Clinical application of the origanic anion transporter family
| Project/Area Number |
18390045
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
ABE Takaaki Tohoku University, Tohoku University Hospital, Lecturer (80292209)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥16,910,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2007: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2006: ¥9,500,000 (Direct Cost: ¥9,500,000)
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| Keywords | organic anion / transporter / cancer / LST-2 / drug delivery / オーダーメード医療 / 有機アニオントランスポーター / OATP-R / LST / 腎不全 / 抗癌剤 |
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| Research Abstract |
Human liver-specific organic anion transporter-2 (LST-2/OATP8/SLCO1B3) has been demonstrated to be expressed in various gastrointestinal carcinomas and also to play pivotal roles in the uptake of a wide variety of both endogenous and exogenous anionic compounds, including bile acids, conjugated steroids and hormones, into hepatocytes in the human liver. However, so far, the biological significance of LST-2 in human carcinomas remains unknown.
We examined the expression of LST-2 in 102 cases of breast carcinoma using immunohistochemistry and correlated the findings with various clinicopathological parameters in order to examine the possible biological and clinical significance of LST-2. LST-2 immunoreactivity was detected in 51 cases (50.0%); of these 51 positive cases, LST-2 immunoreactivity was inversely correlated with tumor size (P=0.0289). In addition, LST-2 immunoreactivity was significantly associated with a decreased risk of recurrence and improved prognosis by both univariate and multivariate analyses. In the estrogen receptor-positive groups, the LST-2-positive patients showed good prognoses. Considering that LST-2 transports estrone-3-sulfate, these results suggest that LST-2 overexpression is associated with a hormone-dependent growth mechanism of the breast cancer. The results of our present study demonstrate that LST-2 immunoreactivity is a potent prognostic factor in human breast cancer.
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Report
(3 results)
Research Products
(63 results)
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[Journal Article] Farnesoid X receptor, hepatocyte nuclear factors lalpha and 3beta are essential fortranscriptional activation of the liver-specific organic anion transporter-2 gene.2006
Author(s)
Ohtsuka H, Abe T, Onogawa T, Kondo N, Sato T, Oshio H, Mizutamari H, Mikkaichi T, Oikawa M, Rikiyama T, Katayose Y, Unno M.
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Journal Title
J Gastroenterol. 41
Pages: 369-369
Description
「研究成果報告書概要(和文)」より
Related Report
Peer Reviewed
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[Journal Article] Farnesoid X receptor, hepatocyte nuclear factors lalpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene2006
Author(s)
Ohtsuka H, Abe T, Onogawa T, Kondo N, Sato T, Oshio H, Mizutamari H, Mikkaichi T, Oikawa M, Rikiyama T, Katayose Y, Unno M
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Journal Title
J Gastroenterol 41
Pages: 369-369
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene.2006
Author(s)
Ohtsuka H, Abe T, Onogawa T, Kondo N, Sato T, Oshio H, Mizutamari H, Mikkaichi T, Oikawa M, Rikiyama T, Katayose Y, Unno M
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Journal Title
J Gastroenterol. 41
Pages: 369-369
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[Presentation] 甲状腺ホルモンと脳の発達機能2007
Author(s)
阿部高明
Organizer
第80回日本内分泌学会学術総会
Place of Presentation
東京国際フォーラム
Year and Date
2007-06-14
Description
「研究成果報告書概要(和文)」より
Related Report
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