| Budget Amount *help |
¥18,530,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2007: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2006: ¥4,100,000 (Direct Cost: ¥4,100,000)
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| Research Abstract |
Methylmercury is an organic metal that is contained in fish at high levels. Proteoglycans are macromolecules that consist of a core protein and glycosaminoglycan side chains. In this study, it was found that biological systems regulated by proteoglycans, including FGF-2 and VEGF systems, are important for the vascular toxicity of methylmercury. In addition, we proposed "Inflammatory hypothesis" as the pathogenesis of cerebellar damage caused by methylmercury.
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