Vesicular Glutamate Transporter as Metabolic Regulator.

• Project/Area Number: 18390026
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Okayama University
• Principal Investigator: MORIYAMA Yoshinori Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Professor (10150658)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥17,060,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥1,560,000); Fiscal Year 2007: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2006: ¥10,300,000 (Direct Cost: ¥10,300,000)
• Keywords: Vesicular Glutamate Transporter / Glutamate / GABA / VGLUT / Purification / VGAT / Glycine / Reconstitution

Research Abstract

Vesicular glutamate transporter (VGLUT) and vesicular inhibitory amino acid transporter (VIAAT) are essential in glutamate- and GABA-mediated chemical transmission, respectively. Using biochemical, cellular biological and molecular biological approaches, we have elucidated structure, function and physiological significance of these transporters. The summaries of the results obtained in the studies are as follows:
(1) We revealed topology of VGLUT2.
(2) We established in vitro assay system for VGLUT using purified VGLUT and liposome, and revealed some essential amino acid residures for the transport and targeting.
(3) We identified essential amino acid residues with purified VIAAT.
Actually speaking VIAAT transports beta-alanine.
(4) We studied physiological significance of the glutamate signaling in the peripheral tissues using VGLUT1 KO mice. We found that osteoclasts secrete glutamate through transcytosis, and its defect caused osteoporosis.
(5) We found strong reversible inhibitors for VGLUT.
(6)We identified vesicular nucleotide transporter (VNUT) that is responsible for vesicular storage of ATP. This transporter seems to play a central role in purinergic neurotransmission.

Research Products

• [Journal Article] A novel variant of mouse MATE-1 H+/organic cation antiporter with a long hydrophobic tail. (2008)
  • Author(s): Kobara, A., Hiasa, M., Matsumoto, T., Otsuka, M., Omote, H., and Morivama. Y.
  • Journal Title: Arch. Biochem. Biophys. 469 Pages: 195-199
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Presence of aquaporin and V-ATPase on the contractile vacuole of Amoeba proteus. (2008)
  • Author(s): Nishihara, E., Yokota, E., Tazaki, A., Orii, II., Katsuhara, M., Kataoka, K., Igarashi, II., Moriyama, Y., Shimmen, T., and Sonobe, S.
  • Journal Title: Biol. Cell 100 Pages: 179-188
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of glutamate residues in substrate recognition by human MATE1 polyspecific H+/organic cation exporter. (2008)
  • Author(s): Matsumoto, T., Kanamoto, T., Otsuka, M., Omote, H., and Moriyama, Y.
  • Journal Title: Am. J. Physol. Cell Physiol. 294
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification of a vesicular nucleotide transporter. (2008)
  • Author(s): Sawada, K., Echigo, N., Juge, N., Miyaji, T., Otsuka, M., Omote, H., Yamamoto, A., and Moriyama, Y.
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 5683-5686
  • NAID: 120002306983
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] MATE-type proteins as anchor transporters for excretion of metabolic waste products and xenobiotics. (review) (2008)
  • Author(s): Moriyama, Y., Hiasa, M., Matsumoto, T., and Omote, H.
  • Journal Title: Xenobiotica (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Vesicular Neurotransmitter Transporter. (2008)
  • Author(s): Omote, H., and Moriyama, Y.
  • Journal Title: Encyclopedic Reference of Neuroscience (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 薬物排出のアンカートランスポーター,MATEの構造と機能 (2008)
  • Author(s): 日浅未来、表 弘志、森山芳則
  • Journal Title: 蛋白質・核酸・酵素 53,(1) Pages: 52-58
  • NAID: 40015771165
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 特集-続発性骨粗鬆症の最近の話題:破骨細胞のトランスサイトーシス小胞に局在するVGLUT1 (2008)
  • Author(s): 上原俊介、森山芳則、宇田川信之、小澤英浩
  • Journal Title: The Bone 22,(2) Pages: 113-117
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A novel variant of mouse MATE-1 H+/organic cation antiporter with a long hydrophobic tail (2008)
  • Author(s): Kobara, A., Hiasa, M., Matsumoto, T., Otsuka, M., Omote, H., Moriyama, Y
  • Journal Title: Arch. Biochem. Biophys 469 Pages: 195-199
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of glutamate residues in substrate recognition by human MATE1 polyspecific H+/organic cation exporter (2008)
  • Author(s): Matsumoto, T., Kanamoto, T., Otsuka, M., Omote, H., Moriyama, Y
  • Journal Title: Am. J. Physol. Cell Physiol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of a vesicular nucleotide transporter (2008)
  • Author(s): Sawada, K., Echigo, N., Juge, N., Miyaji, T., Otsuka, M., Omote, H., Yamamoto, A., Moriyama, Y
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 5683-5686
  • NAID: 120002306983
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Presence of aquaporin and V-ATPase on the contractile vacuole of Amoeba proteus (2008)
  • Author(s): Nishihara, E., Yokota, E., Tazaki, A., Orii, H., Katsuhara, M., Kataoka, K., Igarashi, H., Moriyama, Y., Shimmen, T., Sonobe, S
  • Journal Title: Biol. Cell 100 Pages: 179-188
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Vesicular Neurotransmitter Transporter (2008)
  • Author(s): Omote, H., Moriyama, Y
  • Journal Title: Encyclopedic Reference of Neuroscience (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] MATE-type proteins as anchor transporters for excretion of metabolic waste products and xenobiotics (2008)
  • Author(s): Moriyama, Y., Hiasa, M., Matsumoto, T., Omote, H
  • Journal Title: Xenobiotica (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A novel variant of mouse MATE-1 H+/organic cation antiporter with a long hydrophobic tail. (2008)
  • Author(s): Kobara, A., Hiasa, M., Matsumoto, T., Otsuka, M., Omote, H., and Moriyama, Y.
  • Journal Title: Arch. Biochem. Biophys. 469 Pages: 195-199
  • Peer Reviewed
• [Journal Article] Presence of aquaporin and V-ATPase on the contractile vacuole of Amoeba proteus. (2008)
  • Author(s): Nishihara, E., Yokota, E., Tazaki, A., Orii, H., Katsuhara, M., Kataoka, K., Igarashi, H., Morirama, Y., Shimmen, T., and Sonobe, S.
  • Journal Title: Biol. Cell 100 Pages: 179-188
  • Peer Reviewed
• [Journal Article] Role of glutamate residues in substrate recognition by human MATE1 polyspecific H+/organic cation exporter. (2008)
  • Author(s): Matsumoto, T., Kanamoto, T., Otsuka, M., Omote, H., and Moriyama, Y.
  • Journal Title: Am. J. Physol. Cell Physiol. (in press)
  • Peer Reviewed
• [Journal Article] Identification of a vesicular nucleotide transporter. (2008)
  • Author(s): Sawada, K., Echigo, N., Juge, N., Miyaji, T., Otsuka, M., Omote, H., Yamamoto, A., and Moriyama, Y.
  • Journal Title: Proc. Natl. Acad. Sci. USA (in press)
  • NAID: 120002306983
  • Peer Reviewed
• [Journal Article] Exocytosis of D-asparatate from INS-1E clonal β cells. (2007)
  • Author(s): Iharada, M., Hiasa, M., Kobara, A., and Moriyama, Y.
  • Journal Title: Biol. Pharm. Bull. 30,(7) Pages: 1329-1331
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Functional characterization of testis- specific rodent multidrug and toxic compound extrusion 2, a class III MATE-type polyspecific H+/organic cation exporter. (2007)
  • Author(s): Hiasa, M., Matsumoto, T., Komatsu, T., Omote, H., and Moriyama, Y.
  • Journal Title: Am. J. Physol. Cell Physiol. 293
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Vesicular storage in and secretion of D-aspartate from neuroendocrine cells. In D-amino acids: A new frontier in amino acid and protein research (2007)
  • Author(s): Uehara, S. and Moriyama, Y.
  • Journal Title: Editors: Ryuichi Konno, et. al., pp. 203-213; 2007 Nova Science Publishers, Inc. Pages: 203-213
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] グルタミン酸と骨粗鬆症-トランスポーターが明らかにした思いがけない関係 (2007)
  • Author(s): 森山芳則
  • Journal Title: 化学と生物 45 Pages: 80-81
  • NAID: 10018710915
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] グルタミン酸と骨粗鬆症との意外な関係 (2007)
  • Author(s): 森山芳則
  • Journal Title: 臨床検査 51,(6) Pages: 621-625
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 特集-骨形成と破壊:骨芽細胞と破骨細胞の相互作用 (2007)
  • Author(s): 上原俊介、森山芳則、宇田川信之
  • Journal Title: 生体の科学 58,(3) Pages: 181-185
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 特集-骨形成・骨吸収の最近のトピックスV:破骨細胞のトランスサイトーシスとグルタミン酸シグナル (2007)
  • Author(s): 上原俊介、宇田川信之、森山芳則
  • Journal Title: The Bone 21,(6) Pages: 747-750
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Exocytosis of D-asparatate from INS-1E clonal β cells (2007)
  • Author(s): Iharada, M., Hiasa, M., Kobara, A., Moriyama, Y
  • Journal Title: Biol. Pharm. Bull 30(7) Pages: 1329-1331
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional characterization of testis-specific rodent multidrug and toxic compound extrusion 2, a class III MATE-type polyspecific H+/organic cation exporter (2007)
  • Author(s): Hiasa, M., Matsumoto, T., Komatsu, T., Omote, H., Moriyama, Y
  • Journal Title: Am. J. Physol.Cell Physiol 293 Pages: 1437-1444
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Vesicular storage in and secretion of D-aspartate from neuroendocrine cells. In D-amino acids : A new frontier in amino acid and protein research (2007)
  • Author(s): Uehara, S., Moriyama, Y
  • Journal Title: Editors : Ryuichi Konno, et. al., Nova Science Publishers, Inc Pages: 203-213
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Exocytosis of D-asparatate from INS-IE clonal βcells. (2007)
  • Author(s): Iharada, M., Hiasa, M., Kobara, A., and Moriyama, Y.
  • Journal Title: Biol. Pharm. Bull. 30,(7) Pages: 1329-1331
  • Peer Reviewed
• [Journal Article] Functional characterization of testis-specific rodent multidrug and toxic compound extrusion 2, a class III MATE-type polyspecific H+/organic cation exporter. (2007)
  • Author(s): Hiasa, M., Matsumoto, T., Komatsu, T., Omote, H., and Moriyama, Y.
  • Journal Title: Am. J. Physol. Cell Physiol. 293
  • Peer Reviewed
• [Journal Article] Vesicular storage in and secretion of D-aspartate from neuroendocrine cells. In D-amino acids: A new frontier in amino acid and protein (2007)
  • Author(s): Uehara, S. and Moriyama, Y.
  • Journal Title: Editors: Ryuichi Konno, et. al., pp. 203-213; 2007 Nova Science Publishers, Inc. Pages: 203-213
  • Peer Reviewed
• [Journal Article] グルタミン酸と骨粗鬆症との意外な関係 (2007)
  • Author(s): 森山芳則
  • Journal Title: 臨床検査 51.(6) Pages: 621-625
  • Peer Reviewed
• [Journal Article] 特集-骨形成と破壊:骨芽細胞と破骨細胞の相互作用 (2007)
  • Author(s): 上原俊介、森山芳則、宇田川信之
  • Journal Title: 生体の科学 58.(3) Pages: 181-185
  • Peer Reviewed
• [Journal Article] Immunohistochemical localization of D-aspartate in islets of Langerhans. (2006)
  • Author(s): Hiasa, M., and Moriyama, Y.
  • Journal Title: Biol. Pharm. Bull. 29 Pages: 1251-1253
  • NAID: 110005602277
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations. (2006)
  • Author(s): Hiasa, M., Matsumoto, T., Komatsu, T., and Moriyama, Y.
  • Journal Title: Am. J. Physol. Cell Physiol. 291
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Secretion of L-glutamate from osteoclasts through transcytosis. (2006)
  • Author(s): Morimoto R, Uehara S, Yatsushiro S, Juge N, Hua Z, Senoh S, Echigo N, Hayashi M, Mizoguchi T, Ninomiya T, Udagawa N, Omoto H, Yamamoto A, Edwards RH, Moriyama Y
  • Journal Title: EMBO J. 25 Pages: 4175-4186
  • NAID: 120002306956
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. (2006)
  • Author(s): Omote, H., Hiasa, M., Matsumoto, T., Otsuka, M., and Moriyama, Y.
  • Journal Title: TRENDS in Pharmacol. Sci. 27 Pages: 587-593
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Vesicular glutamate transporter contains two independent transport machineries. (2006)
  • Author(s): Juge, N., Yoshida, Y., Yatsushiro, S., Omote, H., and Moriyama Y
  • Journal Title: J. Biol. Chem. 281 Pages: 39499-39506
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Molecular anatomy of a trafficking organelle. (2006)
  • Author(s): Takamori,S., Holt, M., Lemke.E., Riedec. D., Urlub, H., Scbcnck. S., S〓ins. K., 〓ger B., Ringler. P., 〓ki, Y., 〓ller. S., 〓G., Moriyama, Y., Heuser, J., Grubmuller. H., Heuser. J., Wieland, F., and Jahn. R.
  • Journal Title: Cell 127 Pages: 831-846
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Vesicular storage and secretion of L-glutamate from glucagon-like peptide l-secreting clonal intestianl L cells. (2006)
  • Author(s): Uehara. S., Jung S.K., Morimoto, R., Arioka. S., Miyaji, T., Juge, N. Hiasa. M., Shimizu, K., Ishimura. A., Otsuka. M., Yamamoto, A., Maechier, P., and Moriyama, Y.
  • Journal Title: J. Neurochem. 96 Pages: 550-560
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Vesicular storage and secretion of L-glutamate from glucagon-like peptide 1-secreting clonal intestinal L cells (2006)
  • Author(s): Uehara, S., Jung, S.K., Morimoto, R., Arioka, S., Miyaji, T., Juge, N., Hiasa, M., Shimizu, K., Ishimura, A., Otsuka, M., Yamamoto, A., Maechler, R., Moriyama, Y
  • Journal Title: J. Neurochem 96 Pages: 550-560
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Secretion of L-glutamate from osteoclasts through transcytosis (2006)
  • Author(s): Morimoto, R., Uehara, S., Yatsushiro, S., Juge, N., Hua, Z., Senoh, S., Echigo, N., Hayashi, M., Mizoguchi, T., Ninomiya, T., Udagawa, N., Omote, H., Yamamoto, A., Edwards, R.H., Moriyama, Y
  • Journal Title: EMBO 25 Pages: 4175-4186
  • NAID: 120002306956
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations (2006)
  • Author(s): Hiasa, M., Matsumoto, T., Komatsu, T., Moriyama, Y
  • Journal Title: Am. J. Physol. Cell Physiol 291 Pages: 678-686
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations (2006)
  • Author(s): Omote, H., Hiasa, M., Matsumoto, T., Otsuka, M., Moriyama, Y
  • Journal Title: TRENDS in Pharmacol. Sci 27 Pages: 587-593
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Vesicular glutamate transporter contains two independent transport machineries (2006)
  • Author(s): Juge, N., Yoshida, Y., Yatsushiro, S., Omote, H., Moriyama, Y
  • Journal Title: J. Biol. Chem 281 Pages: 39499-39506
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular anatomy of a trafficking organelle (2006)
  • Author(s): Takamori, S., Holt, M., Lemke, E., Riedel, D., Urlaub, H., Schenck, S., Stenius, K., Bruegger, B., Ringler, P., Krzyzaneki, V., Mueller, S., Rammner, B., Groot, B.D., Mieskes, G., Moriyama, Y., Klingauf, J., Grubmueller, H., Heuser, J., Wieland, F., Jahn, R
  • Journal Title: Cell 127 Pages: 831-846
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Immunohistochemical localization of D-aspartate in islets of Langerhans (2006)
  • Author(s): Hiasa, M., Moriyama, Y
  • Journal Title: Biol. Pharm. Bull 29 Pages: 1251-1253
  • NAID: 110005602277
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Immunohistochemical localization of D-aspartate in islets of Langerhans. (2006)
  • Author(s): Hiasa, M., Moriyama, Y.
  • Journal Title: Biol. Pharm. Bull. 29 Pages: 1251-1253
  • NAID: 110005602277
• [Journal Article] Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations. (2006)
  • Author(s): Hiasa, M., Matsumoto, T., Komura, T., Moriyama, Y.
  • Journal Title: Am. J. Physol. Cell Physiol. 291
• [Journal Article] Secretion of L-glutamate from osteoclasts through transcytosis. (2006)
  • Author(s): Morimoto, R., Uehara, S., Yatsushiro, S., Hua, Z., Juge, N., Senoh, S., Echigo, N., Hayashi, M., Mizoguchi, T., Ninomiya, T., Udagawa, N., Omote, H., Yamamoto, A., Edwards, R.H., Moriyama, Y.
  • Journal Title: EMBO J. 25 Pages: 4175-4186
  • NAID: 120002306956
• [Journal Article] The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. (2006)
  • Author(s): Omote, H., Hiasa, M., Matsumoto, T., Otsuka, M., Moriyama, Y.
  • Journal Title: TRENDS in Pharmacol. Sci. 27 Pages: 587-593
• [Journal Article] Vesicular glutamate transporter contains two independent transport machineries. (2006)
  • Author(s): Juge, N., Yoshida, Y., Yatsushiro, S., Omote, H., Moriyama, Y.
  • Journal Title: J. Biol. Chem. 281 Pages: 39499-39506
• [Journal Article] Molecular anatomy of a trafficking organelle. (2006)
  • Author(s): Takamori, S., Holt, M., Lemke, E., Riedel, D., Urlaub, H., Schenck, S., Stenius, K., Bruegger, B., Ringler, P., Krzyzaneki, V., Mueller, S., Rammner, B., Groot, B.D., Mieskes, G., Moriyama, Y., Klingauf, J., Grubmueller, H., Heuser, J., Wieland, F., Jahn, R.
  • Journal Title: Cell 127 Pages: 831-846
• [Journal Article] Vesicular storage and secretion of L-glutamate from glucagon-like peptide 1-secreting clonal intestinal L cells. (2006)
  • Author(s): Uehara, S., Jung, S.K., Morimoto, R., Arioka, S., Miyaji, T., Juge, N., Hiasa, M., Shimizu, K., Ishimura, A., Otsuka, M., Yamamoto, A., Maechler, P., Moriyama, Y.
  • Journal Title: J. Neurochem. 96 Pages: 550-560
• [Presentation] 小胞型神経伝達物質トランスポーターと消化管の機能制御 (2008)
  • Author(s): 森山芳則
  • Organizer: 日本薬学会第128年会, シンポジウム, オーガナイザーを兼ねる
  • Place of Presentation: パシィフィコ横浜
  • Year and Date: 2008-03-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Purification and reconstitution: A traditional technique illuminates the molecular mechanism of vesicular neurotransmitter transporters. (2007)
  • Author(s): 森山芳則
  • Organizer: 2007(H19年)第80回日本生化学会大会, 第30回日本分子生物学会年会, BMB2007, シンポジウム;トランスポーターの構造・作動機構と細胞機能
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Purification and reconstitution : A traditional technique illuminates the molecular mechanism of vesicular neurotransmitter transporters (2007)
  • Author(s): Yoshinori, Moriyama
  • Organizer: BMB
  • Place of Presentation: Yokohama
  • Year and Date: 2007-12-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Journey into the vesicular neurotransmitter transporters. (2007)
  • Author(s): 森山芳則
  • Organizer: 国際シンポジウム メンブレントラフィック
  • Place of Presentation: 淡路島 夢舞台
  • Year and Date: 2007-11-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] MATE: a mammalian transporter protein that mediate the final excretion step for toxic organic cations. (2007)
  • Author(s): Yoshinori Moriyama
  • Organizer: 4th WCDATD KANAZAWA(金沢)
  • Place of Presentation: 金沢EXCEL HOTEL TOKYU
  • Year and Date: 2007-06-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] MATE : a mammalian transporter protein that mediate the final excretion step for toxic organic cations (2007)
  • Author(s): Yoshinori, Moriyama, Takuya, Matsumoto, Miki, Hiasa, Yoshinori, Komatsu, Takuji, Kanamoto, Ayumi, Kobara, Masato, Otsuka, Hiroshi, Omote
  • Organizer: 4th WCDATD KANAZAWA EXCEL HOTEL TOKYO
  • Place of Presentation: Kanazawa
  • Year and Date: 2007-06-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] MATE: a mammalian transporter protein that mediate the final excretion step for toxic organic cations. (2007)
  • Author(s): Yoshinori Moriyama
  • Organizer: 4th WCDATD KANAZAWA (金沢)
  • Place of Presentation: 金沢EXCEL HOTEL TOKYU
  • Year and Date: 2007-06-20
• [Presentation] Use of VGLUT1 knockout mice to study peripheral glutamatergi systems. (2007)
  • Author(s): Noriko Echigo and Yoshinori Moriyama
  • Organizer: 国際シンポジウム メンブレントラフィック
  • Place of Presentation: 淡路島 夢舞台
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Use of VGLUT1 knockout mice to study peripheral glutamatergic systems. (2007)
  • Author(s): Noriko Echigo and Yoshinori Moriyama
  • Organizer: 国際シンポジウム メンブレントラフィック
  • Place of Presentation: 淡路島 夢舞台
• [Presentation] 小胞型グルタミン酸トランスポーターの部位指定的突然変異導入による機能解析 (2006)
  • Author(s): 樹下成信、福田麻衣子、表弘志、森山芳則
  • Organizer: 第一回トランスポーター研究会
  • Place of Presentation: 共立薬科大学
  • Year and Date: 2006-12-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞型グルタミン酸トランスポーター(VGLUT)の部位特異的変異導入による機能解析 (2006)
  • Author(s): 樹下成信、福田麻衣子、表弘志、森山芳則
  • Organizer: 日本生体エネルギー研究会 第32回討論会
  • Place of Presentation: 東京工業大学
  • Year and Date: 2006-12-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of transporter technology. (2006)
  • Author(s): Moriyama Y. and Omote H.
  • Organizer: International symposium of fifth 21st century COE "towards creating new industries based on inter-nanoscience"
  • Place of Presentation: 淡路島 夢舞台,the Awaji Yumebutai International Conference Center
  • Year and Date: 2006-12-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of transporter technology (2006)
  • Author(s): Moriyama, Y., Omote, H
  • Organizer: Int. sympo. of fifth 21st century COE. the Awaji Yumebutai Int.Confe. Cent
  • Place of Presentation: Hyogo
  • Year and Date: 2006-12-09
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 小胞型グルタミン酸トランスポーターの分泌小胞へのターゲット機構 (2006)
  • Author(s): 森山芳則
  • Organizer: メンブレントラフィック 分子機構から高次機能への展開 第4回全体班会議
  • Place of Presentation: 香川県小豆島・リゾートホテルオリビアン
  • Year and Date: 2006-11-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] MATE型トランスポーターは最も普遍的な有機カチオン・トランスポーターである(Anoverview) (2006)
  • Author(s): 森山芳則、表弘志、松本拓也、日浅未来、大塚正人
  • Organizer: 第28回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 静岡市 静岡県コンベンションアースセンター グランシップ
  • Year and Date: 2006-11-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Kinetic analysis of the purified vesicular glutamate transporter. (2006)
  • Author(s): Narinobu Juge, Maiko Fukuda, Masato Otsuka, Hiroshi Omote, Yoshinori Moriyama
  • Organizer: 三学会合同年会(第49回日本神経化学学会大会)
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2006-09-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Kinetic analysis of the purified vesicular glutamate transporter. (2006)
  • Author(s): Narinabu Juge, Maiko Fukuda, Masato Otsuka, Shouki Yatsushiro, Hiroshi Omote, and Yoshinori Morivama
  • Organizer: 第20回国際生化学・分子生物学会議(第79回日本生化学会大会), 20th IUBMB international congress of biochemistry and molecular biology and 11th FAOBMB congress.
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2006-06-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Kinetic analysis of the purified vesicular glutamate transporter (2006)
  • Author(s): Narinobu, Juge, Maiko, Fukuda, Masato, Otsuka, Shouki, Yatsushiro, Hiroshi, Omote, Yoshinori, Moriyama
  • Organizer: 20th IUBMB international congress of biochemistry and molecular biology,11th FAOBMB congress
  • Place of Presentation: Kyoto
  • Year and Date: 2006-06-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Patent(Industrial Property Rights)] 哺乳動物における新規SLC型(ATP)トランスポータータンパク質およびその利用 (2007)
  • Inventor(s): 森山芳則、表弘志、澤田啓介, 日浅未来
  • Industrial Property Rights Holder: 岡山大学
  • Industrial Property Number: 2007-095055
  • Filing Date: 2007-03-30
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 哺乳動物のアスパラギン酸トランスポータータンパク質およびその利用 (2007)
  • Inventor(s): 森山芳則、表弘志、宮地孝明, 日浅未来
  • Industrial Property Rights Holder: 岡山大学
  • Industrial Property Number: 2007-133435
  • Filing Date: 2007-05-18
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 哺乳動物のアスパラギン酸トランスポータータンパク質およびその利用 (2007)
  • Inventor(s): 森山芳則、表弘志、宮地孝明、日浅未来
  • Industrial Property Rights Holder: 岡山大学
  • Industrial Property Number: 2007-133435
  • Filing Date: 2007-05-18
• [Patent(Industrial Property Rights)] 哺乳動物における新規トランスポータータンパク質を含有するリポソーム組成物およびその利用 (2006)
  • Inventor(s): 森山芳則、日浅未来、松本拓也
  • Industrial Property Rights Holder: 岡山大学
  • Industrial Property Number: 2006-156458
  • Filing Date: 2006-06-05
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 哺乳動物における新規トランスポータータンパク質およびその利田 (2006)
  • Inventor(s): 森山芳則、表弘志
  • Industrial Property Rights Holder: 岡山大学
  • Industrial Property Number: 2006-275623
  • Filing Date: 2006-10-06
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 哺乳動物における新規トランスポータータンパク質およびその利用 (2006)
  • Inventor(s): 森山芳則、日浅未来、松本拓也
  • Industrial Property Rights Holder: 岡山大学
  • Filing Date: 2006-10-12
  • Description: 「研究成果報告書概要(和文)」より
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