Roles of a neuropeptide, PACAP, on psychomotor function and photoentrainment2008

    • Author(s)
      Baba A.
    • Organizer
      The 19th Korea-Japan Joint Seminor on Pharmacology, The 60th Annual meeting of the Korean Society of Pharmacology
    • Place of Presentation
      釜山, 韓国
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Pituitary adenylate cyclase-activating polypeptide (PACAP) : A new risk factor for neuropsychiatric disorders2008

    • Author(s)
      Hashimoto H, et al.
    • Organizer
      The 47th ACNP (American College of Neuropsychopharmacology) Annual Meeting
    • Place of Presentation
      Arizona, USA
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Central PACAP plays a stimulatory role in the stress-induced HPA-axis response2008

    • Author(s)
      Shintani N, et al.
    • Organizer
      The 51st Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      富山
    • Related Report
      2008 Final Research Report
  • [Presentation] Serotonin 1A receptor signaling is implicated in the antihyp erkinetic effects of attention-deficit hyperactivity disorder (ADHD) medications2008

    • Author(s)
      Tsuchida R, et al.
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Altered stress response in PACAP-deficient mice2008

    • Author(s)
      新谷紀人, 他
    • Organizer
      第38回日本神経精神薬理学会
    • Place of Presentation
      品川
    • Related Report
      2008 Annual Research Report
  • [Presentation] Prostanoid CRTH2 receptor signaling regulates light-induced phase advance of circadian rhythm2008

    • Author(s)
      新谷紀人, 他
    • Organizer
      第51回神経化学会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Central PACAP plays a stimulatory role in the stress-induced HPA-axis response2008

    • Author(s)
      新谷紀人, 他
    • Organizer
      第51回神経化学会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Serotonin 1A receptor is involved in the “paradoxical" antihyperkinetic effect of the drugs treating ADHD2008

    • Author(s)
      土田理恵, 他
    • Organizer
      第51回神経化学会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] A new method to generate serotonergic neurons from ES cells2008

    • Author(s)
      嶋田健, 他
    • Organizer
      第51回神経化学会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of environmental factors on behavioral abnormalities in PACAP-KO mice2008

    • Author(s)
      石濱壽紘, 他
    • Organizer
      第51回神経化学会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Involvement of serotonin 1A receptors in antihyperkinetic effect of attention-deficit hyperactivity disorder (ADHD) drugs2008

    • Author(s)
      Tsuchida R, et al.
    • Organizer
      The 4^<th> Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] The roles of PACAP in non-visual photoreception2008

    • Author(s)
      Hatanaka M, et al.
    • Organizer
      The 4^<th> Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] PACAP遺伝子改変マウスの異常行動と環境因子2008

    • Author(s)
      吾郷由希夫
    • Organizer
      生体機能と創薬シンポジウム2008
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dysbindin : pathological clue for developing schizophrenia2008

    • Author(s)
      Hashimoto R
    • Organizer
      XIV World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gene to behavior pathway in schizophrenia : Progress in schizophrenia research in Japan (CREST)2008

    • Author(s)
      Iwata N, et al.
    • Organizer
      XIV World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] PACAP Signaling: A promising drug target for neuropsychological disorders2008

    • Author(s)
      Hashimoto H
    • Organizer
      Ehrlich II-2nd World Conference on Magic Bullets
    • Place of Presentation
      Nurnberg, Germany
    • Related Report
      2007 Annual Research Report
  • [Presentation] Neuropeptide PACAP is involved in certain types of light-induced physiological responses2008

    • Author(s)
      Hatanaka M
    • Organizer
      The 19th Korea-Japan Joint Seminor on Pharmacology
    • Place of Presentation
      釜山, 韓国
    • Related Report
      2007 Annual Research Report
  • [Presentation] 種々のADHD治療薬と5-HT_<1A>受容体アゴニストの併用投与による自発運動抑制作用2007

    • Author(s)
      久保勝裕
    • Organizer
      第112回日本薬理学会近畿部会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] Evidence that the PACAP gene contributes to the risk of schizophrenia2007

    • Author(s)
      Hitoshi Hashimoto
    • Organizer
      8th International Symposium for VIP, PACAP and Related Peptides
    • Place of Presentation
      Manchester, Vermont, USA
    • Year and Date
      2007-09-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] 大阪大学における統合失調症外来について2007

    • Author(s)
      橋本亮太
    • Organizer
      第3回大阪北部精神科症例検討会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症の分子病態と神経ペプチドPACAP2007

    • Author(s)
      新谷紀人
    • Organizer
      第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] PACAP遺伝子欠損マウスの異常行動発現における環境因子の役割2007

    • Author(s)
      石濱壽紘
    • Organizer
      第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 第二世代抗精神病薬と認知機能との関連について-リスペリドンと他剤との比較-2007

    • Author(s)
      橋本亮太
    • Organizer
      第3回大阪中央精神科症例検討会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] 中間表現型と遺伝子2007

    • Author(s)
      橋本亮太
    • Organizer
      第6回Schizophrenia研究会
    • Place of Presentation
      高知
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Translational Research for Schizophrenia2007

    • Author(s)
      Hashimoto R.
    • Organizer
      4th Japanese-German Frontiers of Science Symposium
    • Place of Presentation
      湘南
    • Related Report
      2008 Final Research Report
  • [Presentation] Serotonin 1A(5-HT_<1A>) agonist decreases locomotor activity and prefrontal neuronal activation in amphetamine treted mice2007

    • Author(s)
      Rie Tsuchida
    • Organizer
      Neuro 2007
    • Place of Presentation
      Yokohana, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] ES細胞からの新規神経細胞分化誘導系の確立2007

    • Author(s)
      嶋田健
    • Organizer
      ファーマバイオフォーラム2007
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] Involvement of environmental factors in the expression of psychomotor abnormalities in PACAP knock-out mice2007

    • Author(s)
      Toshihiro Ishihama
    • Organizer
      Neuro2007
    • Place of Presentation
      Yokohana, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Translational Research for Schizophrenia2007

    • Author(s)
      Hashimoto R
    • Organizer
      4^<th>Japanese-German Frontiers of Science Symposium
    • Place of Presentation
      Shonan, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Genetic variations in the dysbindin gene are associated with human memory performance2007

    • Author(s)
      Hashimoto R
    • Organizer
      IPA 2007 Osaka Silver Congress
    • Place of Presentation
      Osaka
    • Related Report
      2007 Annual Research Report
  • [Presentation] Symposium: Pathogenesis of schizophrenia, dysbindin and pathogenesis of schizophrenia2007

    • Author(s)
      Hashimoto R
    • Organizer
      2^<nd> International Congress of Biological Psychiatry
    • Place of Presentation
      Santiago, Chili
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症脆弱性遺伝子ディスバインジンの遺伝子改変動物による分子病態研究2007

    • Author(s)
      橋本亮太
    • Organizer
      統合脳5領域「平成19年度冬の合同班会議」
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] PACAP遺伝子は統合失調症と関連する2007

    • Author(s)
      橋本亮太
    • Organizer
      第50回日本神経化学会・第30回日本神経科学学会・第17回日本神経回路学会合同年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 神経ペプチドであるPACAPと統合失調症の関連:脳構造、記憶、抗精神病薬を用いた統合的解析2007

    • Author(s)
      橋本亮太
    • Organizer
      統合脳5領域「平成19年度夏の合同班会議」
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症脆弱性遺伝子であるディスバインジン欠損マウスにおける異常行動2007

    • Author(s)
      橋本亮太
    • Organizer
      第29回日本生物的精神医学会・第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] DISC1遺伝子Ser704Cys機能多型はうつ病のリスク、ヒトの脳構造、神経細胞保護に影響を与える2007

    • Author(s)
      橋本亮太
    • Organizer
      第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症脆弱性遺伝子ディスバインジンによる統合失調症の病態解明研究2007

    • Author(s)
      橋本亮太
    • Organizer
      第103回日本精神神経学会総会
    • Place of Presentation
      高知
    • Related Report
      2007 Annual Research Report
  • [Book] 遺伝子医学MOOK(8)ペプチドと創薬(神経ペプチドPACAP-新しい創薬標的分子探索へ)2007

    • Author(s)
      馬場明道, 他
    • Publisher
      メデイカルドゥ
    • Related Report
      2008 Final Research Report
  • [Book] Keyword 精神第4版(PACAP欠損マウス)2007

    • Author(s)
      新谷紀人, 他
    • Publisher
      先端医学社
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b10/index.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/psy/www/jp/labo/sp/index.htm

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b010/index.html

    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/psy/www/jp/labo/sp/index.htm

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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