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Application of functional recombinant HSAs as a DDS carrier

Research Project

Project/Area Number 18390051
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionKumamoto University

Principal Investigator

OTAGIRI Masaki  Kumamoto University, 大学院・医学薬学研究部, 教授 (80120145)

Co-Investigator(Kenkyū-buntansha) 赤池 孝章  熊本大学, 大学院・医学薬学研究部, 教授 (20231798)
丸山 徹  熊本大学, 薬学部, 教授 (90423657)
Co-Investigator(Renkei-kenkyūsha) AKAIKE Takaaki  熊本大学, 大学院・医学薬学研究部, 教授 (20231798)
MARUYAMA Toru  熊本大学, 薬学部, 教授 (90423657)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,330,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2006: ¥6,800,000 (Direct Cost: ¥6,800,000)
Keywordsヒト血清アルブミン / 遺伝子組換え型アルブミン / 異種タンパク質 / ドラッグデリバリーシステム / 担体 / 一酸化窒素 / 抗酸化能 / アルブミン / 遺伝子組換え技術 / チオレドキシン / 異型アルブミン / リガンド結合能 / 機能性アルブミン / 組換え体 / DDS / 生理活性 / 変異体 / S-ニトロソタンパク質 / 動態特性
Research Abstract

ヒト血清アルブミン(HSA)は、免疫原性や変異原性が少なく、長い血中滞留性を有するため、近年薬物のドラッグデリバリーシステム(DDS)の担体として期待されている。本研究により、HSAを用いた細胞保護・血管新生のシグナル分子である一酸化窒素(NO)の優れた生体内デリバリーに成功し、虚血再灌流障害での保護効果や抗癌効果も認められた。さらに、抗酸化タンパク質であるチオレドキシン(Trx)をHSAへ融合させ、高い血中滞留性と敗血症モデルマウスでの生存率改善を見出した。本知見は、担体としてのHSAの臨床応用を目指す上で重要な基礎資料になり得る。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (122 results)

All 2009 2008 2007 2006

All Journal Article (43 results) (of which Peer Reviewed: 37 results) Presentation (72 results) Book (1 results) Patent(Industrial Property Rights) (6 results)

  • [Journal Article] Pharmaceutically important pre-and posttranslational modifications on human serum albumin2009

    • Author(s)
      Otagiri M, Chuang VTG
    • Journal Title

      Biological and Pharmaceutical Bulletin 32(4)

      Pages: 527-34

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Study on binding of drug to serum protein2009

    • Author(s)
      Otagiri M
    • Journal Title

      Yakugaku Zasshi 129(4)

      Pages: 413-25

    • NAID

      110007230199

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered chain-length and glycosylation modify the pharmacokinetics of human serum albumin2009

    • Author(s)
      Iwao Y, Hiraike M, Kragh-Hansen U, Kawai K, Suenaga A, Maruyama T, Otagiri M
    • Journal Title

      Biochimica et Biophysica Acta -Proteins and Proteomics 1794(4)

      Pages: 634-41

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetics of single and repeated injection of hemoglobin-vesicles in hemorrhagic shock rat model2009

    • Author(s)
      Taguchi K, Maruyama T, Iwao Y, Sakai H, Kobayashi K, Horinouchi H, Tsuchida E, Kai T, Otagiri M
    • Journal Title

      J Controlled Release (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant effects of a dietary supplement : Reduction of indices of oxidative stress in normal subjects by water-soluble chitosan2009

    • Author(s)
      Anraku M, Fujii T, Furutani N, Kadowaki D, Maruyama T, Otagiri M, Gebicki JM, Tomida H
    • Journal Title

      Food and Chemical Toxicology 47(1)

      Pages: 104-9

    • NAID

      10024330157

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered chain-length and glycosylation modify the pharmacoki netics of human serum albumin.2009

    • Author(s)
      Yasunori Iwao
    • Journal Title

      Biochimica et Biophysica Acta - Proteins & Proteomics 1794(4)

      Pages: 634-641

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant effects of a dietary supplement : reduction of indices of oxidative stress in normal subjects by water-soluble chitosan.2009

    • Author(s)
      Makoto Anraku
    • Journal Title

      Food Chemical Toxicology. 47(1)

      Pages: 104-109

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetics of single and repeated injection of hemoglobin-vesicles in hemorrhagic shock rat model.2009

    • Author(s)
      Kazuaki Taguchi
    • Journal Title

      Journal of Controiled Release (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A site-directed mutagenesis study of drug-binding selectivity in genetic variants of human alpha(l)-acid glycoprctein.2009

    • Author(s)
      Koji Nishi
    • Journal Title

      Journal of Pharmaceutical Sciences (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered chain-length and glycosylation modify the pharmacokinetics of human serum albumin.2009

    • Author(s)
      Yasunori Iwao
    • Journal Title

      Biochimica et Biophysica Acta 1794(4)

      Pages: 634-641

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding2008

    • Author(s)
      Ishima Y, Akaike T, Kragh-Hansen U, Hiroyama S, Sawa T, Suenaga A, Maruyama T, Kai T, Otagiri M
    • Journal Title

      J Biol Chem 283(50)

      Pages: 34966-75

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD36 is one of important receptors promoting renal tubular injury by advanced oxidation protein products2008

    • Author(s)
      Iwao Y, Nakajou K, Nagai R, Kitamura K, Anraku M, Maruyama T, Otagiri M
    • Journal Title

      American Journal of Physiology-Renal Physiology 295(6)

    • NAID

      120005952926

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of intravenous iron administration frequency on AOPP and inflammatory biomarkers in chronic hemodialysis patients : A pilot study2008

    • Author(s)
      Anraku M, Kitamura K, Shintomo R, Takeuchi K, Ikeda H, Nagano J, Ko T, Mera K, Tomita K, Otagiri M
    • Journal Title

      Clin Biochem 41(14-15)

      Pages: 1168-74

    • NAID

      120005952925

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of uremic serum and uremic toxins on hepatic uptake of digoxin2008

    • Author(s)
      Tsujimoto M, Kinoshita Y, Hirata S, Otagiri M, Ohtani H, Sawada Y
    • Journal Title

      Ther Drug Monit 30(5)

      Pages: 576-82

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant protection of human serum albumin by chitosan2008

    • Author(s)
      Anraku M, Kabashima M, Namura H, Maruyama T, Otagiri M, Gebicki JM, Furutani N, Tomida H
    • Journal Title

      Int J Biol Macromol 43(2)

      Pages: 159-64

    • NAID

      120005952924

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Design and evaluation of S-nitrosylated human serum albumin as a novel anticancer drug2008

    • Author(s)
      Katayama N, Nakajou K, Komori H, Uchida K, Yokoe J, Yasui N, Yamamoto H, Kai T, Sato M, Nakagawa T, Takeya M, Maruyama T, Otagiri M
    • Journal Title

      J Pharmacol Exp Ther 325(1)

      Pages: 69-76

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Subdomain IIIA of dog albumin contains a binding site similar to site II of human albumin2008

    • Author(s)
      Kaneko K, Fukuda H, Chuang VTG, Yamasaki K, Kawahara K, Nakayama H, Suenaga A, Maruyama T, Otagiri M
    • Journal Title

      Drug Metab Disposition 36(1)

      Pages: 81-6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding2008

    • Author(s)
      Yu Ishima
    • Journal Title

      The Journal of Biological Chemistry 283(50)

      Pages: 34966-34975

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subdomain IIIA of dog albumin contains a binding site similar to site II of human albumin.2008

    • Author(s)
      Ken-ichi Kaneko
    • Journal Title

      Drug Metabolism and Disposition 36(1)

      Pages: 81-86

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD36 is one of important receptors promoting renal tubular injury by advanced oxidation protein products.2008

    • Author(s)
      Yasunori Iwao
    • Journal Title

      The American Journal of Physiology - Renal Physiology 295(6)

      Pages: 1871-1880

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant protection of human serum albumin by chitosan.2008

    • Author(s)
      Makoto Anraku
    • Journal Title

      International Journal of Biological Macromolecules 43(2)

      Pages: 159-164

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and evaluation of S-nitrosylated human serum albumin as a novel anticancer drug.2008

    • Author(s)
      Naoki Katayama
    • Journal Title

      The Journal of Pharmacology and Experimental Therapeutics 325(1)

      Pages: 69-76

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and evaluation of S-nitrosylated human serum albulmin (SNO-HSA) as anovel anticancer drug2008

    • Author(s)
      Naohisa Katayama
    • Journal Title

      The Journal of Pharmacology and Experimental Therapeutics 325(1)

      Pages: 69-76

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of endogenous ligands on the biological role of human serum albumin in S-nitrosylation2007

    • Author(s)
      Ishima Y, Akaike T, Kragh-Hansen U, Hiroyama S, Sawa T, Maruyama T, Kai T, Otagiri M
    • Journal Title

      Biochem Biophys Res Commun 364(4)

      Pages: 790-5

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes of net charge and α-helical content affect the pharmacokinetic properties of human serum albumin2007

    • Author(s)
      Iwao Y, Hiraike M, Kragh-Hansen U, Mera K, Noguchi T, Anraku M, Kawai K, Maruyama T, Otagiri M
    • Journal Title

      Biochimica et Biophysica Acta-Proteins and Proteomics 1774(12)

      Pages: 1582-90

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural and ligand-binding properties of serum albumin species interacting with a biomembrane interface2007

    • Author(s)
      Kosa T, Nishi K, Maruyama T, Sakai N, Yonemura N, Watanabe H, Suenaga A, Otagiri M
    • Journal Title

      J Pharm Sci 96(11)

      Pages: 3117-24

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recombinant human serum albumin2007

    • Author(s)
      Chuang VTG, Otagiri M
    • Journal Title

      Drugs of Today 43(8)

      Pages: 547-61

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of pathways of advanced glycation end-products accumulation in macrophages2007

    • Author(s)
      Nagai R, Fujiwara Y, Mera K, Otagiri M
    • Journal Title

      Molecular Nutrition and Food Research 51(4)

      Pages: 462-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] S-nitrosylation of human variant albumin liprizzi(R410C)confers potent antibacterial and cytoprotective properties2007

    • Author(s)
      Ishima Y, Sawa T, Kragh-Hansen U, Miyamoto Y, Matsushita S, Akaike T, Otagiri M
    • Journal Title

      J Pharmacol Exp Ther 320(3)

      Pages: 969-77

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of N-acetyl-methioninate as a new stabilizer for albumin products2007

    • Author(s)
      Anraku M, Kouno Y, Kai T, Tsurusaki Y, Yamasaki K, Otagiri M
    • Journal Title

      Int J Pharm 329(1-2)

      Pages: 19-24

    • NAID

      120005894408

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recombinant human serum albumin2007

    • Author(s)
      Tuan Giam Chuang
    • Journal Title

      Drugs Today 43(8)

      Pages: 547-561

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of endogenous ligands on the biological role of human serum albumin in S-nitrosylation2007

    • Author(s)
      Yu Ishima
    • Journal Title

      Biochemical and Biophysical Research Communications 364(4)

      Pages: 790-795

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S-Nitrosylation of Human Variant Albumin Liprizai (R410C) Confers Potent Antibacterial and Cytoprotective Properties.2007

    • Author(s)
      Ishima Y et al.
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics 320・3

      Pages: 969-77

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The role of N-acetyl-methioninate as a new stabilizer for albumin products.2007

    • Author(s)
      Anraku M et al.
    • Journal Title

      International Journal of Pharmaceutics 329・1-2

      Pages: 19-24

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Chain length-dependent binding of fatty acid anions to human serum albumin studied by site-directed mutagenesis2006

    • Author(s)
      Kragh-Hansen U, Watanabe H, Nakajou K, Iwao Y, Otagiri M
    • Journal Title

      J Mol Biol 363(3)

      Pages: 702-12

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recombinant human serum albumin dimer has high blood circulation activity and low vascular permeability in comparison with native human serum albumin2006

    • Author(s)
      Matsushita S, Chuang VTG, Kanazawa M, Tanase S, Kawai K, Maruyama T, Suenaga A, Otagiri M
    • Journal Title

      Pharm Res 23(5)

      Pages: 882-91

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidation of arg-410 promotes the elimination of human serum albumin2006

    • Author(s)
      Iwao Y, Anraku M, Yamasaki K, Kragh-Hansen U, Kawai K, Maruyama T, Otagiri M
    • Journal Title

      Biochimica et Biophysica Acta - Proteins and Proteomics 1764(4)

      Pages: 743-9

    • NAID

      120005499993

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The structural and pharmacokinetic properties of oxidized human serum albumin, advanced oxidation protein products(AOPP)2006

    • Author(s)
      Iwao Y, Anraku M, Hiraike M, Kawai K, Nakajou K, Kai T, Suenaga A, Otagiri M
    • Journal Title

      Drug Metabolism and Pharmacokinetics 21(2)

      Pages: 140-6

    • NAID

      120005499992

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective binding of human serum albumin2006

    • Author(s)
      Chuang VTG, Otagiri M
    • Journal Title

      Chirality 18(3)

      Pages: 159-66

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chain length-dependent binding of fatty acid anions to human serum albumin studied by site-directed mutagenesis.2006

    • Author(s)
      Kragh-Hansen U et al.
    • Journal Title

      Journal of Molecular Biology 363・3

      Pages: 702-12

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Recombinant human serum albumin dimer has high blood circulation activity and low vascular permeability in comparison with native human serum albumin.2006

    • Author(s)
      Matsushita S et al.
    • Journal Title

      Pharmaceutical Research 23・5

      Pages: 882-91

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Oxidation of Arg-410 promotes the elimination of human serum albumin.2006

    • Author(s)
      Iwao Y et al.
    • Journal Title

      Biochimica et Biophysica Acta 1764・4

      Pages: 743-9

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Involvement of disulfide bonds and histidine 172 in a unique beta-sheet to alpha-helix transition of alpha 1-acid glycoprotein at the biomembrane interface.2006

    • Author(s)
      Nishi K et al.
    • Journal Title

      Proteins 63・3

      Pages: 611-20

    • Related Report
      2006 Annual Research Report
  • [Presentation] 新規血液浄化法の開発を目的としたファージディスプレイ法を用いた高親和ビリルビン捕獲型アルブミン変異体の探索2009

    • Author(s)
      蓑毛藍
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] NMRスペクトル法によるアルブミン分子のN-B転移の機構解明2009

    • Author(s)
      渡健太
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗酸化能に富むアルブミンの設計:抗酸化活性に関与するアミノ酸残基の探索2009

    • Author(s)
      末永綾香
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 低分子抗癌剤のDDS担体としての組換え型アルブミン二量体の有用性2009

    • Author(s)
      異島優
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] DDSキャリアーとしてのネオグリコアルブミンの各種肝障害に対する有用性評価2009

    • Author(s)
      平田憲史郎
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト血清アルブミンの薬物結合能に及ぼす中間体アルデヒド修飾の影響2009

    • Author(s)
      米良克美
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 人工酸素運搬体ヘモグロビン小胞体(HbV)の頻回投与時における体内動態特性2009

    • Author(s)
      田口和明
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 組換え型糖鎖付加アルブミンの肝ターゲティング担体としての有用性.2008

    • Author(s)
      平田憲史郎
    • Organizer
      第25回 日本薬学会九州支部大会
    • Place of Presentation
      九州保健福祉大学, 宮崎
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] DDS担体としての組換え型アルブミン二量体の有用性評価.2008

    • Author(s)
      陳 迪
    • Organizer
      第25回 日本薬学会九州支部大会
    • Place of Presentation
      九州保健福祉大学, 宮崎
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト血清アルブミンの抗酸化活性に関与するアミノ酸残基の探索.2008

    • Author(s)
      山田 純嗣
    • Organizer
      第25回 日本薬学会九州支部大会
    • Place of Presentation
      九州保健福祉大学, 宮崎
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] NMRを用いたアルブミン分子におけるN-B転移の機構解明.2008

    • Author(s)
      渡健太
    • Organizer
      第25回 日本薬学会九州支部大会
    • Place of Presentation
      九州保健福祉大学, 宮崎
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肝細胞膜上におけるα1-酸性糖タンパク質と hemoglobin b-chainの相互作用解析.2008

    • Author(s)
      小森 久和
    • Organizer
      第25回 日本薬学会九州支部大会
    • Place of Presentation
      九州保健福祉大学, 宮崎
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒトα1-酸性糖タンパク質の薬物結合特性におけるペプチド部分の重要性2008

    • Author(s)
      小野知実
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館(熊本)
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 糖鎖付加アルブミンの肝ターゲティング担体としての有用性評価2008

    • Author(s)
      平田憲史郎
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館(熊本)
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 家族性ポリアミロイドニューロパチーにおけるアルブミンの抗酸化作用2008

    • Author(s)
      釘宮智江
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館(熊本)
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] SNO-HSAによる細胞内NO輸送機構の解明2008

    • Author(s)
      吉田芙美香
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館(熊本)
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] alpha1-acid glycoprotein(AGP)と細胞膜上のhemoglobin beta chainの相互作用はAGPの肝取り込みに関与する2008

    • Author(s)
      小森久和
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館(熊本)
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 連続投与時におけるヘモグロビン小胞体の体内動態評価2008

    • Author(s)
      田口和明
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館(熊本)
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 脂肪酸はS-ニトロソ化ヒト血清アルブミンによるS-ニトロソ転位反応の新規制御因子になり得る2008

    • Author(s)
      異島優
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館(熊本)
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒトα1-酸性糖タンパク質の薬物結合特性におけるペプチド部分の重要性.2008

    • Author(s)
      小野 知実
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館, 熊本
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 糖鎖付加アルブミンの肝夕-ゲティング担体としての有用性評価.2008

    • Author(s)
      平田憲史郎
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館, 熊本
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 家族性ポリアミロイドニューロパチーにおけるアルブミンの抗酸化作用.2008

    • Author(s)
      釘宮 智江
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館, 熊本
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] SNO-HSAによる細胞内NO輸送機構の解明.2008

    • Author(s)
      吉田 芙美香
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館, 熊本
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] alphal-acid glycoprotein (AGP)と細胞膜上の hemoglobin beta chain の相互作用はAGPの肝取り込みに関与する.2008

    • Author(s)
      小森 久和
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館, 熊本
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 連続投与時におけるヘモグロビン小胞体の体内動態評価.2008

    • Author(s)
      田口 和明
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館, 熊本
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脂肪酸はS-ニトロソ化ヒト血清アルブミンによるS-ニトロソ転位反応の新規制御因子になり得る.2008

    • Author(s)
      異島 優
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館, 熊本
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脂肪酸結合によりSNO-HSAの細胞保護効果は増強する2008

    • Author(s)
      異島優
    • Organizer
      第30回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2008-08-07
    • Related Report
      2008 Final Research Report
  • [Presentation] 脂肪酸結合によりSNO-HSAの細胞保護効果は増強する.2008

    • Author(s)
      異島 優
    • Organizer
      第30回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      札幌コンベンションセンター, 札幌
    • Year and Date
      2008-08-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規抗癌物質としてのS-ニトロソ化アルブミンの設計と評価2008

    • Author(s)
      異島優
    • Organizer
      第24回日本DDS学会
    • Place of Presentation
      六本木アカデミーヒルズ40(東京)
    • Year and Date
      2008-06-29
    • Related Report
      2008 Final Research Report
  • [Presentation] ネオグリコアルブミンの肝ターゲッティング素材としての有用性について2008

    • Author(s)
      平田憲史郎
    • Organizer
      第24回日本DDS学会
    • Place of Presentation
      六本木アカデミーヒルズ40(東京)
    • Year and Date
      2008-06-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 新規抗癌物質としてのS-ニトロソ化アルブミンの設計と評価.2008

    • Author(s)
      異島 優
    • Organizer
      第24回日本DDS学会
    • Place of Presentation
      六本木アカデミーヒルズ40, 東京
    • Year and Date
      2008-06-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] ネオグリコアルブミンの肝ターゲッティング素材としての有用性について.2008

    • Author(s)
      平田憲史郎
    • Organizer
      第24回日本DDS学会
    • Place of Presentation
      六本木アカデミーヒルズ40, 東京
    • Year and Date
      2008-06-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Further study on pharmacokinetics of hemoglobin-vesicles in a rat model of hemorrhagic shock2008

    • Author(s)
      Taguchi K
    • Organizer
      2nd Asian Pacific Regional Meeting
    • Place of Presentation
      Shanghai(China)
    • Year and Date
      2008-05-11
    • Related Report
      2008 Final Research Report
  • [Presentation] The pharmacokinetic properties of AGE-proteins is dependent on their rate of modification by AGEs2008

    • Author(s)
      Mera K
    • Organizer
      2nd Asian Pacific Regional Meeting
    • Place of Presentation
      Shanghai(China)
    • Year and Date
      2008-05-11
    • Related Report
      2008 Final Research Report
  • [Presentation] S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acids binding2008

    • Author(s)
      Ishima Y
    • Organizer
      2nd Asian Pacific Regional Meeting
    • Place of Presentation
      Shanghai(China)
    • Year and Date
      2008-05-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 簡便なS-ニトロソ化アルブミン製剤の調製について2008

    • Author(s)
      廣山秀一
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 光アフィニティラベル法を用いたアルブミン分子におけるN-B転移の機構解明2008

    • Author(s)
      金子健一
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 細胞膜上での一酸化窒素放出における脂肪酸結合の影響2008

    • Author(s)
      異島優
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 腫瘍細胞に対するS-ニトロソアルブミン(NO-HAS)のアポトーシス誘導効果2008

    • Author(s)
      片山直久
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] アルブミン-チオレドキシン融合タンパク質の体内動態と生理作用について2008

    • Author(s)
      中城圭介
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 出血性ショック時におけるヘモグロビン小胞体の体内動態解析2008

    • Author(s)
      田口和明
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] ネオグリコアルブミンの肝ターゲティング素材としての有用性について2008

    • Author(s)
      平田憲史郎
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 薬学会賞受賞講演, 血清タンパク質の分子薬剤学的解明と医薬への応用2008

    • Author(s)
      小田切優樹
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2008-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 血清タンパク質の分子薬剤学的解明と医薬への応用2008

    • Author(s)
      小田切 優樹
    • Organizer
      日本薬学会 (薬学会賞受賞講演)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 虚血再灌流障害を伴う臓器移植や虚血疾患に対するNOトラフィックタンパク質製剤開発について2008

    • Author(s)
      異島優
    • Organizer
      薬学研究フォーラムin東京2008
    • Place of Presentation
      長井記念会館(東京)
    • Year and Date
      2008-03-14
    • Related Report
      2008 Final Research Report
  • [Presentation] チオレドキシン-アルブミン融合タンパク質の設計と機能評価2007

    • Author(s)
      生田祥太郎
    • Organizer
      第24回日本薬学会九州支部大会
    • Place of Presentation
      第一薬科大学(福岡)
    • Year and Date
      2007-12-09
    • Related Report
      2008 Final Research Report
  • [Presentation] 人工酸素運搬体ヘモグロビン小胞体の出血時における体内動態特性評価2007

    • Author(s)
      田口和明
    • Organizer
      第24回日本薬学会九州支部大会
    • Place of Presentation
      第一薬科大学(福岡)
    • Year and Date
      2007-12-09
    • Related Report
      2008 Final Research Report
  • [Presentation] NOトラフィックタンパク質としてのアルブミンの有用性2007

    • Author(s)
      廣山秀一
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2007-11-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 血中滞留性の向上を目的としたチオレドキシン・アルブミン融合タンパクの設計と評価2007

    • Author(s)
      生田祥一郎
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2007-11-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Subdomain IIIa of dog albumin contains a binding site similar to site II of human albumin2007

    • Author(s)
      Kaneko K
    • Organizer
      3rd Scientific Meeting of the Asian Association of School of Pharmacy
    • Place of Presentation
      School of Pharmacy, Centro Escolar University, Manila(the Philippines)
    • Year and Date
      2007-10-25
    • Related Report
      2008 Final Research Report
  • [Presentation] Human serum albumin in S-nitrosylation and S-transnitrosylation2007

    • Author(s)
      Ishima Y
    • Organizer
      3rd Scientific Meeting of the Asian Association of School of Pharmacy
    • Place of Presentation
      School of Pharmacy, Centro Escolar University, Manila(the Philippines)
    • Year and Date
      2007-10-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 出血性ショック時におけるヘモグロビン小胞体の体内動態特性2007

    • Author(s)
      田口和明
    • Organizer
      第14回血液代替物学会年次大会
    • Place of Presentation
      慶應義塾大学(東京)
    • Year and Date
      2007-06-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 異型アルブミンを利用した低抗原性DDS担体の開発2007

    • Author(s)
      米良克美
    • Organizer
      日本薬剤学会第22年会
    • Place of Presentation
      大宮ソニックシティー(埼玉)
    • Year and Date
      2007-05-23
    • Related Report
      2008 Final Research Report
  • [Presentation] イヌアルブミン分子上の薬物結合部位のトポロジー解析2007

    • Author(s)
      金子健一
    • Organizer
      日本薬剤学会第22年会
    • Place of Presentation
      大宮ソニックシティー(埼玉)
    • Year and Date
      2007-05-23
    • Related Report
      2008 Final Research Report
  • [Presentation] 内因性リガンド結合によるヒト血清アルブミンのS-ニトロソ化制御機構の解明2007

    • Author(s)
      異島優
    • Organizer
      日本薬剤学会第22年会
    • Place of Presentation
      大宮ソニックシティー(埼玉)
    • Year and Date
      2007-05-23
    • Related Report
      2008 Final Research Report
  • [Presentation] The role of 34cys of human serum albumin for oxidative stress on iron administrated hemodialysis patients2007

    • Author(s)
      Suenaga A
    • Organizer
      3rd Pharmaceutical Sciences World Congress
    • Place of Presentation
      Amsterdam(the Netherlands)
    • Year and Date
      2007-04-24
    • Related Report
      2008 Final Research Report
  • [Presentation] S-Nitrosylation of human variant albumin Liprizzi(R410C)confers potent antibacterial and cytoprotective properties2007

    • Author(s)
      Ishima Y
    • Organizer
      3rd Pharmaceutical Sciences World Congress
    • Place of Presentation
      Amsterdam(the Netherlands)
    • Year and Date
      2007-04-24
    • Related Report
      2008 Final Research Report
  • [Presentation] The elimination of serum albumin is dependent on its conformational stability2007

    • Author(s)
      Iwao Y
    • Organizer
      3rd Pharmaceutical Sciences World Congress
    • Place of Presentation
      Amsterdam(the Netherlands)
    • Year and Date
      2007-04-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 内因性リガンド結合が及ぼすヒト血清アルブミンのS-ニトロソ化効率への影響2007

    • Author(s)
      異島優
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2007-03-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 腎透析患者への鉄剤投与時の酸化ストレスにおけるヒト血清アルブミン34Cys の役割2007

    • Author(s)
      末永綾香
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2007-03-30
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト血清アルブミンの一残基変異が及ぼす構造・動態特性への影響2007

    • Author(s)
      岩尾康範
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2007-03-30
    • Related Report
      2008 Final Research Report
  • [Presentation] α1-酸性糖タンパク質(AGP)の肝実質細胞取り込みにおけるヘモグロビンβサブユニットの関与2007

    • Author(s)
      丸山徹
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2007-03-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 糖鎖含有アルブミンの肝臓ターゲティング素材としての有用性評価2007

    • Author(s)
      平田憲史郎
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2007-03-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 血液透析患者の酸化ストレスにおいてヒト血清アルブミンの34CYS は重要なアミノ酸残基として機能する2006

    • Author(s)
      竹内耕治
    • Organizer
      日本薬物動態学会第21回年会
    • Place of Presentation
      江戸川区総合区民ホール(東京)
    • Year and Date
      2006-11-29
    • Related Report
      2008 Final Research Report
  • [Presentation] α1-酸性糖タンパク質(AGP)の肝実質細胞への取り込みにおけるヘモグロビンβサブユニットの関与2006

    • Author(s)
      上原奈緒
    • Organizer
      日本薬物動態学会第21回年会
    • Place of Presentation
      江戸川区総合区民ホール(東京)
    • Year and Date
      2006-11-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 糖鎖付加組換え型アルブミンの肝臓特異的DDS担体としての評価2006

    • Author(s)
      平田憲史郎
    • Organizer
      日本薬物動態学会第21回年会
    • Place of Presentation
      江戸川区総合区民ホール(東京)
    • Year and Date
      2006-11-29
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト血清アルブミンの構造変化は体内動態に影響を及ぼす2006

    • Author(s)
      平池美香子
    • Organizer
      日本薬物動態学会第21回年会
    • Place of Presentation
      江戸川区総合区民ホール(東京)
    • Year and Date
      2006-11-29
    • Related Report
      2008 Final Research Report
  • [Presentation] イヌアルブミン分子上の薬物結合部位のトポロジー解析2006

    • Author(s)
      金子健一
    • Organizer
      日本薬物動態学会第21回年会
    • Place of Presentation
      江戸川区総合区民ホール(東京)
    • Year and Date
      2006-11-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 内因性リガンド結合によるS-ニトロソ化ヒト血清アルブミンの肝ターゲッティング2006

    • Author(s)
      異島優
    • Organizer
      第28回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      グランシップ(静岡)
    • Year and Date
      2006-11-10
    • Related Report
      2008 Final Research Report
  • [Presentation] 酸化修飾アルブミンはCD36を介して尿細管間質障害を引き起こす2006

    • Author(s)
      岩尾康範
    • Organizer
      第28回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      グランシップ(静岡)
    • Year and Date
      2006-11-10
    • Related Report
      2008 Final Research Report
  • [Presentation] S-ニトロソ化ヒト血清アルブミンの調製と評価2006

    • Author(s)
      廣山秀一
    • Organizer
      第13回血液代替物学会年次大会
    • Place of Presentation
      慶応義塾大学(東京)
    • Year and Date
      2006-08-25
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスにおけるヘモグロビン小胞体構成脂質の体内動態解析2006

    • Author(s)
      田口和明
    • Organizer
      第13回血液代替物学会年次大会
    • Place of Presentation
      慶応義塾大学(東京)
    • Year and Date
      2006-08-25
    • Related Report
      2008 Final Research Report
  • [Book] RIの逆襲 : アイソトープを活用した簡単・安全バイオ実験2007

    • Author(s)
      安楽誠, 末永綾香, 小田切優樹
    • Publisher
      秀潤社
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 高リガンド親和性アルブミン変異体の製造方法2009

    • Inventor(s)
      蓑毛藍ら
    • Industrial Property Rights Holder
      ニプロ株式会社
    • Industrial Property Number
      2009-019238
    • Filing Date
      2009-01-30
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] S-ニトロソ基含有アルブミン及びその製造方法ならびに抗がん剤2009

    • Inventor(s)
      小田切優樹, ら
    • Industrial Property Rights Holder
      ニプロ株式会社
    • Patent Publication Number
      2009-057318
    • Acquisition Date
      2009-03-19
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 融合タンパク質、該融合タンパク質に関連する遺伝子、ベクター、形質転換体及び抗炎症性医薬組成物2009

    • Inventor(s)
      小田切優樹, ら
    • Industrial Property Rights Holder
      ニプロ株式会社
    • Patent Publication Number
      2009-055838
    • Acquisition Date
      2009-03-19
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 脂肪酸を含有するS-ニトロソタンパク質とその製法2008

    • Inventor(s)
      異島優, ら
    • Industrial Property Rights Holder
      ニプロ株式会社
    • Patent Publication Number
      2008-050294
    • Acquisition Date
      2008-03-06
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 糖鎖含有アルブミン、その製造方法およびその用途2008

    • Inventor(s)
      中城圭介ら
    • Industrial Property Rights Holder
      ニプロ株式会社
    • Patent Publication Number
      2008-043285
    • Acquisition Date
      2008-02-28
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 血清アルブミン多量体を含む遺伝子組換え型蛋白質2006

    • Inventor(s)
      小田切優樹ら
    • Industrial Property Rights Holder
      ニプロ株式会社
    • Patent Publication Number
      2006-238788
    • Acquisition Date
      2006-09-14
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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